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Johanna Margaret Seddon MD, ScM

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentOphthalmology and Visual Sciences
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentOphthalmology and Visual Sciences

    InstitutionT.H. Chan School of Medicine
    DepartmentPopulation and Quantitative Health Sciences

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation


    Collapse Biography 
    Collapse education and training
    University of Pittsburgh, Pittsburgh, PA, United StatesBSChemistry/Physics
    Harvard University School of Public Health, Boston, MA, United StatesMSEpidemiology
    University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. García-Layana A, López-Gálvez M, García-Arumí J, Arias L, Gea-Sánchez A, Marín-Méndez JJ, Sayar-Beristain O, Sedano-Gil G, Aslam TM, Minnella AM, Ibáñez IL, de Dios Hernández JM, Seddon JM. A Screening Tool for Self-Evaluation of Risk for Age-Related Macular Degeneration: Validation in a Spanish Population. Transl Vis Sci Technol. 2022 06 01; 11(6):23. PMID: 35749108.
      Citations:    Fields:    Translation:Humans
    2. García-Layana A, Garhöfer G, Aslam TM, Silva R, Delcourt C, Klaver CCW, Seddon JM, Minnella AM. Exploring Consensus on Preventive Measures and Identification of Patients at Risk of Age-Related Macular Degeneration Using the Delphi Process. J Clin Med. 2021 Nov 20; 10(22). PMID: 34830713.
      Citations:    
    3. Seddon JM, Fortes M, Kelly-Smith M, Sommerlad SF, Hayward JJ, Burmeister L, De Risio L, Mellersh C, Freeman J, Strain GM. Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome-wide association study analyses. Anim Genet. 2021 Oct; 52(5):694-702. PMID: 34318504.
      Citations:    Fields:    Translation:Animals
    4. Kleinerman RA, Schonfeld SJ, Abramson DH, Francis JH, Seddon JM, Morton LM, Tucker MA. Increased Risk of Skin Cancer in 1,851 Long-Term Retinoblastoma Survivors. J Invest Dermatol. 2021 12; 141(12):2849-2857.e3. PMID: 34153328.
      Citations:    Fields:    Translation:Humans
    5. McMahon O, Hallam TM, Patel S, Harris CL, Menny A, Zelek WM, Widjajahakim R, Java A, Cox TE, Tzoumas N, Steel DHW, Shuttleworth VG, Smith-Jackson K, Brocklebank V, Griffiths H, Cree AJ, Atkinson JP, Lotery AJ, Bubeck D, Morgan BP, Marchbank KJ, Seddon JM, Kavanagh D. The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. Hum Mol Genet. 2021 06 17; 30(13):1188-1199. PMID: 33783477.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. van Hoefen Wijsard M, Schonfeld SJ, van Leeuwen FE, Moll AC, Fabius AW, Abramson DH, Seddon JM, Francis JH, Tucker MA, Kleinerman RA, Morton LM. Benign Tumors in Long-Term Survivors of Retinoblastoma. Cancers (Basel). 2021 Apr 08; 13(8). PMID: 33917779.
      Citations:    
    7. Schonfeld SJ, Kleinerman RA, Abramson DH, Seddon JM, Tucker MA, Morton LM. Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors. Br J Cancer. 2021 03; 124(7):1312-1319. PMID: 33473166.
      Citations: 2     Fields:    Translation:Humans
    8. Jager MJ, Seddon JM. Eye Diseases Direct Interest to Complement Pathway and Macrophages as Regulators of Inflammation in COVID-19. Asia Pac J Ophthalmol (Phila). 2020 Dec 07; 10(1):114-120. PMID: 33290288.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Seddon JM, Widjajahakim R, Rosner B. Rare and Common Genetic Variants, Smoking, and Body Mass Index: Progression and Earlier Age of Developing Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2020 12 01; 61(14):32. PMID: 33369641.
      Citations: 2     Fields:    Translation:Humans
    10. Java A, Baciu P, Widjajahakim R, Sung YJ, Yang J, Kavanagh D, Atkinson J, Seddon J. Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration. Transl Vis Sci Technol. 2020 08; 9(9):37. PMID: 32908800.
      Citations: 6     Fields:    Translation:Humans
    11. Merle BMJ, Rosner B, Seddon JM. Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size. Invest Ophthalmol Vis Sci. 2020 05 11; 61(5):17. PMID: 32407518.
      Citations: 4     Fields:    Translation:Humans
    12. Lutty GA, McLeod DS, Bhutto IA, Edwards MM, Seddon JM. Choriocapillaris dropout in early age-related macular degeneration. Exp Eye Res. 2020 03; 192:107939. PMID: 31987759.
      Citations: 15     Fields:    Translation:Humans
    13. Kleinerman RA, Schonfeld SJ, Sigel BS, Wong-Siegel JR, Gilbert ES, Abramson DH, Seddon JM, Tucker MA, Morton LM. Bone and Soft-Tissue Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Treated With Radiation. J Clin Oncol. 2019 12 10; 37(35):3436-3445. PMID: 31622129.
      Citations: 3     Fields:    Translation:Humans
    14. Seddon JM, Dossett JP, Widjajahakim R, Rosner B. Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4469-4478. PMID: 31658355.
      Citations: 3     Fields:    Translation:Humans
    15. Kleinerman RA, Tucker MA, Sigel BS, Abramson DH, Seddon JM, Morton LM. Patterns of Cause-Specific Mortality Among 2053 Survivors of Retinoblastoma, 1914-2016. J Natl Cancer Inst. 2019 09 01; 111(9):961-969. PMID: 30698734.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    16. Sandhu HS, El-Baz A, Seddon JM. Progress in Automated Deep Learning for Macular Degeneration. JAMA Ophthalmol. 2018 12 01; 136(12):1366-1367. PMID: 30242352.
      Citations: 1     Fields:    Translation:Humans
    17. Seddon JM, Rosner B. Validated Prediction Models for Macular Degeneration Progression and Predictors of Visual Acuity Loss Identify High-Risk Individuals. Am J Ophthalmol. 2019 02; 198:223-261. PMID: 30389371.
      Citations: 16     Fields:    Translation:Humans
    18. Seddon JM. Macular Degeneration Epidemiology: Nature-Nurture, Lifestyle Factors, Genetic Risk, and Gene-Environment Interactions - The Weisenfeld Award Lecture. Invest Ophthalmol Vis Sci. 2017 12 01; 58(14):6513-6528. PMID: 29288272.
      Citations: 18     Fields:    Translation:Humans
    19. Layana AG, Minnella AM, Garhöfer G, Aslam T, Holz FG, Leys A, Silva R, Delcourt C, Souied E, Seddon JM. Vitamin D and Age-Related Macular Degeneration. Nutrients. 2017 Oct 13; 9(10). PMID: 29027953.
      Citations: 17     Fields:    Translation:HumansAnimals
    20. Seddon JM, Ferrara D. Rare Genetic Variants in Age-Related Macular Degeneration. JAMA Ophthalmol. 2017 10 01; 135(10):1045-1046. PMID: 28859197.
      Citations:    Fields:    Translation:Humans
    21. Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4569-4578. PMID: 28892825.
      Citations: 17     Fields:    Translation:Humans
    22. Ferrara D, Silver RE, Louzada RN, Novais EA, Collins GK, Seddon JM. Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 07 01; 58(9):3519-3529. PMID: 28715590.
      Citations: 24     Fields:    Translation:Humans
    23. Yu Y, Wagner EK, Souied EH, Seitsonen S, Immonen IJ, Häppölä P, Raychaudhuri S, Daly MJ, Seddon JM. Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†. Hum Mol Genet. 2016 12 01; 25(23):5276-5285. PMID: 28011711.
      Citations: 7     Fields:    Translation:Humans
    24. McLeod DS, Bhutto I, Edwards MM, Silver RE, Seddon JM, Lutty GA. Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):5843-5855. PMID: 27802514.
      Citations: 39     Fields:    Translation:HumansCells
    25. Seddon JM, McLeod DS, Bhutto IA, Villalonga MB, Silver RE, Wenick AS, Edwards MM, Lutty GA. Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration. JAMA Ophthalmol. 2016 Nov 01; 134(11):1272-1280. PMID: 27657855.
      Citations: 70     Fields:    Translation:Humans
    26. Wagner EK, Raychaudhuri S, Villalonga MB, Java A, Triebwasser MP, Daly MJ, Atkinson JP, Seddon JM. Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD. Sci Rep. 2016 08 30; 6:31531. PMID: 27572114.
      Citations: 23     Fields:    Translation:HumansCTClinical Trials
    27. Lane M, Ferrara D, Louzada RN, Fujimoto JG, Seddon JM. Diagnosis and Follow-Up of Nonexudative Choroidal Neovascularization With Multiple Optical Coherence Tomography Angiography Devices: A Case Report. Ophthalmic Surg Lasers Imaging Retina. 2016 08 01; 47(8):778-81. PMID: 27548457.
      Citations: 4     Fields:    Translation:Humans
    28. Seddon JM, Silver RE, Rosner B. Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis. Br J Ophthalmol. 2016 Dec; 100(12):1731-1737. PMID: 27471039.
      Citations: 18     Fields:    Translation:Humans
    29. Kang JH, Wu J, Cho E, Ogata S, Jacques P, Taylor A, Chiu CJ, Wiggs JL, Seddon JM, Hankinson SE, Schaumberg DA, Pasquale LR. Contribution of the Nurses' Health Study to the Epidemiology of Cataract, Age-Related Macular Degeneration, and Glaucoma. Am J Public Health. 2016 Sep; 106(9):1684-9. PMID: 27459452.
      Citations: 12     Fields:    Translation:Humans
    30. Merle BM, Silver RE, Rosner B, Seddon JM. Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr; 103(4):1135-44. PMID: 26961928.
      Citations: 17     Fields:    Translation:Humans
    31. Bhutto IA, McLeod DS, Jing T, Sunness JS, Seddon JM, Lutty GA. Increased choroidal mast cells and their degranulation in age-related macular degeneration. Br J Ophthalmol. 2016 May; 100(5):720-6. PMID: 26931413.
