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Jeffrey A Leppo MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
Address777 North Street
Pittsfield MA 01201
Phone413-395-7580
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine


    Collapse Biography 
    Collapse education and training
    University of Rochester, Rochester, NY, United StatesABMedicine
    State University of New York Downstate Medical College, Brooklyn, NY, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Leppo JA. ASNC at 25. J Nucl Cardiol. 2018 Nov 09. PMID: 30414059.
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    2. Arrighi JA, Leppo JA. ASNC president's page (2013) : ASNC's past, present, and future at 20 years: reflections from the 1st and 20th presidents. J Nucl Cardiol. 2013 Dec; 20(6):1188-90. PMID: 24142262.
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    3. Wackers FJ, Leppo JA. The origins and early years of the American Society of Nuclear Cardiology. J Nucl Cardiol. 2013 Feb; 20(1):6-16. PMID: 23229647.
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    4. Hendel RC, Abbott BG, Bateman TM, Blankstein R, Calnon DA, Leppo JA, Maddahi J, Schumaecker MM, Shaw LJ, Ward RP, Wolinsky DG. The role of radionuclide myocardial perfusion imaging for asymptomatic individuals. J Nucl Cardiol. 2011 Feb; 18(1):3-15. PMID: 21181519.
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    5. Leppo JA. Is more imaging better than less? J Nucl Cardiol. 2009 Nov-Dec; 16(6):849-50. PMID: 19669851.
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    6. Leppo JA. Seventh annual Mario S. Verani, MD Memorial Lecture: "ASNC and integrating cardiac imaging". J Nucl Cardiol. 2009 Mar-Apr; 16(2):184-92. PMID: 19219522.
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    7. Mutlu H, Demir IE, Leppo J, Levy WK. Nonsurgical management of a left ventricular pedunculated papillary fibroelastoma: a case report. J Am Soc Echocardiogr. 2008 Jul; 21(7):877.e4-7. PMID: 18191538.
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    8. Mutlu H, Leppo J. Coronary steal and ST elevation during dipyridamole stress testing leading to coronary artery bypass grafting. J Nucl Cardiol. 2007 Nov-Dec; 14(6):892-7. PMID: 18022117.
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    9. Feng B, Pretorius PH, Farncombe TH, Dahlberg ST, Narayanan MV, Wernick MN, Celler AM, Leppo JA, King MA. Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime. J Nucl Cardiol. 2006 May-Jun; 13(3):354-61. PMID: 16750780.
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    10. Kupinski MA, Hoppin JW, Krasnow J, Dahlberg S, Leppo JA, King MA, Clarkson E, Barrett HH. Comparing cardiac ejection fraction estimation algorithms without a gold standard. Acad Radiol. 2006 Mar; 13(3):329-37. PMID: 16488845.
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    11. Hendel RC, Bateman TM, Cerqueira MD, Iskandrian AE, Leppo JA, Blackburn B, Mahmarian JJ. Initial clinical experience with regadenoson, a novel selective A2A agonist for pharmacologic stress single-photon emission computed tomography myocardial perfusion imaging. J Am Coll Cardiol. 2005 Dec 6; 46(11):2069-75. PMID: 16325044.
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    12. Pretorius PH, King MA, Gifford HC, Dahlberg ST, Spencer F, Simon E, Rashkin J, Botkin N, Berndt W, Narayanan MV, Leppo JA. Myocardial perfusion SPECT reconstruction: receiver operating characteristic comparison of CAD detection accuracy of filtered backprojection reconstruction with all of the clinical imaging information available to readers and solely stress slices iteratively reconstructed with combined compensation. J Nucl Cardiol. 2005 May-Jun; 12(3):284-93. PMID: 15944533.
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    13. Narayanan MV, King MA, Pretorius PH, Dahlberg ST, Spencer F, Simon E, Ewald E, Healy E, MacNaught K, Leppo JA. Human-observer receiver-operating-characteristic evaluation of attenuation, scatter, and resolution compensation strategies for (99m)Tc myocardial perfusion imaging. J Nucl Med. 2003 Nov; 44(11):1725-34. PMID: 14602852.
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    14. Leppo J. Imaging cell injury and death. Curr Cardiol Rep. 2003 Jan; 5(1):40-4. PMID: 12493159.
