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Nikolaus Grigorieff PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
368 Plantation Street AS4-1009
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    University of Bristol, Bristol, , United KingdomPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2426427122. PMID: 40244672.
      Citations:    
    2. Woollard G, Zhou W, Thiede EH, Lin C, Grigorieff N, Cossio P, Dao Duc K, Hanson SM. InstaMap: instant-NGP for cryo-EM density maps. Acta Crystallogr D Struct Biol. 2025 Apr 01; 81(Pt 4):147-169. PMID: 40135651.
      Citations:    
    3. Zhang K, Cossio P, Rangan AV, Lucas BA, Grigorieff N. A new statistical metric for robust target detection in cryo-EM using 2D template matching. IUCrJ. 2025 Mar 01; 12(Pt 2):155-176. PMID: 39819740.
      Citations:    
    4. Elferich J, Kong L, Zottig X, Grigorieff N. CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples. Elife. 2024 Dec 20; 13. PMID: 39704651.
      Citations:    
    5. Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography. bioRxiv. 2024 Oct 18. PMID: 39463923.
      Citations:    
    6. Lucas BA, Himes BA, Grigorieff N. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias. Elife. 2023 Nov 27; 12. PMID: 38010355.
      Citations:    Fields:    Translation:Cells
    7. Zhang K, Lucas B, Grigorieff N. Exploring the Limits of 2D Template Matching for Detecting Targets in Cellular Cryo-EM Images. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):931. PMID: 37613706.
      Citations: 1     Fields:    
    8. Lucas BA, Grigorieff N. Quantification of gallium cryo-FIB milling damage in biological lamellae. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2301852120. PMID: 37216561.
      Citations: 6     Fields:    Translation:Cells
    9. Pitsawong W, P?dua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D. From primordial clocks to circadian oscillators. Nature. 2023 04; 616(7955):183-189. PMID: 36949197.
      Citations: 3     Fields:    Translation:Cells
    10. Elferich J, Schiroli G, Scadden DT, Grigorieff N. Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections. Elife. 2022 11 16; 11. PMID: 36382886.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Lucas BA, Zhang K, Loerch S, Grigorieff N. In situ single particle classification reveals distinct 60S maturation intermediates in cells. Elife. 2022 08 25; 11. PMID: 36005291.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Himes B, Grigorieff N. Cryo-TEM simulations of amorphous radiation-sensitive samples using multislice wave propagation. IUCrJ. 2021 Nov 01; 8(Pt 6):943-953. PMID: 34804546.
      Citations: 8     Fields:    
    13. Lucas BA, Himes BA, Xue L, Grant T, Mahamid J, Grigorieff N. Locating macromolecular assemblies in cells by 2D template matching with cisTEM. Elife. 2021 06 11; 10. PMID: 34114559.
      Citations: 27     Fields:    Translation:Cells
    14. Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN. mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding. Elife. 2020 05 19; 9. PMID: 32427100.
      Citations: 20     Fields:    Translation:Cells
    15. Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol. 2020 03; 27(3):305. PMID: 32066965.
      Citations: 2     Fields:    
    16. Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Structure and assembly of calcium homeostasis modulator proteins. Nat Struct Mol Biol. 2020 02; 27(2):150-159. PMID: 31988524.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    17. Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SC. Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep. 2020 01 07; 30(1):53-60.e5. PMID: 31914397.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    18. Song K, Shang Z, Fu X, Lou X, Grigorieff N, Nicastro D. In situ structure determination at nanometer resolution using TYGRESS. Nat Methods. 2020 02; 17(2):201-208. PMID: 31768058.
      Citations: 27     Fields:    Translation:AnimalsCells
    19. Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC. In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J Mol Biol. 2019 08 09; 431(17):3124-3138. PMID: 31233764.
      Citations: 26     Fields:    Translation:Cells
    20. Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L. High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12828-12832. PMID: 31182604.
      Citations: 34     Fields:    Translation:HumansCellsPHPublic Health
    21. Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, F?ndrich M, Schmidt M. Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids. Nat Commun. 2019 03 07; 10(1):1104. PMID: 30846696.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    22. Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D. Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy. 2019 08; 203:170-180. PMID: 30528101.
