Header Logo

Neal Silverman PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street, LRB 326
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    University of California, Berkeley, Berkeley, CA, United StatesBAMolecular Biology
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPHDBiology
    Collapse awards and honors
    1996 - 1999Helen Hay Whitney Fellow, MCB, Harvard University
    2005 - 2007Ellison Foundation Young Investigator in Global Pathogenesis
    2006GSBS Faculty Achievement Award for Outstanding Contributions in the Classroom Settings
    2006Presidential Early Career Award for Scientists and Engineers (PECASE).
    2007 - 2012GSBS Faculty Achievement Award for outstanding contributions to curriculum development
    2010Dean's Award for Outstanding Faculty Contribution to Graduate Education
    2012Burroughs Welcome Fund, Investigator in Pathogenesis of Infectious Disease
    2015Dean's Award for outstanding faculty contribution to graduate education
    2017Kenneth Rainin Foundation Innovator Award
    2017Dean's Award for Outstanding Faculty Contribution to Graduate Education, UMMS

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pereira M, Ramalho T, Andrade WA, Durso DF, Souza MC, Fitzgerald KA, Golenbock DT, Silverman N, Gazzinelli RT. The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27; 43(2):113795. PMID: 38367238.
    2. Bharadwaj R, Anonick MV, Jaiswal S, Mashayekh S, Brown A, Wodzanowski KA, Okuda K, Silverman N, Grimes CL. Synthesis and validation of click-modified NOD1/2 agonists. Innate Immun. 2023 Nov; 29(8):186-200. PMID: 37828863.
      Citations:    Fields:    
    3. Bharadwaj R, Lusi CF, Mashayekh S, Nagar A, Subbarao M, Kane GI, Wodzanowski KA, Brown AR, Okuda K, Monahan A, Paik D, Nandy A, Anonick MV, Goldman WE, Kanneganti TD, Orzalli MH, Grimes CL, Atukorale PU, Silverman N. Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. Immunity. 2023 05 09; 56(5):998-1012.e8. PMID: 37116499.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Lee S, Jun YW, Linares GR, Butler B, Yuva-Adyemir Y, Moore J, Krishnan G, Ruiz-Juarez B, Santana M, Pons M, Silverman N, Weng Z, Ichida JK, Gao FB. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD. Neuron. 2023 05 03; 111(9):1381-1390.e6. PMID: 36931278.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Gupta A, Dhiman A, Sood A, Bharadwaj R, Silverman N, Agrawal G. Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy. Nanoscale. 2023 Feb 16; 15(7):3273-3283. PMID: 36723053.
      Citations:    Fields:    Translation:HumansCells
    6. Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 2022 08 16; 40(7):111225. PMID: 35977521.
      Citations: 6     Fields:    Translation:HumansCells
    7. Okuda K, Silva Costa Franco MM, Yasunaga A, Gazzinelli R, Rabinovitch M, Cherry S, Silverman N. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. iScience. 2022 Sep 16; 25(9):104909. PMID: 36060064.
    8. Sood A, Gupta A, Bharadwaj R, Ranganath P, Silverman N, Agrawal G. Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer. Carbohydr Polym. 2022 Oct 15; 294:119833. PMID: 35868778.
      Citations: 7     Fields:    Translation:AnimalsCells
    9. West C, Silverman N. cGAS-like receptors put a sting into the evolution of immune defence. Nature. 2021 09; 597(7874):34-35. PMID: 34373639.
      Citations: 1     Fields:    
    10. Hogan DA, Heitman J, Jabra-Rizk MA, Knoll LJ, Leong JM, Silverman N. Editorial overview of Pearls Microbiome Series: E pluribus unum. PLoS Pathog. 2021 08; 17(8):e1009912. PMID: 34464427.
      Citations:    Fields:    Translation:Humans
    11. Rahman T, Nagar A, Duffy EB, Okuda K, Silverman N, Harton JA. NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features. Front Immunol. 2020; 11:1828. PMID: 32983094.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    12. Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL. The Kinase IKK? Regulates a STING-and NF-?B-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2020 01 14; 52(1):200. PMID: 31940269.