      Citations: 29     Fields:    Translation:HumansCells
    32. de Carlo TE, Adhi M, Salz DA, Joseph T, Waheed NK, Seddon JM, Duker JS, Reichel E. Analysis of Choroidal and Retinal Vasculature in Inherited Retinal Degenerations Using Optical Coherence Tomography Angiography. Ophthalmic Surg Lasers Imaging Retina. 2016 Feb; 47(2):120-7. PMID: 26878444.
      Citations: 5     Fields:    Translation:HumansCells
    33. Shah AR, Williams S, Baumal CR, Rosner B, Duker JS, Seddon JM. Predictors of Response to Intravitreal Anti-Vascular Endothelial Growth Factor Treatment of Age-Related Macular Degeneration. Am J Ophthalmol. 2016 Mar; 163:154-166.e8. PMID: 26705092.
      Citations: 16     Fields:    Translation:Humans
    34. Merle BM, Silver RE, Rosner B, Seddon JM. Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. Am J Clin Nutr. 2015 Nov; 102(5):1196-206. PMID: 26490493.
      Citations: 44     Fields:    Translation:Humans
    35. Triebwasser MP, Roberson ED, Yu Y, Schramm EC, Wagner EK, Raychaudhuri S, Seddon JM, Atkinson JP. Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6873-8. PMID: 26501415.
      Citations: 31     Fields:    Translation:Humans
    36. Edwards MM, McLeod DS, Bhutto IA, Villalonga MB, Seddon JM, Lutty GA. Idiopathic preretinal glia in aging and age-related macular degeneration. Exp Eye Res. 2016 09; 150:44-61. PMID: 26220834.
      Citations: 21     Fields:    Translation:HumansCells
    37. Ferrara D, Seddon JM. Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration. JAMA Ophthalmol. 2015 Jul; 133(7):785-91. PMID: 25880396.
      Citations: 20     Fields:    Translation:Humans
    38. Seddon JM, Silver RE, Kwong M, Rosner B. Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2192-202. PMID: 25655794.
      Citations: 44     Fields:    Translation:Humans
    39. Kavanagh D, Yu Y, Schramm EC, Triebwasser M, Wagner EK, Raychaudhuri S, Daly MJ, Atkinson JP, Seddon JM. Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels. Hum Mol Genet. 2015 Jul 01; 24(13):3861-70. PMID: 25788521.
      Citations: 49     Fields:    Translation:Humans
    40. Sommerlad SF, Morton JM, Johnstone I, O'Leary CA, Seddon JM. Consequences of a screening programme on the prevalence of congenital hereditary sensorineural deafness in the Australian Cattle Dog. Anim Genet. 2014 Dec; 45(6):855-62. PMID: 25286978.
      Citations: 2     Fields:    Translation:Animals
    41. Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA. Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy. J Clin Oncol. 2014 Oct 10; 32(29):3284-90. PMID: 25185089.
      Citations: 41     Fields:    Translation:Humans
    42. Schramm EC, Clark SJ, Triebwasser MP, Raychaudhuri S, Seddon J, Atkinson JP. Genetic variants in the complement system predisposing to age-related macular degeneration: a review. Mol Immunol. 2014 Oct; 61(2):118-125. PMID: 25034031.
      Citations: 58     Fields:    Translation:Humans
    43. Hutchinson JN, Fagerness J, Kirby A, Reynolds R, Zak A, Gimelbrant A, Plenge R, Daly M, Chess A, Seddon JM. (Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies. Hum Hered. 2014; 78(2):59-72. PMID: 25033836.
      Citations: 7     Fields:    Translation:HumansCells
    44. Hutchinson JN, Raj T, Fagerness J, Stahl E, Viloria FT, Gimelbrant A, Seddon J, Daly M, Chess A, Plenge R. Allele-specific methylation occurs at genetic variants associated with complex disease. PLoS One. 2014; 9(6):e98464. PMID: 24911414.
      Citations: 17     Fields:    Translation:HumansCells
    45. Yu Y, Triebwasser MP, Wong EK, Schramm EC, Thomas B, Reynolds R, Mardis ER, Atkinson JP, Daly M, Raychaudhuri S, Kavanagh D, Seddon JM. Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration. Hum Mol Genet. 2014 Oct 01; 23(19):5283-93. PMID: 24847005.
      Citations: 53     Fields:    Translation:HumansCells
    46. Little MP, Schaeffer ML, Reulen RC, Abramson DH, Stovall M, Weathers R, de Vathaire F, Diallo I, Seddon JM, Hawkins MM, Tucker MA, Kleinerman RA. Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study. Br J Cancer. 2014 May 13; 110(10):2623-32. PMID: 24755883.
      Citations: 7     Fields:    Translation:Humans
    47. Seddon JM, Reynolds R, Yu Y, Rosner B. Three new genetic loci (R1210C in CFH, variants in COL8A1 and RAD51B) are independently related to progression to advanced macular degeneration. PLoS One. 2014; 9(1):e87047. PMID: 24498017.
      Citations: 29     Fields:    Translation:Humans
    48. Sobrin L, Seddon JM. Nature and nurture- genes and environment- predict onset and progression of macular degeneration. Prog Retin Eye Res. 2014 May; 40:1-15. PMID: 24374240.
      Citations: 83     Fields:    Translation:HumansCells
    49. Seddon JM. Genetic and environmental underpinnings to age-related ocular diseases. Invest Ophthalmol Vis Sci. 2013 Dec 13; 54(14):ORSF28-30. PMID: 24335064.
      Citations: 16     Fields:    Translation:HumansPHPublic Health
    50. Seddon JM, Yu Y, Miller EC, Reynolds R, Tan PL, Gowrisankar S, Goldstein JI, Triebwasser M, Anderson HE, Zerbib J, Kavanagh D, Souied E, Katsanis N, Daly MJ, Atkinson JP, Raychaudhuri S. Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat Genet. 2013 Nov; 45(11):1366-70. PMID: 24036952.
      Citations: 162     Fields:    Translation:HumansCells
    51. Sobrin L, Seddon JM. Regular aspirin use and risk of age-related macular degeneration. Am J Ophthalmol. 2013 Aug; 156(2):213-217.e2. PMID: 23870358.
      Citations: 3     Fields:    Translation:Humans
    52. Seddon JM, Reynolds R, Yu Y, Rosner B. Validation of a prediction algorithm for progression to advanced macular degeneration subtypes. JAMA Ophthalmol. 2013 Apr; 131(4):448-55. PMID: 23411794.
      Citations: 24     Fields:    Translation:Humans
    53. Reynolds R, Rosner B, Seddon JM. Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. Ophthalmology. 2013 May; 120(5):1020-8. PMID: 23481534.
      Citations: 33     Fields:    Translation:Humans
    54. Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC, Cheng CY, Chew EY, Chin KA, Chowers I, Clayton DG, Cojocaru R, Conley YP, Cornes BK, Daly MJ, Dhillon B, Edwards AO, Evangelou E, Fagerness J, Ferreyra HA, Friedman JS, Geirsdottir A, George RJ, Gieger C, Gupta N, Hagstrom SA, Harding SP, Haritoglou C, Heckenlively JR, Holz FG, Hughes G, Ioannidis JP, Ishibashi T, Joseph P, Jun G, Kamatani Y, Katsanis N, N Keilhauer C, Khan JC, Kim IK, Kiyohara Y, Klein BE, Klein R, Kovach JL, Kozak I, Lee CJ, Lee KE, Lichtner P, Lotery AJ, Meitinger T, Mitchell P, Mohand-Saïd S, Moore AT, Morgan DJ, Morrison MA, Myers CE, Naj AC, Nakamura Y, Okada Y, Orlin A, Ortube MC, Othman MI, Pappas C, Park KH, Pauer GJ, Peachey NS, Poch O, Priya RR, Reynolds R, Richardson AJ, Ripp R, Rudolph G, Ryu E, Sahel JA, Schaumberg DA, Scholl HP, Schwartz SG, Scott WK, Shahid H, Sigurdsson H, Silvestri G, Sivakumaran TA, Smith RT, Sobrin L, Souied EH, Stambolian DE, Stefansson H, Sturgill-Short GM, Takahashi A, Tosakulwong N, Truitt BJ, Tsironi EE, Uitterlinden AG, van Duijn CM, Vijaya L, Vingerling JR, Vithana EN, Webster AR, Wichmann HE, Winkler TW, Wong TY, Wright AF, Zelenika D, Zhang M, Zhao L, Zhang K, Klein ML, Hageman GS, Lathrop GM, Stefansson K, Allikmets R, Baird PN, Gorin MB, Wang JJ, Klaver CC, Seddon JM, Pericak-Vance MA, Iyengar SK, Yates JR, Swaroop A, Weber BH, Kubo M, Deangelis MM, Léveillard T, Thorsteinsdottir U, Haines JL, Farrer LA, Heid IM, Abecasis GR. Seven new loci associated with age-related macular degeneration. Nat Genet. 2013 Apr; 45(4):433-9, 439e1-2. PMID: 23455636.
      Citations: 370     Fields:    Translation:Humans
    55. Ioannidis JP, Yu Y, Seddon JM. To Correct or Not to Correct-and How. Epidemiology. 2012 Nov; 23(6):912-3. PMID: 23038115.
      Citations:    Fields:    Translation:Humans
    56. Ioannidis JP, Yu Y, Seddon JM. Correction of phenotype misclassification based on high-discrimination genetic predictive risk models. Epidemiology. 2012 Nov; 23(6):902-9. PMID: 23023008.
      Citations: 2     Fields:    Translation:Humans
    57. Thakkinstian A, McEvoy M, Chakravarthy U, Chakrabarti S, McKay GJ, Ryu E, Silvestri G, Kaur I, Francis P, Iwata T, Akahori M, Arning A, Edwards AO, Seddon JM, Attia J. The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol. 2012 Sep 01; 176(5):361-72. PMID: 22869612.
