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David R Weaver PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street LRB-723
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
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    Michigan State University, East Lansing, MI, United StatesBSZoology
    Michigan State University, East Lansing, MI, United StatesPHDZoology & Neuroscience

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    Academic Background

    B.S., Michigan State University1981
    Ph.D., Michigan State University1985
    Postdoctoral Research Fellow, Mass. General Hospital1985-1987
    Postdoctoral Research Fellow, Harvard Medical School1985-1987
    Assistant in Neurobiology, Massachusetts General Hospital1987-1992
    Instructor, Harvard Medical School1987-1989
    Assistant Professor, Harvard Medical School1989-1994
    Associate Neurobiologist, Massachusetts General Hospital1993-2001
    Associate Professor, Harvard Medical School1994-2001
    Associate Professor, UMass Chan Medical School2001-2006
    Director, Graduate Program in Neuroscience, UMass Chan Medical School2005-
    Professor, UMass Chan Medical School2006-


    Research Program Description: Molecular Physiology of Circadian Rhythms

    The major objective of our research program is to understand the molecular mechanisms for circadian rhythmicity, and the impact of circadian rhythms on physiology and behavior.

    Molecular mechanisms of circadian rhythmicity.

    Daily rhythms in activity levels, alertness/sleep, body temperature, and hormonal profiles will persist in constant conditions, with a cycle length of about 24 hours, demonstrating the presence of an internal time-keeping system. When exposed to a daily light-dark cycle, these rhythms are synchronized (entrained) to a 24-hour period. In mammals, a small area of the anterior hypothalamus called the suprachiasmatic nucleus (SCN) is the principal circadian pacemaker (for review see Weaver, 1998; Reppert & Weaver 2001).

    How do SCN neurons measure out 24 hours? Work on the circadian clocks of species ranging from bacteria to fungi to fruit flies has revealed a common thread, that the molecular basis for circadian rhythmicity is the rhythmic synthesis of "clock" molecules. In each of these species, and in mammals, molecules are synthesized rhythmically, and these molecules then feed back to turn off their own synthesis. This forms what is called a "transcriptional-translational feedback loop." Mutations of specific genes within the feedback loop result in altered or disrupted rhythmicity. Recently, great advances have been made in identifying the components of the circadian feedback loop in mammals, and in defining the specific roles of individual gene products in the circadian clock (reviewed in Reppert & Weaver 2002). The aim of this research is to understand the molecular mechanisms underlying generation and entrainment of circadian rhythms in mammals.

    Current Research Projects:

    We are studying behavioral and molecular phenotypes of mice with genetic defects altering circadian behavior. We continue to generate line of mice with targeted disruption of genes relevant to circadian rhythms. Other areas of interest are to identify the effects of clock gene mutations on other behavioral and physiological processes, including sleep, and to understand the importance of local oscillators in tissues outside the brain.

    Please use the Publications Tab at the top of this page for the most up-to-date description of this research program and my collaborators.



    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Paillard M, Huang KT, Weaver D, Lambert JP, Elrod JW, Hajn├│czky G. Altered composition of the mitochondrial Ca2+uniporter in the failing human heart. Cell Calcium. 2022 07; 105:102618. PMID: 35779476.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Smith CB, van der Vinne V, McCartney E, Stowie AC, Leise TL, Martin-Burgos B, Molyneux PC, Garbutt LA, Brodsky MH, Davidson AJ, Harrington ME, Dallmann R, Weaver DR. Cell-Type-Specific Circadian Bioluminescence Rhythms in Dbp Reporter Mice. J Biol Rhythms. 2022 02; 37(1):53-77. PMID: 35023384.
      Citations:    Fields:    Translation:Animals
    3. Martin-Burgos B, Wang W, William I, Tir S, Mohammad I, Javed R, Smith S, Cui Y, Arzavala J, Mora D, Smith CB, van der Vinne V, Molyneux PC, Miller SC, Weaver DR, Leise TL, Harrington ME. Methods for Detecting PER2:LUCIFERASE Bioluminescence Rhythms in Freely Moving Mice. J Biol Rhythms. 2022 02; 37(1):78-93. PMID: 34873943.
