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Schahram Akbarian MD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurobiology
AddressMount Sinai School of Medicine
1425 Madison Avenue, 4-40
New York NY 10029
Phone508-856-2674
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurobiology

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBrudnick Neuropsychiatric Research Institute


    Collapse Biography 
    Collapse education and training
    Free University of Berlin, Berlin, , GermanyMD
    Freie Kunst-Studien State Otte, Berlin, , GermanyPHDNeurophysiology

    Collapse Overview 
    Collapse overview

    Academic Background

      Clinical Assistant in Psychiatry
      Massachusetts General Hospital and McLean Hospital
      Harvard Medical School
      Belmont, MA
    M.D. Freie Universitaet Berlin, Germany 1989
    Ph.D. Freie Universitaet Berlin, Germany 1991
    Postdoctoral Fellow
    University of California, Irvine, CA
    1991-1994
    Residency in Psychiatry
    Massachusetts General Hospital
    Harvard Medical School, Boston, MA
    1995-1999
    Assistant Professor in Psychiatry
    Massachusetts General Hospital
    Harvard Medical School
    2000-2001

    Schahram Akbarian, PhD, MD

    Epigenetics and the Brain

    Epigenetic marks, including cytosine methylation of genomic DNA and a rich cache of post-translational modifications of nucleosome core histones, could provide a type of cellular memory, and potentially maintained for the remainder of a cell's life and transmitted to daughter cells. Furthermore, evidence is accumulating that there is epigenetic heritability across generations in human, at least in principle. Therefore, the general theme of epigenetics is of great interest to the field of biological psychiatry because (i) it could provide valid and testable alternatives to genetic heritability models and (ii) exploration of chromatin structure and function in healthy and diseased brain could provide novel insights into the pathophysiology of major psychiatric disease. The primary focus of our laboratory is on the exploration of neuronal epigenomes in preclinical model systems and in human (postmortem) brain tissue. The following example highlights an ongoing research project:

    Chromatin Alterations in Developing and Diseased Prefrontal Cortex

    Prolonged maturation of prefrontal cortex (PFC), extending into or even beyond the second decade, plays a key role for normal human development and the neurobiology of schizophrenia, mood spectrum disorders and other disease. Contemporary neurobiological models explaining the protracted maturation of prefrontal and other higher order association areas of the human cerebral cortex-such as (i) changes in supply and expression of certain neurotrophic factors; or (ii) increased axon fiber myelination, or (iii) synaptic pruning- in essence date back more than 20 years, and only few advancements have been made since then. Moreover, many of these hypotheses are built on correlative observations and there is little evidence for causality. Because a number of neuronal genes undergo progressive histone lysine methylation during early childhood years, changes in neuronal chromatin structure and function, in conjunction with transcriptional regulation, could take part in a molecular "clock" operating during an extended period of PFC development, thereby regulating the protracted maturation of its neuronal circuitry. These may involve dynamic adaptations of site-specific histone lysine methylation markings that are thought to contribute to epigenetic control of gene expression. We approach this topic by genome-wide mapping of histone methylation landscapes in prefrontal neurons: (1) across the lifespan to understand normal development and aging; (2) in subjects on the psychosis or autism spectrum in order to gain insight into mechanisms of disease; (3) in genetically engineered mice with brain-specific ablation, or siRNA-mediated knockdown, of selected histone methyltransferase and demethylase enzymes that specifically target the histone H3-lysine 4 residue which is highly regulated at enhancer sequences and transcription start sites (see Figure).

    Figure

    Figure



    Collapse Rotation Projects

    Potential Rotation Projects

    1. Drug-induced adaptations in neuronal circuitry contributing to psychosis or addiction could be viewed as a form of neuronal plasticity and thus may depend on similar molecular mechanisms that operate in learning and memory centers of the brain. The goal of this project is treat mice with chromatin modifying drugs and to explore the resulting molecular adaptations in nuclei of neurons located in fore- and hindbrain. Students will gain experience in mouse genetics, neuroanatomy and various chromatin assays. Furthermore, students will have the opportunity to study current models of major psychiatric disease, including schizophrenia, mood disorders and addiction.