      Citations: 29     Fields:    Translation:Humans
    58. Leveziel N, Yu Y, Reynolds R, Tai A, Meng W, Caillaux V, Calvas P, Rosner B, Malecaze F, Souied EH, Seddon JM. Genetic factors for choroidal neovascularization associated with high myopia. Invest Ophthalmol Vis Sci. 2012 Jul 27; 53(8):5004-9. PMID: 22678500.
      Citations: 14     Fields:    Translation:Humans
    59. Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM. Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology. 2012 Sep; 119(9):1874-85. PMID: 22705344.
      Citations: 38     Fields:    Translation:Humans
    60. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet. 2012 May 05; 379(9827):1728-38. PMID: 22559899.
      Citations: 590     Fields:    Translation:Humans
    61. Yu Y, Reynolds R, Rosner B, Daly MJ, Seddon JM. Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. Invest Ophthalmol Vis Sci. 2012 Mar; 53(3):1548-56. PMID: 22247473.
      Citations: 54     Fields:    Translation:Humans
    62. Kleinerman RA, Yu CL, Little MP, Li Y, Abramson D, Seddon J, Tucker MA. Variation of second cancer risk by family history of retinoblastoma among long-term survivors. J Clin Oncol. 2012 Mar 20; 30(9):950-7. PMID: 22355046.
      Citations: 26     Fields:    Translation:Humans
    63. Quellec G, Russell SR, Seddon JM, Reynolds R, Scheetz T, Mahajan VB, Stone EM, Abràmoff MD. Automated discovery and quantification of image-based complex phenotypes: a twin study of drusen phenotypes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Nov 25; 52(12):9195-206. PMID: 22039249.
      Citations: 4     Fields:    Translation:Humans
    64. Stanton CM, Yates JR, den Hollander AI, Seddon JM, Swaroop A, Stambolian D, Fauser S, Hoyng C, Yu Y, Atsuhiro K, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore AT, Dhillon B, Ueffing M, Wright AF. Complement factor D in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Nov 11; 52(12):8828-34. PMID: 22003108.
      Citations: 38     Fields:    Translation:Humans
    65. Raychaudhuri S, Iartchouk O, Chin K, Tan PL, Tai AK, Ripke S, Gowrisankar S, Vemuri S, Montgomery K, Yu Y, Reynolds R, Zack DJ, Campochiaro B, Campochiaro P, Katsanis N, Daly MJ, Seddon JM. A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Nat Genet. 2011 Oct 23; 43(12):1232-6. PMID: 22019782.
      Citations: 166     Fields:    Translation:Humans
    66. Francis JH, Kleinerman RA, Seddon JM, Abramson DH. Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma. Gynecol Oncol. 2012 Feb; 124(2):254-9. PMID: 22027510.
      Citations: 16     Fields:    Translation:Humans
    67. Seddon JM, Reynolds R, Yu Y, Daly MJ, Rosner B. Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. Ophthalmology. 2011 Nov; 118(11):2203-11. PMID: 21959373.
      Citations: 77     Fields:    Translation:Humans
    68. McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG, Weber BH, Keilhauer CN, Lotery AJ, Ennis S, Klein ML, Francis PJ, Stambolian D, Orlin A, Gorin MB, Weeks DE, Kuo CL, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Wright AF, Hayward C, Baird PN, Guymer RH, Attia J, Thakkinstian A, Silvestri G. Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat. 2011 Dec; 32(12):1407-16. PMID: 21882290.
      Citations: 64     Fields:    Translation:Humans
    69. Peter I, Huggins GS, Ordovas JM, Haan M, Seddon JM. Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. Am J Ophthalmol. 2011 Dec; 152(6):1005-1013.e1. PMID: 21906714.
      Citations: 16     Fields:    Translation:Humans
    70. Yu Y, Reynolds R, Fagerness J, Rosner B, Daly MJ, Seddon JM. Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Jun 28; 52(7):4663-70. PMID: 21447678.
      Citations: 68     Fields:    Translation:Humans
    71. Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011 Sep 15; 20(18):3699-709. PMID: 21665990.
      Citations: 128     Fields:    Translation:Humans
    72. Wise LA, Rosenberg L, Radin RG, Mattox C, Yang EB, Palmer JR, Seddon JM. A prospective study of diabetes, lifestyle factors, and glaucoma among African-American women. Ann Epidemiol. 2011 Jun; 21(6):430-9. PMID: 21549278.
      Citations: 37     Fields:    Translation:Humans
    73. Seddon JM, Reynolds R, Shah HR, Rosner B. Smoking, dietary betaine, methionine, and vitamin D in monozygotic twins with discordant macular degeneration: epigenetic implications. Ophthalmology. 2011 Jul; 118(7):1386-94. PMID: 21620475.
      Citations: 37     Fields:    Translation:Humans
    74. McKay GJ, Silvestri G, Chakravarthy U, Dasari S, Fritsche LG, Weber BH, Keilhauer CN, Klein ML, Francis PJ, Klaver CC, Vingerling JR, Ho L, De Jong PT, Dean M, Sawitzke J, Baird PN, Guymer RH, Stambolian D, Orlin A, Seddon JM, Peter I, Wright AF, Hayward C, Lotery AJ, Ennis S, Gorin MB, Weeks DE, Kuo CL, Hingorani AD, Sofat R, Cipriani V, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Yates JR, Webster AR, Moore AT, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Young IS, Fletcher AE, Patterson CC. Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am J Epidemiol. 2011 Jun 15; 173(12):1357-64. PMID: 21498624.
      Citations: 42     Fields:    Translation:Humans
    75. Weiner DE, Tighiouart H, Reynolds R, Seddon JM. Kidney function, albuminuria and age-related macular degeneration in NHANES III. Nephrol Dial Transplant. 2011 Oct; 26(10):3159-65. PMID: 21339308.
      Citations: 12     Fields:    Translation:Humans
    76. Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein PS, Souied EH, Daly MJ, Seddon JM. ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. Am J Ophthalmol. 2011 Feb; 151(2):345-52.e3. PMID: 21122828.
      Citations: 35     Fields:    Translation:Humans
    77. Seddon JM, Reynolds R, Rosner B. Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Mol Vis. 2010 Nov 17; 16:2412-24. PMID: 21139980.
      Citations: 31     Fields:    Translation:Humans
    78. Peter I, Seddon JM. Genetic epidemiology: successes and challenges of genome-wide association studies using the example of age-related macular degeneration. Am J Ophthalmol. 2010 Oct; 150(4):450-452.e2. PMID: 20863920.
      Citations: 9     Fields:    Translation:Humans
    79. Reynolds R, Rosner B, Seddon JM. Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration. Ophthalmology. 2010 Oct; 117(10):1989-95. PMID: 20888482.
      Citations: 66     Fields:    Translation:Humans
    80. Raychaudhuri S, Ripke S, Li M, Neale BM, Fagerness J, Reynolds R, Sobrin L, Swaroop A, Abecasis G, Seddon JM, Daly MJ. Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. Nat Genet. 2010 Jul; 42(7):553-5; author reply 555-6. PMID: 20581873.
      Citations: 29     Fields:    Translation:Humans
    81. Jun JJ, Duker JS, Baumal CR, McCabe F, Reichel E, Rogers AH, Seddon JM, Tolentino FI. Cystoid macular edema without macular thickening: a retrospective optical coherence tomographic study. Retina. 2010 Jun; 30(6):917-23. PMID: 20168270.
      Citations: 4     Fields:    Translation:Humans
    82. Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7401-6. PMID: 20385819.
      Citations: 281     Fields:    Translation:Humans
    83. Neale BM, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, Tan PL, Oh EC, Merriam JE, Souied E, Bernstein PS, Li B, Frederick JM, Zhang K, Brantley MA, Lee AY, Zack DJ, Campochiaro B, Campochiaro P, Ripke S, Smith RT, Barile GR, Katsanis N, Allikmets R, Daly MJ, Seddon JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7395-400. PMID: 20385826.
      Citations: 232     Fields:    Translation:Humans
    84. Seddon JM, Gensler G, Rosner B. C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology. 2010 Aug; 117(8):1560-6. PMID: 20346514.
      Citations: 31     Fields:    Translation:Humans
    85. Seddon JM, Berggren KT, Fleeman LM. Evolutionary history of DLA class II haplotypes in canine diabetes mellitus through single nucleotide polymorphism genotyping. Tissue Antigens. 2010 Mar; 75(3):218-26. PMID: 20047645.
      Citations: 7     Fields:    Translation:AnimalsCells
    86. Chodick G, Kleinerman RA, Stovall M, Abramson DH, Seddon JM, Smith SA, Tucker MA. Risk of cataract extraction among adult retinoblastoma survivors. Arch Ophthalmol. 2009 Nov; 127(11):1500-4. PMID: 19901216.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    87. Sobrin L, Maller JB, Neale BM, Reynolds RC, Fagerness JA, Daly MJ, Seddon JM. Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach. Eur J Hum Genet. 2010 Apr; 18(4):496-501. PMID: 19844262.
      Citations: 18     Fields:    Translation:Humans
    88. Zerbib J, Seddon JM, Richard F, Reynolds R, Leveziel N, Benlian P, Borel P, Feingold J, Munnich A, Soubrane G, Kaplan J, Rozet JM, Souied EH. rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration. PLoS One. 2009 Oct 05; 4(10):e7341. PMID: 19806217.
      Citations: 25     Fields:    Translation:Humans
    89. Reynolds R, Hartnett ME, Atkinson JP, Giclas PC, Rosner B, Seddon JM. Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5818-27. PMID: 19661236.
      Citations: 142     Fields:    Translation:Humans
    90. Edwards AO, Swaroop A, Seddon JM. Geographic atrophy in age-related macular degeneration and TLR3. N Engl J Med. 2009 May 21; 360(21):2254-5; author reply 2255-6. PMID: 19469037.
      Citations: 10     Fields:    Translation:Humans
    91. Yu CL, Tucker MA, Abramson DH, Furukawa K, Seddon JM, Stovall M, Fraumeni JF, Kleinerman RA. Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst. 2009 Apr 15; 101(8):581-91. PMID: 19351917.
      Citations: 49     Fields:    Translation:HumansPHPublic Health
    92. Seddon JM, Reynolds R, Maller J, Fagerness JA, Daly MJ, Rosner B. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2044-53. PMID: 19117936.
