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Andrea Reboldi PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionBasic Pathology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    Collapse Biography 
    Collapse education and training
    University of Padova, Padova, , ItalyBSBiotechnology
    University of Padova, Padova, , ItalyMSImmunological Biotechnology
    Institute for Research in Biomedicine, Bellinzona, , SwitzerlandPHDMolecular Medicine

    Collapse Overview 
    Collapse overview

    B cell response at the mucosal interface

    The focus of our lab is to understand how the immune system develops and functions at the mucosal interface.


    In the human body the gastrointestinal tract hosts a large number of bacteria that play a critical role in providing essential nutrients and metabolites. The mucosal immune system must selectively remain tolerant to the symbiotic members of the intestinal bacteria (commensals), while simultaneously poised to respond to pathogenic species. Immunoglobulin A (IgA) represents the main antibody class secreted by B lymphocytes at the mucosal surfaces, and is critical in maintaining intestinal homeostasis: patients with specific inability to produce IgA suffer from an increased incidence of gastrointestinal diseases. The mechanisms by which IgAs maintain intestinal homeostasis remain unclear.

    Major Goals:

    (i)   Define the selection mechanisms for IgA maturation to assure intestinal homeostasis.

    (ii)  Decipher the metabolic requirements for mounting a mucosal immune response to commensals.