      Citations: 2     Fields:    Translation:Animals
    4. van der Vinne V, Martin Burgos B, Harrington ME, Weaver DR. Deconstructing circadian disruption: Assessing the contribution of reduced peripheral oscillator amplitude on obesity and glucose intolerance in mice. J Pineal Res. 2020 Aug; 69(1):e12654. PMID: 32243642.
      Citations: 5     Fields:    Translation:Animals
    5. Prior KF, Rijo-Ferreira F, Assis PA, Hirako IC, Weaver DR, Gazzinelli RT, Reece SE. Periodic Parasites and Daily Host Rhythms. Cell Host Microbe. 2020 02 12; 27(2):176-187. PMID: 32053788.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    6. van der Vinne V, Bingaman MJ, Weaver DR, Swoap SJ. Clocks and meals keep mice from being cool. J Exp Biol. 2018 08 06; 221(Pt 15). PMID: 29903839.
      Citations: 6     Fields:    Translation:Animals
    7. Weaver DR, van der Vinne V, Giannaris EL, Vajtay TJ, Holloway KL, Anaclet C. Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre. J Biol Rhythms. 2018 04; 33(2):179-191. PMID: 29671710.
      Citations: 7     Fields:    Translation:Animals
    8. van der Vinne V, Swoap SJ, Vajtay TJ, Weaver DR. Desynchrony between brain and peripheral clocks caused by CK1?/? disruption in GABA neurons does not lead to adverse metabolic outcomes. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2437-E2446. PMID: 29463694.
      Citations: 12     Fields:    Translation:AnimalsCells
    9. Stokes K, Cooke A, Chang H, Weaver DR, Breault DT, Karpowicz P. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. PMID: 28593182.
      Citations: 34     Fields:    
    10. Park J, Zhu H, O'Sullivan S, Ogunnaike BA, Weaver DR, Schwaber JS, Vadigepalli R. Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock. Front Neurosci. 2016; 10:481. PMID: 27826225.
    11. Weaver, DR. In: Circadian Clocks: Role in Health and Disease (M.L. Gumz, ed.). Introduction to Circadian Rhythms and Mechanisms of Circadian Oscillations. 2016; 1-55.
    12. DeBruyne JP, Weaver DR, Dallmann R. The hepatic circadian clock modulates xenobiotic metabolism in mice. J Biol Rhythms. 2014 Aug; 29(4):277-87. PMID: 25238856.
      Citations: 17     Fields:    Translation:Animals
    13. Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec; 123(12):5389-400. PMID: 24270424.
      Citations: 193     Fields:    Translation:AnimalsCells
    14. Punia S, Rumery KK, Yu EA, Lambert CM, Notkins AL, Weaver DR. Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2?. Am J Physiol Endocrinol Metab. 2012 Sep 15; 303(6):E762-76. PMID: 22785238.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Zhu H, Vadigepalli R, Rafferty R, Gonye GE, Weaver DR, Schwaber JS. Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus. PLoS One. 2012; 7(5):e37833. PMID: 22662235.
      Citations: 10     Fields:    Translation:Animals
    16. LeSauter J, Lambert CM, Robotham MR, Model Z, Silver R, Weaver DR. Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus. PLoS One. 2012; 7(4):e35938. PMID: 22558277.
      Citations: 18     Fields:    Translation:Animals
    17. Schwartz WJ, Tavakoli-Nezhad M, Lambert CM, Weaver DR, de la Iglesia HO. Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17219-24. PMID: 21969555.
      Citations: 25     Fields:    Translation:Animals
    18. Dallmann R, DeBruyne JP, Weaver DR. Photic resetting and entrainment in CLOCK-deficient mice. J Biol Rhythms. 2011 Oct; 26(5):390-401. PMID: 21921293.