      Citations: 134     Fields:    Translation:Humans
    93. Seddon JM, Reynolds R, Rosner B. Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):586-91. PMID: 18936151.
      Citations: 27     Fields:    Translation:Humans
    94. SanGiovanni JP, Chew EY, Agrón E, Clemons TE, Ferris FL, Gensler G, Lindblad AS, Milton RC, Seddon JM, Klein R, Sperduto RD. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch Ophthalmol. 2008 Sep; 126(9):1274-9. PMID: 18779490.
      Citations: 76     Fields:    Translation:HumansCTClinical Trials
    95. Yi K, Mujat M, Park BH, Sun W, Miller JW, Seddon JM, Young LH, de Boer JF, Chen TC. Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration. Br J Ophthalmol. 2009 Feb; 93(2):176-81. PMID: 18697811.
      Citations: 34     Fields:    Translation:Humans
    96. Fagerness JA, Maller JB, Neale BM, Reynolds RC, Daly MJ, Seddon JM. Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Genet. 2009 Jan; 17(1):100-4. PMID: 18685559.
      Citations: 182     Fields:    Translation:HumansCells
    97. Sheen V, Tucker MA, Abramson DH, Seddon JM, Kleinerman RA. Cancer screening practices of adult survivors of retinoblastoma at risk of second cancers. Cancer. 2008 Jul 15; 113(2):434-41. PMID: 18473349.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    98. Maki J, Kusakul S, Morley K, Sanguansak T, Seddon J, Hartung L, Morley M. The effect of glasses on visual function following cataract surgery in a cataract camp. Br J Ophthalmol. 2008 Jul; 92(7):883-7. PMID: 18577636.
      Citations: 2     Fields:    Translation:Humans
    99. Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon SC, Schultz DW, Ott J, Seddon JM. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology. 2008 Jun; 115(6):1019-25. PMID: 18423869.
      Citations: 66     Fields:    Translation:Humans
    100. Montezuma SR, Sobrin L, Seddon JM. Review of genetics in age related macular degeneration. Semin Ophthalmol. 2007 Oct-Dec; 22(4):229-40. PMID: 18097986.
      Citations: 47     Fields:    Translation:Humans
    101. Maller JB, Fagerness JA, Reynolds RC, Neale BM, Daly MJ, Seddon JM. Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet. 2007 Oct; 39(10):1200-1. PMID: 17767156.
      Citations: 211     Fields:    Translation:Humans
    102. SanGiovanni JP, Chew EY, Clemons TE, Ferris FL, Gensler G, Lindblad AS, Milton RC, Seddon JM, Sperduto RD. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep; 125(9):1225-32. PMID: 17846363.
      Citations: 142     Fields:    Translation:Humans
    103. SanGiovanni JP, Chew EY, Clemons TE, Davis MD, Ferris FL, Gensler GR, Kurinij N, Lindblad AS, Milton RC, Seddon JM, Sperduto RD. The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20. Arch Ophthalmol. 2007 May; 125(5):671-9. PMID: 17502507.
      Citations: 112     Fields:    Translation:Humans
    104. Seddon JM, Francis PJ, George S, Schultz DW, Rosner B, Klein ML. Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. JAMA. 2007 Apr 25; 297(16):1793-800. PMID: 17456821.
      Citations: 120     Fields:    Translation:Humans
    105. Kennedy LJ, Barnes A, Short A, Brown JJ, Lester S, Seddon J, Happ GM, Ollier WE. Canine DLA diversity: 2. Family studies. Tissue Antigens. 2007 Apr; 69 Suppl 1:289-91. PMID: 17445219.
      Citations: 2     Fields:    Translation:Animals
    106. Francis PJ, George S, Schultz DW, Rosner B, Hamon S, Ott J, Weleber RG, Klein ML, Seddon JM. The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered. 2007; 63(3-4):212-8. PMID: 17347568.
      Citations: 34     Fields:    Translation:Humans
    107. Klein R, Deng Y, Klein BE, Hyman L, Seddon J, Frank RN, Wallace RB, Hendrix SL, Kuppermann BD, Langer RD, Kuller L, Brunner R, Johnson KC, Thomas AM, Haan M. Cardiovascular disease, its risk factors and treatment, and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary study. Am J Ophthalmol. 2007 Mar; 143(3):473-83. PMID: 17317391.
      Citations: 53     Fields:    Translation:Humans
    108. Kleinerman RA, Tucker MA, Abramson DH, Seddon JM, Tarone RE, Fraumeni JF. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst. 2007 Jan 03; 99(1):24-31. PMID: 17202110.
      Citations: 59     Fields:    Translation:HumansPHPublic Health
    109. Seddon JM. Multivitamin-multimineral supplements and eye disease: age-related macular degeneration and cataract. Am J Clin Nutr. 2007 Jan; 85(1):304S-307S. PMID: 17209215.
      Citations: 16     Fields:    Translation:Humans
    110. O'Leary CA, Duffy D, Biros I, Corley S, Seddon JM. Linkage analysis excludes the involvement of the canine PKD2 homologue in bull terrier polycystic kidney disease. Anim Genet. 2006 Oct; 37(5):527-8. PMID: 16978192.
      Citations: 1     Fields:    Translation:AnimalsCells
    111. Maller J, George S, Purcell S, Fagerness J, Altshuler D, Daly MJ, Seddon JM. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet. 2006 Sep; 38(9):1055-9. PMID: 16936732.
      Citations: 267     Fields:    Translation:Humans
    112. Foster MC, Kleinerman RA, Abramson DH, Seddon JM, Tarone RE, Tucker MA. Tobacco use in adult long-term survivors of retinoblastoma. Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1464-8. PMID: 16896033.
      Citations: 11     Fields:    Translation:Humans
    113. Haan MN, Klein R, Klein BE, Deng Y, Blythe LK, Seddon JM, Musch DC, Kuller LH, Hyman LG, Wallace RB. Hormone therapy and age-related macular degeneration: the Women's Health Initiative Sight Exam Study. Arch Ophthalmol. 2006 Jul; 124(7):988-92. PMID: 16832022.
      Citations: 22     Fields:    Translation:Humans
    114. Haddad S, Chen CA, Santangelo SL, Seddon JM. The genetics of age-related macular degeneration: a review of progress to date. Surv Ophthalmol. 2006 Jul-Aug; 51(4):316-63. PMID: 16818082.
      Citations: 108     Fields:    Translation:Humans
    115. Seddon JM, George S, Rosner B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. Arch Ophthalmol. 2006 Jul; 124(7):995-1001. PMID: 16832023.
      Citations: 138     Fields:    Translation:Humans
    116. Seddon JM, George S, Rosner B, Klein ML. CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered. 2006; 61(3):157-65. PMID: 16816528.
      Citations: 69     Fields:    Translation:Humans
    117. Seddon JM, Gensler G, Klein ML, Milton RC. C-reactive protein and homocysteine are associated with dietary and behavioral risk factors for age-related macular degeneration. Nutrition. 2006 Apr; 22(4):441-3. PMID: 16530626.
      Citations: 25     Fields:    Translation:Humans
    118. Seddon JM, Sharma S, Adelman RA. Evaluation of the clinical age-related maculopathy staging system. Ophthalmology. 2006 Feb; 113(2):260-6. PMID: 16458093.
      Citations: 121     Fields:    Translation:Humans
    119. Seddon JM, Gensler G, Klein ML, Milton RC. Evaluation of plasma homocysteine and risk of age-related macular degeneration. Am J Ophthalmol. 2006 Jan; 141(1):201-3. PMID: 16387004.
      Citations: 27     Fields:    Translation:Humans
    120. Young TA, Seddon JM. Choroidal and cutaneous melanoma: distinctly different cousins. Ophthalmic Epidemiol. 2005 Aug; 12(4):221-2. PMID: 16033742.
      Citations: 1     Fields:    Translation:Humans
    121. Fisher SA, Abecasis GR, Yashar BM, Zareparsi S, Swaroop A, Iyengar SK, Klein BE, Klein R, Lee KE, Majewski J, Schultz DW, Klein ML, Seddon JM, Santangelo SL, Weeks DE, Conley YP, Mah TS, Schmidt S, Haines JL, Pericak-Vance MA, Gorin MB, Schulz HL, Pardi F, Lewis CM, Weber BH. Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet. 2005 Aug 01; 14(15):2257-64. PMID: 15987700.
      Citations: 90     Fields:    Translation:Humans
    122. Santangelo SL, Yen CH, Haddad S, Fagerness J, Huang C, Seddon JM. A discordant sib-pair linkage analysis of age-related macular degeneration. Ophthalmic Genet. 2005 Jun; 26(2):61-7. PMID: 16020308.
      Citations: 8     Fields:    Translation:HumansCells
    123. Seddon JM, George S, Rosner B, Rifai N. Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol. 2005 Jun; 123(6):774-82. PMID: 15955978.
      Citations: 146     Fields:    Translation:Humans
    124. Kleinerman RA, Tucker MA, Tarone RE, Abramson DH, Seddon JM, Stovall M, Li FP, Fraumeni JF. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol. 2005 Apr 01; 23(10):2272-9. PMID: 15800318.
      Citations: 120     Fields:    Translation:Humans
    125. Clemons TE, Milton RC, Klein R, Seddon JM, Ferris FL. Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology. 2005 Apr; 112(4):533-9. PMID: 15808240.
      Citations: 221     Fields:    Translation:HumansCTClinical Trials
    126. Seddon JM, Cote J, Page WF, Aggen SH, Neale MC. The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. Arch Ophthalmol. 2005 Mar; 123(3):321-7. PMID: 15767473.
      Citations: 159     Fields:    Translation:Humans
    127. Seddon JM, Ellegren H. A temporal analysis shows major histocompatibility complex loci in the Scandinavian wolf population are consistent with neutral evolution. Proc Biol Sci. 2004 Nov 07; 271(1554):2283-91. PMID: 15539354.