    2. The genome of vertebrates is subject to epigenetic modifications, including the methylation of cytosine residues in symmetrically positioned CpG dinucleotides. DNA-methylation has profound effects on transcriptional activity and chromosomal stability. The goal of this project is to determine the regulation of DNA-methylation in developing and aging brain. Students will apply various techniques to examine DNA-methylation patterns of selected gene sequences in defined cell populations of the CNS.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Filippova E, Weng Z, Akbarian S, Rogaev EI. Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. Transl Psychiatry. 2019 Oct 17; 9(1):256. PMID: 31624234.
      View in: PubMed
    2. Hoffman GE, Bendl J, Voloudakis G, Montgomery KS, Sloofman L, Wang YC, Shah HR, Hauberg ME, Johnson JS, Girdhar K, Song L, Fullard JF, Kramer R, Hahn CG, Gur R, Marenco S, Lipska BK, Lewis DA, Haroutunian V, Hemby S, Sullivan P, Akbarian S, Chess A, Buxbaum JD, Crawford GE, Domenici E, Devlin B, Sieberts SK, Peters MA, Roussos P. CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder. Sci Data. 2019 09 24; 6(1):180. PMID: 31551426.
      View in: PubMed
    3. Peter CJ, Saito A, Hasegawa Y, Tanaka Y, Nagpal M, Perez G, Alway E, Espeso-Gil S, Fayyad T, Ratner C, Dincer A, Gupta A, Devi L, Pappas JG, Lalonde FM, Butman JA, Han JC, Akbarian S, Kamiya A. In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene. Nat Commun. 2019 Sep 11; 10(1):4112. PMID: 31511512.
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    4. Rajarajan P, Flaherty E, Akbarian S, Brennand KJ. CRISPR-based functional evaluation of schizophrenia risk variants. Schizophr Res. 2019 Jul 02. PMID: 31277978.
      View in: PubMed
    5. Rajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Curr Opin Neurobiol. 2019 Jun 27; 59:112-119. PMID: 31255842.
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    6. Kurochkin I, Khrameeva E, Tkachev A, Stepanova V, Vanyushkina A, Stekolshchikova E, Li Q, Zubkov D, Shichkova P, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P. Metabolome signature of autism in the human prefrontal cortex. Commun Biol. 2019; 2:234. PMID: 31263778.
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    7. Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, Rogaev EI. Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons. FASEB J. 2019 Apr 10; fj201802646R. PMID: 30970224.
      View in: PubMed
    8. Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüs ZH, Crawford GE. Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018 Dec 14; 362(6420). PMID: 30545857.
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    9. Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science. 2018 Dec 14; 362(6420). PMID: 30545851.
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    10. Yu Q, He Z, Zubkov D, Huang S, Kurochkin I, Yang X, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P. Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders. Mol Psychiatry. 2018 Aug 08. PMID: 30089790.
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    11. Bryois J, Garrett ME, Song L, Safi A, Giusti-Rodriguez P, Johnson GD, Shieh AW, Buil A, Fullard JF, Roussos P, Sklar P, Akbarian S, Haroutunian V, Stockmeier CA, Wray GA, White KP, Liu C, Reddy TE, Ashley-Koch A, Sullivan PF, Crawford GE. Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia. Nat Commun. 2018 Aug 07; 9(1):3121. PMID: 30087329.
      View in: PubMed
    12. Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, Francoeur NJ, Wang YC, Shah H, Kavanagh DH, Zharovsky E, Jacobov R, Wiseman JR, Park R, Johnson JS, Kassim BS, Sloofman L, Mattei E, Weng Z, Sieberts SK, Peters MA, Harris BT, Lipska BK, Sklar P, Roussos P, Akbarian S. Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome. Nat Neurosci. 2018 Aug; 21(8):1126-1136. PMID: 30038276.
      View in: PubMed
    13. Mao W, Salzberg AC, Uchigashima M, Hasegawa Y, Hock H, Watanabe M, Akbarian S, Kawasawa YI, Futai K. Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1. Cell Rep. 2018 Jun 12; 23(11):3209-3222. PMID: 29898393.
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    14. Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei C, Hoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D. Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. Am J Hum Genet. 2018 Jun 07; 102(6):1169-1184. PMID: 29805045.
      View in: PubMed
    15. LaMarca EA, Powell SK, Akbarian S, Brennand KJ. Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. Front Pediatr. 2018; 6:82. PMID: 29666786.
      View in: PubMed
    16. Rajarajan P, Jiang Y, Kassim BS, Akbarian S. Chromosomal Conformations and Epigenomic Regulation in Schizophrenia. Prog Mol Biol Transl Sci. 2018; 157:21-40. PMID: 29933951.
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    17. Lin CY, Chang KW, Lin CY, Wu JY, Coon H, Huang PH, Ho HN, Akbarian S, Gau SS, Huang HS. Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes. Sci Rep. 2018 Mar 09; 8(1):4277. PMID: 29523860.
