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Nikolaus Grigorieff PhD

InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
368 Plantation Street AS4-1009
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    Collapse Biography 
    Collapse education and training
    University of Bristol, Bristol, , United KingdomPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lucas BA, Himes BA, Grigorieff N. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias. Elife. 2023 Nov 27; 12. PMID: 38010355.
      Citations:    Fields:    Translation:Cells
    2. Zhang K, Lucas B, Grigorieff N. Exploring the Limits of 2D Template Matching for Detecting Targets in Cellular Cryo-EM Images. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):931. PMID: 37613706.
      Citations: 1     Fields:    
    3. Lucas BA, Grigorieff N. Quantification of gallium cryo-FIB milling damage in biological lamellae. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2301852120. PMID: 37216561.
      Citations: 6     Fields:    Translation:Cells
    4. Pitsawong W, P?dua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D. From primordial clocks to circadian oscillators. Nature. 2023 04; 616(7955):183-189. PMID: 36949197.
      Citations: 3     Fields:    Translation:Cells
    5. Elferich J, Schiroli G, Scadden DT, Grigorieff N. Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections. Elife. 2022 11 16; 11. PMID: 36382886.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Lucas BA, Zhang K, Loerch S, Grigorieff N. In situ single particle classification reveals distinct 60S maturation intermediates in cells. Elife. 2022 08 25; 11. PMID: 36005291.
      Citations: 8     Fields:    Translation:AnimalsCells
    7. Himes B, Grigorieff N. Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation. IUCrJ. 2021 Nov 01; 8(Pt 6):943-953. PMID: 34804546.
      Citations: 8     Fields:    
    8. Lucas BA, Himes BA, Xue L, Grant T, Mahamid J, Grigorieff N. Locating macromolecular assemblies in cells by 2D template matching with cisTEM. Elife. 2021 06 11; 10. PMID: 34114559.
      Citations: 27     Fields:    Translation:Cells
    9. Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding. Elife. 2020 05 19; 9. PMID: 32427100.
      Citations: 20     Fields:    Translation:Cells
    10. Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol. 2020 03; 27(3):305. PMID: 32066965.
      Citations: 2     Fields:    
    11. Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol. 2020 02; 27(2):150-159. PMID: 31988524.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    12. Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SC. Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep. 2020 01 07; 30(1):53-60.e5. PMID: 31914397.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    13. Song K, Shang Z, Fu X, Lou X, Grigorieff N, Nicastro D. In situ structure determination at nanometer resolution using TYGRESS. Nat Methods. 2020 02; 17(2):201-208. PMID: 31768058.
      Citations: 27     Fields:    Translation:AnimalsCells
    14. Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC. In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J Mol Biol. 2019 08 09; 431(17):3124-3138. PMID: 31233764.
      Citations: 26     Fields:    Translation:Cells
    15. Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L. High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12828-12832. PMID: 31182604.
      Citations: 34     Fields:    Translation:HumansCellsPHPublic Health
    16. Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, F?ndrich M, Schmidt M. Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids. Nat Commun. 2019 03 07; 10(1):1104. PMID: 30846696.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    17. Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D. Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy. 2019 08; 203:170-180. PMID: 30528101.
      Citations: 17     Fields:    Translation:Cells
    18. Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science. 2018 08 24; 361(6404). PMID: 30139843.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    19. Bartesaghi A, Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, Subramaniam S. Atomic Resolution Cryo-EM Structure of ?-Galactosidase. Structure. 2018 06 05; 26(6):848-856.e3. PMID: 29754826.
      Citations: 53     Fields:    Translation:Cells
    20. Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron. 2018 05 02; 98(3):521-529.e3. PMID: 29656875.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    21. Grant T, Rohou A, Grigorieff N. cisTEM, user-friendly software for single-particle image processing. Elife. 2018 03 07; 7. PMID: 29513216.
      Citations: 408     Fields:    
    22. Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, F?ndrich M. Physical basis of amyloid fibril polymorphism. Nat Commun. 2018 02 16; 9(1):699. PMID: 29453354.
      Citations: 50     Fields:    Translation:HumansCells
    23. Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. Structure of RNA polymerase bound to ribosomal 30S subunit. Elife. 2017 10 13; 6. PMID: 29027901.
      Citations: 43     Fields:    Translation:Cells
    24. Abeyrathne PD, Grigorieff N. Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1. PLoS One. 2017; 12(7):e0180163. PMID: 28692650.
