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Mattocks, Kristin
first name: Kristin
last name: Mattocks
full name: Kristin Michelle Mattocks PhD, MPH
has faculty rank: Professor
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person in primary position: Professor
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preferred title: Professor

Goodman, Ian
first name: Ian
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Person ID: 4052
person in primary position: Assistant Professor
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Molecular, Cell and Cancer Biology
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Obstetrics and Gynecology
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School of Public Health and Health Sciences
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Medicine
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Pathology
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Pediatrics
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Radiology
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RNA Therapeutics Institute
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Systems Biology
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College of Natural Sciences
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Chemistry
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Chemistry Department
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Department of Food Science
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Epidemiology
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Food Science
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Kinesiology
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Psychology And Neuroscience & Behavior Program
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Gastroenterology
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Health Informatics And Implementation Science
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Maternal-Fetal Medicine
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Preventive And Behavioral Medicine
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Biostatistics And Health Services Research
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Biostatistics And Epidemiology
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UMass Chan Medical School
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University of Massachusetts Amherst
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Pagoto, Sherry
first name: Sherry
last name: Pagoto
Featured Videos: https://profiles.umassmed.edu/profile/28867202
Twitter: https://profiles.umassmed.edu/profile/28867032
full name: Sherry L Pagoto PhD
has faculty rank: ADJUNCT PROFESSOR
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Flotte, Terence
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Endowed Chair Honorary Title: Elisabeth Chair for the Dean of Medicine
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Moore Simas, Tiffany
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Obstetrics and Gynecology
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Frazier, Jean
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Endowed Chair Honorary Title: Robert M. and Shirley S. Siff Chair in Autism
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Allison, Jeroan
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Moormann, Ann
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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
preferred title: Professor

Swain, Susan
first name: Susan
last name: Swain
full name: Susan L Swain PhD
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Barton, Bruce
first name: Bruce
last name: Barton
full name: Bruce A Barton PhD
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Latz, Eicke
first name: Eicke
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person in primary position: Adjunct Professor
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Comeau, Anne Marie
first name: Anne Marie
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Person ID: 156
person in primary position: Professor
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preferred title: Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
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Person ID: 202
person in primary position: Professor
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
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Shultz, Leonard
first name: Leonard
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full name: Leonard Donald Shultz PhD
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Lapane, Kate
first name: Kate
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Person ID: 3252
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Puri, Ajit
first name: Ajit
last name: Puri
full name: Ajit Singh Puri MD, DM, DMRE
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Person ID: 3253
person in primary position: Professor
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Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 50.70274210000000
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Person ID: 3432
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
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Person ID: 36
person in primary position: Adjunct Professor
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Hayman, Laura
first name: Laura
last name: Hayman
full name: Laura L Hayman PhD
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latitude: 42.31573630000000
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person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Chasan-Taber, Lisa
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Bertone-Johnson, Elizabeth
first name: Elizabeth
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Kaltashov, Igor
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Rotello, Vincent
first name: Vincent
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full name: Vincent Rotello PhD
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latitude: 42.39565560000000
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Person ID: 3741
person in primary position: Department Head
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preferred title: Department Head

McClements, David
first name: David
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Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
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preferred title: Fergus Clydesdale Endowed Chair

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
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latitude: 42.39565560000000
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Person ID: 3795
person in primary position: Associate Professor
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preferred title: Associate Professor

Spencer, Rebecca
first name: Rebecca
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full name: Rebecca Spencer PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
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Person ID: 3797
person in primary position: Associate Professor
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preferred title: Associate Professor

Debold, Edward
first name: Edward
last name: Debold
full name: Edward P Debold PhD
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latitude: 42.39565560000000
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Person ID: 3802
person in primary position: Assistant Professor
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preferred title: Assistant Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 418
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Lemon, Stephenie
first name: Stephenie
last name: Lemon
full name: Stephenie C Lemon PhD
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Person ID: 689
person in primary position: Professor
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866492

Bandini, Linda
first name: Linda
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full name: Linda Bandini PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 690
person in primary position: Professor
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preferred title: Professor