      Citations: 17     Fields:    Translation:Cells
    23. Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science. 2018 08 24; 361(6404). PMID: 30139843.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    24. Bartesaghi A, Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, Subramaniam S. Atomic Resolution Cryo-EM Structure of ?-Galactosidase. Structure. 2018 06 05; 26(6):848-856.e3. PMID: 29754826.
      Citations: 53     Fields:    Translation:Cells
    25. Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H. Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron. 2018 05 02; 98(3):521-529.e3. PMID: 29656875.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    26. Grant T, Rohou A, Grigorieff N. cisTEM, user-friendly software for single-particle image processing. Elife. 2018 03 07; 7. PMID: 29513216.
      Citations: 408     Fields:    
    27. Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, F?ndrich M. Physical basis of amyloid fibril polymorphism. Nat Commun. 2018 02 16; 9(1):699. PMID: 29453354.
      Citations: 50     Fields:    Translation:HumansCells
    28. Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. Structure of RNA polymerase bound to ribosomal 30S subunit. Elife. 2017 10 13; 6. PMID: 29027901.
      Citations: 43     Fields:    Translation:Cells
    29. Abeyrathne PD, Grigorieff N. Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1. PLoS One. 2017; 12(7):e0180163. PMID: 28692650.
      Citations: 2     Fields:    Translation:Cells
    30. Loveland AB, Demo G, Grigorieff N, Korostelev AA. Ensemble cryo-EM elucidates the mechanism of translation fidelity. Nature. 2017 06 01; 546(7656):113-117. PMID: 28538735.
      Citations: 82     Fields:    Translation:Cells
    31. Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839. PMID: 28506635.
      Citations: 14     Fields:    Translation:Cells
    32. Rickgauer JP, Grigorieff N, Denk W. Single-protein detection in crowded molecular environments in cryo-EM images. Elife. 2017 05 03; 6. PMID: 28467302.
      Citations: 33     Fields:    Translation:Cells
    33. Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B. Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol. 2017 05 15; 91(10). PMID: 28250125.
      Citations: 11     Fields:    Translation:Cells
    34. Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA. Mechanism of ribosome rescue by ArfA and RF2. Elife. 2017 03 16; 6. PMID: 28300532.
      Citations: 27     Fields:    Translation:Cells
    35. Oldham ML, Grigorieff N, Chen J. Structure of the transporter associated with antigen processing trapped by herpes simplex virus. Elife. 2016 12 09; 5. PMID: 27935481.
      Citations: 39     Fields:    Translation:HumansCells
    36. Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. Ribosome?RelA structures reveal the mechanism of stringent response activation. Elife. 2016 07 19; 5. PMID: 27434674.
      Citations: 82     Fields:    Translation:Cells
    37. Grigorieff N. Frealign: An Exploratory Tool for Single-Particle Cryo-EM. Methods Enzymol. 2016; 579:191-226. PMID: 27572728.
      Citations: 89     Fields:    Translation:Cells
    38. Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife. 2016 05 25; 5. PMID: 27223329.
      Citations: 10     Fields:    Translation:Cells
    39. Schmidt A, Annamalai K, Schmidt M, Grigorieff N, F?ndrich M. Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6200-5. PMID: 27185936.
      Citations: 25     Fields:    Translation:HumansCells
    40. Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife. 2016 05 09; 5. PMID: 27159452.
      Citations: 69     Fields:    Translation:AnimalsCells
    41. Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature. 2016 06 02; 534(7605):63-8. PMID: 27135925.
      Citations: 101     Fields:    Translation:AnimalsCells
    42. Zhou A, Rohou A, Schep DG, Bason JV, Montgomery MG, Walker JE, Grigorieff N, Rubinstein JL. Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife. 2015 Oct 06; 4:e10180. PMID: 26439008.
      Citations: 141     Fields:    Translation:AnimalsCells
    43. Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, F?ndrich M, Grigorieff N. Peptide dimer structure in an A?(1-42) fibril visualized with cryo-EM. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11858-63. PMID: 26351699.