      Citations: 16     Fields:    Translation:AnimalsCells
    128. Schaumberg DA, Liu S, Seddon JM, Willett WC, Hankinson SE. Dietary glycemic load and risk of age-related cataract. Am J Clin Nutr. 2004 Aug; 80(2):489-95. PMID: 15277175.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    129. Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol. 2004 Jun; 122(6):883-92. PMID: 15197064.
      Citations: 61     Fields:    Translation:HumansAnimals
    130. Seddon JM, Gensler G, Milton RC, Klein ML, Rifai N. Association between C-reactive protein and age-related macular degeneration. JAMA. 2004 Feb 11; 291(6):704-10. PMID: 14871913.
      Citations: 143     Fields:    Translation:HumansCTClinical Trials
    131. Seddon JM, Chen CA. The epidemiology of age-related macular degeneration. Int Ophthalmol Clin. 2004; 44(4):17-39. PMID: 15577562.
      Citations: 37     Fields:    Translation:Humans
    132. Seddon JM, Cote J, Rosner B. Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol. 2003 Dec; 121(12):1728-37. PMID: 14662593.
      Citations: 113     Fields:    Translation:HumansAnimals
    133. Bressler NM, Bressler SB, Congdon NG, Ferris FL, Friedman DS, Klein R, Lindblad AS, Milton RC, Seddon JM. Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol. 2003 Nov; 121(11):1621-4. PMID: 14609922.
      Citations: 104     Fields:    Translation:HumansPHPublic Health
    134. Seddon JM, Sharma S, Chong S, Hutchinson A, Allikmets R, Adelman RA. Phenotype and genotype correlations in two best families. Ophthalmology. 2003 Sep; 110(9):1724-31. PMID: 13129869.
      Citations: 10     Fields:    Translation:Humans
    135. Seddon JM, Santangelo SL, Book K, Chong S, Cote J. A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet. 2003 Oct; 73(4):780-90. PMID: 12945014.
      Citations: 77     Fields:    Translation:Humans
    136. Seddon JM, Cote J, Davis N, Rosner B. Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio. Arch Ophthalmol. 2003 Jun; 121(6):785-92. PMID: 12796248.
      Citations: 125     Fields:    Translation:Humans
    137. Snow KK, Cote J, Yang W, Davis NJ, Seddon JM. Association between reproductive and hormonal factors and age-related maculopathy in postmenopausal women. Am J Ophthalmol. 2002 Dec; 134(6):842-8. PMID: 12470752.
      Citations: 16     Fields:    Translation:Humans
    138. Weintraub JM, Willett WC, Rosner B, Colditz GA, Seddon JM, Hankinson SE. A prospective study of the relationship between body mass index and cataract extraction among US women and men. Int J Obes Relat Metab Disord. 2002 Dec; 26(12):1588-95. PMID: 12461675.
      Citations: 22     Fields:    Translation:Humans
    139. Bernstein PS, Leppert M, Singh N, Dean M, Lewis RA, Lupski JR, Allikmets R, Seddon JM. Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):466-73. PMID: 11818392.
      Citations: 7     Fields:    Translation:Humans
    140. Weintraub JM, Willett WC, Rosner B, Colditz GA, Seddon JM, Hankinson SE. Smoking cessation and risk of cataract extraction among US women and men. Am J Epidemiol. 2002 Jan 01; 155(1):72-9. PMID: 11772787.
      Citations: 4     Fields:    Translation:Humans
    141. Ayyagari R, Zhang K, Hutchinson A, Yu Z, Swaroop A, Kakuk LE, Seddon JM, Bernstein PS, Lewis RA, Tammur J, Yang Z, Li Y, Zhang H, Yashar BM, Liu J, Petrukhin K, Sieving PA, Allikmets R. Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Ophthalmic Genet. 2001 Dec; 22(4):233-9. PMID: 11803489.
      Citations: 16     Fields:    Translation:Humans
    142. Seddon JM, Afshari MA, Sharma S, Bernstein PS, Chong S, Hutchinson A, Petrukhin K, Allikmets R. Assessment of mutations in the Best macular dystrophy (VMD2) gene in patients with adult-onset foveomacular vitelliform dystrophy, age-related maculopathy, and bull's-eye maculopathy. Ophthalmology. 2001 Nov; 108(11):2060-7. PMID: 11713080.
      Citations: 31     Fields:    Translation:Humans
    143. Seddon JM, Rosner B, Sperduto RD, Yannuzzi L, Haller JA, Blair NP, Willett W. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001 Aug; 119(8):1191-9. PMID: 11483088.
      Citations: 112     Fields:    Translation:Humans
    144. Cho E, Stampfer MJ, Seddon JM, Hung S, Spiegelman D, Rimm EB, Willett WC, Hankinson SE. Prospective study of zinc intake and the risk of age-related macular degeneration. Ann Epidemiol. 2001 Jul; 11(5):328-36. PMID: 11399447.
      Citations: 12     Fields:    Translation:Humans
    145. Cho E, Hung S, Willett WC, Spiegelman D, Rimm EB, Seddon JM, Colditz GA, Hankinson SE. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001 Feb; 73(2):209-18. PMID: 11157315.
      Citations: 84     Fields:    Translation:HumansAnimals
    146. Kleinerman RA, Tarone RE, Abramson DH, Seddon JM, Li FP, Tucker MA. Hereditary retinoblastoma and risk of lung cancer. J Natl Cancer Inst. 2000 Dec 20; 92(24):2037-9. PMID: 11121467.
      Citations: 20     Fields:    Translation:Humans
    147. McCabe P, Nason F, Demers Turco P, Friedman D, Seddon JM. Evaluating the effectiveness of a vision rehabilitation intervention using an objective and subjective measure of functional performance. Ophthalmic Epidemiol. 2000 Dec; 7(4):259-70. PMID: 11262673.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    148. Snow KK, Seddon JM. Age-related eye diseases: impact of hormone replacement therapy, and reproductive and other risk factors. Int J Fertil Womens Med. 2000 Sep-Oct; 45(5):301-13. PMID: 11092701.
      Citations: 1     Fields:    Translation:Humans
    149. Chasan-Taber L, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, Speizer FE, Hankinson SE. A prospective study of alcohol consumption and cataract extraction among U.S. women. Ann Epidemiol. 2000 Aug; 10(6):347-53. PMID: 10964000.
      Citations: 2     Fields:    Translation:Humans
    150. Li W, Judge H, Gragoudas ES, Seddon JM, Egan KM. Patterns of tumor initiation in choroidal melanoma. Cancer Res. 2000 Jul 15; 60(14):3757-60. PMID: 10919647.
      Citations: 9     Fields:    Translation:Humans
    151. Ghosh P, Hale EA, Mayur K, Seddon J, Lakshman MR. Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of rats. Am J Clin Nutr. 2000 Jul; 72(1):190-8. PMID: 10871579.
      Citations: 4     Fields:    Translation:AnimalsCells
    152. Gragoudas ES, Lane AM, Regan S, Li W, Judge HE, Munzenrider JE, Seddon JM, Egan KM. A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol. 2000 Jun; 118(6):773-8. PMID: 10865313.
      Citations: 22     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    153. Cho E, Hankinson SE, Willett WC, Stampfer MJ, Spiegelman D, Speizer FE, Rimm EB, Seddon JM. Prospective study of alcohol consumption and the risk of age-related macular degeneration. Arch Ophthalmol. 2000 May; 118(5):681-8. PMID: 10815161.
      Citations: 20     Fields:    Translation:Humans
    154. Gorin MB, Breitner JC, De Jong PT, Hageman GS, Klaver CC, Kuehn MH, Seddon JM. The genetics of age-related macular degeneration. Mol Vis. 1999 Nov 03; 5:29. PMID: 10562653.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    155. Chasan-Taber L, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, Hankinson SE. A prospective study of vitamin supplement intake and cataract extraction among U.S. women. Epidemiology. 1999 Nov; 10(6):679-84. PMID: 10535780.
      Citations: 10     Fields:    Translation:Humans
    156. Brown L, Rimm EB, Seddon JM, Giovannucci EL, Chasan-Taber L, Spiegelman D, Willett WC, Hankinson SE. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr. 1999 Oct; 70(4):517-24. PMID: 10500021.
      Citations: 42     Fields:    Translation:HumansAnimals
    157. Chasan-Taber L, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, Speizer FE, Hankinson SE. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 1999 Oct; 70(4):509-16. PMID: 10500020.
      Citations: 35     Fields:    Translation:Humans
    158. Mangione CM, Gutierrez PR, Lowe G, Orav EJ, Seddon JM. Influence of age-related maculopathy on visual functioning and health-related quality of life. Am J Ophthalmol. 1999 Jul; 128(1):45-53. PMID: 10482093.
      Citations: 71     Fields:    Translation:Humans
    159. Allikmets R, Seddon JM, Bernstein PS, Hutchinson A, Atkinson A, Sharma S, Gerrard B, Li W, Metzker ML, Wadelius C, Caskey CT, Dean M, Petrukhin K. Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathies. Hum Genet. 1999 Jun; 104(6):449-53. PMID: 10453731.
      Citations: 49     Fields:    Translation:HumansAnimals
    160. Snow KK, Seddon JM. Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol. 1999 Jun; 6(2):125-43. PMID: 10420212.
      Citations: 78     Fields:    Translation:Humans
    161. Chew EY, Sperduto RD, Hiller R, Nowroozi L, Seigel D, Yanuzzi LA, Burton TC, Seddon JM, Gragoudas ES, Haller JA, Blair NP, Farber M. Clinical course of macular holes: the Eye Disease Case-Control Study. Arch Ophthalmol. 1999 Feb; 117(2):242-6. PMID: 10037571.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    162. Sperduto RD, Hiller R, Chew E, Seigel D, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Seddon JM, Yannuzzi LA. Risk factors for hemiretinal vein occlusion: comparison with risk factors for central and branch retinal vein occlusion: the eye disease case-control study. Ophthalmology. 1998 May; 105(5):765-71. PMID: 9593373.