      Citations: 11     Fields:    Translation:Animals
    19. Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C. The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16451-6. PMID: 21930935.
      Citations: 87     Fields:    Translation:AnimalsCells
    20. Yu EA, Weaver DR. Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY). 2011 May; 3(5):479-93. PMID: 21566258.
      Citations: 98     Fields:    Translation:Humans
    21. Dallmann R, Weaver DR. Altered body mass regulation in male mPeriod mutant mice on high-fat diet. Chronobiol Int. 2010 Jul; 27(6):1317-28. PMID: 20653457.
      Citations: 31     Fields:    Translation:Animals
    22. Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR. Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One. 2010 Apr 22; 5(4):e10303. PMID: 20421981.
      Citations: 23     Fields:    Translation:AnimalsCells
    23. Gumz ML, Stow LR, Lynch IJ, Greenlee MM, Rudin A, Cain BD, Weaver DR, Wingo CS. The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. J Clin Invest. 2009 Aug; 119(8):2423-34. PMID: 19587447.
      Citations: 94     Fields:    Translation:AnimalsCells
    24. Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL. Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. FASEB J. 2009 Sep; 23(9):3226-32. PMID: 19433624.
      Citations: 17     Fields:    Translation:AnimalsCells
    25. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66. PMID: 19414593.
      Citations: 107     Fields:    Translation:AnimalsCells
    26. Keaney JF, Weaver DR. Vascular rhythms and adaptation: do your arteries know what time it is? Circulation. 2009 Mar 24; 119(11):1463-6. PMID: 19273717.
      Citations: 3     Fields:    Translation:HumansAnimals
    27. Yasuo S, von Gall C, Weaver DR, Korf HW. Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling. Eur J Neurosci. 2008 Dec; 28(12):2443-50. PMID: 19087172.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9. PMID: 17637349.
      Citations: 71     Fields:    Translation:Animals
    29. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5. PMID: 17417633.
      Citations: 190     Fields:    Translation:Animals
    30. Tavakoli-Nezhad M, Tao-Cheng JH, Weaver DR, Schwartz WJ. PER1-like immunoreactivity in oxytocin cells of the hamster hypothalamo-neurohypophyseal system. J Biol Rhythms. 2007 Feb; 22(1):81-4. PMID: 17229927.
      Citations: 3     Fields:    Translation:Animals
    31. Bae K, Weaver DR. Transient, light-induced rhythmicity in mPer-deficient mice. J Biol Rhythms. 2007 Feb; 22(1):85-8. PMID: 17229928.
      Citations: 9     Fields:    Translation:Animals
    32. von Gall C, Weaver DR. Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus. Neurobiol Aging. 2008 Mar; 29(3):464-70. PMID: 17123666.
      Citations: 12     Fields:    Translation:AnimalsCells
    33. Etchegaray JP, Yang X, DeBruyne JP, Peters AHFM, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-21215. PMID: 16717091.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    34. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 04; 50(3):465-77. PMID: 16675400.
      Citations: 176     Fields:    Translation:AnimalsCells
    35. Lambert CM, Weaver DR. Peripheral gene expression rhythms in a diurnal rodent. J Biol Rhythms. 2006 Feb; 21(1):77-9. PMID: 16461987.
      Citations: 11     Fields:    Translation:Animals
    36. Jilg A, Moek J, Weaver DR, Korf HW, Stehle JH, von Gall C. Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Eur J Neurosci. 2005 Dec; 22(11):2845-54. PMID: 16324119.
      Citations: 25     Fields:    Translation:AnimalsCells
    37. Wang LM, Suthana NA, Chaudhury D, Weaver DR, Colwell CS. Melatonin inhibits hippocampal long-term potentiation. Eur J Neurosci. 2005 Nov; 22(9):2231-7. PMID: 16262661.
      Citations: 50     Fields:    Translation:AnimalsCells
    38. Lambert CM, Machida KK, Smale L, Nunez AA, Weaver DR. Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus). J Biol Rhythms. 2005 Jun; 20(3):206-18. PMID: 15851527.
