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Hardy Kornfeld MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionPulmonary, Allergy And Critical Care Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    Bennington College, North Bennington, VT, United StatesBALiberal Arts
    Boston University School of Medicine, Boston, MA, United StatesMD

    Collapse Overview 
    Collapse overview

    The Kornfeld Laboratory Link


    Medical School: Boston University School of Medicine, Boston, MA, 1978.
    Medical Residency: University Hospital, Boston, MA, 1980.
    St Luke's Hospital, NY, NY, 1981.
    Infectious Disease Fellowship: St Luke's-Roosevelt Hospital Center, NY, NY, 1982.
    Pulmonary Fellowship: Boston University School of Medicine, Boston, MA, 1985.
    Molecular virology Fellowship: Harvard School of Public Health, Boston, MA, 1987.

    Clinical, educational, scientific interests

    Host defense against respiratory pathogens
    Impact of metabolic disorders on host defense
    Critical care

    Research Activities:

    1. Role of macrophage apoptosis in TB defense
    2. Impact of diabetes and hyperlipidemia on TB defense
    3. Role of IL-16 in protective immunity
    4. Heterologous immunity between viruses and mycobacteria

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mave V, Chen L, Ranganathan UD, Kadam D, Vishwanathan V, Lokhande R, S SK, Kagal A, Pradhan NN, Shivakumar SVBY, Paradkar MS, Deshmukh S, Tornheim JA, Kornfeld H, Farhat M, Gupta A, Padmapriyadarsini C, Gupte N, Golub JE, Mathema B, Kreiswirth BN. Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in India. Clin Infect Dis. 2022 Sep 14; 75(5):768-776. PMID: 34984435.
      Citations:    Fields:    
    2. Gupte AN, Kumar P, Araújo-Pereira M, Kulkarni V, Paradkar M, Pradhan N, Menon P, Padmapriyadarsini C, Hanna LE, Yogendra Shivakumar SVB, Rockwood N, Du Bruyn E, Karyakarte R, Gaikwad S, Bollinger R, Golub J, Gupte N, Viswanathan V, Wilkinson RJ, Mave V, Babu S, Kornfeld H, Andrade BB, Gupta A. Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study. Eur Respir J. 2022 04; 59(4). PMID: 34711538.
      Citations: 1     Fields:    Translation:Humans
    3. Nathella PK, Moideen K, Viswanathan V, Sivakumar S, Ahamed SF, Ponnuraja C, Hissar S, Kornfeld H, Babu S. Heightened microbial translocation is a prognostic biomarker of recurrent tuberculosis. Clin Infect Dis. 2022 Mar 30. PMID: 35352112.
      Citations:    Fields:    
    4. Kumar NP, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Sivakumar S, Hissar S, Kornfeld H, Babu S. Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure. Front Immunol. 2021; 12:731878. PMID: 34867953.
      Citations:    Fields:    Translation:Humans
    5. Kumar NP, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Nair D, Banurekha VV, Sivakumar S, Hissar S, Kornfeld H, Babu S. Plasma Chemokines Are Baseline Predictors of Unfavorable Treatment Outcomes in Pulmonary Tuberculosis. Clin Infect Dis. 2021 11 02; 73(9):e3419-e3427. PMID: 32766812.
      Citations: 2     Fields:    Translation:Humans
    6. Kumar NP, Moideen K, Viswanathan V, Sivakumar S, Hissar S, Kornfeld H, Babu S. Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis - Diabetes co-morbidity. J Clin Tuberc Other Mycobact Dis. 2021 May; 23:100237. PMID: 33997311.
    7. Mave V, Gaikwad S, Barthwal M, Chandanwale A, Lokhande R, Kadam D, Dharmshale S, Bharadwaj R, Kagal A, Pradhan N, Deshmukh S, Atre S, Sahasrabudhe T, Meshram S, Kakrani A, Kulkarni V, Raskar S, Suryavanshi N, Kornfeld H, Dooley KE, Chon S, Gupte A, Gupta A, Gupte N, Golub JE. Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India. Open Forum Infect Dis. 2021 Apr; 8(4):ofab097. PMID: 33884278.
