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Patrick E McDonel PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    Indiana University South Bend, South Bend, IN, United StatesBSBiological Sciences
    University of California, Berkeley, Berkeley, CA, United StatesPHDMolecular & Cell Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Quinodoz SA, Ollikainen N, Tabak B, Palla A, Schmidt JM, Detmar E, Lai MM, Shishkin AA, Bhat P, Takei Y, Trinh V, Aznauryan E, Russell P, Cheng C, Jovanovic M, Chow A, Cai L, McDonel P, Garber M, Guttman M. Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. Cell. 2018 Jun 04. PMID: 29887377.
      View in: PubMed
    2. Donnard E, Vangala P, Afik S, McCauley S, Nowosielska A, Kucukural A, Tabak B, Zhu X, Diehl W, McDonel P, Yosef N, Luban J, Garber M. Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon. Cell Syst. 2018 Jan 30. PMID: 29454939.
      View in: PubMed
    3. Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J. Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic. Cell. 2016 Nov 03; 167(4):1088-1098.e6. PMID: 27814506.
      View in: PubMed
    4. Engreitz JM, Haines JE, Perez EM, Munson G, Chen J, Kane M, McDonel PE, Guttman M, Lander ES. Local regulation of gene expression by lncRNA promoters, transcription and splicing. Nature. 2016 Nov 17; 539(7629):452-455. PMID: 27783602.
      View in: PubMed
    5. Chen CK, Blanco M, Jackson C, Aznauryan E, Ollikainen N, Surka C, Chow A, Cerase A, McDonel P, Guttman M. Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science. 2016 Oct 28; 354(6311):468-472. PMID: 27492478.
      View in: PubMed
    6. Ulirsch JC, Nandakumar SK, Wang L, Giani FC, Zhang X, Rogov P, Melnikov A, McDonel P, Do R, Mikkelsen TS, Sankaran VG. Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits. Cell. 2016 Jun 02; 165(6):1530-45. PMID: 27259154.
      View in: PubMed
    7. Wakabayashi A, Ulirsch JC, Ludwig LS, Fiorini C, Yasuda M, Choudhuri A, McDonel P, Zon LI, Sankaran VG. Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4434-9. PMID: 27044088.
      View in: PubMed
    8. Cannon D, Corrigan AM, Miermont A, McDonel P, Chubb JR. Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity. Development. 2015 Aug 15; 142(16):2840-9. PMID: 26209649.
      View in: PubMed
    9. McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco M, Burghard C, Moradian A, Sweredoski MJ, Shishkin AA, Su J, Lander ES, Hess S, Plath K, Guttman M. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. Nature. 2015 May 14; 521(7551):232-6. PMID: 25915022.
      View in: PubMed
    10. Engreitz JM, Sirokman K, McDonel P, Shishkin AA, Surka C, Russell P, Grossman SR, Chow AY, Guttman M, Lander ES. RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites. Cell. 2014 Sep 25; 159(1):188-99. PMID: 25259926.
      View in: PubMed
    11. Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, Kadri S, Xing J, Goren A, Lander ES, Plath K, Guttman M. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science. 2013 Aug 16; 341(6147):1237973. PMID: 23828888.
      View in: PubMed
    12. McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD. Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1; 363(1):62-73. PMID: 22206758.
      View in: PubMed
    13. McDonel P, Costello I, Hendrich B. Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int J Biochem Cell Biol. 2009 Jan; 41(1):108-16. PMID: 18775506.
      View in: PubMed
    14. McDonel P, Jans J, Peterson BK, Meyer BJ. Clustered DNA motifs mark X chromosomes for repression by a dosage compensation complex. Nature. 2006 Nov 30; 444(7119):614-8. PMID: 17122774.
      View in: PubMed
    15. Csankovszki G, McDonel P, Meyer BJ. Recruitment and spreading of the C. elegans dosage compensation complex along X chromosomes. Science. 2004 Feb 20; 303(5661):1182-5. PMID: 14976312.
      View in: PubMed
    16. Meyer BJ, McDonel P, Csankovszki G, Ralston E. Sex and X-chromosome-wide repression in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 2004; 69:71-9. PMID: 16117635.
      View in: PubMed
    17. Schnabel A, McDonel PE, Wendel JF. Phylogenetic relationships in Gleditsia (Leguminosae) based on ITS sequences. Am J Bot. 2003 Feb; 90(2):310-20. PMID: 21659122.
      View in: PubMed
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