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Molecular, Cell and Cancer Biology
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Medicine
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Pediatrics
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Radiology
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College of Natural Sciences
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Cardiovascular Medicine
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Epidemiology
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Psychology And Neuroscience & Behavior Program
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Community Pediatrics
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Geriatrics
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Health Informatics And Implementation Science
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Preventive And Behavioral Medicine
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Biostatistics And Health Services Research
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Rheumatology
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Spine
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Shoulder/Elbow
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UMass Chan Medical School
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University of Massachusetts Amherst
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Pagoto, Sherry
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Kiefe, Catarina
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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Henninger, Nils
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Stauff, Michael
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Hayman, Laura
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Chasan-Taber, Lisa
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Bertone-Johnson, Elizabeth
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Spencer, Rebecca
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DiFranza, Joseph
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Lemon, Stephenie
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Goldberg, Robert
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Shaw, Leslie
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Pediatric Genetics
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Friedmann, Peter
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Politi, Letterio
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Rhein, Lawrence
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Remenschneider, Aaron
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Adjunct Professor
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Assistant Professor
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Parker, Margaret
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Stanier, Philippe
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Sheldrick, Radley
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Driban, Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
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Professor
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Professor
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Chair and Associate Professor
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Pieters, Thomas
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Assistant Professor
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
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Professor
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Radiology at UMass Chan - Lahey
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Chair and Professor
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Professor
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Professor
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Cardio Thoracic Radiology
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Chair and Associate Professor
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Professor
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General Pediatrics
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Pediatric Neonatology
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Stroke and Vascular Neurology
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Chair and Professor
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Geissler, Kimberley
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Associate Professor
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Tan Chingfen Graduate School of Nursing
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McAlindon, Timothy
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Professor Emeritus
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Krings, Timo
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person in primary position: Professor
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Ghogawala, Zoher
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Professor
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Maron, Martin
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Maron, Barry
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Whitmore, Robert
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Adjunct Professor
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Professor
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Chair and Professor
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Reynolds, Matthew
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Rowin, Ethan
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Associate Professor
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Professor
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Instructor
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Professor
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Professor Emeritus
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Assistant Professor
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Associate Professor
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Chair And Professor
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Chair And Associate Professor
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Magge, Subu
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Professor Emeritus
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Associate Professor
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Psychiatry and Behavioral Sciences
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Professor
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Professor
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Professor Emeritus
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Professor
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Associate Professor
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Professor
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Professor
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Professor
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Assistant Professor
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Adjunct Professor
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position in organization: UMass Chan Medical School

Shin, Dong-Soo
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Associate Professor
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Professor
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Narain, Ankur
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Person ID: 10248606
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Assistant Professor
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Adjunct Professor
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Professor
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Professor
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