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Milka Koupenova PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionCardiovascular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    University of California, Los Angeles, Los Angeles, CA, United StatesBSBiochemistry
    Boston University School of Medicine, Boston, MA, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse Summary
    Research in Dr. Koupenova's lab focuses on the contribution of platelets to the immune response during viral infection and the consequent implications of that response to cardiovascular disease. For additional information about projects or joining the lab, contact Dr. Koupenova @ milka.koupenova@umassmed.edu

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Desai C, Koupenova M, Machlus KR, Sen Gupta A. Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer. J Thromb Haemost. 2022 07; 20(7):1523-1534. PMID: 35441793.
      Citations:    Fields:    Translation:HumansCells
    2. Koupenova M, Livada AC, Morrell CN. Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity. Circ Res. 2022 01 21; 130(2):288-308. PMID: 35050690.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    3. Bote J, Corkrey HA, Koupenova M. Human Platelets and Influenza Virus: Internalization and Platelet Activation. Platelets. 2022 Feb 17; 33(2):184-191. PMID: 34369285.
      Citations: 2     Fields:    Translation:HumansCells
    4. Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang JP, Cameron SJ, Rade J, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 09 03; 129(6):631-646. PMID: 34293929.
      Citations: 42     Fields:    Translation:HumansCells
    5. Sahai A, Bhandari R, Koupenova M, Freedman J, Godwin M, McIntyre T, Chung M, Iskandar JP, Kamran H, Aggarwal A, Kalra A, Bartholomew J, McCrae K, Elbadawi A, Svensson L, Kapadia S, Hariri E, Cameron S. SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Res Sq. 2020 Dec 23. PMID: 33398263.
      Citations:    
    6. Koupenova M, Freedman JE. Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions. Circ Res. 2020 11 06; 127(11):1419-1421. PMID: 33151798.
      Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
    7. Palace SG, Vitseva O, Proulx MK, Freedman JE, Goguen JD, Koupenova M. Yersinia pestis escapes entrapment in thrombi by targeting platelet function. J Thromb Haemost. 2020 12; 18(12):3236-3248. PMID: 33470041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Fazzalari A, Basadonna G, Kucukural A, Tanriverdi K, Koupenova M, Pozzi N, Kakuturu J, Friedrich AU, Korstanje R, Fowler N, Belant JL, Beyer DE, Brooks MB, Dickson EW, Blackwood M, Mueller C, Palesty JA, Freedman JE, Cahan MA. A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears. J Surg Res. 2021 01; 257:203-212. PMID: 32858321.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Koupenova M, Freedman JE. Platelets and Immunity: Going Viral. Arterioscler Thromb Vasc Biol. 2020 07; 40(7):1605-1607. PMID: 32579477.
      Citations: 8     Fields:    Translation:Cells
    10. Koupenova M. Potential role of platelets in COVID-19: Implications for thrombosis. Res Pract Thromb Haemost. 2020 Jul; 4(5):737-740. PMID: 32685881.
      Citations:    
    11. Murthy VL, Koupenova M, Shah RV. ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection? Circ Res. 2020 06 05; 126(12):1682-1684. PMID: 32302248.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    12. Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019 Sep 27; 19:916-926. PMID: 31518900.
      Citations:    
    13. Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019 04 16; 10(1):1780. PMID: 30992428.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    14. Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE. Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population. Sci Rep. 2018 04 23; 8(1):6397. PMID: 29686252.
      Citations: 2     Fields:    Translation:HumansCells
    15. Koupenova M, Ravid K. Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Front Pharmacol. 2018; 9:37. PMID: 29441021.
      Citations:    
    16. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res. 2018 01 19; 122(2):337-351. PMID: 29348254.
      Citations: 200     Fields:    Translation:HumansAnimalsCells
    17. Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2017 Mar 14; 38(11):785-791. PMID: 28039338.
      Citations: 106     Fields:    Translation:HumansCells
    18. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova M, Mikhalev E, Tanriverdi K. Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016 06 03; 7:11902. PMID: 27255613.
      Citations: 3     Fields:    
    19. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713.
      Citations: 20     Fields:    Translation:AnimalsCells
    20. Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1030-7. PMID: 25657311.
      Citations: 50     Fields:    Translation:HumansCells
    21. Koupenova M, Freedman JE. Platelets: the unsung hero of the immune response. J Thromb Haemost. 2015 Feb; 13(2):268-70. PMID: 25471925.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    22. Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS One. 2014; 9(6):e98775. PMID: 24892847.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    23. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014 Jul 31; 124(5):791-802. PMID: 24755410.
      Citations: 104     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    24. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1? regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64. PMID: 24458711.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    25. Koupenova M, Ravid K. Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J Cell Physiol. 2013 Mar 04. PMID: 23460239.
      Citations: 22     Fields:    
    26. Koupenova M, Johnston-Cox H, Ravid K. Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors. Curr Atheroscler Rep. 2012 Oct; 14(5):460-8. PMID: 22850979.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    27. Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K. The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One. 2012; 7(7):e40584. PMID: 22848385.
      Citations: 51     Fields:    Translation:HumansAnimals
    28. Johnston-Cox HA, Koupenova M, Ravid K. A2 adenosine receptors and vascular pathologies. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):870-8. PMID: 22423039.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    29. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation. 2012 Jan 17; 125(2):354-63. PMID: 22144568.
      Citations: 41     Fields:    Translation:Animals
    30. Chen H, Koupenova M, Yang D, Sume SS, Trackman PC, Ravid K. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-? signaling. Exp Hematol. 2011 May; 39(5):525-30. PMID: 21320567.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27. PMID: 20102488.
      Citations: 33     Fields:    Translation:AnimalsCells
    32. St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K. TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):292-6. PMID: 18647598.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    33. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):792-6. PMID: 18184815.
      Citations: 56     Fields:    Translation:AnimalsCells
    34. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23. PMID: 16823489.
      Citations: 186     Fields:    Translation:AnimalsCells
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