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Sharone Green MD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentCenter for Infectious Disease and Vaccine Research

    Collapse Biography 
    Collapse education and training
    Queens College, Flushing, NY, United StatesBABiology
    Eastern Virginia Medical School, Norfolk, VA, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background


    • B.A., Queens College, 1983
    • M.D., Eastern Virginia Medical School, 1986

    Post-Graduate Training:

    • Internal Medicine - Washington Hospital Center, 1986-89
    • Infectious Diseases - University of Massachusetts Medical Center, 1989-92
    Photo: Sharone Green, MD

    Research Interests

    • Immunopathogenesis of viral infections
    • Human T cell responses to flavivirus infections including dengue and West Nile virus
    • Human immune responses to novel viral vaccines

    My laboratory studies T lymphocyte responses to viral infections and their role in protection as well as immunopathogenesis of disease. The study of T cell responses to natural viral infections can be utilized towards the development and testing of viral vaccines. Dengue virus, yellow fever virus, West Nile virus and Japanese encephalitis viruses are the current model systems under study.

    Dengue viruses

    Dengue viruses, of which there are four serotypes, are transmitted from human-to-human by mosquitoes in tropical and subtropical regions of the world. In some individuals, dengue virus infections manifest as dengue hemorrhagic fever (DHF), which is characterized by plasma leakage, and can lead to life-threatening shock. Our laboratory hypothesizes that DHF is an example of immunopathology caused by the ‘over’ responses of memory T cells. The role of other arms of the adaptive immune system in regulating disease severity, such as pre-existing antibodies that mediate neutralization, enhancement and antibody-dependent cell cytotoxicity (ADCC) are also under investigation. As part of an ongoing multi-center international NIH-funded Program Project, I spent over 4 years in Thailand trying to elucidate the role of immune activation in the development of plasma leakage in children with DHF. These field studies are currently ongoing and valuble samples from these children are utilized in our laboratory to address these immune mechanisms in disease pathogenesis.

    West Nile virus

    West Nile virus (WNV), another mosquito-borne virus which is rapidly emerging in the United States, often produces subclinical infection or an acute viral syndrome, West Nile fever. Ina minority of infected people the infectioncauses neurological illness -l WNV encephalitis. CD8 + T cells can be demonstrated in the brains of individuals who have succumbed to WNV encephalitis.T cells likely play a role in protecting the host from neuroinvasion and once neuroinvasion has occurred, T cells may also play a role in disease pathogenesis. Studies are underway for detailed analysis of memory T cell responses in humans infected by WNV, including CTL responses and interferon gamma production by WNV-specific T cells using IFN-gamma ELISPOT and intracellular cytokine staining assays. In addition, we have established a murine model of WNV encephalitis to study the role of flavivirus cross-reactive T cells in protection from WNV illness as well as their role in disease pathogenesis.

    Heterologous immunity to flaviviruses

    Flaviviruses co-circulate in many parts of the world. Due to relatively conserved genomic sequences, the effect of pre-existing immunity to one flavivirus on host immune responses to a secondary flavivirus can vary. In the case of dengue viruses, secondary infection may lead to an increase in disease severity. Some human epidemiologic and animal model studies suggest that other combinations of flaviviruses may lead to protection from disease. My laboratory is investigating the role of pre-existent flavivirus cross-reactive T cell and antibody responses on epitope hierarchy, disease outcome and viral burden in murine models, including human HLA transgenic mice.

    Novel vaccines

    Novel vaccines, such as DNA vaccines and chimeric virus vaccines, may induce antibody and/or T cell memory in immunized individuals. My laboratory is actively involved in evaluating T cell responses to such novel vaccines in the hope of developing much needed first and second generation vaccines for the US and the developing world.

    Collapse Rotation Projects

    Sharone Green, M.D.