      Citations: 2     Fields:    Translation:Cells
    25. Loveland AB, Demo G, Grigorieff N, Korostelev AA. Ensemble cryo-EM elucidates the mechanism of translation fidelity. Nature. 2017 06 01; 546(7656):113-117. PMID: 28538735.
      Citations: 82     Fields:    Translation:Cells
    26. Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839. PMID: 28506635.
      Citations: 14     Fields:    Translation:Cells
    27. Rickgauer JP, Grigorieff N, Denk W. Single-protein detection in crowded molecular environments in cryo-EM images. Elife. 2017 05 03; 6. PMID: 28467302.
      Citations: 33     Fields:    Translation:Cells
    28. Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). PMID: 28250125.
      Citations: 11     Fields:    Translation:Cells
    29. Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA. Mechanism of ribosome rescue by ArfA and RF2. Elife. 2017 03 16; 6. PMID: 28300532.
      Citations: 27     Fields:    Translation:Cells
    30. Oldham ML, Grigorieff N, Chen J. Structure of the transporter associated with antigen processing trapped by herpes simplex virus. Elife. 2016 12 09; 5. PMID: 27935481.
      Citations: 39     Fields:    Translation:HumansCells
    31. Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. Ribosome?RelA structures reveal the mechanism of stringent response activation. Elife. 2016 07 19; 5. PMID: 27434674.
      Citations: 82     Fields:    Translation:Cells
    32. Grigorieff N. Frealign: An Exploratory Tool for Single-Particle Cryo-EM. Methods Enzymol. 2016; 579:191-226. PMID: 27572728.
      Citations: 89     Fields:    Translation:Cells
    33. Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife. 2016 05 25; 5. PMID: 27223329.
      Citations: 10     Fields:    Translation:Cells
    34. Schmidt A, Annamalai K, Schmidt M, Grigorieff N, F?ndrich M. Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6200-5. PMID: 27185936.
      Citations: 25     Fields:    Translation:HumansCells
    35. Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife. 2016 05 09; 5. PMID: 27159452.
      Citations: 69     Fields:    Translation:AnimalsCells
    36. Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature. 2016 06 02; 534(7605):63-8. PMID: 27135925.
      Citations: 101     Fields:    Translation:AnimalsCells
    37. Zhou A, Rohou A, Schep DG, Bason JV, Montgomery MG, Walker JE, Grigorieff N, Rubinstein JL. Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife. 2015 Oct 06; 4:e10180. PMID: 26439008.
      Citations: 141     Fields:    Translation:AnimalsCells
    38. Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, F?ndrich M, Grigorieff N. Peptide dimer structure in an A?(1-42) fibril visualized with cryo-EM. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11858-63. PMID: 26351699.
      Citations: 92     Fields:    Translation:Cells
    39. Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. J Struct Biol. 2015 Nov; 192(2):163-73. PMID: 26318383.
      Citations: 12     Fields:    Translation:AnimalsCells
    40. Rohou A, Grigorieff N. CTFFIND4: Fast and accurate defocus estimation from electron micrographs. J Struct Biol. 2015 Nov; 192(2):216-21. PMID: 26278980.
      Citations: 2178     Fields:    
    41. Grant T, Grigorieff N. Automatic estimation and correction of anisotropic magnification distortion in electron microscopes. J Struct Biol. 2015 Nov; 192(2):204-8. PMID: 26278979.
      Citations: 72     Fields:    
    42. Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327. PMID: 26144317.
      Citations: 147     Fields:    Translation:Cells
    43. Grant T, Grigorieff N. Measuring the optimal exposure for single particle cryo-EM using a 2.6 ? reconstruction of rotavirus VP6. Elife. 2015 May 29; 4:e06980. PMID: 26023829.
      Citations: 412     Fields:    Translation:Cells
    44. Cheng Y, Grigorieff N, Penczek PA, Walz T. A primer to single-particle cryo-electron microscopy. Cell. 2015 Apr 23; 161(3):438-449. PMID: 25910204.
      Citations: 205     Fields:    Translation:Cells
    45. Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations. Structure. 2014 Aug 05; 22(8):1210-1218. PMID: 25043550.
      Citations: 50     Fields:    Translation:Cells
    46. Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9139-44. PMID: 24927574.
      Citations: 38     Fields:    Translation:Cells
    47. Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 2014 Jun 05; 157(6):1405-1415. PMID: 24906155.
      Citations: 94     Fields:    Translation:HumansCells
    48. Rohou A, Grigorieff N. Frealix: model-based refinement of helical filament structures from electron micrographs. J Struct Biol. 2014 May; 186(2):234-44. PMID: 24657230.