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    18. Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J. Antipsychotic-induced Hdac2 transcription via NF-?B leads to synaptic and cognitive side effects. Nat Neurosci. 2017 Sep; 20(9):1247-1259. PMID: 28783139.
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    19. Ho SM, Hartley BJ, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani HP, Akbarian S, Brennand KJ. Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem Cell Reports. 2017 08 08; 9(2):615-628. PMID: 28757163.
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    20. Javidfar B, Park R, Kassim BS, Bicks LK, Akbarian S. The epigenomics of schizophrenia, in the mouse. Am J Med Genet B Neuropsychiatr Genet. 2017 Sep; 174(6):631-640. PMID: 28699694.
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    21. Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nat Genet. 2017 Aug; 49(8):1239-1250. PMID: 28671686.
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    22. Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nat Commun. 2017 May 09; 8:15142. PMID: 28485378.
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    23. Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ. Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry. 2017 May 05. PMID: 28577753.
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    24. McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 Apr 28; 356(6336). PMID: 28450582.
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    25. Schmitt A, Martins-de-Souza D, Akbarian S, Cassoli JS, Ehrenreich H, Fischer A, Fonteh A, Gattaz WF, Gawlik M, Gerlach M, Grünblatt E, Halene T, Hasan A, Hashimoto K, Kim YK, Kirchner SK, Kornhuber J, Kraus TF, Malchow B, Nascimento JM, Rossner M, Schwarz M, Steiner J, Talib L, Thibaut F, Riederer P, Falkai P. Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms. World J Biol Psychiatry. 2016 Oct 26; 1-27. PMID: 27782767.
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    26. Rajarajan P, Gil SE, Brennand KJ, Akbarian S. Spatial genome organization and cognition. Nat Rev Neurosci. 2016 Nov; 17(11):681-691. PMID: 27708356.
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    27. Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P. Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS Biol. 2016 Sep; 14(9):e1002558. PMID: 27685936.
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    28. Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun. 2016 Sep 06; 7:12743. PMID: 27597321.
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    29. Chandrasekaran S, Akbarian S. Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds? Biol Psychiatry. 2016 Aug 15; 80(4):260-2. PMID: 27468627.
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    30. Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety. Neuropsychopharmacology. 2016 Dec; 41(13):3103-3113. PMID: 27485686.
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    31. Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2016; 11(7):e0160295. PMID: 27454300.
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    32. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 Jul 15; 80(2):84-6. PMID: 27346079.
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    33. Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15; 80(10):765-774. PMID: 27184921.
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    34. Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, Fromer M, Harris B, Lipska BK, Peters MA, Sklar P, Akbarian S. Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue. Biol Psychiatry. 2017 Jan 15; 81(2):162-170. PMID: 27113501.
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    35. Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P. Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophr Res. 2016 Nov; 177(1-3):115-124. PMID: 26827128.
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    36. Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S. NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure. Schizophr Res. 2016 Feb; 170(2-3):235-44. PMID: 26776227.
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    37. Sharp AJ, Akbarian S. Back to the past in schizophrenia genomics. Nat Neurosci. 2016 Jan; 19(1):1-2. PMID: 26713739.
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    38. Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2015; 10(12):e0143563. PMID: 26636579.
      View in: PubMed
    39. Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z. The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease. PLoS One. 2015; 10(12):e0144398. PMID: 26636336.
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    40. The PsychENCODE project. Nat Neurosci. 2015 Dec; 18(12):1707-12. PMID: 26605881.
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    41. Bicks LK, Koike H, Akbarian S, Morishita H. Prefrontal Cortex and Social Cognition in Mouse and Man. Front Psychol. 2015; 6:1805. PMID: 26635701.
