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Obstetrics and Gynecology
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Medicine
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Neurology
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Pediatrics
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Radiology
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RNA Therapeutics Institute
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Surgery
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College of Natural Sciences
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Cardiovascular Medicine
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Chemistry
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Epidemiology
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Geriatrics
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Health Informatics And Implementation Science
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Maternal-Fetal Medicine
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Pediatric Pulmonology
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Preventive And Behavioral Medicine
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UMass Chan Medical School
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University of Massachusetts Amherst
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Flotte, Terence
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last name: Flotte
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Endowed Chair Honorary Title: Elisabeth Chair for the Dean of Medicine
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Gao, Guangping
first name: Guangping
last name: Gao
full name: Guangping Gao PhD
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Endowed Chair Honorary Title: Penelope Booth Rockwell Chair in Biomedical Research
Lab URL: https://www.umassmed.edu/gaolab/
Summary: Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
preferred title: Chair and Professor

Tang, Qiushi
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last name: Tang
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Brown, Robert
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Person ID: 1239
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Neurosciences
Lab URL: https://www.umassmed.edu/brownlab/
Summary: Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
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Sena-Esteves, Miguel
first name: Miguel
last name: Sena-Esteves
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Summary: Dr. Esteves is a neuroscientist with interest in gene therapy to help treat neurodegenerative diseases.
preferred title: Associate Professor

Punzo, Claudio
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last name: Punzo
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Person ID: 1406
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Rotation Projects: Rotations We always welcome rotation students who are interested in learning more about the eye and the techniques the lab utilizes. Most rotation projects can be integrated into a Ph.D. thesis afterwards if the candidate desires to continue with this line of research. In my lab we use molecular biology, genetics, histology, virology and surgical procedures on mice to conduct our research. You will be working in an environment that is focused on translational research and gaining basic science knowledge on disease that affect vision in order to develop better therapeutic strategies to the currently available strategies. The goal of the lab is to move as quickly as possible from a basic science discovery to a therapeutic application. The basic science research the lab is conducting focuses around the role of metabolism and the Insulin/mTOR pathway in photoreceptors. Interested in a rotation? Email Dr. Punzo and ask if a project is currently available.
preferred title: Associate Professor

Kiernan, Michael
first name: Michael
last name: Kiernan
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Person ID: 1637
person in primary position: Adjunct Assistant Professor
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preferred title: Adjunct Assistant Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
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Person ID: 202
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Meyer, Theo
first name: Theo
last name: Meyer
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Shultz, Leonard
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last name: Shultz
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Lapane, Kate
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Person ID: 3252
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preferred title: Professor

Henninger, Nils
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last name: Henninger
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Person ID: 3265
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Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
preferred title: Associate Professor

Fitzgibbons, Timothy
first name: Timothy
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person in primary position: Associate Professor
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preferred title: Associate Professor

Xie, Jun
first name: Jun
last name: Xie
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Person ID: 3403
person in primary position: Associate Professor
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Summary: Focus: AAV vector technology and AAV-mediated miRNA therapeutics
preferred title: Associate Professor

Khvorova, Anastasia
first name: Anastasia
last name: Khvorova
full name: Anastasia Khvorova PhD
has faculty rank: Professor
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Person ID: 3413
person in primary position: Professor
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Endowed Chair Honorary Title: Remondi Family Chair in Biomedical Research
Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Aurigemma, Gerard
first name: Gerard
last name: Aurigemma
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Hayman, Laura
first name: Laura
last name: Hayman
full name: Laura L Hayman PhD
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Person ID: 3620
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
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Person ID: 3741
person in primary position: Department Head
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preferred title: Department Head

Donahue, J.
first name: J.
last name: Donahue
full name: J. Kevin Donahue MD
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latitude: 42.27721310000000
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Person ID: 3838
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: David J. and Barbara D. Milliken Professor in Preventive Cardiology
preferred title: Professor

Tisminetzky, Mayra
first name: Mayra
last name: Tisminetzky
full name: Mayra S Tisminetzky MPH, MD, PhD
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latitude: 42.27767280000000
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Person ID: 3857
person in primary position: Associate Professor
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Summary: Associate Professor in the Division of Geriatric Medicine in the Department of Medicine at UMMS Chan. Her research focuses on the magnitude, management, and clinical outcomes associated with the presence of multiple chronic conditions in older adults (MCC). I have been awarded a NIA RO1 grant to examine the treatment patterns of selected therapies in patients with heart failure and MCC.
preferred title: Associate Professor

Aronin, Neil
first name: Neil
last name: Aronin
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latitude: 42.27587600000000
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Person ID: 490
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Higgins Family Professor in Neuroscience
Rotation Projects: Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
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Person ID: 78
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Gounis, Matthew
first name: Matthew
last name: Gounis
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McManus, David
first name: David
last name: McManus
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Person ID: 994
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Anesthesiology and Perioperative Medicine
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UMass Chan – Baystate Regional Campus
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Shim, Jae-Hyuck
first name: Jae-Hyuck
last name: Shim
full name: Jae-Hyuck Shim PhD
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latitude: 42.27767280000000
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Person ID: 4421
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Post Docs: Sachin Ramdas
Post Docs: Aijaz John
Post Docs: Yeon-Suk Yang
Post Docs: Mi-Jeong Kim
Post Docs: Ji-Woong Kim
Post Docs: Eric M Kercher
Post Docs: Owen Odegard
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866423

Lagu, Tara
first name: Tara
last name: Lagu
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Gruntman, Alisha
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Silver, Brian
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Person ID: 4785
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Endowed Chair Honorary Title: Endowed Chair in Neuroscience Research
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Department Head
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Lindenauer, Peter
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Keeler-Klunk, Allison
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last name: Keeler-Klunk
full name: Allison May Keeler-Klunk PhD
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Person ID: 4941
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Lab URL: https://www.umassmed.edu/keelerlab
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Pack, Quinn
first name: Quinn
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Person ID: 5039
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Tai, Phillip
first name: Phillip
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Summary: Focus: Virology and vectorology of adeno-associated viruses
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Balsam, Leora
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Gray-Edwards, Heather
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webpage: https://profiles.umassmed.edu/profile/28866538

Alcusky, Matthew
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Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
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Gessler, Dominic
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Wilkie, Gianna
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Walkey, Allan
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Chalhoub, Fadi
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Medicine at UMass Chan - Lahey
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Health System Science
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Innate Immunity
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Professor
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Cardiac Anesthesiology
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Cardio Thoracic Surgery
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Stroke and Vascular Neurology
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Professor
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Dani, Sourbha
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Abu, Hawa
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Goldsweig, Andrew
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Maron, Martin
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Maron, Barry
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Reynolds, Matthew
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Rowin, Ethan
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Ganatra, Sarju
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Genetic and Cellular Medicine
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Adair, Jennifer
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Adjunct Professor
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Shin, Dong-Soo
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Associate Professor
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Karamnov, Sergey
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Kapoor, Alok
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Carneiro, Herman
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