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Health Informatics And Implementation Science
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Biostatistics And Health Services Research
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UMass Chan Medical School
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University of Massachusetts Amherst
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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Gaspari, Romolo
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Shaw, Leslie
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UMass Chan – Baystate Regional Campus
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https://profiles.umassmed.edu/profile/28867032
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Emergency Medicine at UMass Chan - Baystate
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Radiology at UMass Chan - Baystate
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Surgery at UMass Chan - Baystate
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Professor
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Professor
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Professor
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Sheldrick, Radley
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Adjunct Professor
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Driban, Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
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Professor
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Walkey, Allan
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Professor
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Professor
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Administrative Leadership
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Ultrasound
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Mosenthal, Anne
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Emergency Medicine at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA Current State of the OAI & Intro to the Knowledgebase
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Current State of the OAI & Intro to the Knowledgebase The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Current State of the OAI & Intro to the Knowledgebase Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Current State of the OAI & Intro to the Knowledgebase Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Current State of the OAI & Intro to the Knowledgebase Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury Current State of the OAI & Intro to the Knowledgebase Playing the Long Game: Consensus for Preventing OA Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Current State of the OAI & Intro to the Knowledgebase Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Current State of the OAI & Intro to the Knowledgebase Preventing Osteoarthritis After an ACL Injury Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
ProfilesRNS Plugin Searchable Data: Current State of the OAI & Intro to the Knowledgebase Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA

Professor
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Radiology at UMass Chan - Lahey
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Chair and Professor
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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Professor
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Adjunct Professor
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Professor
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Professor
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General Pediatrics
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Stroke and Vascular Neurology
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Chair and Professor
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Geissler, Kimberley
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Professor Emeritus
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McAlindon, Timothy
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Martinez, Fernando
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Professor
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Professor Emeritus
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Krings, Timo
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Goldsmith, Andrew
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Maron, Martin
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Maron, Barry
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Professor
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Reynolds, Matthew
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Rowin, Ethan
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Associate Professor
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Psychiatry and Behavioral Sciences
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Professor Emeritus
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Professor
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Adjunct Professor
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Shin, Dong-Soo
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Associate Professor
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Professor
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Professor
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Adjunct Professor
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Professor
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Associate Professor
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