      Citations: 43     Fields:    Translation:Humans
    163. Wong FL, Boice JD, Abramson DH, Tarone RE, Kleinerman RA, Stovall M, Goldman MB, Seddon JM, Tarbell N, Fraumeni JF, Li FP. Cancer incidence after retinoblastoma. Radiation dose and sarcoma risk. JAMA. 1997 Oct 15; 278(15):1262-7. PMID: 9333268.
      Citations: 140     Fields:    Translation:Humans
    164. Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS, Peiffer A, Zabriskie NA, Li Y, Hutchinson A, Dean M, Lupski JR, Leppert M. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science. 1997 Sep 19; 277(5333):1805-7. PMID: 9295268.
      Citations: 249     Fields:    Translation:Humans
    165. De la Paz MA, Pericak-Vance MA, Haines JL, Seddon JM. Phenotypic heterogeneity in families with age-related macular degeneration. Am J Ophthalmol. 1997 Sep; 124(3):331-43. PMID: 9439359.
      Citations: 2     Fields:    Translation:Humans
    166. De La Paz MA, Pericak-Vance MA, Lennon F, Haines JL, Seddon JM. Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci. 1997 May; 38(6):1060-5. PMID: 9152225.
      Citations: 19     Fields:    Translation:Humans
    167. Seddon JM, Ajani UA, Mitchell BD. Familial aggregation of age-related maculopathy. Am J Ophthalmol. 1997 Feb; 123(2):199-206. PMID: 9186125.
      Citations: 100     Fields:    Translation:Humans
    168. Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA. 1996 Oct 09; 276(14):1141-6. PMID: 8827966.
      Citations: 161     Fields:    Translation:Humans
    169. Bernstein PS, Seddon JM. Decision-making in the treatment of subfoveal neovascularization in age-related macular degeneration. An analysis from the patient's perspective. Retina. 1996; 16(2):112-6. PMID: 8724953.
      Citations: 1     Fields:    Translation:Humans
    170. Hiller R, Seigel D, Sperduto RD, Blair N, Burton TC, Farber MD, Gragoudas ES, Gunter EW, Haller J, Seddon JM, et al. Serum zinc and serum lipid profiles in 778 adults. Ann Epidemiol. 1995 Nov; 5(6):490-6. PMID: 8680613.
      Citations: 6     Fields:    Translation:Humans
    171. Mangione CM, Orav EJ, Lawrence MG, Phillips RS, Seddon JM, Goldman L. Prediction of visual function after cataract surgery. A prospectively validated model. Arch Ophthalmol. 1995 Oct; 113(10):1305-11. PMID: 7575265.
      Citations: 10     Fields:    Translation:HumansCells
    172. Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 09; 272(18):1413-20. PMID: 7933422.
      Citations: 287     Fields:    Translation:Humans
    173. Mangione CM, Phillips RS, Lawrence MG, Seddon JM, Orav EJ, Goldman L. Improved visual function and attenuation of declines in health-related quality of life after cataract extraction. Arch Ophthalmol. 1994 Nov; 112(11):1419-25. PMID: 7980131.
      Citations: 55     Fields:    Translation:Humans
    174. Christen WG, Glynn RJ, Seddon JM, Manson JE, Buring JE, Hennekens CH. Confirmation of self-reported cataract in the Physicians' Health Study. Ophthalmic Epidemiol. 1994 Jun; 1(2):85-91. PMID: 8790615.
      Citations: 3     Fields:    Translation:Humans
    175. Ajani UA, Willett WC, Seddon JM. Reproducibility of a food frequency questionnaire for use in ocular research. Eye Disease Case-Control Study Group. Invest Ophthalmol Vis Sci. 1994 May; 35(6):2725-33. PMID: 8188466.
      Citations: 6     Fields:    Translation:Humans
    176. Seddon JM, Christen WG, Manson JE, LaMotte FS, Glynn RJ, Buring JE, Hennekens CH. The use of vitamin supplements and the risk of cataract among US male physicians. Am J Public Health. 1994 May; 84(5):788-92. PMID: 8179050.
      Citations: 21     Fields:    Translation:Humans
    177. Manson JE, Christen WG, Seddon JM, Glynn RJ, Hennekens CH. A prospective study of alcohol consumption and risk of cataract. Am J Prev Med. 1994 May-Jun; 10(3):156-61. PMID: 7917442.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    178. Seddon JM, Hennekens CH. Vitamins, minerals, and macular degeneration. Promising but unproven hypotheses. Arch Ophthalmol. 1994 Feb; 112(2):176-9. PMID: 8311768.
      Citations: 10     Fields:    Translation:Humans
    179. Seddon J, Fong D. Introducing "public health and the eye". Surv Ophthalmol. 1994 Jan-Feb; 38(4):325. PMID: 8160106.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    180. Fong DS, Seddon JM. Diagnostic tests: an overview. Int Ophthalmol Clin. 1994; 34(3):187-95. PMID: 7960513.
      Citations:    Fields:    Translation:HumansPHPublic Health
    181. Gragoudas ES, Egan KM, Saornil MA, Walsh SM, Albert DM, Seddon JM. The time course of irradiation changes in proton beam-treated uveal melanomas. Ophthalmology. 1993 Oct; 100(10):1555-9; discussion 1560. PMID: 8414415.
      Citations: 9     Fields:    Translation:HumansPHPublic Health
    182. Egan KM, Walsh SM, Seddon JM, Gragoudas ES. An evaluation of the influence of reproductive factors on the risk of metastases from uveal melanoma. Ophthalmology. 1993 Aug; 100(8):1160-5; discussion 1166. PMID: 8341495.
      Citations: 4     Fields:    Translation:Humans
    183. Eng C, Li FP, Abramson DH, Ellsworth RM, Wong FL, Goldman MB, Seddon J, Tarbell N, Boice JD. Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst. 1993 Jul 21; 85(14):1121-8. PMID: 8320741.
      Citations: 100     Fields:    Translation:Humans
    184. Mangione CM, Seddon JM, Cook EF, Krug JH, Sahagian CR, Campion EW, Glynn RJ. Correlates of cognitive function scores in elderly outpatients. J Am Geriatr Soc. 1993 May; 41(5):491-7. PMID: 8486880.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    185. Hankinson SE, Seddon JM, Colditz GA, Stampfer MJ, Rosner B, Speizer FE, Willett WC. A prospective study of aspirin use and cataract extraction in women. Arch Ophthalmol. 1993 Apr; 111(4):503-8. PMID: 8470984.
      Citations: 7     Fields:    Translation:Humans
    186. Weinberg DV, Egan KM, Seddon JM. Asymmetric distribution of arteriovenous crossings in the normal retina. Ophthalmology. 1993 Jan; 100(1):31-6. PMID: 8433824.
      Citations: 9     Fields:    Translation:Humans
    187. Christen WG, Seddon JM. Cigarette smoking and cataract. Am J Prev Med. 1993 Jan-Feb; 9(1):65-6. PMID: 8439443.
      Citations: 1     Fields:    Translation:Humans
    188. Ajani UA, Seddon JM, Hsieh CC, Egan KM, Albert DM, Gragoudas ES. Occupation and risk of uveal melanoma. An exploratory study. Cancer. 1992 Dec 15; 70(12):2891-900. PMID: 1451071.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    189. Mangione CM, Phillips RS, Seddon JM, Lawrence MG, Cook EF, Dailey R, Goldman L. Development of the 'Activities of Daily Vision Scale'. A measure of visual functional status. Med Care. 1992 Dec; 30(12):1111-26. PMID: 1453816.
      Citations: 94     Fields:    Translation:HumansPHPublic Health
    190. Hankinson SE, Willett WC, Colditz GA, Seddon JM, Rosner B, Speizer FE, Stampfer MJ. A prospective study of cigarette smoking and risk of cataract surgery in women. JAMA. 1992 Aug 26; 268(8):994-8. PMID: 1501325.
      Citations: 30     Fields:    Translation:Humans
    191. Christen WG, Manson JE, Seddon JM, Glynn RJ, Buring JE, Rosner B, Hennekens CH. A prospective study of cigarette smoking and risk of cataract in men. JAMA. 1992 Aug 26; 268(8):989-93. PMID: 1501324.
      Citations: 48     Fields:    Translation:Humans
    192. Hankinson SE, Stampfer MJ, Seddon JM, Colditz GA, Rosner B, Speizer FE, Willett WC. Nutrient intake and cataract extraction in women: a prospective study. BMJ. 1992 Aug 08; 305(6849):335-9. PMID: 1392884.
      Citations: 39     Fields:    Translation:Humans
    193. Saornil MA, Egan KM, Gragoudas ES, Seddon JM, Walsh SM, Albert DM. Histopathology of proton beam-irradiated vs enucleated uveal melanomas. Arch Ophthalmol. 1992 Aug; 110(8):1112-8. PMID: 1323252.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    194. Guyer DR, Mukai S, Egan KM, Seddon JM, Walsh SM, Gragoudas ES. Radiation maculopathy after proton beam irradiation for choroidal melanoma. Ophthalmology. 1992 Aug; 99(8):1278-85. PMID: 1325044.
      Citations: 30     Fields:    Translation:HumansPHPublic Health
    195. Seddon JM, Egan KM, Zhang Y, Gelles EJ, Glynn RJ, Tucker CA, Gragoudas ES. Evaluation of skin microtopography as a measure of ultraviolet exposure. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1903-8. PMID: 1582796.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    196. Gragoudas ES, Egan KM, Seddon JM, Walsh SM, Munzenrider JE. Intraocular recurrence of uveal melanoma after proton beam irradiation. Ophthalmology. 1992 May; 99(5):760-6. PMID: 1594223.
      Citations: 12     Fields:    Translation:Humans
    197. Gragoudas ES, Egan KM, Arrigg PG, Seddon JM, Glynn RJ, Munzenrider JE. Cataract extraction after proton beam irradiation for malignant melanoma of the eye. Arch Ophthalmol. 1992 Apr; 110(4):475-9. PMID: 1562251.
      Citations: 8     Fields:    Translation:Humans
    198. Egan KM, Gragoudas ES, Seddon JM, Walsh SM. Smoking and the risk of early metastases from uveal melanoma. Ophthalmology. 1992 Apr; 99(4):537-41. PMID: 1584571.