      Citations: 92     Fields:    Translation:Cells
    44. Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. J Struct Biol. 2015 Nov; 192(2):163-73. PMID: 26318383.
      Citations: 12     Fields:    Translation:AnimalsCells
    45. Rohou A, Grigorieff N. CTFFIND4: Fast and accurate defocus estimation from electron micrographs. J Struct Biol. 2015 Nov; 192(2):216-21. PMID: 26278980.
      Citations: 2178     Fields:    
    46. Grant T, Grigorieff N. Automatic estimation and correction of anisotropic magnification distortion in electron microscopes. J Struct Biol. 2015 Nov; 192(2):204-8. PMID: 26278979.
      Citations: 72     Fields:    
    47. Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ. Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327. PMID: 26144317.
      Citations: 147     Fields:    Translation:Cells
    48. Grant T, Grigorieff N. Measuring the optimal exposure for single particle cryo-EM using a 2.6 ? reconstruction of rotavirus VP6. Elife. 2015 May 29; 4:e06980. PMID: 26023829.
      Citations: 412     Fields:    Translation:Cells
    49. Cheng Y, Grigorieff N, Penczek PA, Walz T. A primer to single-particle cryo-electron microscopy. Cell. 2015 Apr 23; 161(3):438-449. PMID: 25910204.
      Citations: 205     Fields:    Translation:Cells
    50. Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations. Structure. 2014 Aug 05; 22(8):1210-1218. PMID: 25043550.
      Citations: 50     Fields:    Translation:Cells
    51. Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9139-44. PMID: 24927574.
      Citations: 38     Fields:    Translation:Cells
    52. Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 2014 Jun 05; 157(6):1405-1415. PMID: 24906155.
      Citations: 94     Fields:    Translation:HumansCells
    53. Rohou A, Grigorieff N. Frealix: model-based refinement of helical filament structures from electron micrographs. J Struct Biol. 2014 May; 186(2):234-44. PMID: 24657230.
      Citations: 13     Fields:    Translation:Cells
    54. Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N. Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20994-9. PMID: 24324137.
      Citations: 89     Fields:    Translation:Cells
    55. Ruskin AI, Yu Z, Grigorieff N. Quantitative characterization of electron detectors for transmission electron microscopy. J Struct Biol. 2013 12; 184(3):385-93. PMID: 24189638.
      Citations: 64     Fields:    
    56. Lyumkis D, Brilot AF, Theobald DL, Grigorieff N. Likelihood-based classification of cryo-EM images using FREALIGN. J Struct Biol. 2013 Sep; 183(3):377-388. PMID: 23872434.
      Citations: 136     Fields:    Translation:Cells
    57. Grigorieff N. Direct detection pays off for electron cryo-microscopy. Elife. 2013 Feb 19; 2:e00573. PMID: 23426864.
      Citations: 21     Fields:    
    58. Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC. Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles. J Mol Biol. 2013 Jan 09; 425(1):124-32. PMID: 23089332.
      Citations: 44     Fields:    Translation:Cells
    59. Deaconescu AM, Artsimovitch I, Grigorieff N. Interplay of DNA repair with transcription: from structures to mechanisms. Trends Biochem Sci. 2012 Dec; 37(12):543-52. PMID: 23084398.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    60. Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure. 2012 Nov 07; 20(11):1823-8. PMID: 23022349.
      Citations: 138     Fields:    Translation:Cells
    61. Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE. Maturation in action: CryoEM study of a viral capsid caught during expansion. Structure. 2012 Aug 08; 20(8):1384-90. PMID: 22748764.
      Citations: 12     Fields:    Translation:Cells
    62. Sindelar CV, Grigorieff N. Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter. J Struct Biol. 2012 Oct; 180(1):26-38. PMID: 22613568.
      Citations: 18     Fields:    Translation:Cells
    63. Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff N. Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol. 2012 Mar; 177(3):630-7. PMID: 22366277.
      Citations: 166     Fields:    
    64. Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N. Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3353-8. PMID: 22331906.