    8. Smulan LJ, Martinez N, Kiritsy MC, Kativhu C, Cavallo K, Sassetti CM, Singhal A, Remold HG, Kornfeld H. Sirtuin 3 Downregulation in Mycobacterium tuberculosis-Infected Macrophages Reprograms Mitochondrial Metabolism and Promotes Cell Death. mBio. 2021 02 02; 12(1). PMID: 33531400.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Auld SC, Kornfeld H, Maenetje P, Mlotshwa M, Chase W, Vangu MD, Torigian DA, Wallis RS, Churchyard G, Bisson GP. Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis. BMC Pulm Med. 2021 Jan 07; 21(1):19. PMID: 33413293.
      Citations: 3     Fields:    Translation:Humans
    10. Kornfeld H, Sahukar SB, Procter-Gray E, Kumar NP, West K, Kane K, Natarajan M, Li W, Babu S, Viswanathan V. Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes. Clin Infect Dis. 2020 12 03; 71(9):e392-e398. PMID: 31955202.
      Citations: 13     Fields:    Translation:Humans
    11. Kumar NP, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Sivakumar S, Hissar S, Nair D, Banurekha VV, Kornfeld H, Babu S. Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis. JAMA Netw Open. 2020 12 01; 3(12):e2027754. PMID: 33258908.
      Citations: 2     Fields:    Translation:Humans
    12. Böhme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal A. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nat Commun. 2020 10 16; 11(1):5225. PMID: 33067434.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Ravimohan S, Maenetje P, Auld SC, Ncube I, Mlotshwa M, Chase W, Tiemessen CT, Vangu MD, Wallis RS, Churchyard G, Weissman D, Kornfeld H, Bisson GP. A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis. Clin Infect Dis. 2020 08 14; 71(4):924-932. PMID: 31751447.
      Citations: 5     Fields:    Translation:HumansCells
    14. Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP. Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clin Infect Dis. 2020 04 15; 70(9):1845-1854. PMID: 31242296.
      Citations: 4     Fields:    Translation:HumansCells
    15. Auld SC, Maenetje P, Ravimohan S, Weissman D, Ncube I, Mlotshwa M, Ratsela N, Chase W, Vangu MD, Wallis R, Churchyard G, Kornfeld H, Bisson GP. Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis. 2020 04 10; 70(8):1750-1753. PMID: 31552412.
      Citations: 5     Fields:    Translation:HumansCells
    16. Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Hissar S, Kornfeld H, Babu S. Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy. BMC Infect Dis. 2019 Dec 09; 19(1):1039. PMID: 31818258.
      Citations: 2     Fields:    Translation:HumansCells
    17. Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S. Plasma chemokines are biomarkers of disease severity, higher bacterial burden and delayed sputum culture conversion in pulmonary tuberculosis. Sci Rep. 2019 12 03; 9(1):18217. PMID: 31796883.
      Citations: 12     Fields:    Translation:HumansCells
    18. Pavan Kumar N, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Shanmugam S, Hissar S, Kornfeld H, Babu S. Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden. Front Cell Infect Microbiol. 2019; 9:335. PMID: 31632923.
      Citations: 8     Fields:    Translation:Humans
    19. Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S. Heterogeneity in the cytokine profile of tuberculosis - diabetes co-morbidity. Cytokine. 2020 01; 125:154824. PMID: 31472402.
      Citations: 1     Fields:    Translation:HumansCells
    20. Kumar NP, Fukutani KF, Shruthi BS, Alves T, Silveira-Mattos PS, Rocha MS, West K, Natarajan M, Viswanathan V, Babu S, Andrade BB, Kornfeld H. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. Elife. 2019 07 04; 8. PMID: 31271354.
      Citations: 13     Fields:    Translation:HumansCells
    21. Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H. mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine. 2019 Jul; 45:314-327. PMID: 31279779.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Martinez N, Kornfeld H. Tuberculosis and diabetes: from bench to bedside and back. Int J Tuberc Lung Dis. 2019 06 01; 23(6):669-677. PMID: 31315698.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Magee MJ, Salindri AD, Kornfeld H, Singhal A. Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins. Eur Respir J. 2019 03; 53(3). PMID: 30523163.
      Citations: 17     Fields:    Translation:Humans
    24. Kumar NP, Moideen K, Bhootra Y, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S. Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity. Immunology. 2019 03; 156(3):249-258. PMID: 30427060.
