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Jeanmarie Houghton MD, PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    Collapse Biography 
    Collapse education and training
    Rutgers University- New Brunswick, New Brunswick, NJ, United StatesBABiology
    University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesMD
    University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesPHDMicrobiology & Molecular Gene

    Collapse Overview 
    Collapse overview

    Academic Background

    B. A., Rutgers University, New Brunswick, NJ
    MD,UMDNJ-New Jersey Medical School, Newark, NJ
    PhD, UMDNJ-Graduate School of Biological Sciences, Newark, NJ

    Post-Graduate Training:
    UMDNJ-University Hospital, Newark, New Jersey
    Internal Medicine Residency

    UMDNJ-University Hospital, Newark, New Jersey
    Chief Medical Resident

    UMDNJ-University Hospital, Newark, New Jersey
    Gastroenterology Fellowship

    Research Interests:

    Host immune response to Helicobacter pylori infection, immune modulation of gastric cell signaling and growth regulation in response to Helicobacter infection.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA. The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis. Cell Metab. 2023 08 08; 35(8):1441-1456.e9. PMID: 37494932.
      Citations:    Fields:    Translation:AnimalsCells
    2. Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 06 08; 54(6):1137-1153.e8. PMID: 34051146.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    3. Metwally AM, Li H, Houghton J. Alterations of epigenetic regulators and P53 mutations in murine mesenchymal stem cell cultures: A possible mechanism of spontaneous transformation. Cancer Biomark. 2021; 32(3):327-337. PMID: 34151835.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020 03; 21(3):274-286. PMID: 32066947.
      Citations: 43     Fields:    Translation:HumansCells
    5. Miska J, Lui JB, Toomer KH, Devarajan P, Cai X, Houghton J, Lopez DM, Abreu MT, Wang G, Chen Z. Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines. J Exp Med. 2018 03 05; 215(3):841-858. PMID: 29374027.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    6. Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci. 2014 Jun; 59(6):1169-79. PMID: 24798995.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    7. Donnelly JM, Engevik A, Feng R, Xiao C, Boivin GP, Li J, Houghton J, Zavros Y. Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 15; 306(12):G1075-88. PMID: 24789207.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Donnelly JM, Chawla A, Houghton J, Zavros Y. Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PLoS One. 2013; 8(9):e75225. PMID: 24069395.
      Citations: 13     Fields:    Translation:AnimalsCells
    9. Stoicov C, Li H, Liu JH, Houghton J. Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation. Dig Dis Sci. 2013 Sep; 58(9):2466-77. PMID: 23873382.
      Citations: 8     Fields:    Translation:AnimalsCells
    10. Houghton JM. Helicobacter species methods and protocols. Introduction. Methods Mol Biol. 2012; 921:1-5. PMID: 23015484.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Moore N, Houghton J, Lyle S. Slow-cycling therapy-resistant cancer cells. Stem Cells Dev. 2012 Jul 01; 21(10):1822-30. PMID: 21973238.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    12. Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011 Jan; 20(1):11-7. PMID: 20677919.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    13. Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE. Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 2010 Aug; 19(8):1153-66. PMID: 20199238.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    14. Martin J, Donnelly JM, Houghton J, Zavros Y. The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci. 2010 Jun; 55(6):1516-24. PMID: 20437100.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    15. Cerny J, Trneny M, Slavickova A, Pytlik R, Salkova J, Valkova V, Liu Q, Houghton J, Klener P. Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders. Hematology. 2009 Aug; 14(4):187-97. PMID: 19635181.
      Citations: 1     Fields:    Translation:Humans
    16. Stoicov C, Fan X, Liu JH, Bowen G, Whary M, Kurt-Jones E, Houghton J. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol. 2009 Jul 01; 183(1):642-9. PMID: 19535625.
      Citations: 14     Fields:    Translation:AnimalsCells
    17. Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. Gastroenterology. 2009 Sep; 137(3):934-44, 944.e1-4. PMID: 19524576.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    18. Stoicov C, Saffari R, Houghton J. Green tea inhibits Helicobacter growth in vivo and in vitro. Int J Antimicrob Agents. 2009 May; 33(5):473-8. PMID: 19157800.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    19. Rogers AB, Houghton J. Helicobacter-based mouse models of digestive system carcinogenesis. Methods Mol Biol. 2009; 511:267-95. PMID: 19347301.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    20. Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007 Nov 15; 67(22):10889-98. PMID: 18006834.