      Citations: 2     Fields:    Translation:Humans
    199. Seddon JM. The differential burden of blindness in the United States. N Engl J Med. 1991 Nov 14; 325(20):1440-2. PMID: 1922257.
      Citations: 3     Fields:    Translation:Humans
    200. Levin LA, Seddon JM, Topping T. Retinal pigment epithelial tears associated with trauma. Am J Ophthalmol. 1991 Oct 15; 112(4):396-400. PMID: 1928241.
      Citations: 8     Fields:    Translation:Humans
    201. Seddon J, Gragoudas E, Egan K, Polivogianis L, Finn S, Albert D. Standardized data collection and coding in eye disease epidemiology: the Uveal Melanoma Data System. Ophthalmic Surg. 1991 Mar; 22(3):127-36. PMID: 2030892.
      Citations: 2     Fields:    Translation:Humans
    202. Gragoudas ES, Egan KM, Seddon JM, Glynn RJ, Walsh SM, Finn SM, Munzenrider JE, Spar MD. Survival of patients with metastases from uveal melanoma. Ophthalmology. 1991 Mar; 98(3):383-9; discussion 390. PMID: 2023760.
      Citations: 97     Fields:    Translation:Humans
    203. Glynn RJ, Seddon JM, Krug JH, Sahagian CR, Chiavelli ME, Campion EW. Falls in elderly patients with glaucoma. Arch Ophthalmol. 1991 Feb; 109(2):205-10. PMID: 1993029.
      Citations: 22     Fields:    Translation:Humans
    204. Seddon JM, Christen WG, Manson JE, Buring JE, Sperduto RD, Hennekens CH. Low-dose aspirin and risks of cataract in a randomized trial of US physicians. Arch Ophthalmol. 1991 Feb; 109(2):252-5. PMID: 1993037.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    205. Glynn RJ, Schein OD, Seddon JM, Poggio EC, Goodfellow JR, Scardino VA, Shannon MJ, Kenyon KR. The incidence of ulcerative keratitis among aphakic contact lens wearers in New England. Arch Ophthalmol. 1991 Jan; 109(1):104-7. PMID: 1987926.
      Citations:    Fields:    Translation:Humans
    206. Austin KL, Palmer JR, Seddon JM, Glynn RJ, Rosenberg L, Gragoudas ES, Kaufman DW, Shapiro S. Case-control study of idiopathic retinal detachment. Int J Epidemiol. 1990 Dec; 19(4):1045-50. PMID: 2083988.
      Citations: 6     Fields:    Translation:Humans
    207. Seddon JM, Gragoudas ES, Glynn RJ, Egan KM, Albert DM, Blitzer PH. Host factors, UV radiation, and risk of uveal melanoma. A case-control study. Arch Ophthalmol. 1990 Sep; 108(9):1274-80. PMID: 2400347.
      Citations: 31     Fields:    Translation:Humans
    208. Seddon JM, Sahagian CR, Glynn RJ, Sperduto RD, Gragoudas ES. Evaluation of an iris color classification system. The Eye Disorders Case-Control Study Group. Invest Ophthalmol Vis Sci. 1990 Aug; 31(8):1592-8. PMID: 2201662.
      Citations: 34     Fields:    Translation:HumansCTClinical Trials
    209. Seddon JM, Gragoudas ES, Egan KM, Glynn RJ, Howard S, Fante RG, Albert DM. Relative survival rates after alternative therapies for uveal melanoma. Ophthalmology. 1990 Jun; 97(6):769-77. PMID: 2374681.
      Citations: 32     Fields:    Translation:Humans
    210. Smith EV, Kolodny NH, Gragoudas ES, Egan KM, Finn S, D'Amico DJ, Seddon JM. An NMR blood test for uveal melanoma? Invest Ophthalmol Vis Sci. 1990 May; 31(5):993-7. PMID: 2335461.
      Citations:    Fields:    Translation:Humans
    211. Lischko AM, Seddon JM, Gragoudas ES, Egan KM, Glynn RJ. Evaluation of prior primary malignancy as a determinant of uveal melanoma. A case-control study. Ophthalmology. 1989 Dec; 96(12):1716-21. PMID: 2622616.
      Citations: 4     Fields:    Translation:Humans
    212. Glynn RJ, Seddon JM, Gragoudas ES, Egan KM, Hart LJ. Evaluation of tumor regression and other prognostic factors for early and late metastasis after proton irradiation of uveal melanoma. Ophthalmology. 1989 Oct; 96(10):1566-73. PMID: 2685710.
      Citations: 13     Fields:    Translation:Humans
    213. Poggio EC, Glynn RJ, Schein OD, Seddon JM, Shannon MJ, Scardino VA, Kenyon KR. The incidence of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. N Engl J Med. 1989 Sep 21; 321(12):779-83. PMID: 2770809.
      Citations: 75     Fields:    Translation:Humans
    214. Schein OD, Glynn RJ, Poggio EC, Seddon JM, Kenyon KR. The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. A case-control study. Microbial Keratitis Study Group. N Engl J Med. 1989 Sep 21; 321(12):773-8. PMID: 2671733.
      Citations: 75     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    215. Egan KM, Gragoudas ES, Seddon JM, Glynn RJ, Munzenreider JE, Goitein M, Verhey L, Urie M, Koehler A. The risk of enucleation after proton beam irradiation of uveal melanoma. Ophthalmology. 1989 Sep; 96(9):1377-82; discussion 1382-3. PMID: 2550868.
      Citations: 18     Fields:    Translation:Humans
    216. Flotte TJ, Seddon JM, Zhang YQ, Glynn RJ, Egan KM, Gragoudas ES. A computerized image analysis method for measuring elastic tissue. J Invest Dermatol. 1989 Sep; 93(3):358-62. PMID: 2475547.
      Citations: 3     Fields:    Translation:Humans
    217. Munzenrider JE, Verhey LJ, Gragoudas ES, Seddon JM, Urie M, Gentry R, Birnbaum S, Ruotolo DM, Crowell C, McManus P, et al. Conservative treatment of uveal melanoma: local recurrence after proton beam therapy. Int J Radiat Oncol Biol Phys. 1989 Sep; 17(3):493-8. PMID: 2550395.
      Citations: 12     Fields:    Translation:Humans
    218. Friedman E, Ivry M, Ebert E, Glynn R, Gragoudas E, Seddon J. Increased scleral rigidity and age-related macular degeneration. Ophthalmology. 1989 Jan; 96(1):104-8. PMID: 2919041.
      Citations: 31     Fields:    Translation:Humans
    219. Polivogianis L, Seddon JM, Glynn RJ, Gragoudas ES, Albert DM. Comparison of transillumination and histologic slide measurements of tumor diameter in uveal melanoma. Ophthalmology. 1988 Nov; 95(11):1576-82. PMID: 3062526.
      Citations:    Fields:    Translation:Humans
    220. Munzenrider JE, Gragoudas ES, Seddon JM, Sisterson J, McNulty P, Birnbaum S, Johnson K, Austin-Seymour M, Slater J, Goitein MM, et al. Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. Int J Radiat Oncol Biol Phys. 1988 Sep; 15(3):553-8. PMID: 2843486.
      Citations: 10     Fields:    Translation:Humans
    221. Gragoudas ES, Seddon JM, Egan KM, Glynn RJ, Goitein M, Munzenrider J, Verhey L, Urie M, Koehler A. Metastasis from uveal melanoma after proton beam irradiation. Ophthalmology. 1988 Jul; 95(7):992-9. PMID: 2845324.
      Citations: 13     Fields:    Translation:Humans
    222. Adams KS, Abramson DH, Ellsworth RM, Haik BG, Bedford M, Packer S, Seddon J, Albert D, Polivogianis L. Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates. Br J Ophthalmol. 1988 Jul; 72(7):494-7. PMID: 3415941.
      Citations: 12     Fields:    Translation:Humans
    223. Glynn RJ, Seddon JM, Berlin BM. The incidence of eye injuries in New England adults. Arch Ophthalmol. 1988 Jun; 106(6):785-9. PMID: 3370007.
      Citations: 19     Fields:    Translation:Humans
    224. Cevc G, Seddon JM, Hartung R, Eggert W. Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures. Biochim Biophys Acta. 1988 May 24; 940(2):219-40. PMID: 2835979.
      Citations: 8     Fields:    
    225. Kolodny NH, Gragoudas ES, D'Amico DJ, Seddon JM, Minichiello M, Murphy EJ, Albert DM. Preliminary results on phosphorus-31 nuclear magnetic resonance evaluation of human uveal melanoma in enucleated eyes. Ophthalmology. 1988 May; 95(5):666-73. PMID: 3174026.
      Citations:    Fields:    Translation:Humans
    226. Schein OD, Hibberd PL, Shingleton BJ, Kunzweiler T, Frambach DA, Seddon JM, Fontan NL, Vinger PF. The spectrum and burden of ocular injury. Ophthalmology. 1988 Mar; 95(3):300-5. PMID: 3173996.
      Citations: 40     Fields:    Translation:Humans
    227. Bressler NM, Bressler SB, Seddon JM, Gragoudas ES, Jacobson LP. Drusen characteristics in patients with exudative versus non-exudative age-related macular degeneration. Retina. 1988; 8(2):109-14. PMID: 3420311.
      Citations: 20     Fields:    Translation:Humans
    228. Egan KM, Seddon JM, Glynn RJ, Gragoudas ES, Albert DM. Epidemiologic aspects of uveal melanoma. Surv Ophthalmol. 1988 Jan-Feb; 32(4):239-51. PMID: 3279559.
      Citations: 114     Fields:    Translation:Humans
    229. Bressler SB, Bressler NM, Seddon JM, Gragoudas ES, Jacobson LP. Interobserver and intraobserver reliability in the clinical classification of drusen. Retina. 1988; 8(2):102-8. PMID: 3420310.