      Citations: 12     Fields:    Translation:HumansCells
    25. Smith S, Wu PW, Seo JJ, Fernando T, Jin M, Contreras J, Montano EN, Gabhann JN, Cunningham K, Widaa A, McCarthy EM, Molloy ES, Kearns G, Murphy CC, Kong W, Björkbacka H, Kornfeld H, Forbess L, Venuturupalli S, Ishimori M, Wallace D, Weisman MH, Jefferies CA. IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation. JCI Insight. 2018 08 09; 3(15). PMID: 30089723.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    26. Kumar NP, Moideen K, Viswanathan V, Shruthi BS, Sivakumar S, Menon PA, Kornfeld H, Babu S. Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment. BMC Infect Dis. 2018 07 25; 18(1):345. PMID: 30045688.
      Citations: 14     Fields:    Translation:Humans
    27. Dai Y, Wen Z, Ye T, Deng G, Zhang M, Deng Q, Yang Q, Shan W, Kornfeld H, Cai Y, Chen X. Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis. Diagn Microbiol Infect Dis. 2018 Nov; 92(3):245-249. PMID: 30076042.
      Citations: 1     Fields:    Translation:HumansCells
    28. Kornfeld H, Singhal A. Enlisting the Host to Fight TB. Chest. 2018 06; 153(6):1292-1293. PMID: 29884247.
      Citations: 1     Fields:    Translation:Humans
    29. Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC. Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid. Infect Dis Poverty. 2018 Mar 24; 7(1):22. PMID: 29580276.
      Citations: 6     Fields:    Translation:HumansCells
    30. Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev. 2018 Mar 31; 27(147). PMID: 29491034.
      Citations: 93     Fields:    Translation:HumansCells
    31. Kumar NP, Moideen K, Viswanathan V, Sivakumar S, Menon PA, Kornfeld H, Babu S. Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment. PLoS One. 2017; 12(9):e0184753. PMID: 28910369.
      Citations: 6     Fields:    Translation:Humans
    32. Prada-Medina CA, Fukutani KF, Pavan Kumar N, Gil-Santana L, Babu S, Lichtenstein F, West K, Sivakumar S, Menon PA, Viswanathan V, Andrade BB, Nakaya HI, Kornfeld H. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Sci Rep. 2017 05 17; 7(1):1999. PMID: 28515464.
      Citations: 54     Fields:    Translation:HumansCellsPHPublic Health
    33. Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H. "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report. Vaccine. 2017 06 14; 35(27):3433-3440. PMID: 28476627.
      Citations: 7     Fields:    Translation:HumansCells
    34. Ronacher K, van Crevel R, Critchley JA, Bremer AA, Schlesinger LS, Kapur A, Basaraba R, Kornfeld H, Restrepo BI. Defining a Research Agenda to Address the Converging Epidemics of Tuberculosis and Diabetes: Part 2: Underlying Biologic Mechanisms. Chest. 2017 07; 152(1):174-180. PMID: 28434937.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    35. Critchley JA, Restrepo BI, Ronacher K, Kapur A, Bremer AA, Schlesinger LS, Basaraba R, Kornfeld H, van Crevel R. Defining a Research Agenda to Address the Converging Epidemics of Tuberculosis and Diabetes: Part 1: Epidemiology and Clinical Management. Chest. 2017 07; 152(1):165-173. PMID: 28434936.
      Citations: 33     Fields:    Translation:HumansPHPublic Health
    36. Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. Sci Immunol. 2017 Mar; 2(9). PMID: 28707004.
      Citations: 46     Fields:    
    37. Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H, Vankayalapati R. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PLoS Pathog. 2016 Oct; 12(10):e1005972. PMID: 27783671.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    38. Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S. Modulation of dendritic cell and monocyte subsets in tuberculosis-diabetes co-morbidity upon standard tuberculosis treatment. Tuberculosis (Edinb). 2016 12; 101:191-200. PMID: 27865391.
      Citations: 6     Fields:    Translation:HumansCells
    39. Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S. Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors. J Infect. 2017 01; 74(1):10-21. PMID: 27717783.
      Citations: 5     Fields:    Translation:Humans
    40. Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM. Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. mBio. 2016 09 20; 7(5). PMID: 27651361.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    41. Martinez N, Ketheesan N, West K, Vallerskog T, Kornfeld H. Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice. J Infect Dis. 2016 Dec 01; 214(11):1629-1637. PMID: 27630197.
      Citations: 28     Fields:    Translation:AnimalsCells
    42. Kumar NP, Moideen K, Viswanathan V, Kornfeld H, Babu S. Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity. Immunology. 2016 09; 149(1):87-97. PMID: 27289086.