      Citations: 22     Fields:    Translation:AnimalsCells
    39. von Gall C, Weaver DR, Moek J, Jilg A, Stehle JH, Korf HW. Melatonin plays a crucial role in the regulation of rhythmic clock gene expression in the mouse pars tuberalis. Ann N Y Acad Sci. 2005 Apr; 1040:508-11. PMID: 15891103.
      Citations: 32     Fields:    Translation:Animals
    40. Shiromani PJ, Xu M, Winston EM, Shiromani SN, Gerashchenko D, Weaver DR. Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R47-57. PMID: 15031135.
      Citations: 55     Fields:    Translation:Animals
    41. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94. PMID: 14701732.
      Citations: 62     Fields:    Translation:AnimalsCells
    42. von Gall C, Noton E, Lee C, Weaver DR. Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus. Eur J Neurosci. 2003 Jul; 18(1):125-33. PMID: 12859345.
      Citations: 15     Fields:    Translation:Animals
    43. Bae K, Weaver DR. Light-induced phase shifts in mice lacking mPER1 or mPER2. J Biol Rhythms. 2003 Apr; 18(2):123-33. PMID: 12693867.
      Citations: 13     Fields:    Translation:Animals
    44. Olcese J, Domagalski R, Bednorz A, Weaver DR, Urbanski HF, Reuss S, Middendorff R. Expression and regulation of mPer1 in immortalized GnRH neurons. Neuroreport. 2003 Mar 24; 14(4):613-8. PMID: 12657897.
      Citations: 13     Fields:    Translation:AnimalsCells
    45. Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60. PMID: 12529409.
      Citations: 67     Fields:    Translation:AnimalsCells
    46. Forger DB, Dean DA, Gurdziel K, Leloup JC, Lee C, Von Gall C, Etchegaray JP, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME, Weaver DR. Development and validation of computational models for mammalian circadian oscillators. OMICS. 2003; 7(4):387-400. PMID: 14683611.
      Citations: 6     Fields:    Translation:HumansAnimals
    47. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41. PMID: 12198538.
      Citations: 1396     Fields:    Translation:AnimalsCells
    48. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23; 417(6887):405-10. PMID: 12024206.
      Citations: 231     Fields:    Translation:HumansAnimalsCells
    49. von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. 2002 Jul; 309(1):151-62. PMID: 12111545.
      Citations: 104     Fields:    Translation:AnimalsCells
    50. von Gall C, Garabette ML, Kell CA, Frenzel S, Dehghani F, Schumm-Draeger PM, Weaver DR, Korf HW, Hastings MH, Stehle JH. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci. 2002 Mar; 5(3):234-8. PMID: 11836530.
      Citations: 57     Fields:    Translation:AnimalsCells
    51. Shearman LP, Weaver DR. Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleus. J Biol Rhythms. 2001 Dec; 16(6):531-40. PMID: 11760011.
      Citations: 5     Fields:    Translation:Animals
    52. Weaver DR, Capodice CE. Postmortem stability of melatonin receptor binding and clock-relevant mRNAs in mouse suprachiasmatic nucleus. J Biol Rhythms. 2001 Jun; 16(3):216-23. PMID: 11407781.
      Citations: 1     Fields:    Translation:AnimalsCells
    53. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron. 2001 May; 30(2):525-36. PMID: 11395012.
      Citations: 330     Fields:    Translation:AnimalsCells
    54. Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol. 2001; 63:647-76. PMID: 11181971.
      Citations: 437     Fields:    Translation:Animals
    55. Reppert SM, Weaver DR. Comparing clockworks: mouse versus fly. J Biol Rhythms. 2000 Oct; 15(5):357-64. PMID: 11039914.
      Citations: 17     Fields:    Translation:Animals
    56. Shearman LP, Jin X, Lee C, Reppert SM, Weaver DR. Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol. 2000 Sep; 20(17):6269-75. PMID: 10938103.
