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Last Name

Sonia I Ortiz-Miranda PhD

TitleAdjunct Assistant Professor
InstitutionUniversity of Massachusetts Medical School
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionUMMS - School of Medicine

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    Collapse Biography 
    Collapse education and training
    University of Puerto Rico, Cayey, PR, United StatesBSBiology/Chemistry
    University of Puerto Rico, Cayey, PR, United StatesMSBiological Sciences
    University of California, Davis, Davis, CA, United StatesPHDNeurosciences

    Collapse Overview 
    Collapse overview

    Academic Background

    1983, B.S., University of Puerto Rico, Rio Piedras
    1986, M.S., University of Puerto Rico, Pio Piedras
    1997, Ph.D., University of California, Davis

    Opioid effects on ion channels and neuropeptide release

    Sonia PicMy work focuses on opioid regulation of ion channel conductances in peptidergic nerve terminals. Magnocellular neurons (MCN) in the hypothalamus control neuroendocrine processes such as parturition, lactation, and sodium and water retention, by releasing the neuropeptides Oxytocin and Vasopressin into the blood circulation at their nerve endings in the Neurohypophysis. Endogenous and exogenous opioids modulate neuropeptide release in MCN by targeting voltage-gated channels at the cell’s soma as well as at their nerve endings. We study how the activation of the μ and κ opioid receptors can selectively inhibit the release of these neuropeptides.My laboratory is also interested in studying the cellular mechanisms used by exogenous drugs such as nicotine and alcohol to modulate synaptic efficacy at these presynaptic nerve endings.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Velázquez-Marrero C, Custer EE, Marrero H, Ortiz-Miranda S, Lemos JR. Voltage-induced Ca2+ release by ryanodine receptors causes neuropeptide secretion from nerve terminals. J Neuroendocrinol. 2020 Feb 25; e12840. PMID: 32227430.
      View in: PubMed
    2. Custer EE, Knott TK, Ortiz-Miranda S, Lemos JR. Effects of calcium and sodium on ATP-induced vasopressin release from rat isolated neurohypophysial terminals. J Neuroendocrinol. 2018 May 04; e12605. PMID: 29729039.
      View in: PubMed
    3. Paskavitz AL, Quintana J, Cangussu D, Tavera-Montañez C, Xiao Y, Ortiz-Miranda S, Navea JG, Padilla-Benavides T. Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts. J Trace Elem Med Biol. 2018 Sep; 49:27-34. PMID: 29895369.
      View in: PubMed
    4. Lemos JR, Custer EE, Ortiz-Miranda S. Purinergic receptor types in the hypothalamic-neurohypophysial system. J Neuroendocrinol. 2018 Mar 07. PMID: 29512852.
      View in: PubMed
    5. Ortiz-Miranda S, Ji R, Jurczyk A, Aryee KE, Mo S, Fletcher T, Shaffer SA, Greiner DL, Bortell R, Gregg RG, Cheng A, Hennings LJ, Rittenhouse AR. A novel transgenic mouse model of lysosomal storage disorder. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 01; 311(5):G903-G919. PMID: 27659423.
      View in: PubMed
    6. McNally JM, Custer EE, Ortiz-Miranda S, Woodbury DJ, Kraner SD, Salzberg BM, Lemos JR. Functional ryanodine receptors in the membranes of neurohypophysial secretory granules. J Gen Physiol. 2014 Jun; 143(6):693-702. PMID: 24863930.
      View in: PubMed
    7. Velázquez-Marrero C, Ortiz-Miranda S, Marrero HG, Custer EE, Treistman SN, Lemos JR. µ-Opioid inhibition of Ca2+ currents and secretion in isolated terminals of the neurohypophysis occurs via ryanodine-sensitive Ca2+ stores. J Neurosci. 2014 Mar 5; 34(10):3733-42. PMID: 24599471.
      View in: PubMed
    8. Pietrzykowski AZ, Ortiz-Miranda S, Knott TK, Custer E, Puig S, Lemos JR, Treistman SN. Molecular tolerance of voltage-gated calcium channels is evident after short exposures to alcohol in vasopressin-releasing nerve terminals. Alcohol Clin Exp Res. 2013 Jun; 37(6):933-40. PMID: 23421938.
      View in: PubMed
    9. Knott TK, Hussy N, Cuadra AE, Lee RH, Ortiz-Miranda S, Custer EE, Lemos JR. Adenosine trisphosphate appears to act via different receptors in terminals versus somata of the hypothalamic neurohypophysial system. J Neuroendocrinol. 2012 Apr; 24(4):681-9. PMID: 22340013.
      View in: PubMed
    10. Custer EE, Knott TK, Cuadra AE, Ortiz-Miranda S, Lemos JR. P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis. J Neuroendocrinol. 2012 Apr; 24(4):674-80. PMID: 22340257.
      View in: PubMed
    11. Lemos JR, Ortiz-Miranda SI, Cuadra AE, Velázquez-Marrero C, Custer EE, Dad T, Dayanithi G. Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium. 2012 Mar-Apr; 51(3-4):284-92. PMID: 22341671.
      View in: PubMed
    12. Ortiz-Miranda SI, Dayanithi G, Velázquez-Marrero C, Custer EE, Treistman SN, Lemos JR. Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals. J Cell Physiol. 2010 Oct; 225(1):276-88. PMID: 20509142.
      View in: PubMed
    13. Custer EE, Ortiz-Miranda S, Knott TK, Rawson R, Elvey C, Lee RH, Lemos JR. Identification of the neuropeptide content of individual rat neurohypophysial terminals. J Neurosci Methods. 2007 Jul 30; 163(2):226-34. PMID: 17452053.
      View in: PubMed
    14. Ortiz-Miranda S, Dayanithi G, Custer E, Treistman SN, Lemos JR. Micro-opioid receptor preferentially inhibits oxytocin release from neurohypophysial terminals by blocking R-type Ca2+ channels. J Neuroendocrinol. 2005 Sep; 17(9):583-90. PMID: 16101897.
      View in: PubMed
    15. Ortiz-Miranda SI, Dayanithi G, Coccia V, Custer EE, Alphandery S, Mazuc E, Treistman S, Lemos JR. mu-Opioid receptor modulates peptide release from rat neurohypophysial terminals by inhibiting Ca(2+) influx. J Neuroendocrinol. 2003 Sep; 15(9):888-94. PMID: 12899684.
      View in: PubMed
    16. Pappone PA, Ortiz-Miranda SI. Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells. Am J Physiol. 1993 Apr; 264(4 Pt 1):C1014-9. PMID: 8476010.
      View in: PubMed
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