      Citations: 8     Fields:    Translation:HumansCells
    43. Martinez N, Ketheesan N, Martens GW, West K, Lien E, Kornfeld H. Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes Infect. 2016 Oct; 18(10):649-655. PMID: 27256462.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Almeida-Junior JL, Gil-Santana L, Oliveira CA, Castro S, Cafezeiro AS, Daltro C, Netto EM, Kornfeld H, Andrade BB. Glucose Metabolism Disorder Is Associated with Pulmonary Tuberculosis in Individuals with Respiratory Symptoms from Brazil. PLoS One. 2016; 11(4):e0153590. PMID: 27078026.
      Citations: 12     Fields:    Translation:Humans
    45. Kornfeld H, West K, Kane K, Kumpatla S, Zacharias RR, Martinez-Balzano C, Li W, Viswanathan V. High Prevalence and Heterogeneity of Diabetes in Patients With TB in South India: A Report from the Effects of Diabetes on Tuberculosis Severity (EDOTS) Study. Chest. 2016 06; 149(6):1501-8. PMID: 26973015.
      Citations: 41     Fields:    Translation:Humans
    46. Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity. 2016 Feb 16; 44(2):368-79. PMID: 26885859.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    47. Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM, Andrade BB. Diabetes Is Associated with Worse Clinical Presentation in Tuberculosis Patients from Brazil: A Retrospective Cohort Study. PLoS One. 2016; 11(1):e0146876. PMID: 26752596.
      Citations: 22     Fields:    Translation:Humans
    48. Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X. Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells. Sci Rep. 2015 Dec 08; 5:17918. PMID: 26643453.
      Citations: 12     Fields:    Translation:HumansCells
    49. Lee J, Martinez N, West K, Kornfeld H. Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production. PLoS One. 2015; 10(4):e0123165. PMID: 25875128.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Repasy T, Martinez N, Lee J, West K, Li W, Kornfeld H. Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis. Microbes Infect. 2015 Aug; 17(8):564-74. PMID: 25862076.
      Citations: 16     Fields:    Translation:AnimalsCells
    51. Kumar NP, Banurekha VV, Nair D, Sridhar R, Kornfeld H, Nutman TB, Babu S. Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis. PLoS One. 2014; 9(11):e112108. PMID: 25393696.
      Citations: 17     Fields:    Translation:Humans
    52. Moraco AH, Kornfeld H. Cell death and autophagy in tuberculosis. Semin Immunol. 2014 Dec; 26(6):497-511. PMID: 25453227.
      Citations: 39     Fields:    Translation:HumansCells
    53. Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X. IP-10 and MIG are compartmentalized at the site of disease during pleural and meningeal tuberculosis and are decreased after antituberculosis treatment. Clin Vaccine Immunol. 2014 Dec; 21(12):1635-44. PMID: 25274803.
      Citations: 9     Fields:    Translation:Humans
    54. Martinez N, Vallerskog T, West K, Nunes-Alves C, Lee J, Martens GW, Behar SM, Kornfeld H. Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia. J Immunol. 2014 Nov 01; 193(9):4457-68. PMID: 25246495.
      Citations: 13     Fields:    Translation:AnimalsCells
    55. Martinez N, Kornfeld H. Diabetes and immunity to tuberculosis. Eur J Immunol. 2014 Mar; 44(3):617-26. PMID: 24448841.
      Citations: 82     Fields:    Translation:Humans
    56. Lee J, Brehm MA, Greiner D, Shultz LD, Kornfeld H. Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. BMC Immunol. 2013 Dec 07; 14:53. PMID: 24313934.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    57. Reed GW, Choi H, Lee SY, Lee M, Kim Y, Park H, Lee J, Zhan X, Kang H, Hwang S, Carroll M, Cai Y, Cho SN, Barry CE, Via LE, Kornfeld H. Impact of diabetes and smoking on mortality in tuberculosis. PLoS One. 2013; 8(2):e58044. PMID: 23469139.
      Citations: 41     Fields:    Translation:Humans
    58. Repasy T, Lee J, Marino S, Martinez N, Kirschner DE, Hendricks G, Baker S, Wilson AA, Kotton DN, Kornfeld H. Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo. PLoS Pathog. 2013 Feb; 9(2):e1003190. PMID: 23436998.
      Citations: 57     Fields:    Translation:AnimalsCells
    59. Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?. Nat Immunol. 2013 Jan; 14(1):52-60. PMID: 23160153.
