Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.
Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Nat Cell Biol. 2018 05; 20(5):586-596.
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Animals
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Carrier Proteins
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Cell Line, Tumor
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Cell Proliferation
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Cell Survival
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Neoplastic
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HEK293 Cells
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Humans
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Lymphoma, Large B-Cell, Diffuse
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Mice, Inbred NOD
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Mice, SCID
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Mutation
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NF-kappa B
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Protein Stability
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Proteolysis
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Receptors, Antigen, B-Cell
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Repressor Proteins
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RNA Stability
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RNA, Messenger
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Signal Transduction
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Tumor Necrosis Factor alpha-Induced Protein 3
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Tumor Suppressor Proteins
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Tyrosine
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Ubiquitination