    Academic Role: Associate Professor

    Faculty Appointment(s) In:

    Other Affiliation(s):
    Center for Infectious Disease and Vaccine Research

    Potential Rotation Projects

    • Flavivirus-specific T lymphocytes -characterization of T lymphocytes (human or murine) with novel specificities for epitopes ofdengue, yellow fever, Japanese encephalitis or West Nile viruses; functional characterization of T cell effector responses; quantitation of epitope-specific CD4 and/or CD8 T cells

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Haltaufderhyde K, Srikiatkhachorn A, Green S, Macareo L, Park S, Kalayanarooj S, Rothman AL, Mathew A. Activation of Peripheral T Follicular Helper Cells During Acute Dengue Virus Infection. J Infect Dis. 2018 10 05; 218(10):1675-1685. PMID: 29917084.
      Citations: 25     Fields:    Translation:HumansCells
    2. Park S, Srikiatkhachorn A, Kalayanarooj S, Macareo L, Green S, Friedman JF, Rothman AL. Use of structural equation models to predict dengue illness phenotype. PLoS Negl Trop Dis. 2018 10; 12(10):e0006799. PMID: 30273334.
      Citations: 3     Fields:    Translation:Humans
    3. Fairchild AL, Bayer R, Green SH, Colgrove J, Kilgore E, Sweeney M, Varma JK. The Two Faces of Fear: A History of Hard-Hitting Public Health Campaigns Against Tobacco and AIDS. Am J Public Health. 2018 09; 108(9):1180-1186. PMID: 30088996.
      Citations: 9     Fields:    
    4. Moulton SL, Mulligan J, Srikiatkhachorn A, Kalayanarooj S, Grudic GZ, Green S, Gibbons RV, Muniz GW, Hinojosa-Laborde C, Rothman AL, Thomas SJ, Convertino VA. State-of-the-art monitoring in treatment of dengue shock syndrome: a case series. J Med Case Rep. 2016 Aug 24; 10(1):233. PMID: 27553703.
      Citations: 5     Fields:    Translation:Humans
    5. Woda M, Friberg H, Currier JR, Srikiatkhachorn A, Macareo LR, Green S, Jarman RG, Rothman AL, Mathew A. Dynamics of Dengue Virus (DENV)-Specific B Cells in the Response to DENV Serotype 1 Infections, Using Flow Cytometry With Labeled Virions. J Infect Dis. 2016 Oct 01; 214(7):1001-9. PMID: 27443614.
      Citations: 14     Fields:    Translation:HumansCells
    6. Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Rep. 2016 06 28; 16(1):232-246. PMID: 27342126.
      Citations: 209     Fields:    Translation:HumansCells
    7. Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL. The IFITMs Inhibit Zika Virus Replication. Cell Rep. 2016 06 14; 15(11):2323-30. PMID: 27268505.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    8. Clapham HE, Rodriguez-Barraquer I, Azman AS, Althouse BM, Salje H, Gibbons RV, Rothman AL, Jarman RG, Nisalak A, Thaisomboonsuk B, Kalayanarooj S, Nimmannitya S, Vaughn DW, Green S, Yoon IK, Cummings DA. Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection. J Infect Dis. 2016 May 01; 213(9):1428-35. PMID: 26704615.
      Citations: 25     Fields:    Translation:HumansCells
    9. Kirawittaya T, Yoon IK, Wichit S, Green S, Ennis FA, Gibbons RV, Thomas SJ, Rothman AL, Kalayanarooj S, Srikiatkhachorn A. Evaluation of Cardiac Involvement in Children with Dengue by Serial Echocardiographic Studies. PLoS Negl Trop Dis. 2015; 9(7):e0003943. PMID: 26226658.
      Citations: 12     Fields:    Translation:Humans
    10. Bhoomiboonchoo P, Nisalak A, Chansatiporn N, Yoon IK, Kalayanarooj S, Thipayamongkolgul M, Endy T, Rothman AL, Green S, Srikiatkhachorn A, Buddhari D, Mammen MP, Gibbons RV. Sequential dengue virus infections detected in active and passive surveillance programs in Thailand, 1994-2010. BMC Public Health. 2015 Mar 14; 15:250. PMID: 25886528.
      Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
