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Emergency Medicine
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Medicine
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Mello, Craig
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Tapper, Andrew
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Rando, Oliver
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Moore, Melissa
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preferred title: Professor

Zhu, Lihua
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Weng, Zhiping
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Post Docs: The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
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Ambros, Victor
first name: Victor
last name: Ambros
full name: Victor R Ambros PhD
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Gao, Guangping
first name: Guangping
last name: Gao
full name: Guangping Gao PhD
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Person ID: 1177
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Penelope Booth Rockwell Chair in Biomedical Research
Lab URL: https://www.umassmed.edu/gaolab/
Summary: Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
preferred title: Chair and Professor

Brown, Robert
first name: Robert
last name: Brown
full name: Robert H Brown MD, DPhil
has faculty rank: Professor
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Person ID: 1239
person in primary position: Professor
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Neurosciences
Lab URL: https://www.umassmed.edu/brownlab/
Summary: Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
preferred title: Professor

Harlan, David
first name: David
last name: Harlan
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Person ID: 1355
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Endowed Chair Honorary Title: William and Doris Krupp Professor in Medicine
preferred title: Professor

Kent, Sally
first name: Sally
last name: Kent
full name: Sally C Kent PhD
has faculty rank: Associate Professor
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preferred title: Associate Professor

Shaffer, Scott
first name: Scott
last name: Shaffer
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Person ID: 1425
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preferred title: Professor Emeritus
webpage: https://profiles.umassmed.edu/profile/28866549
webpage: https://profiles.umassmed.edu/profile/28866441

Mick, Eric
first name: Eric
last name: Mick
full name: Eric O Mick ScD
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Person ID: 1641
person in primary position: Associate Professor
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preferred title: Associate Professor

Luban, Jeremy
first name: Jeremy
last name: Luban
full name: Jeremy Luban MD
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Person ID: 1684
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Endowed Chair Honorary Title: David J. Freelander Memorial Professor in AIDS Research
Post Docs: PostDoc Position available
Rotation Projects: Lab rotation position is available
preferred title: Professor

Corvera, Silvia
first name: Silvia
last name: Corvera
full name: Silvia Corvera MD
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Person ID: 220
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Endowed Chair Honorary Title: Endowed Chair in Diabetes Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Corvera for additional details.
Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866593

Shultz, Leonard
first name: Leonard
last name: Shultz
full name: Leonard Donald Shultz PhD
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Greenough, Thomas
first name: Thomas
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Maehr, Rene
first name: Rene
last name: Maehr
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Post Docs: A postdoctoral position is available
Rotation Projects: A rotation project is available
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webpage: https://profiles.umassmed.edu/profile/28866422
webpage: https://profiles.umassmed.edu/profile/28866495

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Garber, Manuel
first name: Manuel
last name: Garber
full name: Manuel Garber PhD
has faculty rank: Professor
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Person ID: 3318
person in primary position: Professor
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Rotation Projects: If you are interesting in applying computational methods to biological problems please contact me. Potential projects in my lab are Modeling of transcription factor gene expression control in innate immune cells Evolutionary analysis of gene transcription factor networks in mammals Epigenetics inheritance in mice: From male sperm to phenotypic effect in grandchildren Application of genome and exome sequencing to newborn screening Development of computational methods for analysis of RNA-protein interactions
preferred title: Professor

Xie, Jun
first name: Jun
last name: Xie
full name: Jun Xie PhD
has faculty rank: Associate Professor
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Person ID: 3403
person in primary position: Associate Professor
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Summary: Focus: AAV vector technology and AAV-mediated miRNA therapeutics
preferred title: Associate Professor

Dominov, Janice
first name: Janice
last name: Dominov
full name: Janice A Dominov PhD
has faculty rank: Assistant Professor
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Person ID: 3435
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Summary: Investigates neuromuscular disease with an emphasis on muscular dystrophies, cell death mechanisms, inflammatory pathway regulation and therapeutics for muscular dystrophies.
preferred title: Assistant Professor

Lifshitz, Lawrence
first name: Lawrence
last name: Lifshitz
full name: Lawrence Lifshitz PhD
has faculty rank: Associate Professor
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Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 418
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Houghton, Jeanmarie
first name: Jeanmarie
last name: Houghton
full name: Jeanmarie Houghton MD, PhD
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preferred title: Professor