      Citations: 30     Fields:    Translation:Cells
    65. Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schr?der GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL. Outcome of the first electron microscopy validation task force meeting. Structure. 2012 Feb 08; 20(2):205-14. PMID: 22325770.
      Citations: 275     Fields:    Translation:HumansAnimalsCells
    66. Henderson R, Chen S, Chen JZ, Grigorieff N, Passmore LA, Ciccarelli L, Rubinstein JL, Crowther RA, Stewart PL, Rosenthal PB. Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy. J Mol Biol. 2011 Nov 11; 413(5):1028-46. PMID: 21939668.
      Citations: 84     Fields:    Translation:AnimalsCells
    67. Lewandowski JR, van der Wel PC, Rigney M, Grigorieff N, Griffin RG. Structural complexity of a composite amyloid fibril. J Am Chem Soc. 2011 Sep 21; 133(37):14686-98. PMID: 21766841.
      Citations: 42     Fields:    Translation:AnimalsCells
    68. Sindelar CV, Grigorieff N. An adaptation of the Wiener filter suitable for analyzing images of isolated single particles. J Struct Biol. 2011 Oct; 176(1):60-74. PMID: 21757012.
      Citations: 18     Fields:    Translation:Cells
    69. F?ndrich M, Schmidt M, Grigorieff N. Recent progress in understanding Alzheimer's ?-amyloid structures. Trends Biochem Sci. 2011 Jun; 36(6):338-45. PMID: 21411326.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    70. Grigorieff N, Harrison SC. Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol. 2011 Apr; 21(2):265-73. PMID: 21333526.
      Citations: 86     Fields:    Translation:Cells
    71. Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19; 30(2):408-16. PMID: 21157433.
      Citations: 140     Fields:    Translation:Cells
    72. Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E. The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature. 2010 Oct 14; 467(7317):805-10. PMID: 20944740.
      Citations: 185     Fields:    Translation:HumansCells
    73. Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL. Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol. 2010 Jun 28; 189(7):1087-96. PMID: 20566685.
      Citations: 96     Fields:    Translation:AnimalsCells
    74. Li X, Grigorieff N, Cheng Y. GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors. J Struct Biol. 2010 Dec; 172(3):407-12. PMID: 20558298.
      Citations: 22     Fields:    
    75. Wolf M, Garcea RL, Grigorieff N, Harrison SC. Subunit interactions in bovine papillomavirus. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6298-303. PMID: 20308582.
      Citations: 85     Fields:    Translation:Cells
    76. Sachse C, Grigorieff N, F?ndrich M. Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined by electron cryo-microscopy. Angew Chem Int Ed Engl. 2010 Feb 08; 49(7):1321-3. PMID: 20069616.
      Citations: 15     Fields:    Translation:HumansCells
    77. Xing Y, B?cking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC. Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65. PMID: 20033059.
      Citations: 62     Fields:    Translation:AnimalsCells
    78. Schmidt M, Sachse C, Richter W, Xu C, F?ndrich M, Grigorieff N. Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19813-8. PMID: 19843697.
      Citations: 110     Fields:    Translation:Cells
    79. Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10644-8. PMID: 19487668.
      Citations: 80     Fields:    Translation:Cells
    80. F?ndrich M, Meinhardt J, Grigorieff N. Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion. 2009 Apr-Jun; 3(2):89-93. PMID: 19597329.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    81. Dementieva IS, Tereshko V, McCrossan ZA, Solomaha E, Araki D, Xu C, Grigorieff N, Goldstein SA. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. J Mol Biol. 2009 Mar 20; 387(1):175-91. PMID: 19361449.
      Citations: 37     Fields:    Translation:HumansCells
    82. Sachse C, Grigorieff N, F?ndrich M. Bioforum. 2009; 32(2):26. PMID: 20126429.
      Citations:    
    83. Stroupe ME, Xu C, Goode BL, Grigorieff N. Actin filament labels for localizing protein components in large complexes viewed by electron microscopy. RNA. 2009 Feb; 15(2):244-8. PMID: 19095618.