    11. Vejbaesya S, Thongpradit R, Kalayanarooj S, Luangtrakool K, Luangtrakool P, Gibbons RV, Srinak D, Ngammthaworn S, Apisawes K, Yoon IK, Thomas SJ, Jarman RG, Srikiakthachorn A, Green S, Chandanayingyong D, Park S, Friedman J, Rothman AL, Stephens HA. HLA Class I Supertype Associations With Clinical Outcome of Secondary Dengue Virus Infections in Ethnic Thais. J Infect Dis. 2015 Sep 15; 212(6):939-47. PMID: 25740956.
      Citations: 14     Fields:    Translation:HumansCells
    12. Trobaugh D, Green S. Of Mice and Men: Protective and Pathogenic Immune Responses to West Nile virus Infection. Curr Trop Med Rep. 2015 Mar 01; 2(1):41-48. PMID: 26120511.
    13. Bhoomiboonchoo P, Gibbons RV, Huang A, Yoon IK, Buddhari D, Nisalak A, Chansatiporn N, Thipayamongkolgul M, Kalanarooj S, Endy T, Rothman AL, Srikiatkhachorn A, Green S, Mammen MP, Cummings DA, Salje H. The spatial dynamics of dengue virus in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis. 2014 Sep; 8(9):e3138. PMID: 25211127.
      Citations: 26     Fields:    Translation:HumansCells
    14. Soller B, Srikiatkachorn A, Zou F, Rothman AL, Yoon IK, Gibbons RV, Kalayanarooj S, Thomas SJ, Green S. Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever. BMC Infect Dis. 2014 Jul 17; 14:396. PMID: 25033831.
      Citations: 4     Fields:    Translation:Humans
    15. Townsley E, Woda M, Thomas SJ, Kalayanarooj S, Gibbons RV, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Rothman AL, Mathew A. Distinct activation phenotype of a highly conserved novel HLA-B57-restricted epitope during dengue virus infection. Immunology. 2014 Jan; 141(1):27-38. PMID: 23941420.
      Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
    16. Yoon IK, Srikiatkhachorn A, Hermann L, Buddhari D, Scott TW, Jarman RG, Aldstadt J, Nisalak A, Thammapalo S, Bhoomiboonchoo P, Mammen MP, Green S, Gibbons RV, Endy TP, Rothman AL. Characteristics of mild dengue virus infection in Thai children. Am J Trop Med Hyg. 2013 Dec; 89(6):1081-7. PMID: 24127167.
      Citations: 22     Fields:    Translation:HumansCells
    17. Anderson KB, Gibbons RV, Cummings DA, Nisalak A, Green S, Libraty DH, Jarman RG, Srikiatkhachorn A, Mammen MP, Darunee B, Yoon IK, Endy TP. A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand. J Infect Dis. 2014 Feb 01; 209(3):360-8. PMID: 23964110.
      Citations: 96     Fields:    Translation:Humans
    18. Srikiatkhachorn A, Wichit S, Gibbons RV, Green S, Libraty DH, Endy TP, Ennis FA, Kalayanarooj S, Rothman AL. Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status. PLoS One. 2012; 7(12):e51335. PMID: 23284680.
      Citations: 22     Fields:    Translation:HumansCells
    19. Yoon IK, Getis A, Aldstadt J, Rothman AL, Tannitisupawong D, Koenraadt CJ, Fansiri T, Jones JW, Morrison AC, Jarman RG, Nisalak A, Mammen MP, Thammapalo S, Srikiatkhachorn A, Green S, Libraty DH, Gibbons RV, Endy T, Pimgate C, Scott TW. Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. PLoS Negl Trop Dis. 2012; 6(7):e1730. PMID: 22816001.
      Citations: 83     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Shrestha B, Pinto AK, Green S, Bosch I, Diamond MS. CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons. J Virol. 2012 Sep; 86(17):8937-48. PMID: 22740407.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    21. Yoon IK, Rothman AL, Tannitisupawong D, Srikiatkhachorn A, Jarman RG, Aldstadt J, Nisalak A, Mammen MP, Thammapalo S, Green S, Libraty DH, Gibbons RV, Getis A, Endy T, Jones JW, Koenraadt CJ, Morrison AC, Fansiri T, Pimgate C, Scott TW. Underrecognized mildly symptomatic viremic dengue virus infections in rural Thai schools and villages. J Infect Dis. 2012 Aug 01; 206(3):389-98. PMID: 22615312.
      Citations: 60     Fields:    Translation:HumansCells
    22. Kurane I, Matsutani T, Suzuki R, Takasaki T, Kalayanarooj S, Green S, Rothman AL, Ennis FA. T-cell responses to dengue virus in humans. Trop Med Health. 2011 Dec; 39(4 Suppl):45-51. PMID: 22500136.