      Citations: 263     Fields:    Translation:HumansAnimalsCells
    60. Richmond JM, Lee J, Green DS, Kornfeld H, Cruikshank WW. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol. 2012 Dec 15; 189(12):5886-95. PMID: 23129756.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    61. Richmond JM, Duffy ER, Lee J, Kaboli K, Kim YS, Remick DG, Kornfeld H, Cruikshank WW. Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces soluble tumor necrosis factor receptor production through tumor necrosis factor alpha-converting enzyme activation. Infect Immun. 2012 Nov; 80(11):3858-68. PMID: 22927046.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    62. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J. Intrathymic programming of effector fates in three molecularly distinct ?? T cell subtypes. Nat Immunol. 2012 Apr 01; 13(5):511-8. PMID: 22473038.
      Citations: 93     Fields:    Translation:AnimalsCells
    63. Martens GW, Vallerskog T, Kornfeld H. Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity. J Leukoc Biol. 2012 Jun; 91(6):849-57. PMID: 22227965.
      Citations: 10     Fields:    Translation:AnimalsCells
    64. Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. J Heart Lung Transplant. 2011 Dec; 30(12):1409-17. PMID: 22055099.
      Citations: 6     Fields:    Translation:Animals
    65. Hartman ML, Kornfeld H. Interactions between naïve and infected macrophages reduce Mycobacterium tuberculosis viability. PLoS One. 2011; 6(11):e27972. PMID: 22125644.
      Citations: 17     Fields:    Translation:AnimalsCells
    66. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. 2011 Mar 31; 6(3):e18367. PMID: 21483832.
      Citations: 66     Fields:    Translation:AnimalsCells
    67. Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem. 2011 Mar 18; 286(11):9587-97. PMID: 21228274.
      Citations: 372     Fields:    Translation:AnimalsCells
    68. Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL. IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS One. 2010 Oct 21; 5(10):e13561. PMID: 21042409.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    69. Vallerskog T, Martens GW, Kornfeld H. Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 2010 Jun 01; 184(11):6275-82. PMID: 20421645.
      Citations: 72     Fields:    Translation:AnimalsCells
    70. Lee J, Kornfeld H. Interferon-? Regulates the Death of M. tuberculosis-Infected Macrophages. J Cell Death. 2010 Mar 03; 3:1-11. PMID: 21072140.
    71. Kashino SS, Vallerskog T, Martens G, Troudt J, Keyser A, Taylor J, Izzo A, Kornfeld H, Campos-Neto A. Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis. Am J Pathol. 2010 Jan; 176(1):198-204. PMID: 20008132.
      Citations: 10     Fields:    Translation:AnimalsCells
    72. Han R, Kornfeld H, Martens G. Is hypercholesterolemia a friend or a foe of tuberculosis? Infect Immun. 2009 Aug; 77(8):3514; author reply 3514-5. PMID: 19617455.
      Citations: 3     Fields:    Translation:Animals
    73. Lee J, Hartman M, Kornfeld H. Macrophage apoptosis in tuberculosis. Yonsei Med J. 2009 Feb 28; 50(1):1-11. PMID: 19259342.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    74. Mathurin KS, Martens GW, Kornfeld H, Welsh RM. CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses. J Virol. 2009 Apr; 83(8):3528-39. PMID: 19193795.
      Citations: 44     Fields:    Translation:AnimalsCells
    75. Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med. 2009 Feb 16; 206(2):421-34. PMID: 19188497.
      Citations: 121     Fields:    Translation:AnimalsCells
    76. Gan H, Lee J, Ren F, Chen M, Kornfeld H, Remold HG. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nat Immunol. 2008 Oct; 9(10):1189-97. PMID: 18794848.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    77. Martens GW, Arikan MC, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008 Aug; 76(8):3464-72. PMID: 18505807.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    78. Kornfeld H. An ounce of tuberculosis prevention. Chest. 2008 Apr; 133(4):835-6. PMID: 18398110.
      Citations:    Fields:    Translation:Humans
    79. Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb). 2008 Jul; 88(4):366-70. PMID: 18068490.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    80. Moise L, McMurry J, Rivera DS, Carter EJ, Lee J, Kornfeld H, Martin WD, De Groot AS. Progress towards a genome-derived, epitope-driven vaccine for latent TB infection. Med Health R I. 2007 Oct; 90(10):301-3. PMID: 18019185.