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    15. Dahlberg S, Leppo J. Risk stratification of the normal perfusion scan: does normal stress perfusion always mean very low risk? J Nucl Cardiol. 2003 Jan-Feb; 10(1):87-91. PMID: 12569336.
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    16. Eagle KA, Berger PB, Calkins H, Chaitman BR, Ewy GA, Fleischmann KE, Fleisher LA, Froehlich JB, Gusberg RJ, Leppo JA, Ryan T, Schlant RC, Winters WL, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Gregoratos G, Jacobs AK, Hiratzka LF, Russell RO, Smith SC. ACC/AHA Guideline Update for Perioperative Cardiovascular Evaluation for Noncardiac Surgery--Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Anesth Analg. 2002 May; 94(5):1052-64. PMID: 11973163.
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    17. Eagle KA, Berger PB, Calkins H, Chaitman BR, Ewy GA, Fleischmann KE, Fleisher LA, Froehlich JB, Gusberg RJ, Leppo JA, Ryan T, Schlant RC, Winters WL, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Gregoratos G, Jacobs AK, Hiratzka LF, Russell RO, Smith SC. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery---executive summary a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation. 2002 Mar 12; 105(10):1257-67. PMID: 11889023.
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    18. Eagle KA, Berger PB, Calkins H, Chaitman BR, Ewy GA, Fleischmann KE, Fleisher LA, Froehlich JB, Gusberg RJ, Leppo JA, Ryan T, Schlant RC, Winters WL, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Gregoratos G, Jacobs AK, Hiratzka LF, Russell RO, Smith SC. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). J Am Coll Cardiol. 2002 Feb 6; 39(3):542-53. PMID: 11823097.
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    19. Narula J, Acio ER, Narula N, Samuels LE, Fyfe B, Wood D, Fitzpatrick JM, Raghunath PN, Tomaszewski JE, Kelly C, Steinmetz N, Green A, Tait JF, Leppo J, Blankenberg FG, Jain D, Strauss HW. Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med. 2001 Dec; 7(12):1347-52. PMID: 11726976.
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    20. Pretorius PH, Narayanan MV, Dahlberg ST, Leppo JA, King MA. The influence of attenuation and scatter compensation on the apparent distribution of Tc-99m sestamibi in cardiac slices. J Nucl Cardiol. 2001 May-Jun; 8(3):356-64. PMID: 11391306.
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    21. Reinhardt CP, Dalhberg S, Tries MA, Marcel R, Leppo JA. Stable labeled microspheres to measure perfusion: validation of a neutron activation assay technique. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H108-16. PMID: 11123224.
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    22. Udelson JE, He ZX, Leppo JA, Allman KC, Underwood R, Lele V, Chua T, Bavelaar-Croon CD, van der Wall EE, Prigent FM. Journal of Nuclear Cardiology Nuclear Cardiology News Update. J Nucl Cardiol. 2000 Mar; 7(2):194-5. PMID: 27517561.
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    23. Holly TA, Leppo JA, Gilmore MP, Reinhardt CP, Dahlberg ST. The effect of ischemic injury on the cardiac transport of Tc-99m N-NOET in the isolated rabbit heart. J Nucl Cardiol. 1999 Nov-Dec; 6(6):633-40. PMID: 10608591.
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    24. Leppo JA. "If you can't stand the heat, get out of the kitchen". Am J Med. 1999 Sep; 107(3):290-2. PMID: 10492326.
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    25. Leppo JA, Dahlberg ST. The question: to test or not to test in preoperative cardiac risk evaluation. J Nucl Cardiol. 1998 May-Jun; 5(3):332-42. PMID: 9669587.
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    26. Zafrir N, Leppo JA, Reinhardt CP, Dahlberg ST. Thallium reinjection versus standard stress/delay redistribution imaging for prediction of cardiac events. J Am Coll Cardiol. 1998 May; 31(6):1280-5. PMID: 9581721.
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    27. Weinstein H, Reinhardt CP, Leppo JA. Direct detection of regional myocardial ischemia with technetium-99m nitroimidazole in rabbits. J Nucl Med. 1998 Apr; 39(4):598-607. PMID: 9544663.
