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Wolfe, Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Goldberg, Robert
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HR job title: Professor
position in organization: UMass Chan – Baystate Regional Campus

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Adjunct Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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HR job title: Adjunct Professor
position in organization: UMass Chan – Baystate Regional Campus

Driban, Jeffrey
first name: Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
full name: Jeffrey B Driban PhD, AT Ret, CSCS
has faculty rank: Professor
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Professor
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Surgery
position in division: Vascular Surgery
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Associate Professor
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position in division: Spine
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type: Position
HR job title: Chair and Associate Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Neurological Surgery
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HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Family Medicine and Community Health
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Pieters, Thomas
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person in primary position: Assistant Professor
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Assistant Professor
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position in department: Neurological Surgery
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Walkey, Allan
first name: Allan
last name: Walkey
full name: Allan Jay Walkey MD, MSc
has faculty rank: Professor
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Person ID: 10247602
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Moffatt-Bruce, Susan
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full name: Susan D Moffatt-Bruce MD, PhD, FRCSC, MBOE, MBA,FACS
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Person ID: 10247633
person in primary position: Professor
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Mosenthal, Anne
first name: Anne
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latitude: 42.48526100000000
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Person ID: 10247657
person in primary position: Professor
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preferred title: Professor

Medicine at UMass Chan - Lahey
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type: Organization

Surgery at UMass Chan - Lahey
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/40402890
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Radiology at UMass Chan - Lahey
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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type: Position
HR job title: Professor
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Chair and Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Colorectal & Rectal Surgery
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Health System Science
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type: Organization

Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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position in division: Epidemiology
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type: Position
HR job title: Professor Emeritus
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Professor
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position in department: Medicine
position in division: Geriatrics
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Surgery
position in division: Colorectal & Rectal Surgery
sort order: 1
type: Position
HR job title: Associate Professor
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology
position in division: Neurointerventional Radiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Obstetrics and Gynecology
position in division: Ob/Gyn General
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Cardio Thoracic Surgery
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type: Organization

Ob/Gyn General
type: Division
type: Organization

Stroke and Vascular Neurology
type: Division
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Chair and Professor
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position in department: Medicine
position in division: Cardiovascular Medicine
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type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Surgery
position in division: Cardio Thoracic Surgery
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Molecular, Cell and Cancer Biology
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Tan Chingfen Graduate School of Nursing
type: Department
type: Organization

Shekar, Prem
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last name: Shekar
full name: Prem S Shekar MD, FRCSEd, MCh, MBA
has faculty rank: Professor
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Person ID: 10247825
person in primary position: Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

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McAlindon, Timothy
first name: Timothy
last name: McAlindon
full name: Timothy Edward McAlindon MD, MPH, MRCP
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Person ID: 10247852
person in primary position: Professor
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preferred title: Professor

Martinez, Fernando
first name: Fernando
last name: Martinez
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latitude: 42.27525000000000
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Person ID: 10247895
person in primary position: Professor
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
preferred title: Professor

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Krings, Timo
first name: Timo
last name: Krings
full name: Timo Krings MD, PhD, FRCP
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Person ID: 10247952
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Goldsweig, Andrew
first name: Andrew
last name: Goldsweig
full name: Andrew Goldsweig MD, MS
has faculty rank: Associate Professor
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Person ID: 10248018
person in primary position: Associate Professor
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preferred title: Associate Professor

Ghogawala, Zoher
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Person ID: 10248062
person in primary position: Professor
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Associate Professor
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position in department: Medicine at UMass Chan - Baystate
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HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Maron, Martin
first name: Martin
last name: Maron
full name: Martin S Maron MD, MSPH
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
first name: Barry
last name: Maron
full name: Barry J Maron MD
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latitude: 42.48526100000000
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Person ID: 10248130
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Whitmore, Robert
first name: Robert
last name: Whitmore
full name: Robert G Whitmore MD
has faculty rank: Associate Professor
latitude: 42.48526100000000
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Person ID: 10248133
person in primary position: Associate Professor
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preferred title: Associate Professor

Adjunct Professor
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Associate Professor
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sort order: 1
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HR job title: Associate Professor
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Professor
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position in department: Medicine
position in division: Rheumatology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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sort order: 1
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HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Reynolds, Matthew
first name: Matthew
last name: Reynolds
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Person ID: 10248173
person in primary position: Professor
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preferred title: Professor

Rowin, Ethan
first name: Ethan
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has faculty rank: Associate Professor
latitude: 42.48817480000000
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Person ID: 10248175
person in primary position: Associate Professor
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
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Professor
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position in department: Radiology
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HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
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type: Faculty Rank

Professor
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type: Faculty Rank

Professor Emeritus
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type: Faculty Rank

Assistant Professor
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type: Faculty Rank

Associate Professor
sort order: 10
type: Faculty Rank

Chair And Professor
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Chair And Associate Professor
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type: Faculty Rank

Magge, Subu
first name: Subu
last name: Magge
full name: Subu Magge MD, FAANS, FCNS
has faculty rank: Associate Professor
latitude: 42.48526100000000
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Person ID: 10248247
person in primary position: Associate Professor
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preferred title: Associate Professor

Associate Professor
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Psychiatry and Behavioral Sciences
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Chair and Professor
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position in department: Psychiatry and Behavioral Sciences
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sort order: 1
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HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Tan Chingfen Graduate School of Nursing
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Obstetrics and Gynecology
position in division: Ob/Gyn General
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Neurology
position in division: Stroke and Vascular Neurology
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Ophthalmology and Visual Sciences
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Surgery at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
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Person ID: 10248397
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Vanni, Alex
first name: Alex
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has faculty rank: Professor
Person ID: 10248404
person in primary position: Professor
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preferred title: Professor

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Narain, Ankur
first name: Ankur
last name: Narain
full name: Ankur Narain MD
has faculty rank: Assistant Professor
Person ID: 10248606
person in primary position: Assistant Professor
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preferred title: Assistant Professor

Assistant Professor
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position in department: Orthopedics and Physical Rehabilitation
position in division: Shoulder/Elbow
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type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Family Medicine and Community Health
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Surgery
position in division: Cardio Thoracic Surgery
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School