      Citations: 2     Fields:    Translation:HumansAnimals
    81. Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):518-24. PMID: 17585110.
      Citations: 80     Fields:    Translation:AnimalsCells
    82. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9. PMID: 17548646.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    83. McMurry JA, Kimball S, Lee JH, Rivera D, Martin W, Weiner DB, Kutzler M, Sherman DR, Kornfeld H, De Groot AS. Epitope-driven TB vaccine development: a streamlined approach using immuno-informatics, ELISpot assays, and HLA transgenic mice. Curr Mol Med. 2007 Jun; 7(4):351-68. PMID: 17584075.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    84. Lee J, Remold HG, Ieong MH, Kornfeld H. Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J Immunol. 2006 Apr 01; 176(7):4267-74. PMID: 16547264.
      Citations: 114     Fields:    Translation:AnimalsCells
    85. El Bassam S, Pinsonneault S, Kornfeld H, Ren F, Menezes J, Laberge S. Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells. Immunology. 2006 Jan; 117(1):89-96. PMID: 16423044.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    86. Stabile E, Kinnaird T, la Sala A, Hanson SK, Watkins C, Campia U, Shou M, Zbinden S, Fuchs S, Kornfeld H, Epstein SE, Burnett MS. CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation. 2006 Jan 03; 113(1):118-24. PMID: 16380545.
      Citations: 64     Fields:    Translation:AnimalsCells
    87. Wilson KC, Cattel DJ, Wan Z, Rahangdale S, Ren F, Kornfeld H, Sullivan BA, Cruikshank WW, Center DM. Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. Cell Immunol. 2005 Sep; 237(1):17-27. PMID: 16289056.
      Citations: 7     Fields:    Translation:HumansCells
    88. Gan H, He X, Duan L, Mirabile-Levens E, Kornfeld H, Remold HG. Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential. J Infect Dis. 2005 Apr 15; 191(8):1292-300. PMID: 15776376.
      Citations: 31     Fields:    Translation:HumansCells
    89. Ren F, Zhan X, Martens G, Lee J, Center D, Hanson SK, Kornfeld H. Pro-IL-16 regulation in activated murine CD4+ lymphocytes. J Immunol. 2005 Mar 01; 174(5):2738-45. PMID: 15728482.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    90. Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol. 2003 Nov; 29(5):545-51. PMID: 12748057.
      Citations: 40     Fields:    Translation:HumansCells
    91. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S. PMID: 12629022.
      Citations: 4     Fields:    Translation:Humans
    92. Riendeau CJ, Kornfeld H. THP-1 cell apoptosis in response to Mycobacterial infection. Infect Immun. 2003 Jan; 71(1):254-9. PMID: 12496173.
      Citations: 84     Fields:    Translation:HumansCells
    93. Saukkonen JJ, Bazydlo B, Thomas M, Strieter RM, Keane J, Kornfeld H. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect Immun. 2002 Apr; 70(4):1684-93. PMID: 11895930.
      Citations: 48     Fields:    Translation:HumansCells
    94. Zhang Y, Kornfeld H, Cruikshank WW, Kim S, Reardon CC, Center DM. Nuclear translocation of the N-terminal prodomain of interleukin-16. J Biol Chem. 2001 Jan 12; 276(2):1299-303. PMID: 11032842.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    95. Ieong MH, Reardon CC, Levitz SM, Kornfeld H. Human immunodeficiency virus type 1 infection of alveolar macrophages impairs their innate fungicidal activity. Am J Respir Crit Care Med. 2000 Sep; 162(3 Pt 1):966-70. PMID: 10988114.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    96. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol. 2000 Jun; 67(6):757-66. PMID: 10857846.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    97. Liu Y, Cruikshank WW, O'Loughlin T, O'Reilly P, Center DM, Kornfeld H. Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation. J Biol Chem. 1999 Aug 13; 274(33):23387-95. PMID: 10438516.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    98. Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW, Kornfeld H. Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem. 1998 Jan 09; 273(2):1144-9. PMID: 9422780.
      Citations: 51     Fields:    Translation:AnimalsCells
    99. Fenton MJ, Vermeulen MW, Kim S, Burdick M, Strieter RM, Kornfeld H. Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect Immun. 1997 Dec; 65(12):5149-56. PMID: 9393809.