      Citations: 13     Fields:    Translation:Cells
    49. Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20994-9. PMID: 24324137.
      Citations: 89     Fields:    Translation:Cells
    50. Ruskin AI, Yu Z, Grigorieff N. Quantitative characterization of electron detectors for transmission electron microscopy. J Struct Biol. 2013 12; 184(3):385-93. PMID: 24189638.
      Citations: 64     Fields:    
    51. Lyumkis D, Brilot AF, Theobald DL, Grigorieff N. Likelihood-based classification of cryo-EM images using FREALIGN. J Struct Biol. 2013 Sep; 183(3):377-388. PMID: 23872434.
      Citations: 136     Fields:    Translation:Cells
    52. Grigorieff N. Direct detection pays off for electron cryo-microscopy. Elife. 2013 Feb 19; 2:e00573. PMID: 23426864.
      Citations: 21     Fields:    
    53. Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC. Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol. 2013 Jan 09; 425(1):124-32. PMID: 23089332.
      Citations: 44     Fields:    Translation:Cells
    54. Deaconescu AM, Artsimovitch I, Grigorieff N. Interplay of DNA repair with transcription: from structures to mechanisms. Trends Biochem Sci. 2012 Dec; 37(12):543-52. PMID: 23084398.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    55. Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012 Nov 07; 20(11):1823-8. PMID: 23022349.
      Citations: 138     Fields:    Translation:Cells
    56. Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE. Maturation in action: CryoEM study of a viral capsid caught during expansion. Structure. 2012 Aug 08; 20(8):1384-90. PMID: 22748764.
      Citations: 12     Fields:    Translation:Cells
    57. Sindelar CV, Grigorieff N. Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter. J Struct Biol. 2012 Oct; 180(1):26-38. PMID: 22613568.
      Citations: 18     Fields:    Translation:Cells
    58. Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff N. Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol. 2012 Mar; 177(3):630-7. PMID: 22366277.
      Citations: 166     Fields:    
    59. Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N. Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3353-8. PMID: 22331906.
      Citations: 30     Fields:    Translation:Cells
    60. Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schr?der GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL. Outcome of the first electron microscopy validation task force meeting. Structure. 2012 Feb 08; 20(2):205-14. PMID: 22325770.
      Citations: 275     Fields:    Translation:HumansAnimalsCells
    61. Henderson R, Chen S, Chen JZ, Grigorieff N, Passmore LA, Ciccarelli L, Rubinstein JL, Crowther RA, Stewart PL, Rosenthal PB. Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy. J Mol Biol. 2011 Nov 11; 413(5):1028-46. PMID: 21939668.
      Citations: 84     Fields:    Translation:AnimalsCells
    62. Lewandowski JR, van der Wel PC, Rigney M, Grigorieff N, Griffin RG. Structural complexity of a composite amyloid fibril. J Am Chem Soc. 2011 Sep 21; 133(37):14686-98. PMID: 21766841.
      Citations: 42     Fields:    Translation:AnimalsCells
    63. Sindelar CV, Grigorieff N. An adaptation of the Wiener filter suitable for analyzing images of isolated single particles. J Struct Biol. 2011 Oct; 176(1):60-74. PMID: 21757012.
      Citations: 18     Fields:    Translation:Cells
    64. F?ndrich M, Schmidt M, Grigorieff N. Recent progress in understanding Alzheimer's ?-amyloid structures. Trends Biochem Sci. 2011 Jun; 36(6):338-45. PMID: 21411326.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    65. Grigorieff N, Harrison SC. Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol. 2011 Apr; 21(2):265-73. PMID: 21333526.
      Citations: 86     Fields:    Translation:Cells
    66. Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19; 30(2):408-16. PMID: 21157433.
      Citations: 140     Fields:    Translation:Cells
    67. Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E. The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature. 2010 Oct 14; 467(7317):805-10. PMID: 20944740.
      Citations: 185     Fields:    Translation:HumansCells
    68. Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL. Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol. 2010 Jun 28; 189(7):1087-96. PMID: 20566685.
      Citations: 96     Fields:    Translation:AnimalsCells
    69. Li X, Grigorieff N, Cheng Y. GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors. J Struct Biol. 2010 Dec; 172(3):407-12. PMID: 20558298.
      Citations: 22     Fields:    
    70. Wolf M, Garcea RL, Grigorieff N, Harrison SC. Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6298-303. PMID: 20308582.