      Citations: 115     Fields:    Translation:AnimalsCells
    57. Gotter AL, Manganaro T, Weaver DR, Kolakowski LF, Possidente B, Sriram S, MacLaughlin DT, Reppert SM. A time-less function for mouse timeless. Nat Neurosci. 2000 Aug; 3(8):755-6. PMID: 10903565.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    58. von Gall C, Weaver DR, Kock M, Korf HW, Stehle JH. Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor. Neuroreport. 2000 Jun 26; 11(9):1803-7. PMID: 10884023.
      Citations: 13     Fields:    Translation:AnimalsCells
    59. Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM. Interacting molecular loops in the mammalian circadian clock. Science. 2000 May 12; 288(5468):1013-9. PMID: 10807566.
      Citations: 431     Fields:    Translation:AnimalsCells
    60. Field MD, Maywood ES, O'Brien JA, Weaver DR, Reppert SM, Hastings MH. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron. 2000 Feb; 25(2):437-47. PMID: 10719897.
      Citations: 108     Fields:    Translation:AnimalsCells
    61. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 1999 Jul 23; 98(2):193-205. PMID: 10428031.
      Citations: 560     Fields:    Translation:HumansAnimalsCells
    62. Hastings MH, Field MD, Maywood ES, Weaver DR, Reppert SM. Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanism. J Neurosci. 1999 Jun 15; 19(12):RC11. PMID: 10366649.
      Citations: 48     Fields:    Translation:AnimalsCells
    63. Shearman LP, Zylka MJ, Reppert SM, Weaver DR. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus. Neuroscience. 1999 Mar; 89(2):387-97. PMID: 10077321.
      Citations: 19     Fields:    Translation:AnimalsCells
    64. Shearman LP, Weaver DR. Photic induction of Period gene expression is reduced in Clock mutant mice. Neuroreport. 1999 Feb 25; 10(3):613-8. PMID: 10208599.
      Citations: 15     Fields:    Translation:Animals
    65. Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell. 1999 Jan 08; 96(1):57-68. PMID: 9989497.
      Citations: 244     Fields:    Translation:AnimalsCells
    66. Weaver DR. The roles of melatonin in development. Adv Exp Med Biol. 1999; 460:199-214. PMID: 10810515.
      Citations: 2     Fields:    Translation:Animals
    67. Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR, Reppert SM. Molecular analysis of mammalian timeless. Neuron. 1998 Nov; 21(5):1115-22. PMID: 9856466.
      Citations: 40     Fields:    Translation:AnimalsCells
    68. Zylka MJ, Shearman LP, Weaver DR, Reppert SM. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron. 1998 Jun; 20(6):1103-10. PMID: 9655499.
      Citations: 209     Fields:    Translation:AnimalsCells
    69. Weaver DR. The suprachiasmatic nucleus: a 25-year retrospective. J Biol Rhythms. 1998 Apr; 13(2):100-12. PMID: 9554572.
      Citations: 118     Fields:    Translation:Animals
    70. Liu C, Weaver DR, Strogatz SH, Reppert SM. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell. 1997 Dec 12; 91(6):855-60. PMID: 9413994.
      Citations: 133     Fields:    Translation:AnimalsCells
    71. Weaver DR. Reproductive safety of melatonin: a "wonder drug" to wonder about. J Biol Rhythms. 1997 Dec; 12(6):682-9. PMID: 9406045.
      Citations: 6     Fields:    Translation:HumansAnimals
    72. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec; 19(6):1261-9. PMID: 9427249.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    73. Shearman LP, Zeitzer J, Weaver DR. Widespread expression of functional D1-dopamine receptors in fetal rat brain. Brain Res Dev Brain Res. 1997 Aug 18; 102(1):105-15. PMID: 9298239.
      Citations: 16     Fields:    Translation:Animals
    74. Shearman LP, Weaver DR. Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice. Brain Res Mol Brain Res. 1997 Jul; 47(1-2):275-85. PMID: 9221926.