    23. Mathew A, West K, Kalayanarooj S, Gibbons RV, Srikiatkhachorn A, Green S, Libraty D, Jaiswal S, Rothman AL. B-cell responses during primary and secondary dengue virus infections in humans. J Infect Dis. 2011 Nov 15; 204(10):1514-22. PMID: 21930609.
      Citations: 45     Fields:    Translation:HumansCells
    24. Bigham AW, Buckingham KJ, Husain S, Emond MJ, Bofferding KM, Gildersleeve H, Rutherford A, Astakhova NM, Perelygin AA, Busch MP, Murray KO, Sejvar JJ, Green S, Kriesel J, Brinton MA, Bamshad M. Host genetic risk factors for West Nile virus infection and disease progression. PLoS One. 2011; 6(9):e24745. PMID: 21935451.
      Citations: 65     Fields:    Translation:Humans
    25. Friberg H, Bashyam H, Toyosaki-Maeda T, Potts JA, Greenough T, Kalayanarooj S, Gibbons RV, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Rothman AL, Mathew A. Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans. Sci Rep. 2011; 1:51. PMID: 22355570.
      Citations: 47     Fields:    Translation:HumansCells
    26. Endy TP, Anderson KB, Nisalak A, Yoon IK, Green S, Rothman AL, Thomas SJ, Jarman RG, Libraty DH, Gibbons RV. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis. 2011 Mar 01; 5(3):e975. PMID: 21390158.
      Citations: 112     Fields:    Translation:HumansCells
    27. Stewart BS, Demarest VL, Wong SJ, Green S, Bernard KA. Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection. BMC Immunol. 2011 Jan 20; 12:6. PMID: 21251256.
      Citations: 28     Fields:    Translation:AnimalsCells
    28. Smith HL, Monath TP, Pazoles P, Rothman AL, Casey DM, Terajima M, Ennis FA, Guirakhoo F, Green S. Development of antigen-specific memory CD8+ T cells following live-attenuated chimeric West Nile virus vaccination. J Infect Dis. 2011 Feb 15; 203(4):513-22. PMID: 21216868.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    29. Green S, Ennis FA, Mathew A. Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines. Vaccine. 2011 Feb 11; 29(8):1666-76. PMID: 21195803.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Potts JA, Thomas SJ, Srikiatkhachorn A, Supradish PO, Li W, Nisalak A, Nimmannitya S, Endy TP, Libraty DH, Gibbons RV, Green S, Rothman AL, Kalayanarooj S. Classification of dengue illness based on readily available laboratory data. Am J Trop Med Hyg. 2010 Oct; 83(4):781-8. PMID: 20889865.
      Citations: 15     Fields:    Translation:Humans
    31. Potts JA, Gibbons RV, Rothman AL, Srikiatkhachorn A, Thomas SJ, Supradish PO, Lemon SC, Libraty DH, Green S, Kalayanarooj S. Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators. PLoS Negl Trop Dis. 2010 Aug 03; 4(8):e769. PMID: 20689812.
      Citations: 50     Fields:    Translation:HumansCells
    32. Singh R, Rothman AL, Potts J, Guirakhoo F, Ennis FA, Green S. Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses. J Infect Dis. 2010 Jul 15; 202(2):223-33. PMID: 20536361.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    33. Trobaugh DW, Yang L, Ennis FA, Green S. Altered effector functions of virus-specific and virus cross-reactive CD8+ T cells in mice immunized with related flaviviruses. Eur J Immunol. 2010 May; 40(5):1315-27. PMID: 20213733.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    34. Friberg H, Burns L, Woda M, Kalayanarooj S, Endy TP, Stephens HA, Green S, Rothman AL, Mathew A. Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive. Immunol Cell Biol. 2011 Jan; 89(1):122-9. PMID: 20421879.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    35. Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, Endy TP, Vaughn DW, Nisalak A, Ennis FA, Rothman AL, Nimmannitaya S, Kalayanarooj S. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis. 2010 Apr 15; 50(8):1135-43. PMID: 20205587.
      Citations: 39     Fields:    Translation:HumansCells