      Citations: 1     Fields:    
    13. West C, Rus F, Chen Y, Kleino A, Gangloff M, Gammon DB, Silverman N. IIV-6 Inhibits NF-?B Responses in Drosophila. Viruses. 2019 05 01; 11(5). PMID: 31052481.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Kleino A, Silverman N. Regulation of the Drosophila Imd pathway by signaling amyloids. Insect Biochem Mol Biol. 2019 05; 108:16-23. PMID: 30857831.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Nandy A, Lin L, Velentzas PD, Wu LP, Baehrecke EH, Silverman N. The NF-?B Factor Relish Regulates Atg1 Expression and Controls Autophagy. Cell Rep. 2018 11 20; 25(8):2110-2120.e3. PMID: 30463009.
      Citations: 21     Fields:    Translation:Animals
    16. Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL. The Kinase IKK? Regulates a STING- and NF-?B-Dependent Antiviral Response Pathway in Drosophila. Immunity. 2018 08 21; 49(2):225-234.e4. PMID: 30119996.
      Citations: 51     Fields:    Translation:AnimalsCells
    17. Zheng W, Rus F, Hernandez A, Kang P, Goldman W, Silverman N, Tatar M. Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells. BMC Biol. 2018 05 31; 16(1):60. PMID: 29855367.
      Citations: 24     Fields:    Translation:AnimalsCells
    18. West C, Silverman N. p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila. PLoS Pathog. 2018 05; 14(5):e1007020. PMID: 29746571.
      Citations: 20     Fields:    Translation:AnimalsCells
    19. Okuda K, Silverman N. Drosophila Model of Leishmania amazonensis Infection. Bio Protoc. 2017 Dec 05; 7(23). PMID: 29276726.
    20. Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H, Li J, Silverman N. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-?B Signaling. Immunity. 2017 10 17; 47(4):635-647.e6. PMID: 29045898.
      Citations: 30     Fields:    Translation:AnimalsCells
    21. Monahan AJ, Silverman N. Relish the Thought and Channel Your Chloride, for Bacterial Clearance Depends on It. Cell Host Microbe. 2017 Jun 14; 21(6):657-659. PMID: 28618263.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Paik D, Monahan A, Caffrey DR, Elling R, Goldman WE, Silverman N. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol. 2017 07 01; 199(1):263-270. PMID: 28539433.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    23. West C, Silverman N. Drosophilosophical: Re-thinking Adaptive Immunity in the Fly. Cell. 2017 04 06; 169(2):188-190. PMID: 28388404.
      Citations: 5     Fields:    Translation:HumansAnimals
    24. Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N. Innate immune signaling in Drosophila is regulated by transforming growth factor ? (TGF?)-activated kinase (Tak1)-triggered ubiquitin editing. J Biol Chem. 2017 05 26; 292(21):8738-8749. PMID: 28377500.
      Citations: 15     Fields:    Translation:AnimalsCells
    25. Gammon DB, Ishidate T, Li L, Gu W, Silverman N, Mello CC. The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans. Curr Biol. 2017 Mar 20; 27(6):795-806. PMID: 28262484.
      Citations: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Monahan A, Kleino A, Silverman N. ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation. Immunity. 2016 11 15; 45(5):951-953. PMID: 27851920.
      Citations: 1     Fields:    Translation:AnimalsCells
    27. Okuda K, Tong M, Dempsey B, Moore KJ, Gazzinelli RT, Silverman N. Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation. PLoS Pathog. 2016 06; 12(6):e1005669. PMID: 27280707.
      Citations: 18     Fields:    Translation:AnimalsCells
    28. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 08; 17(8):922-9. PMID: 27270400.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    29. Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayll?n N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calder?n GI, Grabowski JM, Jiang D, Khalil SMS, Kim D, Kocan KM, Koci J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, S?nchez-Gracia A, Severo MS, Silverman N, ?imo L, Tojo M, Tornador C, Van Zee JP, V?zquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJP, Park Y, Rozas J, Benton R, Pedra JHF, Nelson DR, Unger MF, Tubio JMC, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA. Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nat Commun. 2016 Feb 09; 7:10507. PMID: 26856261.
      Citations: 225     Fields:    Translation:AnimalsCellsPHPublic Health
    30. Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D. Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell. 2016 Jan 28; 164(3):406-19. PMID: 26824654.
      Citations: 121     Fields:    Translation:AnimalsCells
    31. Buchon N, Silverman N, Cherry S. Immunity in Drosophila melanogaster--from microbial recognition to whole-organism physiology. Nat Rev Immunol. 2014 Dec; 14(12):796-810. PMID: 25421701.