      Citations: 1     Fields:    Translation:Animals
    75. Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK, Reppert SM. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997 Jul; 19(1):91-102. PMID: 9247266.
      Citations: 133     Fields:    Translation:Animals
    76. Reppert SM, Weaver DR. Forward genetic approach strikes gold: cloning of a mammalian clock gene. Cell. 1997 May 16; 89(4):487-90. PMID: 9160739.
      Citations: 7     Fields:    Translation:HumansAnimals
    77. Shearman LP, Weaver DR. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptor subtypes in rat brain. Brain Res. 1997 Jan 16; 745(1-2):10-20. PMID: 9037389.
      Citations: 9     Fields:    Translation:Animals
    78. Weaver DR, Reppert SM. The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei. Neuroreport. 1996 Dec 20; 8(1):109-12. PMID: 9051762.
      Citations: 21     Fields:    Translation:Humans
    79. Weaver DR, Liu C, Reppert SM. Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov; 10(11):1478-87. PMID: 8923472.
      Citations: 42     Fields:    Translation:AnimalsCells
    80. Roca AL, Godson C, Weaver DR, Reppert SM. Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor. Endocrinology. 1996 Aug; 137(8):3469-77. PMID: 8754776.
      Citations: 21     Fields:    Translation:AnimalsCells
    81. Weaver DR. A1-adenosine receptor gene expression in fetal rat brain. Brain Res Dev Brain Res. 1996 Jul 20; 94(2):205-23. PMID: 8836580.
      Citations: 14     Fields:    Translation:Animals
    82. Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett. 1996 May 20; 386(2-3):219-24. PMID: 8647286.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    83. Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol Sci. 1996 Mar; 17(3):100-2. PMID: 8936344.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    84. Reppert SM, Weaver DR. Melatonin madness. Cell. 1995 Dec 29; 83(7):1059-62. PMID: 8548792.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    85. Reppert SM, Weaver DR, Cassone VM, Godson C, Kolakowski LF. Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain. Neuron. 1995 Nov; 15(5):1003-15. PMID: 7576645.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    86. Weaver DR, Reppert SM. Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1995 Oct; 33(1):136-48. PMID: 8774955.
      Citations: 19     Fields:    Translation:Animals
    87. Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA, Gusella JF. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8734-8. PMID: 7568007.
      Citations: 138     Fields:    Translation:HumansCells
    88. Weaver DR, Roca AL, Reppert SM. c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation. Brain Res Dev Brain Res. 1995 Apr 18; 85(2):293-7. PMID: 7600678.
      Citations: 3     Fields:    Translation:Animals
    89. Weaver DR, Deeds JD, Lee K, Segre GV. Localization of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor mRNAs in rat brain. Brain Res Mol Brain Res. 1995 Feb; 28(2):296-310. PMID: 7723628.
      Citations: 17     Fields:    Translation:Animals
    90. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron. 1994 Nov; 13(5):1177-85. PMID: 7946354.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    91. Viswanathan N, Weaver DR, Reppert SM, Davis FC. Entrainment of the fetal hamster circadian pacemaker by prenatal injections of the dopamine agonist SKF 38393. J Neurosci. 1994 Sep; 14(9):5393-8. PMID: 7916044.
      Citations: 25     Fields:    Translation:Animals
    92. Weaver DR. A2a adenosine receptor gene expression in developing rat brain. Brain Res Mol Brain Res. 1993 Dec; 20(4):313-27. PMID: 8114618.
      Citations: 27     Fields:    Translation:Animals
    93. Roca AL, Weaver DR, Reppert SM. Serotonin receptor gene expression in the rat suprachiasmatic nuclei. Brain Res. 1993 Apr 09; 608(1):159-65. PMID: 8495340.
      Citations: 8     Fields:    Translation:Animals
    94. Weaver DR, Stehle JH, Stopa EG, Reppert SM. Melatonin receptors in human hypothalamus and pituitary: implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab. 1993 Feb; 76(2):295-301. PMID: 8381796.