    36. Fried JR, Gibbons RV, Kalayanarooj S, Thomas SJ, Srikiatkhachorn A, Yoon IK, Jarman RG, Green S, Rothman AL, Cummings DA. Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006. PLoS Negl Trop Dis. 2010 Mar 02; 4(3):e617. PMID: 20209155.
      Citations: 136     Fields:    Translation:HumansCells
    37. Srikiatkhachorn A, Green S. Markers of dengue disease severity. Curr Top Microbiol Immunol. 2010; 338:67-82. PMID: 19802579.
      Citations: 70     Fields:    Translation:HumansCells
    38. Vejbaesya S, Luangtrakool P, Luangtrakool K, Kalayanarooj S, Vaughn DW, Endy TP, Mammen MP, Green S, Libraty DH, Ennis FA, Rothman AL, Stephens HA. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. J Infect Dis. 2009 May 15; 199(10):1442-8. PMID: 19392621.
      Citations: 31     Fields:    Translation:HumansCells
    39. Mammen MP, Pimgate C, Koenraadt CJ, Rothman AL, Aldstadt J, Nisalak A, Jarman RG, Jones JW, Srikiatkhachorn A, Ypil-Butac CA, Getis A, Thammapalo S, Morrison AC, Libraty DH, Green S, Scott TW. Spatial and temporal clustering of dengue virus transmission in Thai villages. PLoS Med. 2008 Nov 04; 5(11):e205. PMID: 18986209.
      Citations: 154     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    40. Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS One. 2008 Oct 02; 3(10):e3323. PMID: 18830408.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Pavlin JA, Hickey AC, Ulbrandt N, Chan YP, Endy TP, Boukhvalova MS, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Ennis FA, Jarman R, Gibbons RV, Broder CC. Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein. J Infect Dis. 2008 Sep 15; 198(6):836-42. PMID: 18680407.
      Citations: 28     Fields:    Translation:HumansCells
    42. Wang S, Kennedy JS, West K, Montefiori DC, Coley S, Lawrence J, Shen S, Green S, Rothman AL, Ennis FA, Arthos J, Pal R, Markham P, Lu S. Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Vaccine. 2008 Jul 23; 26(31):3947-57. PMID: 18724414.
      Citations: 73     Fields:    Translation:HumansCellsCTClinical Trials
    43. Putnak JR, de la Barrera R, Burgess T, Pardo J, Dessy F, Gheysen D, Lobet Y, Green S, Endy TP, Thomas SJ, Eckels KH, Innis BL, Sun W. Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies. Am J Trop Med Hyg. 2008 Jul; 79(1):115-22. PMID: 18606774.
      Citations: 29     Fields:    Translation:Cells
    44. Kennedy JS, Co M, Green S, Longtine K, Longtine J, O'Neill MA, Adams JP, Rothman AL, Yu Q, Johnson-Leva R, Pal R, Wang S, Lu S, Markham P. The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers. Vaccine. 2008 Aug 18; 26(35):4420-4. PMID: 18588934.
      Citations: 36     Fields:    Translation:HumansCTClinical Trials
    45. Wang S, Kennedy JS, West K, Montefiori DC, Coley S, Lawrence J, Shen S, Green S, Rothman AL, Ennis FA, Arthos J, Pal R, Markham P, Lu S. Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Vaccine. 2008 Feb 20; 26(8):1098-110. PMID: 18243434.
      Citations: 40     Fields:    Translation:HumansCellsCTClinical Trials
    46. Libraty DH, Myint KS, Murray CK, Gibbons RV, Mammen MP, Endy TP, Li W, Vaughn DW, Nisalak A, Kalayanarooj S, Hospenthal DR, Green S, Rothman AL, Ennis FA. A comparative study of leptospirosis and dengue in Thai children. PLoS Negl Trop Dis. 2007 Dec 26; 1(3):e111. PMID: 18160980.
      Citations: 26     Fields:    Translation:Humans
    47. Anderson KB, Chunsuttiwat S, Nisalak A, Mammen MP, Libraty DH, Rothman AL, Green S, Vaughn DW, Ennis FA, Endy TP. Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study. Lancet. 2007 Apr 28; 369(9571):1452-1459. PMID: 17467515.
      Citations: 79     Fields:    Translation:HumansPHPublic Health
    48. Srikiatkhachorn A, Krautrachue A, Ratanaprakarn W, Wongtapradit L, Nithipanya N, Kalayanarooj S, Nisalak A, Thomas SJ, Gibbons RV, Mammen MP, Libraty DH, Ennis FA, Rothman AL, Green S. Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study. Pediatr Infect Dis J. 2007 Apr; 26(4):283-90; discussion 291-2. PMID: 17414388.