Craig, Roger
first name: Roger
last name: Craig
full name: Roger W Craig PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 73
person in primary position: Professor
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Craig for additional details.
Rotation Projects: Potential Rotation Projects Project #1: Lipid-Layer Protein Crystallization for Electron Microscopy.While individual protein molecules can be readily visualized by EM, structural information is greatly enhanced if the molecules can by crystallized into 2-dimensional ordered arrays. Methods for achieving this are well established, making use of lipid monolayers at an air-water interface. Follow literature methods to crystallize "standard" proteins using the lipid-layer method. Observe results by electron microscopy following negative staining. If time permits, carry out preliminary image processing of micrographs and/or crystallization of unknown proteins. Techniques to be learned: lipid layer crystallization methods; grid preparation; use of electron microscope; image processing.
preferred title: Professor

Dekker, Job
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full name: Job Dekker PhD
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latitude: 42.27587600000000
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Person ID: 759
person in primary position: Professor
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Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866525
webpage: https://profiles.umassmed.edu/profile/28866572

Goldberg, Robert
first name: Robert
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full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
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Person ID: 78
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Byatt, Nancy
first name: Nancy
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full name: Nancy Byatt DO, MS, MBA
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Shaw, Leslie
first name: Leslie
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Pediatric Genetics
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Friedmann, Peter
first name: Peter
last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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UMass Chan – Baystate Regional Campus
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Rhein, Lawrence
first name: Lawrence
last name: Rhein
full name: Lawrence M Rhein MD, MPH
has faculty rank: Chair And Associate Professor
latitude: 42.27287580000000
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Person ID: 4408
person in primary position: Chair and Associate Professor
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Endowed Chair Honorary Title: Stoddard Chair of Pediatrics
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Visintainer, Paul
first name: Paul
last name: Visintainer
full name: Paul Visintainer PhD
has faculty rank: Professor Emeritus
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Mader, Timothy
first name: Timothy
last name: Mader
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Shin, Masahiro
first name: Masahiro
last name: Shin
full name: Masahiro Shin PhD
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latitude: 42.27673450000000
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Person ID: 4707
person in primary position: Assistant Professor
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Vaidya, Ruben
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full name: Ruben Vaidya MD
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latitude: 42.12294230000000
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Person ID: 4744
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Professor
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position in department: School of Public Health and Health Sciences
position in division: Epidemiology
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Associate Professor
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Lindenauer, Peter
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Strauss, Kevin
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Population and Quantitative Health Sciences
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Schlaug, Gottfried
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Yonkers, Kimberly
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Garg, Arvin
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Broder-Fingert, Sarabeth
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Medicine at UMass Chan - Baystate
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Professor
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Assistant Professor
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Parker, Margaret
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Goebel, Mathew
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Professor Emeritus
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Sheldrick, Radley
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https://profiles.umassmed.edu/profile/34727929
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Wilkie, Gianna
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Associate Professor
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Whelan, Anna
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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Emergency Medicine at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Professor
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Basic Pathology
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Endocrinology & Diabetes
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Health System Science
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Professor
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Professor
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Professor
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Professor
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Professor
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Adjunct Professor
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Chair and Associate Professor
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Assistant Professor
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Professor
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General Pediatrics
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Martinez, Fernando
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Professor
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Wilcox, Susan
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Professor
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Professor
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Professor Emeritus
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Krings, Timo
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Maron, Martin
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Maron, Barry
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Chair and Professor
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Reynolds, Matthew
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Professor
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Instructor
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Professor
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Psychiatry and Behavioral Sciences
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Professor
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Professor
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Chair and Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Genetic and Cellular Medicine
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https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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https://profiles.umassmed.edu/profile/66923959
publication date: 2020
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publication date: 2017
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https://profiles.umassmed.edu/profile/66924043
publication date: 2018
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https://profiles.umassmed.edu/profile/66924060
publication date: 2020
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publication date: 2021
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Chair and Professor
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Adjunct Professor
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Shin, Dong-Soo
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Associate Professor
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Professor
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Adjunct Professor
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Professor
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Associate Professor
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Professor
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