      Citations: 85     Fields:    Translation:AnimalsCells
    21. Li H, Cai X, Fan X, Moquin B, Stoicov C, Houghton J. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G263-75. PMID: 17991709.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology. 2007 Aug; 133(2):659-72. PMID: 17681184.
      Citations: 262     Fields:    Translation:HumansAnimalsCells
    23. Li H, Fan X, Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem. 2007 Jul 01; 101(4):805-15. PMID: 17226777.
      Citations: 274     Fields:    Translation:HumansAnimalsCells
    24. Houghton J. Bone-marrow-derived cells and cancer--an opportunity for improved therapy. Nat Clin Pract Oncol. 2007 Jan; 4(1):2-3. PMID: 17183348.
      Citations: 3     Fields:    Translation:HumansCells
    25. Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun. 2007 Jan; 75(1):471-80. PMID: 17101660.
      Citations: 43     Fields:    Translation:AnimalsCells
    26. Cui G, Takaishi S, Ai W, Betz KS, Florholmen J, Koh TJ, Houghton J, Pritchard DM, Wang TC. Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. Lab Invest. 2006 Oct; 86(10):1037-51. PMID: 16894354.
      Citations: 26     Fields:    Translation:AnimalsCells
    27. Houghton J, Morozov A, Smirnova I, Wang TC. Stem cells and cancer. Semin Cancer Biol. 2007 Jun; 17(3):191-203. PMID: 16762563.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    28. Li HC, Stoicov C, Rogers AB, Houghton J. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol. 2006 Jan 21; 12(3):363-71. PMID: 16489634.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    29. Stoicov C, Li H, Carlson J, Houghton J. Bone marrow cells as the origin of stomach cancer. Future Oncol. 2005 Dec; 1(6):851-62. PMID: 16556065.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Cai X, Stoicov C, Li H, Carlson J, Whary M, Fox JG, Houghton J. Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice. Cancer Res. 2005 Dec 01; 65(23):10912-20. PMID: 16322238.
      Citations: 10     Fields:    Translation:AnimalsCells
    31. Stoicov C, Cai X, Li H, Klucevsek K, Carlson J, Saffari R, Houghton J. Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation. Infect Immun. 2005 Oct; 73(10):6311-21. PMID: 16177302.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology. 2005 Jun; 128(7):1937-52. PMID: 15940628.
      Citations: 64     Fields:    Translation:AnimalsCells
    33. Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology. 2005 Jun; 128(7):1965-83. PMID: 15940630.
      Citations: 48     Fields:    Translation:AnimalsCells
    34. Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology. 2005 May; 128(6):1567-78. PMID: 15887152.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    35. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 26; 306(5701):1568-71. PMID: 15567866.
      Citations: 398     Fields:    Translation:AnimalsCells
    36. Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun. 2004 Nov; 72(11):6446-54. PMID: 15501775.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    37. Stoicov C, Saffari R, Cai X, Hasyagar C, Houghton J. Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling. Gene. 2004 Oct 27; 341:1-17. PMID: 15474284.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    38. Stoicov C, Whary M, Rogers AB, Lee FS, Klucevsek K, Li H, Cai X, Saffari R, Ge Z, Khan IA, Combe C, Luster A, Fox JG, Houghton J. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol. 2004 Sep 01; 173(5):3329-36. PMID: 15322196.
      Citations: 29     Fields:    Translation:AnimalsCells
    39. Koh TJ, Field JK, Varro A, Liloglou T, Fielding P, Cui G, Houghton J, Dockray GJ, Wang TC. Glycine-extended gastrin promotes the growth of lung cancer. Cancer Res. 2004 Jan 01; 64(1):196-201. PMID: 14729624.
      Citations: 11     Fields:    Translation:HumansAnimals
    40. Li H, Stoicov C, Cai X, Wang TC, Houghton J. Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility. Curr Gastroenterol Rep. 2003 Dec; 5(6):459-67. PMID: 14602053.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    41. Zivny J, Wang TC, Yantiss R, Kim KH, Houghton J. Role of therapy or monitoring in preventing progression to gastric cancer. J Clin Gastroenterol. 2003 May-Jun; 36(5 Suppl):S50-60; discussion S61-2. PMID: 12702966.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    42. Houghton J, Fox JG, Wang TC. Gastric cancer: laboratory bench to clinic. J Gastroenterol Hepatol. 2002 Apr; 17(4):495-502. PMID: 11982733.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    43. Houghton J, Ramamoorthy R, Pandya H, Dhirmalani R, Kim KH. Human plasma is directly bacteriocidal against Helicobacter pylori in vitro, potentially explaining the decreased detection of Helicobacter pylori during acute upper GI bleeding. Gastrointest Endosc. 2002 Jan; 55(1):11-6. PMID: 11756907.
      Citations: 8     Fields:    Translation:HumansCells
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