      Citations: 326     Fields:    Translation:AnimalsCells
    32. Dissel S, Seugnet L, Thimgan MS, Silverman N, Angadi V, Thacher PV, Burnham MM, Shaw PJ. Differential activation of immune factors in neurons and glia contribute to individual differences in resilience/vulnerability to sleep disruption. Brain Behav Immun. 2015 Jul; 47:75-85. PMID: 25451614.
      Citations: 25     Fields:    Translation:AnimalsCells
    33. Donlea JM, Ramanan N, Silverman N, Shaw PJ. Genetic rescue of functional senescence in synaptic and behavioral plasticity. Sleep. 2014 Sep 01; 37(9):1427-37. PMID: 25142573.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014 Sep 01; 193(5):2519-2530. PMID: 25063877.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    35. Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. Elife. 2014 Jun 25; 3. PMID: 24966209.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    36. Kim CH, Paik D, Rus F, Silverman N. The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35. J Biol Chem. 2014 Jul 18; 289(29):20092-101. PMID: 24891502.
      Citations: 19     Fields:    Translation:AnimalsCells
    37. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      Citations: 154     Fields:    Translation:AnimalsCells
    38. Gupta R, Ghosh S, Monks B, DeOliveira RB, Tzeng TC, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock DT. RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem. 2014 May 16; 289(20):13701-5. PMID: 24692555.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    39. Marinotti O, Cerqueira GC, de Almeida LG, Ferro MI, Loreto EL, Zaha A, Teixeira SM, Wespiser AR, Almeida E Silva A, Schlindwein AD, Pacheco AC, Silva AL, Graveley BR, Walenz BP, Lima Bde A, Ribeiro CA, Nunes-Silva CG, de Carvalho CR, Soares CM, de Menezes CB, Matiolli C, Caffrey D, Ara?jo DA, de Oliveira DM, Golenbock D, Grisard EC, Fantinatti-Garboggini F, de Carvalho FM, Barcellos FG, Prosdocimi F, May G, Azevedo Junior GM, Guimar?es GM, Goldman GH, Padilha IQ, Batista Jda S, Ferro JA, Ribeiro JM, Fietto JL, Dabbas KM, Cerdeira L, Agnez-Lima LF, Brocchi M, de Carvalho MO, Teixeira Mde M, Diniz Maia Mde M, Goldman MH, Cruz Schneider MP, Felipe MS, Hungria M, Nicol?s MF, Pereira M, Montes MA, Cant?o ME, Vincentz M, Rafael MS, Silverman N, Stoco PH, Souza RC, Vicentini R, Gazzinelli RT, Neves Rde O, Silva R, Astolfi-Filho S, Maciel TE, Urm?nyi TP, Tadei WP, Camargo EP, de Vasconcelos AT. The genome of Anopheles darlingi, the main neotropical malaria vector. Nucleic Acids Res. 2013 Aug; 41(15):7387-400. PMID: 23761445.
      Citations: 62     Fields:    Translation:AnimalsCellsPHPublic Health
    40. Kleino A, Silverman N. The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol. 2014 Jan; 42(1):25-35. PMID: 23721820.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    41. Rus F, Flatt T, Tong M, Aggarwal K, Okuda K, Kleino A, Yates E, Tatar M, Silverman N. Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity. EMBO J. 2013 May 29; 32(11):1626-38. PMID: 23652443.
      Citations: 63     Fields:    Translation:AnimalsCells
    42. Warmbold C, Uliczka K, Rus F, Suck R, Petersen A, Silverman N, Ulmer AJ, Heine H, Roeder T. Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster. J Immunol. 2013 Jan 01; 190(1):366-71. PMID: 23203927.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    43. Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495.
      Citations: 160     Fields:    Translation:AnimalsCells
    44. Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Serine/threonine acetylation of TGF?-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12710-5. PMID: 22802624.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    45. Meinander A, Runchel C, Tenev T, Chen L, Kim CH, Ribeiro PS, Broemer M, Leulier F, Zvelebil M, Silverman N, Meier P. Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 2012 Jun 13; 31(12):2770-83. PMID: 22549468.
      Citations: 50     Fields:    Translation:AnimalsCells
    46. Kleino A, Silverman N. UnZIPping mechanisms of effector-triggered immunity in animals. Cell Host Microbe. 2012 Apr 19; 11(4):320-2. PMID: 22520459.