      Citations: 31     Fields:    Translation:HumansAnimals
    95. Rivkees SA, Weaver DR, Reppert SM. Circadian and developmental regulation of Oct-2 gene expression in the suprachiasmatic nuclei. Brain Res. 1992 Dec 11; 598(1-2):332-6. PMID: 1486497.
      Citations: 2     Fields:    Translation:Animals
    96. Weaver DR, Reppert SM. Adenosine receptor gene expression in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 2):F991-5. PMID: 1481890.
      Citations: 16     Fields:    Translation:Animals
    97. Weaver DR, Rivkees SA, Reppert SM. D1-dopamine receptors activate c-fos expression in the fetal suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):9201-4. PMID: 1384044.
      Citations: 23     Fields:    Translation:Animals
    98. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95. PMID: 1279342.
      Citations: 152     Fields:    Translation:AnimalsCells
    99. Reppert SM, Weaver DR, Stehle JH, Rivkees SA, Grabbe S, Granstein RD. Molecular cloning of a G protein-coupled receptor that is highly expressed in lymphocytes and proliferative areas of developing brain. Mol Cell Neurosci. 1992 Jun; 3(3):206-14. PMID: 19912862.
      Citations: 1     Fields:    
    100. Stehle JH, Rivkees SA, Lee JJ, Weaver DR, Deeds JD, Reppert SM. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar; 6(3):384-93. PMID: 1584214.
      Citations: 49     Fields:    Translation:AnimalsCells
    101. Reppert SM, Weaver DR, Stehle JH, Rivkees SA. Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord. Mol Endocrinol. 1991 Aug; 5(8):1037-48. PMID: 1658635.
      Citations: 73     Fields:    Translation:AnimalsCells
    102. Carlson LL, Weaver DR, Reppert SM. Melatonin receptors and signal transduction during development in Siberian hamsters (Phodopus sungorus). Brain Res Dev Brain Res. 1991 Mar 18; 59(1):83-8. PMID: 1645629.
      Citations: 3     Fields:    Translation:AnimalsCells
    103. Weaver DR, Provencio I, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in photorefractory Siberian hamsters (Phodopus sungorus). Endocrinology. 1991 Feb; 128(2):1086-92. PMID: 1846576.
      Citations: 10     Fields:    Translation:AnimalsCells
    104. Bittman EL, Weaver DR. The distribution of melatonin binding sites in neuroendocrine tissues of the ewe. Biol Reprod. 1990 Dec; 43(6):986-93. PMID: 2291931.
      Citations: 11     Fields:    Translation:AnimalsCells
    105. Weaver DR, Reppert SM. Melatonin receptors are present in the ferret pars tuberalis and pars distalis, but not in brain. Endocrinology. 1990 Nov; 127(5):2607-9. PMID: 2171920.
      Citations: 13     Fields:    Translation:AnimalsCells
    106. Weaver DR, Carlson LL, Reppert SM. Melatonin receptors and signal transduction in melatonin-sensitive and melatonin-insensitive populations of white-footed mice (Peromyscus leucopus). Brain Res. 1990 Jan 08; 506(2):353-7. PMID: 2154292.
      Citations: 10     Fields:    Translation:AnimalsCells
    107. Carlson LL, Weaver DR, Reppert SM. Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology. 1989 Nov; 125(5):2670-6. PMID: 2551662.
      Citations: 13     Fields:    Translation:AnimalsCells
    108. Rivkees SA, Cassone VM, Weaver DR, Reppert SM. Melatonin receptors in chick brain: characterization and localization. Endocrinology. 1989 Jul; 125(1):363-8. PMID: 2544407.
      Citations: 15     Fields:    Translation:AnimalsCells
    109. Weaver DR, Rivkees SA, Reppert SM. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. J Neurosci. 1989 Jul; 9(7):2581-90. PMID: 2545841.