      Citations: 9     Fields:    Translation:Humans
    230. Kolodny NH, Gragoudas ES, D'Amico DJ, Kohler SJ, Seddon JM, Murphy EJ, Yun C, Albert DM. Proton and sodium 23 magnetic resonance imaging of human ocular tissues. A model study. Arch Ophthalmol. 1987 Nov; 105(11):1532-6. PMID: 2823760.
      Citations: 3     Fields:    Translation:Humans
    231. Seddon JM, Polivogianis L, Hsieh CC, Albert DM, Gamel JW, Gragoudas ES. Death from uveal melanoma. Number of epithelioid cells and inverse SD of nucleolar area as prognostic factors. Arch Ophthalmol. 1987 Jun; 105(6):801-6. PMID: 3579712.
      Citations: 18     Fields:    Translation:HumansCells
    232. Li FP, Thurber WA, Seddon J, Holmes GE. Hepatoblastoma in families with polyposis coli. JAMA. 1987 May 08; 257(18):2475-7. PMID: 3033343.
      Citations: 6     Fields:    Translation:Humans
    233. Gragoudas ES, Seddon JM, Egan K, Glynn R, Munzenrider J, Austin-Seymour M, Goitein M, Verhey L, Urie M, Koehler A. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology. 1987 Apr; 94(4):349-53. PMID: 3035451.
      Citations: 29     Fields:    Translation:HumansPHPublic Health
    234. Seddon JM, Gragoudas ES, Egan KM, Glynn RJ, Munzenrider JE, Austin-Seymour M, Goitein M, Verhey L, Urie M, Koehler A. Uveal melanomas near the optic disc or fovea. Visual results after proton beam irradiation. Ophthalmology. 1987 Apr; 94(4):354-61. PMID: 3587916.
      Citations: 14     Fields:    Translation:Humans
    235. Gamel J, Seddon J, Polivogianis L, Albert D, Greenberg R. A method for assessing potential bias among cancer patients recorded as "dead of other causes." Application to cases of intraocular melanoma. Cancer. 1986 Jun 01; 57(11):2246-9. PMID: 3697925.
      Citations: 2     Fields:    Translation:Humans
    236. Seddon JM, Gragoudas ES, Polivogianis L, Hsieh CC, Egan KM, Goitein M, Verhey L, Munzenrider J, Austin-Seymour M, Urie M, et al. Visual outcome after proton beam irradiation of uveal melanoma. Ophthalmology. 1986 May; 93(5):666-74. PMID: 3014415.
      Citations: 20     Fields:    Translation:Humans
    237. Gragoudas ES, Seddon JM, Egan KM, Polivogianis L, Hsieh CC, Goitein M, Verhey L, Munzenrider J, Austin-Seymour M, Urie M, et al. Prognostic factors for metastasis following proton beam irradiation of uveal melanomas. Ophthalmology. 1986 May; 93(5):675-80. PMID: 3014416.
      Citations: 11     Fields:    Translation:Humans
    238. Gamel JW, Greenberg RA, McLean IW, Seddon JM, Albert DM, Naids RE, Folberg R, Donoso LA. A clinically useful method for combining gross and microscopic measurements to select high-risk patients after enucleation for ciliochoroidal melanoma. Cancer. 1986 Apr 01; 57(7):1341-4. PMID: 2418937.
      Citations: 2     Fields:    Translation:HumansCells
    239. Seddon JM, Polivogianis L, Gragoudas ES, Hsieh CC, Egan KM. Enucleation vs cobalt 60 irradiation of melanomas. Arch Ophthalmol. 1986 Feb; 104(2):175-6. PMID: 3947285.
      Citations: 1     Fields:    Translation:Humans
    240. Seddon JM, Gragoudas E, Albert D, Hsieh CC, Polivogianis L, Egan K. Echographic and histologic tumor height measurements in uveal melanoma. Am J Ophthalmol. 1986 Jan 15; 101(1):126-8. PMID: 3942170.
      Citations:    Fields:    Translation:Humans
    241. Gragoudas ES, Seddon JM. Management of choroidal melanomas. Int Ophthalmol Clin. 1986; 26(2):145-58. PMID: 3011694.
      Citations:    Fields:    Translation:Humans
    242. Riedel KG, Svitra PP, Seddon JM, Albert DM, Gragoudas ES, Koehler AM, Coleman DJ, Torpey J, Lizzi FL, Driller J. Proton beam irradiation and hyperthermia. Effects on experimental choroidal melanoma. Arch Ophthalmol. 1985 Dec; 103(12):1862-9. PMID: 3000327.
      Citations: 5     Fields:    Translation:Animals
    243. Fournier GA, Saulenas AM, Seddon JM, Goitein M, Albert DM, Polivogianis L, Gragoudas E. The effects of pre-enucleation irradiation on the development of metastases from intraocular Greene melanoma in hamsters. Am J Ophthalmol. 1985 Nov 15; 100(5):669-77. PMID: 4061547.
      Citations: 1     Fields:    Translation:Animals
    244. Weinhaus RS, Seddon JM, Albert DM, Gragoudas ES, Robinson N. Prognostic factor study of survival after enucleation for juxtapapillary melanomas. Arch Ophthalmol. 1985 Nov; 103(11):1673-7. PMID: 4062633.
      Citations: 5     Fields:    Translation:Humans
    245. Seddon JM, Savory L, Scott-Conner C. Cryptorchidism: the role of medical education in diagnosis. South Med J. 1985 Oct; 78(10):1201-4. PMID: 2864743.
      Citations: 4     Fields:    Translation:Humans
    246. Pascal SG, Saulenas AM, Fournier GA, Seddon JM, Hatfield RM, Albert DM. An investigation into the association between liver damage and metastatic uveal melanoma. Am J Ophthalmol. 1985 Sep 15; 100(3):448-53. PMID: 4037035.
      Citations: 1     Fields:    Translation:Animals
    247. Gamel JW, McLean I, Greenberg RA, Naids RM, Folberg R, Donoso LA, Seddon JM, Albert DM. Objective assessment of the malignant potential of intraocular melanomas with standard microslides stained with hematoxylin-eosin. Hum Pathol. 1985 Jul; 16(7):689-92. PMID: 2408986.
      Citations: 4     Fields:    Translation:HumansCells
    248. Seddon JM, Gragoudas ES, Albert DM, Hsieh CC, Polivogianis L, Friedenberg GR. Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. Am J Ophthalmol. 1985 Mar 15; 99(3):282-90. PMID: 2983558.
      Citations: 15     Fields:    Translation:Humans
    249. Gragoudas ES, Seddon J, Goitein M, Verhey L, Munzenrider J, Urie M, Suit HD, Blitzer P, Koehler A. Current results of proton beam irradiation of uveal melanomas. Ophthalmology. 1985 Feb; 92(2):284-91. PMID: 2984625.
      Citations: 15     Fields:    Translation:Humans
    250. Austin-Seymour M, Munzenrider JE, Goitein M, Gentry R, Gragoudas E, Koehler AM, McNulty P, Osborne E, Ryugo DK, Seddon J, et al. Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. Radiat Res Suppl. 1985; 8:S219-26. PMID: 3003784.
      Citations: 5     Fields:    Translation:HumansCells
    251. Gragoudas ES, Goitein M, Seddon J, Verhey L, Munzenrider J, Urie M, Suit HD, Blitzer P, Johnson KN, Koehler A. Preliminary results of proton beam irradiation of macular and paramacular melanomas. Br J Ophthalmol. 1984 Jul; 68(7):479-85. PMID: 6329261.
      Citations: 3     Fields:    Translation:Humans
    252. Albert DM, McGhee CN, Seddon JM, Weichselbaum RR. Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy. Am J Ophthalmol. 1984 Feb; 97(2):189-96. PMID: 6696029.
      Citations: 1     Fields:    Translation:Humans
    253. Fournier GA, Albert DM, Arrigg CA, Cohen AM, Lamping KA, Seddon JM. Resection of solitary metastasis. Approach to palliative treatment of hepatic involvement with choroidal melanoma. Arch Ophthalmol. 1984 Jan; 102(1):80-2. PMID: 6200095.
      Citations: 6     Fields:    Translation:Humans
    254. Lavin PT, Albert DM, Seddon JM. A deficit survival analysis to assess the natural history of uveal melanoma. J Chronic Dis. 1984; 37(6):481-7. PMID: 6725501.
      Citations: 2     Fields:    Translation:Humans
    255. Seddon JM, Albert DM, Lavin PT, Robinson N. A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma. Arch Ophthalmol. 1983 Dec; 101(12):1894-9. PMID: 6651594.
      Citations: 44     Fields:    Translation:Humans
    256. Seddon JM, Gragoudas ES, Albert DM. Ciliary body and choroidal melanomas treated by proton beam irradiation. Histopathologic study of eyes. Arch Ophthalmol. 1983 Sep; 101(9):1402-8. PMID: 6311146.
      Citations: 15     Fields:    Translation:Humans
    257. Seddon JM, Schwartz B, Flowerdew G. Case-control study of ocular hypertension. Arch Ophthalmol. 1983 Jun; 101(6):891-4. PMID: 6860199.
      Citations: 12     Fields:    Translation:Humans
    258. Seddon JM, MacLaughlin DT, Albert DM, Gragoudas ES, Ference M. Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas. Br J Ophthalmol. 1982 Nov; 66(11):695-704. PMID: 7126514.
      Citations: 9     Fields:    Translation:Humans
    259. Seddon JM, Corwin JM, Weiter JJ, Brisbane JU, Sutula FC. Solitary extramedullary plasmacytoma of the palpebral conjunctiva. Br J Ophthalmol. 1982 Jul; 66(7):450-4. PMID: 7093184.
      Citations: 5     Fields:    Translation:Humans
    260. Kuo PK, Ni C, Seddon JM, Wu BF, Chen YJ. Orbital tumors among Chinese in the Shanghai area. Int Ophthalmol Clin. 1982; 22(1):87-98. PMID: 7061200.
      Citations: 2     Fields:    Translation:Humans
    261. Schwartz B, Seddon JM. Increased plasma cortisol levels in ocular hypertension. Arch Ophthalmol. 1981 Oct; 99(10):1791-4. PMID: 7295128.
      Citations: 2     Fields:    Translation:Humans
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