      Citations: 66     Fields:    Translation:Humans
    49. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Ennis FA, Rothman AL, Green S. Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication. J Infect Dis. 2007 Apr 15; 195(8):1108-16. PMID: 17357046.
      Citations: 39     Fields:    Translation:HumansCells
    50. Kalayanarooj S, Gibbons RV, Vaughn D, Green S, Nisalak A, Jarman RG, Mammen MP, Perng GC. Blood group AB is associated with increased risk for severe dengue disease in secondary infections. J Infect Dis. 2007 Apr 01; 195(7):1014-7. PMID: 17330792.
      Citations: 31     Fields:    Translation:HumansCells
    51. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever. J Virol. 2007 Feb; 81(4):1592-600. PMID: 17151115.
      Citations: 73     Fields:    Translation:HumansCells
    52. Green S, Rothman A. Immunopathological mechanisms in dengue and dengue hemorrhagic fever. Curr Opin Infect Dis. 2006 Oct; 19(5):429-36. PMID: 16940865.
      Citations: 145     Fields:    Translation:HumansCells
    53. Myint KS, Endy TP, Mongkolsirichaikul D, Manomuth C, Kalayanarooj S, Vaughn DW, Nisalak A, Green S, Rothman AL, Ennis FA, Libraty DH. Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis. J Infect Dis. 2006 Sep 01; 194(5):600-7. PMID: 16897658.
      Citations: 23     Fields:    Translation:HumansCells
    54. Monath TP, Liu J, Kanesa-Thasan N, Myers GA, Nichols R, Deary A, McCarthy K, Johnson C, Ermak T, Shin S, Arroyo J, Guirakhoo F, Kennedy JS, Ennis FA, Green S, Bedford P. A live, attenuated recombinant West Nile virus vaccine. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6694-9. PMID: 16617103.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    55. Bashyam HS, Green S, Rothman AL. Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes. J Immunol. 2006 Mar 01; 176(5):2817-24. PMID: 16493038.
      Citations: 62     Fields:    Translation:HumansCells
    56. Rothman AL, Green S, Libraty DH, Ennis FA. Dengue: translating scientific progress into workable solutions. Expert Rev Anti Infect Ther. 2005 Oct; 3(5):689-92. PMID: 16207158.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    57. Raekiansyah M, Pramesyanti A, Bela B, Kosasih H, Ma'roef CN, Tobing SY, Rudiman PI, Alisjahbana B, Endi TP, Green S, Kalayanarooj S, Rothman AL, Sudiro TM. Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand. Southeast Asian J Trop Med Public Health. 2005 Sep; 36(5):1187-97. PMID: 16438144.
      Citations: 9     Fields:    Translation:HumansCells
    58. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Reed G, Ennis FA, Rothman AL, Green S. Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection. J Infect Dis. 2005 Aug 01; 192(3):510-9. PMID: 15995967.
      Citations: 41     Fields:    Translation:HumansCells
    59. Mathew A, Terajima M, West K, Green S, Rothman AL, Ennis FA, Kennedy JS. Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles. J Immunol. 2005 Feb 15; 174(4):2212-9. PMID: 15699154.
      Citations: 24     Fields:    Translation:AnimalsCells
    60. Endy TP, Nisalak A, Chunsuttitwat S, Vaughn DW, Green S, Ennis FA, Rothman AL, Libraty DH. Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis. 2004 Mar 15; 189(6):990-1000. PMID: 14999601.
      Citations: 169     Fields:    Translation:HumansCells
    61. Pichyangkul S, Endy TP, Kalayanarooj S, Nisalak A, Yongvanitchit K, Green S, Rothman AL, Ennis FA, Libraty DH. A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J Immunol. 2003 Nov 15; 171(10):5571-8. PMID: 14607965.
      Citations: 43     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    62. Stephens HA, Klaythong R, Sirikong M, Vaughn DW, Green S, Kalayanarooj S, Endy TP, Libraty DH, Nisalak A, Innis BL, Rothman AL, Ennis FA, Chandanayingyong D. HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. Tissue Antigens. 2002 Oct; 60(4):309-18. PMID: 12472660.