      Citations: 85     Fields:    Translation:Cells
    71. Sachse C, Grigorieff N, F?ndrich M. Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Angew Chem Int Ed Engl. 2010 Feb 08; 49(7):1321-3. PMID: 20069616.
      Citations: 15     Fields:    Translation:HumansCells
    72. Xing Y, B?cking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. PMID: 20033059.
      Citations: 62     Fields:    Translation:AnimalsCells
    73. Schmidt M, Sachse C, Richter W, Xu C, F?ndrich M, Grigorieff N. Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19813-8. PMID: 19843697.
      Citations: 110     Fields:    Translation:Cells
    74. Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10644-8. PMID: 19487668.
      Citations: 80     Fields:    Translation:Cells
    75. F?ndrich M, Meinhardt J, Grigorieff N. Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion. 2009 Apr-Jun; 3(2):89-93. PMID: 19597329.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    76. Dementieva IS, Tereshko V, McCrossan ZA, Solomaha E, Araki D, Xu C, Grigorieff N, Goldstein SA. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J Mol Biol. 2009 Mar 20; 387(1):175-91. PMID: 19361449.
      Citations: 37     Fields:    Translation:HumansCells
    77. Sachse C, Grigorieff N, F?ndrich M. Bioforum. 2009; 32(2):26. PMID: 20126429.
    78. Stroupe ME, Xu C, Goode BL, Grigorieff N. Actin filament labels for localizing protein components in large complexes viewed by electron microscopy. RNA. 2009 Feb; 15(2):244-8. PMID: 19095618.
      Citations: 8     Fields:    Translation:AnimalsCells
    79. Meinhardt J, Sachse C, Hortschansky P, Grigorieff N, F?ndrich M. Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol. 2009 Feb 27; 386(3):869-77. PMID: 19038266.
      Citations: 119     Fields:    Translation:HumansCells
    80. Sachse C, F?ndrich M, Grigorieff N. Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7462-6. PMID: 18483195.
      Citations: 78     Fields:    Translation:HumansCells
    81. Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N. Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1867-72. PMID: 18238898.
      Citations: 187     Fields:    Translation:Cells
    82. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326.
      Citations: 16     Fields:    Translation:AnimalsCells
    83. Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. A dose-rate effect in single-particle electron microscopy. J Struct Biol. 2008 Jan; 161(1):92-100. PMID: 17977018.
      Citations: 21     Fields:    Translation:Cells
    84. Zeng X, Stahlberg H, Grigorieff N. A maximum likelihood approach to two-dimensional crystals. J Struct Biol. 2007 Dec; 160(3):362-74. PMID: 17964808.
      Citations: 17     Fields:    Translation:Cells
    85. Sachse C, Chen JZ, Coureux PD, Stroupe ME, F?ndrich M, Grigorieff N. High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol. 2007 Aug 17; 371(3):812-35. PMID: 17585939.
      Citations: 103     Fields:    Translation:Cells
    86. Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, F?ndrich M. Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. J Mol Biol. 2006 Sep 15; 362(2):347-54. PMID: 16920151.
      Citations: 23     Fields:    Translation:HumansCells
    87. Sousa D, Grigorieff N. Ab initio resolution measurement for single particle structures. J Struct Biol. 2007 Jan; 157(1):201-10. PMID: 17029845.
      Citations: 66     Fields:    Translation:Cells
    88. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. PMID: 16908193.
      Citations: 18     Fields:    Translation:Cells
    89. Chen JZ, Grigorieff N. SIGNATURE: a single-particle selection system for molecular electron microscopy. J Struct Biol. 2007 Jan; 157(1):168-73. PMID: 16870473.
      Citations: 91     Fields:    
    90. Stroupe ME, Tange T?, Thomas DR, Moore MJ, Grigorieff N. The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21; 360(4):743-9. PMID: 16797590.
      Citations: 16     Fields:    Translation:HumansCells
    91. Grigorieff N. FREALIGN: high-resolution refinement of single particle structures. J Struct Biol. 2007 Jan; 157(1):117-25. PMID: 16828314.
      Citations: 274     Fields:    
    92. Wolf M, DeRosier DJ, Grigorieff N. Ewald sphere correction for single-particle electron microscopy. Ultramicroscopy. 2006 Mar; 106(4-5):376-82. PMID: 16384646.
      Citations: 30     Fields:    Translation:Cells
    93. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. PMID: 16343539.
