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Fiachra Emanuel Humphries PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
Phone508-856-6940
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInnate Immunity

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    National University of Ireland, Maynooth, KLDARE, IrelandBSBiotechnology
    National University of Ireland, Maynooth, KLDARE, IrelandPHDImmunology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen Y, Lei X, Jiang Z, Humphries F, Parsi KM, Mustone NJ, Ramos I, Mutetwa T, Fernandez-Sesma A, Maehr R, Caffrey DR, Fitzgerald KA. Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates. Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47):e2308355120. PMID: 37963251.
      Citations:    Fields:    Translation:AnimalsCells
    2. Humphries F. cGAS-like receptors: back to the future. Trends Immunol. 2023 Oct; 44(10):760-762. PMID: 37718174.
      Citations: 1     Fields:    
    3. Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA. Targeting STING oligomerization with small-molecule inhibitors. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2305420120. PMID: 37549268.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, Shklyar B, Joannas L, Mustone N, Sherman S, Ward D, Houghton J, Baer CE, O'Hara A, Henao-Mejia J, Hoebe K, Fitzgerald KA. The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis. Cell Metab. 2023 08 08; 35(8):1441-1456.e9. PMID: 37494932.
      Citations:    Fields:    Translation:AnimalsCells
    5. Sciaudone A, Corkrey H, Humphries F, Koupenova M. Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond. Circ Res. 2023 05 12; 132(10):1272-1289. PMID: 37167360.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Hariharan VN, Shin M, Chang CW, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2023 03 14; 120(11):e2219523120. PMID: 36893269.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Humphries F. Biochemical Methods for Assessing Gasdermin D Inactivation in Macrophages. Methods Mol Biol. 2023; 2641:125-133. PMID: 37074646.
      Citations:    Fields:    Translation:Cells
    8. Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Front Immunol. 2022; 13:995412. PMID: 36172366.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Fitzgerald K, Chen Y, Lei X, Jiang Z, Humphries F, Mustone N, Ramos I, Mutetwa T, Fernandez-Sesma A. CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates. Res Sq. 2022 May 02. PMID: 35547851.
      Citations:    
    10. Humphries F, Fitzgerald KA. Igniting the firestorm: The inflammasome in autoinflammatory syndromes. J Allergy Clin Immunol. 2021 12; 148(6):1470-1472. PMID: 34403657.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 06 08; 54(6):1137-1153.e8. PMID: 34051146.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    12. Humphries F, Fitzgerald KA. Loosening the grip on nuclear cGAS. Nat Genet. 2020 12; 52(12):1269-1270. PMID: 33230301.
      Citations:    Fields:    Translation:Cells
    13. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637. PMID: 32820063.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    14. Humphries F, Fitzgerald KA. hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus. Mol Cell. 2019 10 03; 76(1):8-10. PMID: 31585104.
      Citations:    Fields:    Translation:Cells
    15. Humphries F, Fitzgerald KA. Assembling the Inflammasome, Piece by Piece. J Immunol. 2019 09 01; 203(5):1093-1094. PMID: 31427397.
      Citations: 1     Fields:    Translation:Humans
    16. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 04; 7(8):4890-901. PMID: 37695732.
      Citations:    Fields:    Translation:Humans
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