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    28. Ferry DR, O'Rourke RA, Blaustein AS, Crawford MH, Deedwania PC, Carson PE, Pepine CJ, Thomas RG, Hlatky MA, Leppo JA, Iwane MK, Kleiger RE, Zoble RG, Dai H, Chow BK, Lavori PW, Boden WE. Design and baseline characteristics of the Veterans Affairs Non-Q-Wave Infarction Strategies In-Hospital (VANQWISH) trial. VANQWISH Trial Research Investigators. J Am Coll Cardiol. 1998 Feb; 31(2):312-20. PMID: 9462573.
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    29. Takahashi N, Reinhardt CP, Marcel R, Leppo JA. Correlations between uptake of technetium-99m Q12 and thallium-201: myocardial perfusion and viability in a model of acute coronary reperfusion. J Nucl Med. 1998 Jan; 39(1):159-65. PMID: 9443756.
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    30. Lapuerta P, L'Italien GJ, Paul S, Hendel RC, Leppo JA, Fleisher LA, Cohen MC, Eagle KA, Giugliano RP. Neural network assessment of perioperative cardiac risk in vascular surgery patients. Med Decis Making. 1998 Jan-Mar; 18(1):70-5. PMID: 9456211.
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    31. Takahashi N, Dahlberg ST, Gilmore MP, Leppo JA. Effects of acute ischemia and reperfusion on the myocardial kinetics of technetium 99m-labeled tetrofosmin and thallium-201. J Nucl Cardiol. 1997 Nov-Dec; 4(6):524-31. PMID: 9456193.
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    32. Leppo JA. The road to Florence. J Nucl Cardiol. 1997 Sep-Oct; 4(5):403-5. PMID: 9410557.
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    33. Heller LI, Cates C, Popma J, Deckelbaum LI, Joye JD, Dahlberg ST, Villegas BJ, Arnold A, Kipperman R, Grinstead WC, Balcom S, Ma Y, Cleman M, Steingart RM, Leppo JA. Intracoronary Doppler assessment of moderate coronary artery disease: comparison with 201Tl imaging and coronary angiography. FACTS Study Group. Circulation. 1997 Jul 15; 96(2):484-90. PMID: 9244216.
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    34. Eagle KA, Brundage BH, Chaitman BR, Ewy GA, Fleisher LA, Hertzer NR, Leppo JA, Ryan T, Schlant RC, Spencer WH, Spittell JA, Twiss RD. Guidelines for perioperative cardiovascular evaluation for noncardiac surgery: an abridged version of the report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Mayo Clin Proc. 1997 Jun; 72(6):524-31. PMID: 9179136.
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    35. Massie MT, Rohrer MJ, Leppo JA, Cutler BS. Is coronary angiography necessary for vascular surgery patients who have positive results of dipyridamole thallium scans? J Vasc Surg. 1997 Jun; 25(6):975-82; discussion 982-3. PMID: 9201157.
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    36. Takahashi N, Reinhardt CP, Marcel R, Leppo JA. Myocardial uptake of 99mTc-tetrofosmin, sestamibi, and 201Tl in a model of acute coronary reperfusion. Circulation. 1996 Nov 15; 94(10):2605-13. PMID: 8921807.
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    37. Leppo JA. Comparison of pharmacologic stress agents. J Nucl Cardiol. 1996 Nov-Dec; 3(6 Pt 2):S22-6. PMID: 8989683.
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    38. Leppo JA. An approach to myocardial viability based on perfusion, function and metabolic substrates. Isr J Med Sci. 1996 Oct; 32(10):800-3. PMID: 8950240.
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    39. Zafrir N, Dahlberg ST, Villegas BJ, Leppo JA. Prognostic utility of increased pulmonary thallium uptake in patients without ischemia. J Nucl Cardiol. 1996 Jul-Aug; 3(4):301-7. PMID: 8799248.
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    40. Emlein G, Villegas B, Dahlberg S, Leppo J. Left ventricular cavity size determined by preoperative dipyridamole thallium scintigraphy as a predictor of late cardiac events in vascular surgery patients. Am Heart J. 1996 May; 131(5):907-14. PMID: 8615309.