      Citations: 72     Fields:    Translation:HumansCells
    100. Saukkonen JJ, Furfaro S, Mahoney KM, Strieter RM, Burdick M, Wright EA, Kornfeld H, Berman JS. In vitro transendothelial migration of blood T lymphocytes from HIV-infected individuals. AIDS. 1997 Nov; 11(13):1595-601. PMID: 9365764.
      Citations: 5     Fields:    Translation:HumansCells
    101. Cruikshank WW, Doctrow SR, Falvo MS, Huffman K, Maciaszek J, Viglianti G, Raina J, Kornfeld H, Malfroy B. A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Mar 01; 14(3):193-203. PMID: 9117450.
      Citations: 4     Fields:    Translation:Cells
    102. Keane J, Balcewicz-Sablinska MK, Remold HG, Chupp GL, Meek BB, Fenton MJ, Kornfeld H. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun. 1997 Jan; 65(1):298-304. PMID: 8975927.
      Citations: 175     Fields:    Translation:HumansCells
    103. Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol. 1997 Jan 01; 158(1):5-8. PMID: 8977168.
      Citations: 21     Fields:    Translation:HumansCells
    104. Reardon CC, Kim SJ, Wagner RP, Kornfeld H. Interferon-gamma reduces the capacity of human alveolar macrophages to inhibit growth of Cryptococcus neoformans in vitro. Am J Respir Cell Mol Biol. 1996 Dec; 15(6):711-5. PMID: 8969264.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    105. Cruikshank WW, Long A, Tarpy RE, Kornfeld H, Carroll MP, Teran L, Holgate ST, Center DM. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):738-47. PMID: 7576712.
      Citations: 12     Fields:    Translation:HumansCells
    106. Ryan TC, Cruikshank WW, Kornfeld H, Collins TL, Center DM. The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration. J Biol Chem. 1995 Jul 21; 270(29):17081-6. PMID: 7615501.
      Citations: 14     Fields:    Translation:AnimalsCells
    107. Center DM, Kornfeld H, Wu MJ, Falvo M, Theodore AC, Bernardo J, Berman JS, Cruikshank WW, Djukanovic R, Teran L, et al. Cytokine binding to CD4+ inflammatory cells: implications for asthma. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 2):S59-62. PMID: 7952594.
      Citations:    Fields:    Translation:HumansAnimalsCells
    108. Graven KK, Troxler RF, Kornfeld H, Panchenko MV, Farber HW. Regulation of endothelial cell glyceraldehyde-3-phosphate dehydrogenase expression by hypoxia. J Biol Chem. 1994 Sep 30; 269(39):24446-53. PMID: 7929107.
      Citations: 39     Fields:    Translation:AnimalsCells
    109. Theodore AC, Kornfeld H, Wallace RP, Cruikshank WW. CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120: contribution to the immunosuppression seen in HIV-1 infection by induction of CD4 and CD3 unresponsiveness. J Acquir Immune Defic Syndr (1988). 1994 Sep; 7(9):899-907. PMID: 7914230.
      Citations: 4     Fields:    Translation:HumansCells
    110. Saukkonen JJ, Kornfeld H, Berman JS. Expansion of a CD8+CD28- cell population in the blood and lung of HIV-positive patients. J Acquir Immune Defic Syndr (1988). 1993 Nov; 6(11):1194-204. PMID: 8229654.
      Citations: 23     Fields:    Translation:HumansCells
    111. Tarpy SP, Kornfeld H, Moroz K, Lazar HL. Unusual presentation of a large tension bronchogenic cyst in an adult. Thorax. 1993 Sep; 48(9):951-2. PMID: 8236082.
      Citations:    Fields:    Translation:Humans
    112. Oh SK, Cruikshank WW, Raina J, Blanchard GC, Adler WH, Walker J, Kornfeld H. Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J Acquir Immune Defic Syndr (1988). 1992; 5(3):251-6. PMID: 1740750.
      Citations: 88     Fields:    Translation:HumansCells
    113. Berman JS, Cruikshank WW, Beer DJ, Kornfeld H, Bernardo J, Theodore AC, Center DM. Lymphocyte motility and lymphocyte chemoattractant factors. Immunol Invest. 1988 Nov-Dec; 17(8-9):625-77. PMID: 3068125.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    114. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. 1988 Sep 29; 335(6189):445-8. PMID: 2843775.
      Citations: 53     Fields:    Translation:HumansCells
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