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    42. Akbarian S, Kundakovic M. CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors! Am J Psychiatry. 2015 Nov 1; 172(11):1054-6. PMID: 26575444.
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    43. Jakovcevski M, Akbarian S, Di Benedetto B. Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders. Curr Opin Pharmacol. 2016 Feb; 26:61-6. PMID: 26515273.
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    44. Nestler EJ, Peña CJ, Kundakovic M, Mitchell A, Akbarian S. Epigenetic Basis of Mental Illness. Neuroscientist. 2016 Oct; 22(5):447-63. PMID: 26450593.
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    45. de Boni L, Riedel L, Schmitt I, Kraus TF, Kaut O, Piston D, Akbarian S, Wüllner U. DNA methylation levels of a-synuclein intron 1 in the aging brain. Neurobiol Aging. 2015 Dec; 36(12):3334.e7-11. PMID: 26422361.
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    46. Koike H, Demars MP, Short JA, Nabel EM, Akbarian S, Baxter MG, Morishita H. Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse. Neuropsychopharmacology. 2016 Mar; 41(4):1014-23. PMID: 26224620.
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    47. Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 2015 Jul 1; 87(1):77-94. PMID: 26139371.
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    48. Mahajan S, Crisci J, Wong A, Akbarian S, Foll M, Jensen JD. Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection. Front Genet. 2015; 6:190. PMID: 26074949.
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    49. Shen EY, Jiang Y, Mao W, Futai K, Hock H, Akbarian S. Cognition and mood-related behaviors in L3mbtl1 null mutant mice. PLoS One. 2015; 10(4):e0121252. PMID: 25849281.
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    50. Morishita H, Kundakovic M, Bicks L, Mitchell A, Akbarian S. Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia. Neurobiol Learn Mem. 2015 Oct; 124:104-10. PMID: 25849095.
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    51. Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF, Ernst P, Yao WD, Akbarian S. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci. 2015 Apr 1; 35(13):5097-108. PMID: 25834037.
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    52. Hoss AG, Labadorf A, Latourelle JC, Kartha VK, Hadzi TC, Gusella JF, MacDonald ME, Chen JF, Akbarian S, Weng Z, Vonsattel JP, Myers RH. miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics. 2015 Mar 01; 8:10. PMID: 25889241.
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    53. Hess JL, Quinn TP, Akbarian S, Glatt SJ. Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan; 168B(1):14-35. PMID: 25522715.
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    54. Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015 Mar 1; 24(5):1441-56. PMID: 25480889.
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    55. Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, Dickson DW, Petrucelli L, Sun D, Jiao J, Zhou H, Jakovcevski M, Akbarian S, Yao WD, Gao FB. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med. 2014 Dec; 20(12):1444-51. PMID: 25401692.
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    56. Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood MA, Akbarian S. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 2014 Dec 03; 84(5):997-1008. PMID: 25467983.
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    57. Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Plenge RM, Raychaudhuri S, Fromer M, Purcell SM, Brennand KJ, Robakis NK, Schadt EE, Akbarian S, Sklar P. A role for noncoding variation in schizophrenia. Cell Rep. 2014 Nov 20; 9(4):1417-29. PMID: 25453756.
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    58. Mitchell AC, Jiang Y, Peter C, Akbarian S. Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia. Schizophr Res. 2015 Sep; 167(1-3):28-34. PMID: 25458568.
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    59. Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ. Analytical tools and current challenges in the modern era of neuroepigenomics. Nat Neurosci. 2014 Nov; 17(11):1476-90. PMID: 25349914.
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    60. Shen E, Shulha H, Weng Z, Akbarian S. Regulation of histone H3K4 methylation in brain development and disease. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26; 369(1652). PMID: 25135975.
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    61. Chen CT, Hehnly H, Yu Q, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S. A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation. Curr Biol. 2014 Oct 06; 24(19):2327-34. PMID: 25220058.
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    62. Akbarian S. Epigenetic mechanisms in schizophrenia. Dialogues Clin Neurosci. 2014 Sep; 16(3):405-17. PMID: 25364289.