    (iii) Characterize the cell-intrinsic and environmental cues required for the generation and maintenance of memory B cells at mucosal barriers.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kellogg TD, Ceglia S, Mortzfeld BM, Zeamer AL, Foley SE, Ward DV, Bhattarai SK, McCormick BA, Reboldi A, Bucci V. Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine. bioRxiv. 2024 Jan 31. PMID: 38352546.
    2. Raso F, Liu S, Simpson MJ, Barton GM, Mayer CT, Acharya M, Muppidi JR, Marshak-Rothstein A, Reboldi A. Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation. Immunity. 2023 10 10; 56(10):2373-2387.e8. PMID: 37714151.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Howley K, Berthelette A, Ceglia S, Kang J, Reboldi A. Embryonic type 3 innate lymphoid cells sense maternal dietary cholesterol to control local Peyer's patch development. bioRxiv. 2023 Mar 23. PMID: 36993524.
    4. Frascoli M, Ferraj E, Miu B, Malin J, Spidale NA, Cowan J, Shissler SC, Brink R, Xu Y, Cyster JG, Bhandoola A, Kang J, Reboldi A. Skin ?d T?cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity. 2023 03 14; 56(3):562-575.e6. PMID: 36842431.
      Citations: 5     Fields:    Translation:HumansAnimals
    5. Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos A, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Nakadar MZ, Wong J, Erlich EC, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith J, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S. Gut-associated lymphoid tissue attrition associates with response to anti-a4?7 therapy in ulcerative colitis. bioRxiv. 2023 Jan 20. PMID: 36711839.
    6. Ceglia S, Berthelette A, Howley K, Li Y, Mortzfeld B, Bhattarai SK, Yiew NKH, Xu Y, Brink R, Cyster JG, Hooper LV, Randolph GJ, Bucci V, Reboldi A. An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells. Nat Immunol. 2023 03; 24(3):531-544. PMID: 36658240.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Frascoli M, Reboldi A, Kang J. Dietary Cholesterol Metabolite Regulation of Tissue Immune Cell Development and Function. J Immunol. 2022 08 15; 209(4):645-653. PMID: 35961669.
      Citations: 2     Fields:    Translation:Humans
    8. Lei X, Ketelut-Carneiro N, Shmuel-Galia L, Xu W, Wilson R, Vierbuchen T, Chen Y, Reboldi A, Kang J, Edelblum KL, Ward D, Fitzgerald KA. Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules. J Exp Med. 2022 08 01; 219(8). PMID: 35792863.
      Citations: 7     Fields:    Translation:AnimalsCells
    9. Bonami RH, Thurman CE, Verma S, Westlake CS, Nyhoff LE, Barron BB, Reboldi A, Kendall PL. Bruton's Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis. Front Immunol. 2022; 13:748284. PMID: 35422819.
      Citations: 3     Fields:    Translation:Animals
    10. Trindade BC, Ceglia S, Berthelette A, Raso F, Howley K, Muppidi JR, Reboldi A. The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. Immunity. 2021 10 12; 54(10):2273-2287.e6. PMID: 34644558.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ. Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). PMID: 34452995.
      Citations: 12     Fields:    Translation:AnimalsCells
    12. Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 06 08; 54(6):1137-1153.e8. PMID: 34051146.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    13. Hand TW, Reboldi A. Production and Function of Immunoglobulin A. Annu Rev Immunol. 2021 04 26; 39:695-718. PMID: 33646857.
      Citations: 22     Fields:    Translation:HumansAnimals
    14. Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ. CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. Immunohorizons. 2020 02 07; 4(2):57-71. PMID: 32034085.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Albright AR, Kabat J, Li M, Raso F, Reboldi A, Muppidi JR. TGF? signaling in germinal center B cells promotes the transition from light zone to dark zone. J Exp Med. 2019 11 04; 216(11):2531-2545. PMID: 31506281.
      Citations: 14     Fields:    Translation:AnimalsCells
    16. Leng Y, Romero R, Xu Y, Galaz J, Slutsky R, Arenas-Hernandez M, Garcia-Flores V, Motomura K, Hassan SS, Reboldi A, Gomez-Lopez N. Are B cells altered in the decidua of women with preterm or term labor? Am J Reprod Immunol. 2019 05; 81(5):e13102. PMID: 30768818.
      Citations: 17     Fields:    Translation:HumansCells
    17. Cho HS, Reboldi A, Hall JA, Berg LJ. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019 02 15; 10(1):784. PMID: 30770814.
      Citations: 13     Fields:    Translation:AnimalsCells
    18. Reboldi A, Dang E. Cholesterol metabolism in innate and adaptive response. F1000Res. 2018; 7. PMID: 30364153.
      Citations: 18     Fields:    Translation:HumansAnimals
    19. Reboldi A. In Vivo Imaging of Immune Cells in Peyer's Patches. Methods Mol Biol. 2018; 1763:109-118. PMID: 29476492.
      Citations: 1     Fields:    Translation:Animals
    20. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9816-21. PMID: 27540116.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    21. Ronchi F, Basso C, Preite S, Reboldi A, Baumjohann D, Perlini L, Lanzavecchia A, Sallusto F. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1? production by myeloid cells. Nat Commun. 2016 05 18; 7:11541. PMID: 27189410.
      Citations: 52     Fields:    Translation:AnimalsCells
    22. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. PMID: 27174992.
      Citations: 135     Fields:    Translation:AnimalsCells
    23. Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45. PMID: 27088918.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    24. Li Z, Hodgkinson T, Gothard EJ, Boroumand S, Lamb R, Cummins I, Narang P, Sawtell A, Coles J, Leonov G, Reboldi A, Buckley CD, Cupedo T, Siebel C, Bayat A, Coles MC, Ambler CA. Epidermal Notch1 recruits ROR?(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun. 2016 Apr 21; 7:11394. PMID: 27099134.
      Citations: 40     Fields:    Translation:AnimalsCells
    25. Cyster JG, Dang EV, Reboldi A, Yi T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43. PMID: 25324126.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    26. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 08; 345(6197):679-84. PMID: 25104388.
      Citations: 210     Fields:    Translation:AnimalsCells
    27. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605. PMID: 23499493.
      Citations: 266     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009 May; 10(5):514-23. PMID: 19305396.
      Citations: 536     Fields:    Translation:HumansAnimalsCells
    29. Indraccolo S, Minuzzo S, Masiero M, Pusceddu I, Persano L, Moserle L, Reboldi A, Favaro E, Mecarozzi M, Di Mario G, Screpanti I, Ponzoni M, Doglioni C, Amadori A. Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res. 2009 Feb 15; 69(4):1314-23. PMID: 19208840.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    30. Mart?n-Fontecha A, Baumjohann D, Guarda G, Reboldi A, Hons M, Lanzavecchia A, Sallusto F. CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med. 2008 Oct 27; 205(11):2561-74. PMID: 18838544.
      Citations: 31     Fields:    Translation:AnimalsCells
    31. Gr?goire C, Cognet C, Chasson L, Coupet CA, Dalod M, Reboldi A, Marvel J, Sallusto F, Vivier E, Walzer T. Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation. Eur J Immunol. 2008 Aug; 38(8):2076-84. PMID: 18624307.
      Citations: 25     Fields:    Translation:AnimalsCells
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