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    41. Eagle KA, Brundage BH, Chaitman BR, Ewy GA, Fleisher LA, Hertzer NR, Leppo JA, Ryan T, Schlant RC, Spencer WH, Spittell JA, Twiss RD, Ritchie JL, Cheitlin MD, Gardner TJ, Garson A, Lewis RP, Gibbons RJ, O'Rourke RA, Ryan TJ. Guidelines for perioperative cardiovascular evaluation for noncardiac surgery. Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Committee on Perioperative Cardiovascular Evaluation for Noncardiac Surgery. Circulation. 1996 Mar 15; 93(6):1278-317. PMID: 8653858.
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    42. L'Italien GJ, Paul SD, Hendel RC, Leppo JA, Cohen MC, Fleisher LA, Brown KA, Zarich SW, Cambria RP, Cutler BS, Eagle KA. Development and validation of a Bayesian model for perioperative cardiac risk assessment in a cohort of 1,081 vascular surgical candidates. J Am Coll Cardiol. 1996 Mar 15; 27(4):779-86. PMID: 8613603.
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    43. Eagle KA, Brundage BH, Chaitman BR, Ewy GA, Fleisher LA, Hertzer NR, Leppo JA, Ryan T, Schlant RC, Spencer WH, Spittell JA, Twiss RD, Ritchie JL, Cheitlin MD, Gardner TJ, Garson A, Lewis RP, Gibbons RJ, O'Rourke RA, Ryan TJ. Guidelines for perioperative cardiovascular evaluation for noncardiac surgery. Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). J Am Coll Cardiol. 1996 Mar 15; 27(4):910-48. PMID: 8613622.
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    44. Heller LI, Villegas BJ, Reinhardt CP, Dahlberg ST, Marcel R, Leppo JA. Teboroxime is a marker of reperfusion after myocardial infarction. J Nucl Cardiol. 1996 Jan-Feb; 3(1):2-8. PMID: 8799222.
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    45. Leppo JA. Preoperative cardiac risk assessment for noncardiac surgery. J Nucl Cardiol. 1995 Sep-Oct; 2(5):461-5. PMID: 9420825.
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    46. Reinhardt CP, Weinstein H, Marcel R, Leppo JA. Comparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion. J Nucl Med. 1995 Sep; 36(9):1645-53. PMID: 7658226.
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    47. Reinhardt CP, Leppo JA. A method to evaluate tracer kinetics in small laboratory animals using a series of thermoluminescent dosimeters. Med Phys. 1995 Aug; 22(8):1299-305. PMID: 7476717.
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    48. L'Italien GJ, Cambria RP, Cutler BS, Leppo JA, Paul SD, Brewster DC, Hendel RC, Abbott WM, Eagle KA. Comparative early and late cardiac morbidity among patients requiring different vascular surgery procedures. J Vasc Surg. 1995 Jun; 21(6):935-44. PMID: 7776473.
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    49. Leppo JA. Preoperative cardiac risk assessment for noncardiac surgery. Am J Cardiol. 1995 Apr 13; 75(11):42D-51D. PMID: 7726113.
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    50. Hendel RC, Chen MH, L'Italien GJ, Newell JB, Paul SD, Eagle KA, Leppo JA. Sex differences in perioperative and long-term cardiac event-free survival in vascular surgery patients. An analysis of clinical and scintigraphic variables. Circulation. 1995 Feb 15; 91(4):1044-51. PMID: 7850940.
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    51. Lette J, Tatum JL, Fraser S, Miller DD, Waters DD, Heller G, Stanton EB, Bom HS, Leppo J, Nattel S. Safety of dipyridamole testing in 73,806 patients: the Multicenter Dipyridamole Safety Study. J Nucl Cardiol. 1995 Jan-Feb; 2(1):3-17. PMID: 9420757.
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    52. Hendel RC, Leppo JA. The value of perioperative clinical indexes and dipyridamole thallium scintigraphy for the prediction of myocardial infarction and cardiac death in patients undergoing vascular surgery. J Nucl Cardiol. 1995 Jan-Feb; 2(1):18-25. PMID: 9420758.
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    53. Weinstein H, Reinhardt CP, Wironen JF, Leppo JA. Myocardial uptake of thallium 201 and technetium 99m-labeled sestamibi after ischemia and reperfusion: comparison by quantitative dual-tracer autoradiography in rabbits. J Nucl Cardiol. 1994 Jul-Aug; 1(4):351-64. PMID: 9420718.
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    54. Adzamli K, Mei H, Leppo JA. Macromolecular infarct-specific magnetic resonance contrast agents. Invest Radiol. 1994 Jun; 29 Suppl 2:S15-7. PMID: 7928214.
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    55. Meerdink DJ, Leppo JA. Transcapillary exchange of indium 111-labeled anticardiac myosin Fab and thallium 201 in isolated reperfused rabbit hearts. J Nucl Cardiol. 1994 May-Jun; 1(3):236-45. PMID: 9420706.
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    56. Dahlberg ST, Leppo JA. Physiologic properties of myocardial perfusion tracers. Cardiol Clin. 1994 May; 12(2):169-85. PMID: 8033171.
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    57. Dahlberg ST, Gilmore MP, Leppo JA. Interaction of technetium 99m-labeled teboroxime with red blood cells reduces the compound's extraction and increases apparent cardiac washout. J Nucl Cardiol. 1994 May-Jun; 1(3):270-9. PMID: 9420710.
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    58. Heller LI, Villegas BJ, Weiner BH, McSherry BA, Dahlberg ST, Leppo JA. Use of sequential teboroxime imaging for the detection of coronary artery occlusion and reperfusion in ischemic and infarcted myocardium. Am Heart J. 1994 Apr; 127(4 Pt 1):779-85. PMID: 8154415.
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    59. Leppo JA. Dipyridamole myocardial perfusion imaging. J Nucl Med. 1994 Apr; 35(4):730-3. PMID: 8151403.
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    60. Dahlberg ST, Leppo JA. Myocardial kinetics of radiolabeled perfusion agents: basis for perfusion imaging. J Nucl Cardiol. 1994 Mar-Apr; 1(2 Pt 1):189-97. PMID: 9420686.
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    61. Walsh EG, Minematsu K, Leppo J, Moore SC. Radioactive microsphere validation of a volume localized continuous saturation perfusion measurement. Magn Reson Med. 1994 Feb; 31(2):147-53. PMID: 8133750.
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    62. Weinstein H, King MA, Reinhardt CP, McSherry BA, Leppo JA. A method of simultaneous dual-radionuclide cardiac imaging with technetium 99m and thallium 201. I: Analysis of interradionuclide crossover and validation in phantoms. J Nucl Cardiol. 1994 Jan-Feb; 1(1):39-51. PMID: 9420669.
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    63. Adzamli IK, Weinstein H, Leppo JA. Gadolinium phosphonates as MR imaging contrast agents: physiologic effects in rabbit hearts. J Magn Reson Imaging. 1993 Nov-Dec; 3(6):821-8. PMID: 8280969.
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    64. Leppo JA, Iskandrian A, Brown KA, Verani MS. Noninvasive testing for silent myocardial ischemia in stable coronary patients. JAMA. 1993 Oct 20; 270(15):1809; author reply 1810. PMID: 8411515.
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    65. Reinhardt CP, Weinstein H, Wironen J, Leppo JA. Effect of triphenyl tetrazolium chloride staining on the distribution of radiolabeled pharmaceuticals. J Nucl Med. 1993 Oct; 34(10):1722-7. PMID: 7692020.
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    66. Hendel RC, Dahlberg ST, Weinstein H, Leppo JA. Comparison of teboroxime and thallium for the reversibility of exercise-induced myocardial perfusion defects. Am Heart J. 1993 Oct; 126(4):856-62. PMID: 8213442.
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    67. Senior R, Bhattacharya S, Manspeaker P, Liu XJ, Leppo JA, Lahiri A. 99mTc-antimyosin antibody imaging for the detection of acute myocardial infarction in human beings. Am Heart J. 1993 Sep; 126(3 Pt 1):536-42. PMID: 8362706.
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    68. Weinstein H, Reinhardt CP, Leppo JA. Teboroxime, sestamibi and thallium-201 as markers of myocardial hypoperfusion: comparison by quantitative dual-isotope autoradiography in rabbits. J Nucl Med. 1993 Sep; 34(9):1510-7. PMID: 8355072.
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    69. Villegas BJ, Hendel RC, Dahlberg ST, McSherry BA, Leppo JA. Comparison of 3- versus 6-minute infusions of adenosine in thallium-201 myocardial perfusion imaging. Am Heart J. 1993 Jul; 126(1):103-7. PMID: 8322650.
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    70. Dahlberg ST, Meerdink DJ, Gilmore MP, Leppo JA. Myocardial extraction of technetium-99m-[2-(1-methoxybutyl) isonitrile] in the isolated rabbit heart: a myocardial perfusion agent with high extraction and stable retention. J Nucl Med. 1993 Jun; 34(6):927-31. PMID: 8509860.
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    71. Heller LI, Villegas BJ, Weiner BH, McSherry BA, Dahlberg ST, Leppo JA. Sequential teboroxime imaging during and after balloon occlusion of a coronary artery. J Am Coll Cardiol. 1993 May; 21(6):1319-27. PMID: 8473636.
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    72. Weinstein H, Dahlberg ST, McSherry BA, Hendel RC, Leppo JA. Rapid redistribution of teboroxime. Am J Cardiol. 1993 Apr 1; 71(10):848-52. PMID: 8456765.
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    73. Hendel RC, Whitfield SS, Villegas BJ, Cutler BS, Leppo JA. Prediction of late cardiac events by dipyridamole thallium imaging in patients undergoing elective vascular surgery. Am J Cardiol. 1992 Nov 15; 70(15):1243-9. PMID: 1442573.
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    74. Dahlberg ST, Weinstein H, Hendel RC, McSherry B, Leppo JA. Planar myocardial perfusion imaging with technetium-99m-teboroxime: comparison by vascular territory with thallium-201 and coronary angiography. J Nucl Med. 1992 Oct; 33(10):1783-8. PMID: 1403145.
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    75. Cutler BS, Hendel RC, Leppo JA. Dipyridamole-thallium scintigraphy predicts perioperative and long-term survival after major vascular surgery. J Vasc Surg. 1992 Jun; 15(6):972-9; discussion 980-1. PMID: 1597895.
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    76. Hendel RC, Cohn S, Aurigemma G, Whitfield S, Dahlberg S, Pape L, Leppo J. Focal myocardial injury following blunt chest trauma: a comparison of indium-111 antimyosin scintigraphy with other noninvasive methods. Am Heart J. 1992 May; 123(5):1208-15. PMID: 1575135.
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    77. Leppo JA. A thallium scan goes to court. J Nucl Med. 1992 Jan; 33(1):120-6. PMID: 1730976.
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    78. Bhattacharya S, Liu XJ, Senior R, Jain D, Leppo JA, Lahiri A. 111In antimyosin antibody uptake is related to the age of myocardial infarction. Am Heart J. 1991 Dec; 122(6):1583-7. PMID: 1957752.
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    79. Leppo JA, DePuey EG, Johnson LL. A review of cardiac imaging with sestamibi and teboroxime. J Nucl Med. 1991 Oct; 32(10):2012-22. PMID: 1833519.
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    80. Okada RD, Glover DK, Leppo JA. Dipyridamole 201Tl scintigraphy in the evaluation of prognosis after myocardial infarction. Circulation. 1991 Sep; 84(3 Suppl):I132-9. PMID: 1884479.
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    81. Whitfield S, Aurigemma G, Pape L, Leppo J. Two-dimensional Doppler echocardiographic correlation of dipyridamole-thallium stress testing with isometric handgrip. Am Heart J. 1991 May; 121(5):1367-73. PMID: 2017969.
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    82. Hendel RC, Gore JM, Alpert JS, Leppo JA. Prognosis following interventional therapy for acute myocardial infarction: utility of dipyridamole thallium scintigraphy. Cardiology. 1991; 79(1):73-80. PMID: 1777916.
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    83. Chipkin SR, Gottlieb P, Lundstrom R, Leppo J, Aronin N. Transient myocardial perfusion abnormalities in diabetic patients: a prospective study using thallium exercise tolerance testing. Cardiology. 1991; 79(3):172-9. PMID: 1769034.
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    84. Hendel RC, McSherry BA, Leppo JA. Myocardial uptake of indium-111-labeled antimyosin in acute subendocardial infarction: clinical, histochemical, and autoradiographic correlation of myocardial necrosis. J Nucl Med. 1990 Nov; 31(11):1851-3. PMID: 2231000.
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    85. Hendel RC, McSherry B, Karimeddini M, Leppo JA. Diagnostic value of a new myocardial perfusion agent, teboroxime (SO 30,217), utilizing a rapid planar imaging protocol: preliminary results. J Am Coll Cardiol. 1990 Nov; 16(6):855-61. PMID: 2229806.
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    86. Meerdink DJ, Leppo JA. Experimental studies of the physiologic properties of technetium-99m agents: myocardial transport of perfusion imaging agents. Am J Cardiol. 1990 Oct 16; 66(13):9E-15E. PMID: 2145753.
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    87. Meerdink DJ, Leppo JA. Myocardial transport of hexakis(2-methoxyisobutylisonitrile) and thallium before and after coronary reperfusion. Circ Res. 1990 Jun; 66(6):1738-46. PMID: 2140539.
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    88. Leppo JA, Meerdink DJ. Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium. J Nucl Med. 1990 Jan; 31(1):67-74. PMID: 2295943.
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    89. Hendel RC, Layden JJ, Leppo JA. Prognostic value of dipyridamole thallium scintigraphy for evaluation of ischemic heart disease. J Am Coll Cardiol. 1990 Jan; 15(1):109-16. PMID: 2295718.
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    90. Leppo JA, Meerdink DJ. Comparison of the myocardial uptake of a technetium-labeled isonitrile analogue and thallium. Circ Res. 1989 Sep; 65(3):632-9. PMID: 2527638.
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    91. Meerdink DJ, Leppo JA. Comparison of hypoxia and ouabain effects on the myocardial uptake kinetics of technetium-99m hexakis 2-methoxyisobutyl isonitrile and thallium-201. J Nucl Med. 1989 Sep; 30(9):1500-6. PMID: 2527973.
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    92. Connelly CM, Leppo JA, Weitzman PW, Vogel WM, Apstein CS. Effect of coronary occlusion and reperfusion on myocardial blood flow during infarct healing. Am J Physiol. 1989 Aug; 257(2 Pt 2):H365-74. PMID: 2764125.
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    93. Meerdink DJ, Okada RD, Leppo JA. The effect of dipyridamole on transmural blood flow gradients. Chest. 1989 Aug; 96(2):400-5. PMID: 2752823.
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    94. Leppo JA. Dipyridamole-thallium imaging: the lazy man's stress test. J Nucl Med. 1989 Mar; 30(3):281-7. PMID: 2661748.
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    95. Rothendler JA, Schick EC, Leppo J, Birmingham MJ, Green AM, Ryan TJ. Diagnosis of pericardial effusions from routine gated blood-pool imaging. J Nucl Med. 1987 Sep; 28(9):1419-23. PMID: 3040929.
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    96. Leppo J. Thallium washout analysis: fact or fiction? J Nucl Med. 1987 Jun; 28(6):1058-60. PMID: 3295137.
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    97. Leppo JA. Myocardial uptake of thallium and rubidium during alterations in perfusion and oxygenation in isolated rabbit hearts. J Nucl Med. 1987 May; 28(5):878-85. PMID: 3572547.
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    98. Leppo J, Plaja J, Gionet M, Tumolo J, Paraskos JA, Cutler BS. Noninvasive evaluation of cardiac risk before elective vascular surgery. J Am Coll Cardiol. 1987 Feb; 9(2):269-76. PMID: 3805515.
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    99. Cutler BS, Leppo JA. Dipyridamole thallium 201 scintigraphy to detect coronary artery disease before abdominal aortic surgery. J Vasc Surg. 1987 Jan; 5(1):91-100. PMID: 3795395.
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    100. Leppo JA, Macneil PB, Moring AF, Apstein CS. Separate effects of ischemia, hypoxia, and contractility on thallium-201 kinetics in rabbit myocardium. J Nucl Med. 1986 Jan; 27(1):66-74. PMID: 3941367.
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    101. Bianco JA, Elmaleh DR, Leppo JA, King MA, Moring A, Livni E, Espinoza E, Alpert JS, Strauss HW. Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid. Eur J Nucl Med. 1986; 12(3):120-4. PMID: 3530771.
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    102. Leppo JA, Okada RD, Strauss HW, Pohost GM. Effect of hyperaemia on thallium-201 redistribution in normal canine myocardium. Cardiovasc Res. 1985 Nov; 19(11):679-85. PMID: 4075358.
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    103. Leppo JA, Simons M, Hood WB. Effect of adenosine on transmural flow gradients in normal canine myocardium. J Cardiovasc Pharmacol. 1984 Nov-Dec; 6(6):1115-9. PMID: 6084768.
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    104. Leppo JA, O'Brien J, Rothendler JA, Getchell JD, Lee VW. Dipyridamole-thallium-201 scintigraphy in the prediction of future cardiac events after acute myocardial infarction. N Engl J Med. 1984 Apr 19; 310(16):1014-8. PMID: 6708976.
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    105. Leppo J, Boucher CA, Okada RD, Newell JB, Strauss HW, Pohost GM. Serial thallium-201 myocardial imaging after dipyridamole infusion: diagnostic utility in detecting coronary stenoses and relationship to regional wall motion. Circulation. 1982 Sep; 66(3):649-57. PMID: 7094276.
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    106. Callahan RJ, Froelich JW, McKusick KA, Leppo J, Strauss HW. A modified method for the in vivo labeling of red blood cells with Tc-99m: concise communication. J Nucl Med. 1982 Apr; 23(4):315-8. PMID: 6279801.
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    107. Okada RD, Leppo JA, Strauss HW, Boucher CA, Pohost GM. Mechanisms and time course for the disappearance of thallium-201 defects at rest in dogs. Relation of time to peak activity to myocardial blood flow. Am J Cardiol. 1982 Mar; 49(4):699-706. PMID: 7064821.
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    108. Okada RD, Leppo JA, Boucher CA, Pohost GM. Myocardial kinetics of thallium-201 after dipyridamole infusion in normal canine myocardium and in myocardium distal to a stenosis. J Clin Invest. 1982 Jan; 69(1):199-209. PMID: 7054239.
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    109. Okada RD, Jacobs ML, Daggett WM, Leppo J, Strauss HW, Newell JB, Moore R, Boucher CA, O'Keefe D, Pohost GM. Thallium-201 kinetics in nonischemic canine myocardium. Circulation. 1982 Jan; 65(1):70-7. PMID: 7053290.
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    110. Pohost GM, Okada RD, O'Keefe DD, Gewirtz H, Beller G, Strauss HW, Chaffin JS, Leppo J, Daggett WM. Thallium redistribution in dogs with severe coronary artery stenosis of fixed caliber. Circ Res. 1981 Mar; 48(3):439-46. PMID: 7460217.
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    111. Leppo J, Rosenkrantz J, Rosenthal R, Bontemps R, Yipintsoi T. Quantitative thallium-201 redistribution with a fixed coronary stenosis in dogs. Circulation. 1981 Mar; 63(3):632-9. PMID: 7460249.
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    112. Leppo JA, Scheuer J, Pohost GM, Freeman LM, Strauss HW. The evaluation of ischemic heart disease thallium-210 with comments on radionuclide angiography. Semin Nucl Med. 1980 Apr; 10(2):115-26. PMID: 6994233.
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    113. Leppo J, Yipintsoi T, Blankstein R, Bontemps R, Freeman LM, Zohman L, Scheuer J. Thallium-201 myocardial scintigraphy in patients with triple-vessel disease and ischemic exercise stress tests. Circulation. 1979 Apr; 59(4):714-21. PMID: 421310.
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    114. Rackow EC, Fein IA, Leppo J. Colloid osmotic pressure as a prognostic indicator of pulmonary edema and mortality in the critically ill. Chest. 1977 Dec; 72(6):709-13. PMID: 923305.
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    115. Conde CA, Leppo J, Lipski J, Stimmel B, Litwak R, Donoso E, Dack S. Effectiveness of pacemaker treatment in the bradycardia-tachycardia syndrome. Am J Cardiol. 1973 Aug; 32(2):209-14. PMID: 4721118.
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