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    63. Shen EY, Ahern TH, Cheung I, Straubhaar J, Dincer A, Houston I, de Vries GJ, Akbarian S, Forger NG. Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice. Exp Neurol. 2015 Jun; 268:21-9. PMID: 25131640.
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    64. Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, Weng Z, Myers RH. MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis. PLoS Genet. 2014 Feb; 10(2):e1004188. PMID: 24586208.
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    65. Akbarian S, Lubin F. Preface. Epigenetics and neuroplasticity--evidence and debate. Prog Mol Biol Transl Sci. 2014; 128:xi-xiii. PMID: 25410547.
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    66. Mitchell A, Roussos P, Peter C, Tsankova N, Akbarian S. The future of neuroepigenetics in the human brain. Prog Mol Biol Transl Sci. 2014; 128:199-228. PMID: 25410546.
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    67. Ginns EI, Mak SK, Ko N, Karlgren J, Akbarian S, Chou VP, Guo Y, Lim A, Samuelsson S, LaMarca ML, Vazquez-DeRose J, Manning-Bog AB. Neuroinflammation and a-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction. Mol Genet Metab. 2014 Feb; 111(2):152-62. PMID: 24388731.
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    68. Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD. Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nat Med. 2013 Nov; 19(11):1473-7. PMID: 24141422.
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    69. Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S. The genome in three dimensions: a new frontier in human brain research. Biol Psychiatry. 2014 Jun 15; 75(12):961-9. PMID: 23958183.
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    70. Bharadwaj R, Jiang Y, Mao W, Jakovcevski M, Dincer A, Krueger W, Garbett K, Whittle C, Tushir JS, Liu J, Sequeira A, Vawter MP, Gardner PD, Casaccia P, Rasmussen T, Bunney WE, Mirnics K, Futai K, Akbarian S. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. J Neurosci. 2013 Jul 17; 33(29):11839-51. PMID: 23864674.
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    71. Akbarian S, Beeri MS, Haroutunian V. Epigenetic determinants of healthy and diseased brain aging and cognition. JAMA Neurol. 2013 Jun; 70(6):711-8. PMID: 23571692.
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    72. Jakovcevski M, Bharadwaj R, Straubhaar J, Gao G, Gavin DP, Jakovcevski I, Mitchell AC, Akbarian S. Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. Biol Psychiatry. 2013 Nov 1; 74(9):696-705. PMID: 23664640.
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    73. Akbarian S, Halene T. The neuroepigenetics of suicide. Am J Psychiatry. 2013 May; 170(5):462-5. PMID: 23632831.
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    74. Shulha HP, Cheung I, Guo Y, Akbarian S, Weng Z. Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood. PLoS Genet. 2013 Apr; 9(4):e1003433. PMID: 23593028.
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    75. Hasan A, Mitchell A, Schneider A, Halene T, Akbarian S. Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors. Eur Arch Psychiatry Clin Neurosci. 2013 Jun; 263(4):273-84. PMID: 23381549.
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    76. Hope BT, Skinner MK, Kenny PJ, Akbarian S. Exploring the epigenetics of cocaine resistance. Nat Med. 2013 Feb; 19(2):136-7. PMID: 23389607.
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    77. Akbarian S, Nestler EJ. Epigenetic mechanisms in psychiatry. Neuropsychopharmacology. 2013 Jan; 38(1):1-2. PMID: 23147478.
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    78. Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 2012; 10(11):e1001427. PMID: 23185133.
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    79. Jakovcevski M, Akbarian S. Epigenetic mechanisms in neurological disease. Nat Med. 2012 Aug; 18(8):1194-204. PMID: 22869198.
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    80. Connor CM, Dincer A, Straubhaar J, Galler JR, Houston IB, Akbarian S. Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome. Schizophr Res. 2012 Sep; 140(1-3):175-84. PMID: 22804924.
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    81. Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 7; 11(3):319-32. PMID: 22770845.
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    82. Houston I, Peter CJ, Mitchell A, Straubhaar J, Rogaev E, Akbarian S. Epigenetics in the human brain. Neuropsychopharmacology. 2013 Jan; 38(1):183-97. PMID: 22643929.
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    83. Rane P, Shields J, Heffernan M, Guo Y, Akbarian S, King JA. The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD. Neuropharmacology. 2012 Jun; 62(7):2409-12. PMID: 22353286.
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    84. Gavin DP, Akbarian S. Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease. Neurobiol Dis. 2012 May; 46(2):255-62. PMID: 22182689.