      Citations: 100     Fields:    Translation:HumansCells
    63. Raengsakulrach B, Nisalak A, Maneekarn N, Yenchitsomanus PT, Limsomwong C, Jairungsri A, Thirawuth V, Green S, Kalayanarooj S, Suntayakorn S, Sittisombut N, Malasit P, Vaughn D. Comparison of four reverse transcription-polymerase chain reaction procedures for the detection of dengue virus in clinical specimens. J Virol Methods. 2002 Sep; 105(2):219-32. PMID: 12270655.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    64. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 01; 156(1):40-51. PMID: 12076887.
      Citations: 170     Fields:    Translation:HumansPHPublic Health
    65. Endy TP, Nisalak A, Chunsuttiwat S, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 01; 156(1):52-9. PMID: 12076888.
      Citations: 63     Fields:    Translation:HumansCells
    66. Zivna I, Green S, Vaughn DW, Kalayanarooj S, Stephens HA, Chandanayingyong D, Nisalak A, Ennis FA, Rothman AL. T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity. J Immunol. 2002 Jun 01; 168(11):5959-65. PMID: 12023403.
      Citations: 65     Fields:    Translation:HumansCells
    67. Mangada MM, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Libraty DH, Green S, Ennis FA, Rothman AL. Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren. J Infect Dis. 2002 Jun 15; 185(12):1697-703. PMID: 12085313.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    68. Gagnon SJ, Mori M, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL. Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections. J Med Virol. 2002 May; 67(1):41-6. PMID: 11920816.
      Citations: 26     Fields:    Translation:HumansCells
    69. Libraty DH, Endy TP, Kalayanarooj S, Chansiriwongs W, Nisalak A, Green S, Ennis FA, Rothman AL. Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue. Trans R Soc Trop Med Hyg. 2002 May-Jun; 96(3):295-9. PMID: 12174783.
      Citations: 6     Fields:    Translation:Humans
    70. Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S, Chansiriwongs W, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis. 2002 May 01; 185(9):1213-21. PMID: 12001037.
      Citations: 225     Fields:    Translation:Humans
    71. Krishnamurti C, Kalayanarooj S, Cutting MA, Peat RA, Rothwell SW, Reid TJ, Green S, Nisalak A, Endy TP, Vaughn DW, Nimmannitya S, Innis BL. Mechanisms of hemorrhage in dengue without circulatory collapse. Am J Trop Med Hyg. 2001 Dec; 65(6):840-7. PMID: 11791984.
      Citations: 47     Fields:    Translation:HumansCells
    72. Sudiro TM, Zivny J, Ishiko H, Green S, Vaughn DW, Kalayanarooj S, Nisalak A, Norman JE, Ennis FA, Rothman AL. Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription-polymerase chain reaction. J Med Virol. 2001 Jan; 63(1):29-34. PMID: 11130884.
      Citations: 23     Fields:    Translation:HumansCells
    73. Gagnon SJ, Leporati A, Green S, Kalayanarooj S, Vaughn DW, Stephens HA, Suntayakorn S, Kurane I, Ennis FA, Rothman AL. T cell receptor Vbeta gene usage in Thai children with dengue virus infection. Am J Trop Med Hyg. 2001 Jan-Feb; 64(1-2):41-8. PMID: 11425161.
      Citations: 3     Fields:    Translation:Humans
    74. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, Nisalak A. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000 Jan; 181(1):2-9. PMID: 10608744.
      Citations: 648     Fields:    Translation:HumansCells
    75. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Rothman AL, Ennis FA. Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. J Med Virol. 1999 Nov; 59(3):329-34. PMID: 10502265.
      Citations: 81     Fields:    Translation:Humans