      Citations: 8     Fields:    Translation:AnimalsCells
    84. Meinhardt J, Sachse C, Hortschansky P, Grigorieff N, F?ndrich M. Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol. 2009 Feb 27; 386(3):869-77. PMID: 19038266.
      Citations: 119     Fields:    Translation:HumansCells
    85. Sachse C, F?ndrich M, Grigorieff N. Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7462-6. PMID: 18483195.
      Citations: 78     Fields:    Translation:HumansCells
    86. Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N. Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1867-72. PMID: 18238898.
      Citations: 187     Fields:    Translation:Cells
    87. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326.
      Citations: 16     Fields:    Translation:AnimalsCells
    88. Chen JZ, Sachse C, Xu C, Mielke T, Spahn CM, Grigorieff N. A dose-rate effect in single-particle electron microscopy. J Struct Biol. 2008 Jan; 161(1):92-100. PMID: 17977018.
      Citations: 21     Fields:    Translation:Cells
    89. Zeng X, Stahlberg H, Grigorieff N. A maximum likelihood approach to two-dimensional crystals. J Struct Biol. 2007 Dec; 160(3):362-74. PMID: 17964808.
      Citations: 17     Fields:    Translation:Cells
    90. Sachse C, Chen JZ, Coureux PD, Stroupe ME, F?ndrich M, Grigorieff N. High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol. 2007 Aug 17; 371(3):812-35. PMID: 17585939.
      Citations: 103     Fields:    Translation:Cells
    91. Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, F?ndrich M. Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. J Mol Biol. 2006 Sep 15; 362(2):347-54. PMID: 16920151.
      Citations: 23     Fields:    Translation:HumansCells
    92. Sousa D, Grigorieff N. Ab initio resolution measurement for single particle structures. J Struct Biol. 2007 Jan; 157(1):201-10. PMID: 17029845.
      Citations: 66     Fields:    Translation:Cells
    93. Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y. Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60. PMID: 16908193.
      Citations: 18     Fields:    Translation:Cells
    94. Chen JZ, Grigorieff N. SIGNATURE: a single-particle selection system for molecular electron microscopy. J Struct Biol. 2007 Jan; 157(1):168-73. PMID: 16870473.
      Citations: 91     Fields:    
    95. Stroupe ME, Tange T?, Thomas DR, Moore MJ, Grigorieff N. The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21; 360(4):743-9. PMID: 16797590.
      Citations: 16     Fields:    Translation:HumansCells
    96. Grigorieff N. FREALIGN: high-resolution refinement of single particle structures. J Struct Biol. 2007 Jan; 157(1):117-25. PMID: 16828314.
      Citations: 274     Fields:    
    97. Wolf M, DeRosier DJ, Grigorieff N. Ewald sphere correction for single-particle electron microscopy. Ultramicroscopy. 2006 Mar; 106(4-5):376-82. PMID: 16384646.
      Citations: 30     Fields:    Translation:Cells
    98. Cheng Y, Wolf E, Larvie M, Zak O, Aisen P, Grigorieff N, Harrison SC, Walz T. Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol. 2006 Feb 03; 355(5):1048-65. PMID: 16343539.
      Citations: 33     Fields:    Translation:HumansCells
    99. Rodal AA, Sokolova O, Robins DB, Daugherty KM, Hippenmeyer S, Riezman H, Grigorieff N, Goode BL. Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol. 2005 Jan; 12(1):26-31. PMID: 15592479.
      Citations: 92     Fields:    Translation:AnimalsCells
    100. Stewart A, Grigorieff N. Noise bias in the refinement of structures derived from single particles. Ultramicroscopy. 2004 Dec; 102(1):67-84. PMID: 15556702.
      Citations: 63     Fields:    
    101. Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. PMID: 15502812.
      Citations: 215     Fields:    Translation:AnimalsCells
    102. Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T. Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53. PMID: 15502813.
      Citations: 74     Fields:    Translation:AnimalsCells
    103. Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron. 2004 Feb 19; 41(4):513-9. PMID: 14980201.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    104. Jurica MS, Sousa D, Moore MJ, Grigorieff N. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 2004 Mar; 11(3):265-9. PMID: 14981503.