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    85. Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, Guo Y, Lessard A, Akbarian S, Weng Z. Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons. Arch Gen Psychiatry. 2012 Mar; 69(3):314-24. PMID: 22065254.
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    86. Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011 Oct; 1236:30-43. PMID: 22032400.
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    87. Peter CJ, Akbarian S. Balancing histone methylation activities in psychiatric disorders. Trends Mol Med. 2011 Jul; 17(7):372-9. PMID: 21429800.
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    88. Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z. The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PLoS One. 2010 Dec 31; 5(12):e15878. PMID: 21209826.
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    89. Akbarian S, Davis RJ. Keep the 'phospho' on MAPK, be happy. Nat Med. 2010 Nov; 16(11):1187-8. PMID: 21052065.
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    90. Jiang Y, Matevossian A, Guo Y, Akbarian S. Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun; 60(7-8):1088-97. PMID: 20869373.
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    91. Mellios N, Galdzicka M, Ginns E, Baker SP, Rogaev E, Xu J, Akbarian S. Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. Schizophr Bull. 2012 May; 38(3):433-43. PMID: 20732949.
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    92. Connor CM, Crawford BC, Akbarian S. White matter neuron alterations in schizophrenia and related disorders. Int J Dev Neurosci. 2011 May; 29(3):325-34. PMID: 20691252.
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    93. Huang HS, Cheung I, Akbarian S. RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. Autism Res. 2010 Aug; 3(4):153-61. PMID: 20632321.
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    94. Connor C, Cheung I, Simon A, Jakovcevski M, Weng Z, Akbarian S. A simple method for improving the specificity of anti-methyl histone antibodies. Epigenetics. 2010 Jul 1; 5(5):392-5. PMID: 20458167.
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    95. Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H. Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem. 2010 Sep 03; 285(36):27767-75. PMID: 20592034.
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    96. Jiang Y, Jakovcevski M, Bharadwaj R, Connor C, Schroeder FA, Lin CL, Straubhaar J, Martin G, Akbarian S. Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci. 2010 May 26; 30(21):7152-67. PMID: 20505083.
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    97. Cheung I, Shulha HP, Jiang Y, Matevossian A, Wang J, Weng Z, Akbarian S. Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8824-9. PMID: 20421462.
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    98. Jakovcevski M, Guo Y, Su Q, Gao G, Akbarian S. rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5417. PMID: 20360371.
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    99. Akbarian S. Epigenetics of schizophrenia. Curr Top Behav Neurosci. 2010; 4:611-28. PMID: 21312415.
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    100. Akbarian S. The molecular pathology of schizophrenia--focus on histone and DNA modifications. Brain Res Bull. 2010 Sep 30; 83(3-4):103-7. PMID: 19729053.
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    101. Febo M, Akbarian S, Schroeder FA, Ferris CF. Cocaine-induced metabolic activation in cortico-limbic circuitry is increased after exposure to the histone deacetylase inhibitor, sodium butyrate. Neurosci Lett. 2009 Nov 20; 465(3):267-71. PMID: 19638299.
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    102. Connor CM, Guo Y, Akbarian S. Cingulate white matter neurons in schizophrenia and bipolar disorder. Biol Psychiatry. 2009 Sep 1; 66(5):486-93. PMID: 19559403.
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    103. Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry. 2009 Jun 15; 65(12):1006-14. PMID: 19121517.
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    104. Akbarian S. Restoring GABAergic signaling and neuronal synchrony in schizophrenia. Am J Psychiatry. 2008 Dec; 165(12):1507-9. PMID: 19047328.
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    105. Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC. Epigenetics in the nervous system. J Neurosci. 2008 Nov 12; 28(46):11753-9. PMID: 19005036.
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    106. Akbarian S. Approaching the molecular pathology of suicide. Biol Psychiatry. 2008 Oct 15; 64(8):643-4. PMID: 18926170.
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    107. Matevossian A, Akbarian S. Neuronal nuclei isolation from human postmortem brain tissue. J Vis Exp. 2008 Oct 01; (20). PMID: 19078943.
