Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.
Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Nat Cell Biol. 2018 05; 20(5):586-596.
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Animals
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Carrier Proteins
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Cell Line, Tumor
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Cell Proliferation
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Cell Survival
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Neoplastic
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Humans
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Lymphoma, Large B-Cell, Diffuse
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Mice, Inbred NOD
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Mice, SCID
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Mutation
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NF-kappa B
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Protein Stability
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Receptors, Antigen, B-Cell
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Repressor Proteins
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RNA Stability
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RNA, Messenger
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Signal Transduction
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Tumor Suppressor Proteins
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Tyrosine
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Ubiquitination