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Molecular, Cell and Cancer Biology
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School of Public Health and Health Sciences
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Emergency Medicine
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Family Medicine and Community Health
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Medicine
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Pediatrics
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Psychology
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Cardiovascular Medicine
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Epidemiology
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Kinesiology
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Psychology And Neuroscience & Behavior Program
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Community Pediatrics
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Development & Behavioral Pediatrics
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Health Informatics And Implementation Science
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Preventive And Behavioral Medicine
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Biostatistics And Health Services Research
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College of Fine Arts, Humanities & Social Sciences
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UMass Chan Medical School
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University of Massachusetts Lowell
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University of Massachusetts Amherst
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Pagoto, Sherry
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last name: Pagoto
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Zhu, Lihua
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Weng, Zhiping
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Endowed Chair Honorary Title: Li Weibo Chair in Biomedical Research
Post Docs: The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
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Smelson, David
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Frazier, Jean
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Allison, Jeroan
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Kiefe, Catarina
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Boudreaux, Edwin
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Moormann, Ann
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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Ash, Arlene
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Barton, Bruce
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Person, Sharina
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Stanish, Heidi
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Lyons, Michael
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Rosen, Amy
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Lapane, Kate
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Hillier, Ashleigh
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Hayman, Laura
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Meyer, Jerrold
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Alhassan, Sofiya
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Spencer, Rebecca
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Rogaev, Evgeny
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
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Crawford, Sybil
first name: Sybil
last name: Crawford
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Person ID: 465
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Rosal, Milagros
first name: Milagros
last name: Rosal
full name: Milagros Rosal PhD
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Person ID: 594
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Endowed Chair Honorary Title: Imoigele P. Aisiku, MD’97 Chair in Health Equity and Diversity
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webpage: https://profiles.umassmed.edu/profile/28866430

Wolfe, Scot
first name: Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Lemon, Stephenie
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
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Bandini, Linda
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Curtin, Carol
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Goldberg, Robert
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Shaw, Leslie
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Moser, Richard
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McManus, David
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Pediatric Genetics
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Research
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UMass Chan – Baystate Regional Campus
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Lindenauer, Peter
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Liu, Shao-Hsien
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Gardiner, Paula
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Copeland, Laurel
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Griswold, Michele
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Strauss, Kevin
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Population and Quantitative Health Sciences
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Neurological Surgery
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Forrester, Sarah
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Post Docs: Isabelle Pierre-Louis, PhD (Former)
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Schlaug, Gottfried
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Bokhour, Barbara
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Lim, Elaine
first name: Elaine
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Twitter: https://profiles.umassmed.edu/profile/28867074
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Post Docs: Post-doc positions are available, please contact me via email.
Rotation Projects: Rotation projects are designed to aim to train students in both computational genetics/genomics and experimental technologies such as brain organoids. Please contact me via email to discuss.
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Sayej, Wael
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Garg, Arvin
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Gerber, Ben
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Broder-Fingert, Sarabeth
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Lin, Honghuang
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Adjunct Professor
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HR job title: Adjunct Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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HR job title: Associate Professor
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Assistant Professor
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Parker, Margaret
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Sheldrick, Radley
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Evans, Elizabeth
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Walkey, Allan
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Genomics and Computational Biology
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Medicine at UMass Chan - Lahey
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Adjunct Assistant Professor
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Professor
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Radiology at UMass Chan - Lahey
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Professor
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Chair and Professor
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Professor
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position in division: Biostatistics And Health Services Research
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Professor
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position in division: Biostatistics And Health Services Research
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Biostatistics And Health Services Research
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HR job title: Professor
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Professor
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HR job title: Professor
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Health System Science
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Infectious Diseases
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Innate Immunity
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Pulmonary Medicine
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Professor Emeritus
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Professor
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position in division: Epidemiology
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HR job title: Professor
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Professor
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Professor
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position in division: Epidemiology
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type: Position
HR job title: Professor
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Professor
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Associate Professor
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Professor
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HR job title: Professor
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Professor
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General Pediatrics
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Pediatric Neonatology
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Chair and Professor
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Professor
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Tan Chingfen Graduate School of Nursing
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Assistant Professor
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Frost, Kyle
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Person ID: 10247805
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Assistant Professor
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Professor
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Chair and Professor
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Martinez, Fernando
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Person ID: 10247895
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Krings, Timo
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Person ID: 10247952
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Associate Professor
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HR job title: Associate Professor
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Eche-Ugwu, Ijeoma
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last name: Eche-Ugwu
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Person ID: 10247962
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Assistant Professor
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Assistant Professor
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Grossman, Nicole
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Person ID: 10248100
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Maron, Martin
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
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Person ID: 10248130
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Adjunct Professor
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HR job title: Adjunct Professor
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Assistant Professor
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Associate Professor
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Chair and Professor
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Professor
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Professor Emeritus
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Research Professor
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Assistant Professor
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Associate Professor
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Chair And Professor
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Psychiatry and Behavioral Sciences
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Assistant Professor
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Professor
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Professor
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Professor
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Professor
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Professor Emeritus
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HR job title: Professor Emeritus
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Professor
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Professor
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Professor
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Professor
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Associate Professor
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position in division: Epidemiology
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HR job title: Associate Professor
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Associate Professor
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position in division: Development & Behavioral Pediatrics
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Crehan, Eileen
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Person ID: 10248470
person in primary position: Associate Professor
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Associate Professor
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HR job title: Associate Professor
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Professor
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Adjunct Professor
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Professor
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Associate Professor
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Professor
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Adjunct Professor
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