      Citations: 45     Fields:    Translation:AnimalsCells
    110. Weaver DR, Reppert SM. Direct in utero perception of light by the mammalian fetus. Brain Res Dev Brain Res. 1989 May 01; 47(1):151-5. PMID: 2736762.
      Citations: 2     Fields:    Translation:Animals
    111. Weaver DR, Reppert SM. Periodic feeding of SCN-lesioned pregnant rats entrains the fetal biological clock. Brain Res Dev Brain Res. 1989 Apr 01; 46(2):291-6. PMID: 2720961.
      Citations: 12     Fields:    Translation:Animals
    112. Reppert SM, Weaver DR, Rivkees SA, Stopa EG. Putative melatonin receptors in a human biological clock. Science. 1988 Oct 07; 242(4875):78-81. PMID: 2845576.
      Citations: 58     Fields:    Translation:HumansCells
    113. Rivkees SA, Hall DA, Weaver DR, Reppert SM. Djungarian hamsters exhibit reproductive responses to changes in daylength at extreme photoperiods. Endocrinology. 1988 Jun; 122(6):2634-8. PMID: 3371260.
      Citations: 1     Fields:    Translation:Animals
    114. Weaver DR, Namboodiri MA, Reppert SM. Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain. FEBS Lett. 1988 Feb 08; 228(1):123-7. PMID: 3342869.
      Citations: 14     Fields:    Translation:AnimalsCells
    115. Clemens LG, Wee BE, Weaver DR, Roy EJ, Goldman BD, Rakerd B. Retention of masculine sexual behavior following castration in male B6D2F1 mice. Physiol Behav. 1988; 42(1):69-76. PMID: 3387479.
      Citations: 16     Fields:    Translation:Animals
    116. Wee BE, Weaver DR, Clemens LG. Hormonal restoration of masculine sexual behavior in long-term castrated B6D2F1 mice. Physiol Behav. 1988; 42(1):77-82. PMID: 3387481.
      Citations: 3     Fields:    Translation:Animals
    117. Reppert SM, Weaver DR, Rivkees SA. Maternal communication of circadian phase to the developing mammal. Psychoneuroendocrinology. 1988; 13(1-2):63-78. PMID: 3287418.
      Citations: 13     Fields:    Translation:Animals
    118. Weaver DR, Keohan JT, Reppert SM. Definition of a prenatal sensitive period for maternal-fetal communication of day length. Am J Physiol. 1987 Dec; 253(6 Pt 1):E701-4. PMID: 3425712.
      Citations: 13     Fields:    Translation:Animals
    119. Weaver DR, Reppert SM. Maternal-fetal communication of circadian phase in a precocious rodent, the spiny mouse. Am J Physiol. 1987 Oct; 253(4 Pt 1):E401-9. PMID: 3661701.
      Citations: 3     Fields:    Translation:Animals
    120. Jacques SL, Weaver DR, Reppert SM. Penetration of light into the uterus of pregnant animals. Photochem Photobiol. 1987 May; 45(5):637-41. PMID: 3602113.
      Citations: 6     Fields:    Translation:Animals
    121. Reppert SM, Henshaw D, Schwartz WJ, Weaver DR. The circadian-gated timing of birth in rats: disruption by maternal SCN lesions or by removal of the fetal brain. Brain Res. 1987 Feb 17; 403(2):398-402. PMID: 3828831.
      Citations: 9     Fields:    Translation:Animals
    122. Weaver DR, Reppert SM. Maternal melatonin communicates daylength to the fetus in Djungarian hamsters. Endocrinology. 1986 Dec; 119(6):2861-3. PMID: 3780553.
      Citations: 8     Fields:    Translation:Animals
    123. Dohanich GP, Witcher JA, Weaver DR, Clemens LG. Alteration of muscarinic binding in specific brain areas following estrogen treatment. Brain Res. 1982 Jun 10; 241(2):347-50. PMID: 7104717.
      Citations: 10     Fields:    Translation:AnimalsCells
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