      Citations: 33     Fields:    Translation:HumansCells
    105. Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. J Biol Chem. 2004 Feb 13; 279(7):5549-54. PMID: 14623880.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    106. Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N. Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12607-12. PMID: 14569011.
      Citations: 28     Fields:    Translation:AnimalsCells
    107. Chen JZ, F?rst J, Chapman MS, Grigorieff N. Low-resolution structure refinement in electron microscopy. J Struct Biol. 2003 Oct-Nov; 144(1-2):144-51. PMID: 14643217.
      Citations: 26     Fields:    Translation:Cells
    108. Wolf M, Eberhart A, Glossmann H, Striessnig J, Grigorieff N. Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy. J Mol Biol. 2003 Sep 05; 332(1):171-82. PMID: 12946355.
      Citations: 49     Fields:    Translation:AnimalsCells
    109. Furst J, Sutton RB, Chen J, Brunger AT, Grigorieff N. Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. EMBO J. 2003 Sep 01; 22(17):4365-74. PMID: 12941689.
      Citations: 25     Fields:    Translation:AnimalsCells
    110. Mindell JA, Grigorieff N. Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol. 2003 Jun; 142(3):334-47. PMID: 12781660.
      Citations: 957     Fields:    
    111. McGovern SL, Caselli E, Grigorieff N, Shoichet BK. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem. 2002 Apr 11; 45(8):1712-22. PMID: 11931626.
      Citations: 325     Fields:    Translation:Cells
    112. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002 Apr; 8(4):426-39. PMID: 11991638.
      Citations: 188     Fields:    Translation:Cells
    113. Pirruccello MM, Grigorieff N, Mindell JA. Electron diffraction of a bacterial ClC-type chloride channel. Novartis Found Symp. 2002; 245:193-203; discussion 203-6, 261-4. PMID: 12027008.
      Citations:    Fields:    
    114. Sokolova O, Kolmakova-Partensky L, Grigorieff N. Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution. Structure. 2001 Mar 07; 9(3):215-20. PMID: 11286888.
      Citations: 44     Fields:    Translation:AnimalsCells
    115. Mindell JA, Maduke M, Miller C, Grigorieff N. Projection structure of a ClC-type chloride channel at 6.5 A resolution. Nature. 2001 Jan 11; 409(6817):219-23. PMID: 11196649.
      Citations: 31     Fields:    Translation:Cells
    116. Nogales E, Grigorieff N. Molecular Machines: putting the pieces together. J Cell Biol. 2001 Jan 08; 152(1):F1-10. PMID: 11149934.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    117. Grigorieff N. Resolution measurement in structures derived from single particles. Acta Crystallogr D Biol Crystallogr. 2000 Oct; 56(Pt 10):1270-7. PMID: 10998623.
      Citations: 48     Fields:    Translation:Cells
    118. Grigorieff N. Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I) Curr Opin Struct Biol. 1999 Aug; 9(4):476-83. PMID: 10449365.
      Citations: 15     Fields:    Translation:AnimalsCells
    119. Smith CJ, Grigorieff N, Pearse BM. Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors. EMBO J. 1998 Sep 01; 17(17):4943-53. PMID: 9724631.
      Citations: 44     Fields:    Translation:AnimalsCells
    120. Grigorieff N. Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 A in ice. J Mol Biol. 1998 Apr 17; 277(5):1033-46. PMID: 9571020.
      Citations: 91     Fields:    Translation:AnimalsCells
    121. Grigorieff N, Ceska TA, Downing KH, Baldwin JM, Henderson R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J Mol Biol. 1996 Jun 14; 259(3):393-421. PMID: 8676377.
      Citations: 214     Fields:    Translation:Cells
    122. Grigorieff N, Beckmann E, Zemlin F. Lipid location in deoxycholate-treated purple membrane at 2.6 A. J Mol Biol. 1995 Dec 01; 254(3):404-15. PMID: 7490759.
      Citations: 10     Fields:    Translation:Cells
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