      Citations: 9     Fields:    
    47. Rus F, Morlock K, Silverman N, Pham N, Kotwal GJ, Marshall WL. Characterization of poxvirus-encoded proteins that regulate innate immune signaling pathways. Methods Mol Biol. 2012; 890:273-88. PMID: 22688773.
      Citations: 3     Fields:    Translation:HumansCells
    48. Boyer L, Paquette N, Silverman N, Stuart LM. Bacterial effectors: learning on the fly. Adv Exp Med Biol. 2012; 710:29-36. PMID: 22127883.
      Citations: 7     Fields:    Translation:AnimalsCells
    49. Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM. Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity. 2011 Oct 28; 35(4):536-49. PMID: 22018470.
      Citations: 55     Fields:    Translation:HumansCells
    50. Ganesan S, Aggarwal K, Paquette N, Silverman N. NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol. 2011; 349:25-60. PMID: 20852987.
      Citations: 99     Fields:    Translation:AnimalsCells
    51. Charri?re GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J Biol Chem. 2010 Jun 25; 285(26):20147-54. PMID: 20406817.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    52. Paquette N, Broemer M, Aggarwal K, Chen L, Husson M, Ert?rk-Hasdemir D, Reichhart JM, Meier P, Silverman N. Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell. 2010 Jan 29; 37(2):172-82. PMID: 20122400.
      Citations: 73     Fields:    Translation:AnimalsCells
    53. Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y. NOD1 and NOD2 mediate sensing of periodontal pathogens. J Dent Res. 2010 Feb; 89(2):186-91. PMID: 20040739.
      Citations: 25     Fields:    Translation:HumansCells
    54. Troll JV, Bent EH, Pacquette N, Wier AM, Goldman WE, Silverman N, McFall-Ngai MJ. Taming the symbiont for coexistence: a host PGRP neutralizes a bacterial symbiont toxin. Environ Microbiol. 2010 Aug; 12(8):2190-203. PMID: 21966913.
      Citations: 48     Fields:    Translation:AnimalsCells
    55. Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ. Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18710-5. PMID: 19846771.
      Citations: 49     Fields:    Translation:AnimalsCells
    56. Ert?rk-Hasdemir D, Broemer M, Leulier F, Lane WS, Paquette N, Hwang D, Kim CH, St?ven S, Meier P, Silverman N. Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9779-84. PMID: 19497884.
      Citations: 78     Fields:    Translation:AnimalsCells
    57. Silverman N, Paquette N, Aggarwal K. Specificity and signaling in the Drosophila immune response. Invertebrate Surviv J. 2009 Jun 01; 6(2):163-174. PMID: 21625362.
    58. Troll JV, Adin DM, Wier AM, Paquette N, Silverman N, Goldman WE, Stadermann FJ, Stabb EV, McFall-Ngai MJ. Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host tissue development in a beneficial animal-bacterial symbiosis. Cell Microbiol. 2009 Jul; 11(7):1114-27. PMID: 19416268.
      Citations: 50     Fields:    Translation:AnimalsCells
    59. Aggarwal K, Rus F, Vriesema-Magnuson C, Ert?rk-Hasdemir D, Paquette N, Silverman N. Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog. 2008 Aug 08; 4(8):e1000120. PMID: 18688280.
      Citations: 52     Fields:    Translation:AnimalsCells
    60. Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, Garbuzov A, Palli SR, Tatar M, Silverman N. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 2008 Aug; 211(Pt 16):2712-24. PMID: 18689425.
      Citations: 107     Fields:    Translation:AnimalsCells
    61. Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol. 2008 Aug; 9(8):908-16. PMID: 18604211.
      Citations: 190     Fields:    Translation:AnimalsCells
    62. Aggarwal K, Silverman N. Positive and negative regulation of the Drosophila immune response. BMB Rep. 2008 Apr 30; 41(4):267-77. PMID: 18452646.
      Citations: 72     Fields:    Translation:AnimalsCells
    63. Silverman N, Paquette N. Immunology. The right resident bugs. Science. 2008 Feb 08; 319(5864):734-5. PMID: 18218861.
      Citations: 7     Fields:    Translation:AnimalsCells
    64. Aggrawal K, Silverman N. Peptidoglycan recognition in Drosophila. Biochem Soc Trans. 2007 Dec; 35(Pt 6):1496-500. PMID: 18031252.