Rittenhouse, Ann
first name: Ann
last name: Rittenhouse
full name: Ann R Rittenhouse PhD
has faculty rank: Associate Professor
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Person ID: 485
person in primary position: Associate Professor
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Lab URL: https://www.umassmed.edu/maps/research-labs/rittenhouse/
Rotation Projects: Rotation Projects Please contact me if you are interested in hearing more about current lab projects and potential rotation projects: ann.rittenhouse@umassmed.edu.
Summary: Focus: Voltage-Gated Calcium channels and neuronal plasticity
preferred title: Associate Professor

Wolfe, Scot
first name: Scot
last name: Wolfe
full name: Scot Wolfe PhD
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latitude: 42.27587600000000
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Person ID: 595
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
preferred title: Professor

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
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Brodsky, Michael
first name: Michael
last name: Brodsky
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has faculty rank: Assistant Professor
latitude: 42.27587600000000
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Person ID: 640
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Brodsky for additional details.
Rotation Projects: Potential Rotation Projects We are utilizing a variety of technologies to study p53 regulation and function in Drosophila. These include genetic screens, molecular biology, fluorescence and scanning electron microscopy, tissue culture, RNAi, homologous recombination, and others. Rotation projects in this lab will be determined based on a combination of the student's and PI's interests. Possible projects are listed below: Project 1: A genetic screen for new regulators of Drosophila p53. Project 2: Using RNAi and homologous recombination to study regulators of p53. Project 3: Characterization of p53 activation in Drosophila tissue culture cells by flurescence microscopy, Real-Time PCR, and RNAi. Project 4: Genetic analysis of Drosophila p53 targets identified in microarray experiments.
preferred title: Assistant Professor

Basadonna, Giacomo
first name: Giacomo
last name: Basadonna
full name: Giacomo P. Basadonna MD, PhD
has faculty rank: Professor Emeritus
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Lawson, Nathan
first name: Nathan
last name: Lawson
full name: Nathan Lawson PhD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 755
person in primary position: Professor
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Rotation Projects: Rotation Projects Please contact Nathan Lawson (nathan.lawson@umassmed.edu) for information regarding potential rotation projects. For information concerning recent research in the lab, please see:lawsonlab.umassmed.edu/research.html
preferred title: Professor

Walhout, Marian
first name: Marian
last name: Walhout
full name: Marian Walhout PhD
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Endowed Chair Honorary Title: Maroun Semaan Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Please contact Dr. Walhout for additional details.
preferred title: Chair and Professor

Wang, Jennifer
first name: Jennifer
last name: Wang
full name: Jennifer Wang MD
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latitude: 42.27985300000000
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Kennedy, Norman
first name: Norman
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Dickson, Eric
first name: Eric
last name: Dickson
full name: Eric W Dickson MD, MHCM
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Cahan, Mitchell
first name: Mitchell
last name: Cahan
full name: Mitchell A Cahan MD
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UMass Chan – Baystate Regional Campus
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Koupenova, Milka
first name: Milka
last name: Koupenova
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Person ID: 4386
person in primary position: Assistant Professor
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Lab URL: https://www.umassmed.edu/koupenovalab
Summary: Research in Dr. Koupenova's lab focuses on the contribution of platelets to the immune response during viral infection and the consequent implications of that response to cardiovascular disease. For additional information about projects or joining the lab, contact Dr. Koupenova @ milka.koupenova@umassmed.edu
preferred title: Assistant Professor

Blodgett, David
first name: David
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Shin, Masahiro
first name: Masahiro
last name: Shin
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Trombly, Melanie
first name: Melanie
last name: Trombly
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Organ Transplantation
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Wang, Dan
first name: Dan
last name: Wang
full name: Dan Wang PhD
has faculty rank: Assistant Professor
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Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
preferred title: Assistant Professor
webpage: https://profiles.umassmed.edu/profile/28866581
webpage: https://profiles.umassmed.edu/profile/28866425
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Population and Quantitative Health Sciences
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Biochemistry and Molecular Biotechnology
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Genomics and Computational Biology
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Innate Immunity
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Professor
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Professor Emeritus
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Microbiology
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Instructor
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Professor
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Professor Emeritus
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Assistant Professor
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Associate Professor
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Chair And Professor
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Distinguished Professor
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Professor
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Adjunct Assistant Professor
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Professor
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Professor
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Associate Professor
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Associate Professor
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Assistant Professor
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Genetic and Cellular Medicine
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Professor
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Chair and Professor
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Chair and Professor
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Distinguished Professor
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Professor
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Associate Professor
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Chair and Professor
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Assistant Professor
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Yu, Tianxiong
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