      Citations: 33     Fields:    Translation:HumansCells
    94. Rodal AA, Sokolova O, Robins DB, Daugherty KM, Hippenmeyer S, Riezman H, Grigorieff N, Goode BL. Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol. 2005 Jan; 12(1):26-31. PMID: 15592479.
      Citations: 92     Fields:    Translation:AnimalsCells
    95. Stewart A, Grigorieff N. Noise bias in the refinement of structures derived from single particles. Ultramicroscopy. 2004 Dec; 102(1):67-84. PMID: 15556702.
      Citations: 63     Fields:    
    96. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. PMID: 15502812.
      Citations: 215     Fields:    Translation:AnimalsCells
    97. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. PMID: 15502813.
      Citations: 74     Fields:    Translation:AnimalsCells
    98. Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron. 2004 Feb 19; 41(4):513-9. PMID: 14980201.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    99. Jurica MS, Sousa D, Moore MJ, Grigorieff N. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 2004 Mar; 11(3):265-9. PMID: 14981503.
      Citations: 33     Fields:    Translation:HumansCells
    100. Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13; 279(7):5549-54. PMID: 14623880.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    101. Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N. Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12607-12. PMID: 14569011.
      Citations: 28     Fields:    Translation:AnimalsCells
    102. Chen JZ, F?rst J, Chapman MS, Grigorieff N. Low-resolution structure refinement in electron microscopy. J Struct Biol. 2003 Oct-Nov; 144(1-2):144-51. PMID: 14643217.
      Citations: 26     Fields:    Translation:Cells
    103. Wolf M, Eberhart A, Glossmann H, Striessnig J, Grigorieff N. Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy. J Mol Biol. 2003 Sep 05; 332(1):171-82. PMID: 12946355.
      Citations: 49     Fields:    Translation:AnimalsCells
    104. Furst J, Sutton RB, Chen J, Brunger AT, Grigorieff N. Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. EMBO J. 2003 Sep 01; 22(17):4365-74. PMID: 12941689.
      Citations: 25     Fields:    Translation:AnimalsCells
    105. Mindell JA, Grigorieff N. Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol. 2003 Jun; 142(3):334-47. PMID: 12781660.
      Citations: 957     Fields:    
    106. McGovern SL, Caselli E, Grigorieff N, Shoichet BK. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem. 2002 Apr 11; 45(8):1712-22. PMID: 11931626.
      Citations: 325     Fields:    Translation:Cells
    107. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002 Apr; 8(4):426-39. PMID: 11991638.
      Citations: 188     Fields:    Translation:Cells
    108. Pirruccello MM, Grigorieff N, Mindell JA. Electron diffraction of a bacterial ClC-type chloride channel. Novartis Found Symp. 2002; 245:193-203; discussion 203-6, 261-4. PMID: 12027008.
      Citations:    Fields:    
    109. Sokolova O, Kolmakova-Partensky L, Grigorieff N. Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. Structure. 2001 Mar 07; 9(3):215-20. PMID: 11286888.
      Citations: 44     Fields:    Translation:AnimalsCells
    110. Nogales E, Grigorieff N. Molecular Machines: putting the pieces together. J Cell Biol. 2001 Jan 08; 152(1):F1-10. PMID: 11149934.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    111. Grigorieff N. Resolution measurement in structures derived from single particles. Acta Crystallogr D Biol Crystallogr. 2000 Oct; 56(Pt 10):1270-7. PMID: 10998623.
      Citations: 48     Fields:    Translation:Cells
    112. Grigorieff N. Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I) Curr Opin Struct Biol. 1999 Aug; 9(4):476-83. PMID: 10449365.
      Citations: 15     Fields:    Translation:AnimalsCells
    113. Smith CJ, Grigorieff N, Pearse BM. Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors. EMBO J. 1998 Sep 01; 17(17):4943-53. PMID: 9724631.
      Citations: 44     Fields:    Translation:AnimalsCells
    114. Grigorieff N. Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 A in ice. J Mol Biol. 1998 Apr 17; 277(5):1033-46. PMID: 9571020.
      Citations: 91     Fields:    Translation:AnimalsCells
    115. Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol. 1996 Jun 14; 259(3):393-421. PMID: 8676377.
      Citations: 214     Fields:    Translation:Cells
    116. Grigorieff N, Beckmann E, Zemlin F. Lipid location in deoxycholate-treated purple membrane at 2.6 A. J Mol Biol. 1995 Dec 01; 254(3):404-15. PMID: 7490759.
      Citations: 10     Fields:    Translation:Cells
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