    76. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Nisalak A, Kurane I, Rothman AL, Ennis FA. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis. 1999 Nov; 180(5):1429-35. PMID: 10515800.
      Citations: 103     Fields:    Translation:HumansCells
    77. Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL. Impaired T cell proliferation in acute dengue infection. J Immunol. 1999 May 01; 162(9):5609-15. PMID: 10228044.
      Citations: 31     Fields:    Translation:HumansCells
    78. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Lew R, Innis BL, Kurane I, Rothman AL, Ennis FA. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis. 1999 Apr; 179(4):755-62. PMID: 10068569.
      Citations: 130     Fields:    Translation:Humans
    79. Sudiro TM, Ishiko H, Rothman AL, Kershaw DE, Green S, Vaughn DW, Nisalak A, Kalayanarooj S, Ennis FA. Microplate-reverse hybridization method to determine dengue virus serotype. J Virol Methods. 1998 Aug; 73(2):229-35. PMID: 9766894.
      Citations: 3     Fields:    Translation:HumansCells
    80. Mathew A, Kurane I, Green S, Stephens HA, Vaughn DW, Kalayanarooj S, Suntayakorn S, Chandanayingyong D, Ennis FA, Rothman AL. Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. J Virol. 1998 May; 72(5):3999-4004. PMID: 9557687.
      Citations: 44     Fields:    Translation:HumansCells
    81. Rothman AL, Yamada Y, Jameson J, Cruz J, West K, Green S, Ennis FA. Assessment of human CD4+ and CD8+ T lymphocyte responses in experimental viral vaccine studies. Dev Biol Stand. 1998; 95:95-104. PMID: 9855419.
      Citations: 1     Fields:    Translation:HumansCells
    82. Rico-Hesse R, Harrison LM, Nisalak A, Vaughn DW, Kalayanarooj S, Green S, Rothman AL, Ennis FA. Molecular evolution of dengue type 2 virus in Thailand. Am J Trop Med Hyg. 1998 Jan; 58(1):96-101. PMID: 9452299.
      Citations: 39     Fields:    Translation:HumansCells
    83. Green S, Kurane I, Pincus S, Paoletti E, Ennis FA. Recognition of dengue virus NS1-NS2a proteins by human CD4+ cytotoxic T lymphocyte clones. Virology. 1997 Aug 04; 234(2):383-6. PMID: 9268170.
      Citations: 13     Fields:    Translation:HumansCells
    84. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Rothman AL, Ennis FA, Nisalak A. Dengue in the early febrile phase: viremia and antibody responses. J Infect Dis. 1997 Aug; 176(2):322-30. PMID: 9237696.
      Citations: 141     Fields:    Translation:HumansCells
    85. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 1997 Aug; 176(2):313-21. PMID: 9237695.
      Citations: 164     Fields:    Translation:Humans
    86. Sudiro TM, Ishiko H, Green S, Vaughn DW, Nisalak A, Kalayanarooj S, Rothman AL, Raengsakulrach B, Janus J, Kurane I, Ennis FA. Rapid diagnosis of dengue viremia by reverse transcriptase-polymerase chain reaction using 3'-noncoding region universal primers. Am J Trop Med Hyg. 1997 Apr; 56(4):424-9. PMID: 9158052.
      Citations: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    87. Kurane I, Rothman AL, Livingston PG, Green S, Gagnon SJ, Janus J, Innis BL, Nimmannitya S, Nisalak A, Ennis FA. Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome. Arch Virol Suppl. 1994; 9:59-64. PMID: 8032282.
      Citations: 34     Fields:    Translation:HumansCells
    88. Green S, Kurane I, Edelman R, Tacket CO, Eckels KH, Vaughn DW, Hoke CH, Ennis FA. Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination. J Virol. 1993 Oct; 67(10):5962-7. PMID: 8371350.
      Citations: 22     Fields:    Translation:HumansCells
    89. Kobayashi K, Takeda A, Green S, Tuazon CU, Ennis FA. Direct detection of infectious human immunodeficiency virus type 1 (HIV-1) immune complexes in the sera of HIV-1-infected persons. J Infect Dis. 1993 Sep; 168(3):729-32. PMID: 8354914.
      Citations: 3     Fields:    Translation:HumansCells
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