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    108. Akbarian S, Huang HS. Epigenetic regulation in human brain-focus on histone lysine methylation. Biol Psychiatry. 2009 Feb 1; 65(3):198-203. PMID: 18814864.
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    109. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet. 2008 Oct 1; 17(19):3030-42. PMID: 18632683.
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    110. Jiang Y, Matevossian A, Huang HS, Straubhaar J, Akbarian S. Isolation of neuronal chromatin from brain tissue. BMC Neurosci. 2008 Apr 28; 9:42. PMID: 18442397.
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    111. Matevossian A, Akbarian S. A chromatin assay for human brain tissue. J Vis Exp. 2008 Mar 21; (13). PMID: 19066569.
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    112. Connor CM, Akbarian S. DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics. 2008 Mar-Apr; 3(2):55-8. PMID: 18398310.
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    113. Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology. 2008 Nov; 33(12):2981-92. PMID: 18288092.
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    114. Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S. Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17; 27(42):11254-62. PMID: 17942719.
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    115. Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One. 2007; 2(9):e895. PMID: 17878930.
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    116. Huang HS, Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS One. 2007 Aug 29; 2(8):e809. PMID: 17726539.
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    117. Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry. 2007 Jul 1; 62(1):55-64. PMID: 16945350.
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    118. Akbarian S, Huang HS. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev. 2006 Sep; 52(2):293-304. PMID: 16759710.
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    119. Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R, Lu B. NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn Mem. 2006 May-Jun; 13(3):307-15. PMID: 16705139.
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    120. Huang HS, Matevossian A, Jiang Y, Akbarian S. Chromatin immunoprecipitation in postmortem brain. J Neurosci Methods. 2006 Sep 30; 156(1-2):284-92. PMID: 16574239.
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    121. Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. J Neurobiol. 2006 Mar; 66(4):408-20. PMID: 16408297.
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    122. Akbarian S, Jiang Y, Laforet G. The molecular pathology of Rett syndrome: synopsis and update. Neuromolecular Med. 2006; 8(4):485-94. PMID: 17028371.
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    123. Akbarian S, Ruehl MG, Bliven E, Luiz LA, Peranelli AC, Baker SP, Roberts RC, Bunney WE, Conley RC, Jones EG, Tamminga CA, Guo Y. Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia. Arch Gen Psychiatry. 2005 Aug; 62(8):829-40. PMID: 16061760.
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    124. Stadler F, Kolb G, Rubusch L, Baker SP, Jones EG, Akbarian S. Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. J Neurochem. 2005 Jul; 94(2):324-36. PMID: 15998284.
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    125. Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C, Akbarian S. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J Neurochem. 2004 Sep; 90(5):1117-31. PMID: 15312167.
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    126. Akbarian S. The neurobiology of Rett syndrome. Neuroscientist. 2003 Feb; 9(1):57-63. PMID: 12580340.
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    127. Tudor M, Akbarian S, Chen RZ, Jaenisch R. Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15536-41. PMID: 12432090.
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    128. Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry. 2002 Aug; 59(8):705-12. PMID: 12150646.
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    129. Akbarian S. Diseases of the mind and brain: Rett's syndrome, part II. Am J Psychiatry. 2002 Aug; 159(8):1294. PMID: 12153818.
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    130. Akbarian S. Diseases of the mind and brain: Rett's syndrome. Am J Psychiatry. 2002 Jul; 159(7):1103. PMID: 12091185.
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    131. Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. J Neurosci. 2002 May 15; 22(10):4153-62. PMID: 12019333.
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    132. Akbarian S. Clinical experts on Rett disorder. Pediatr Rehabil. 2002 Apr-Jun; 5(2):117-8. PMID: 12596822.
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    133. Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA. Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis. 2002 Feb; 9(1):24-37. PMID: 11848682.
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