      Citations: 17     Fields:    Translation:AnimalsCells
    65. Sweet CR, Conlon J, Golenbock DT, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007 Nov; 9(11):2700-15. PMID: 17608743.
      Citations: 71     Fields:    Translation:HumansCells
    66. Wu L, Silverman N. Fighting infection fly-style. Fly (Austin). 2007 Mar-Apr; 1(2):106-9. PMID: 19378452.
      Citations: 4     Fields:    Translation:AnimalsCells
    67. Cherry S, Silverman N. Host-pathogen interactions in drosophila: new tricks from an old friend. Nat Immunol. 2006 Sep; 7(9):911-7. PMID: 16924255.
      Citations: 70     Fields:    Translation:AnimalsCells
    68. Mitchell JA, Fitzgerald KA, Coyle A, Silverman N, Cartwright N. TOLLing away in Brazil. Nat Immunol. 2006 Jul; 7(7):675-9. PMID: 16785880.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    69. Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y, Peach C, Erturk-Hasdemir D, Goldman WE, Oh BH, Kurata S, Silverman N. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol. 2006 Jul; 7(7):715-23. PMID: 16767093.
      Citations: 156     Fields:    Translation:AnimalsCells
    70. Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, Aggarwal K, Goldman WE, Silverman N, Kurata S, Oh BH. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. J Biol Chem. 2006 Mar 24; 281(12):8286-95. PMID: 16428381.
      Citations: 70     Fields:    Translation:AnimalsCells
    71. Swaminathan CP, Brown PH, Roychowdhury A, Wang Q, Guan R, Silverman N, Goldman WE, Boons GJ, Mariuzza RA. Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):684-9. PMID: 16407132.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    72. Ert?rk-Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005 Oct 21; 123(2):190-2. PMID: 16239137.
      Citations: 2     Fields:    Translation:AnimalsCells
    73. Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ, Maniatis T. The role of ubiquitination in Drosophila innate immunity. J Biol Chem. 2005 Oct 07; 280(40):34048-55. PMID: 16081424.
      Citations: 56     Fields:    Translation:AnimalsCells
    74. Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell Signal. 2006 Apr; 18(4):441-8. PMID: 16014325.
      Citations: 25     Fields:    Translation:AnimalsCells
    75. Zerofsky M, Harel E, Silverman N, Tatar M. Aging of the innate immune response in Drosophila melanogaster. Aging Cell. 2005 Apr; 4(2):103-8. PMID: 15771614.
      Citations: 100     Fields:    Translation:AnimalsCells
    76. Kaneko T, Silverman N. Bacterial recognition and signalling by the Drosophila IMD pathway. Cell Microbiol. 2005 Apr; 7(4):461-9. PMID: 15760446.
      Citations: 47     Fields:    Translation:AnimalsCells
    77. Kaneko T, Golenbock D, Silverman N. Peptidoglycan recognition by the Drosophila Imd pathway. J Endotoxin Res. 2005; 11(6):383-9. PMID: 16303095.
      Citations: 12     Fields:    Translation:AnimalsCells
    78. Silverman N, Fitzgerald K. DUBbing down innate immunity. Nat Immunol. 2004 Oct; 5(10):1010-2. PMID: 15454928.
      Citations: 2     Fields:    Translation:Animals
    79. Kaneko T, Goldman WE, Mellroth P, Steiner H, Fukase K, Kusumoto S, Harley W, Fox A, Golenbock D, Silverman N. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity. 2004 May; 20(5):637-49. PMID: 15142531.
      Citations: 162     Fields:    Translation:AnimalsCells
    80. Silverman N, Zhou R, Erlich RL, Hunter M, Bernstein E, Schneider D, Maniatis T. Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem. 2003 Dec 05; 278(49):48928-34. PMID: 14519762.
      Citations: 117     Fields:    Translation:Animals
    81. Stoven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, Engstrom Y, Maniatis T, Hultmark D. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5991-6. PMID: 12732719.
      Citations: 135     Fields:    Translation:AnimalsCells
    82. Silverman N. Flies kNOw how to signal. Dev Cell. 2003 Jan; 4(1):5-6. PMID: 12530956.
      Citations:    Fields:    Translation:AnimalsCells
    Silverman's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (422)
    Co-Authors (20)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors