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Last Name

Shashi Kant PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North, AS7-1046
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DivisionCardiovascular Medicine

    Collapse Biography 
    Collapse education and training
    University of Agricultural Sciences, Dharwad, KA, IndiaBSAgriculture
    Madurai Kamaraj University, Madurai, TN, IndiaMABiotechnology
    Medical University School of Hannover, Hannover, , GermanyPHDMolecular Medicine

    Collapse Overview 
    Collapse overview

    T2DM patients are 4 times more likely to develop atherosclerosis and other cardiovascular diseases than the healthy population. Our research focuses on finding a link between Type 2 Diabetes Mellitus (T2DM) and atherosclerosis that can be a drug target for both diseases. Atherosclerosis is an inflammatory disease that is enhanced by small proteins called cytokines. Chronic inflammation is a very serious condition that can promote the progression of T2DM, but precisely how inflammation leads to T2DM is unknown. By pinpointing what links T2DM, atherosclerosis, and accompanying inflammation we can further focus disease therapy development for both clinical conditions.

     Education & Research Experience       

    20013–2017: InstructorDepartment of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, (USA).

    2007–2013: Postdoctoral associate: Howard Hughes Medical Institute Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, (USA).

    2006–2007: Postdoctoral associate:  Department of Physiological Chemistry, Institute for Biochemistry, Hannover Medical School, Hannover (Germany).

    2002-2006: PhD degree:  MD/PhD Postgraduate Program “Molecular Medicine” under the Hannover Biomedical Research School, Hannover Medical School, Hannover (Germany).

     Research Grants

    Ø  AHA Scientific Development Grant: 2016 - 2019

    Ø  American Diabetes Association-Takeda Postdoctoral Fellowship Award: 2007–2009

     Honors, Scholarships & Awards

    Ø  Peer reviewer in a Bioeng BSc3 study section of American Heart Association grant review committee. (2014 – present)

    Ø  Reviewer for Molecular and Cellular Biology of American Society of Microbiology. (2009 – present)

     Professional Memberships

    2015 – present                        Member, American Heart Association

    2013 - 2014                            Member, American Society for Microbiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Craige S, Chen K, Blanton R, Keaney J, Kant S. JNK and cardiometabolic dysfunction. Biosci Rep. 2019 Jul 03. PMID: 31270248.
      View in: PubMed
    2. Min SY, Learnard H, Kant S, Gealikman O, Rojas-Rodriguez R, DeSouza T, Desai A, Keaney JF, Corvera S, Craige SM. Exercise Rescues Gene Pathways Involved in Vascular Expansion and Promotes Functional Angiogenesis in Subcutaneous White Adipose Tissue. Int J Mol Sci. 2019 Apr 25; 20(8). PMID: 31027261.
      View in: PubMed
    3. Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19; 20(12):2775-2783. PMID: 28930674.
      View in: PubMed
    4. Zimmerman W, Vertii A, Kant S. Cells Signal Before Driving the Cycle: Metabolic Signaling Regulates Cell Division. Curr Updates Endocrinol Diabetes. 2017; 1(2):1.
    5. Nam M, Akie TE, Sanosaka M, Craige SM, Kant S, Keaney JF, Cooper MP. Mitochondrial retrograde signaling connects respiratory capacity to thermogenic gene expression. Sci Rep. 2017 May 17; 7(1):2013. PMID: 28515438.
      View in: PubMed
    6. Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF. PGC-1a dictates endothelial function through regulation of eNOS expression. Sci Rep. 2016 Dec 02; 6:38210. PMID: 27910955.
      View in: PubMed
    7. Craige SM, Reif MM, Kant S. Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states. Biochim Biophys Acta. 2016 Sep; 1862(9):1581-6. PMID: 27259981.
      View in: PubMed
    8. Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release. Dev Cell. 2016 May 23; 37(4):377-86. PMID: 27219065.
      View in: PubMed
    9. Li C, Reif MM, Craige SM, Kant S, Keaney JF. Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric Oxide. 2016 May 1; 55-56:45-53. PMID: 26989010.
      View in: PubMed
    10. Craige SM, Kant S, Reif M, Chen K, Pei Y, Angoff R, Sugamura K, Fitzgibbons T, Keaney JF. Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med. 2015 Dec; 89:1-7. PMID: 26169727.
      View in: PubMed
    11. Craige SM, Kant S, Keaney JF. Reactive oxygen species in endothelial function - from disease to adaptation - . Circ J. 2015; 79(6):1145-55. PMID: 25986771.
      View in: PubMed
    12. Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Rep. 2013 Aug 29; 4(4):681-8. PMID: 23954791.
      View in: PubMed
    13. Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A. The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Mol Cell Biol. 2012 Jul; 32(13):2467-78. PMID: 22508986.
      View in: PubMed
    14. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
      View in: PubMed
    15. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92. PMID: 21965325.
      View in: PubMed
    16. Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 1; 25(19):2069-78. PMID: 21979919.
      View in: PubMed
    17. Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. J Biol Chem. 2006 Nov 17; 281(46):35511-9. PMID: 16973613.
      View in: PubMed
    18. Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M. Scaffolding by ERK3 regulates MK5 in development. EMBO J. 2004 Dec 8; 23(24):4770-9. PMID: 15538386.
      View in: PubMed
    19. Kant S, Bagaria A, Ramakumar S. Putative homeodomain proteins identified in prokaryotes based on pattern and sequence similarity. Biochem Biophys Res Commun. 2002 Nov 29; 299(2):229-32. PMID: 12437974.
      View in: PubMed
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