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linked information resource: Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.

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linked information resource: Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.

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linked information resource: Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection.

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linked information resource: Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.

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linked information resource: Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.

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linked information resource: The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs.

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linked information resource: C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo.

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linked information resource: Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility.

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linked information resource: Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.

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linked information resource: Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.

Authorship 146299
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linked information resource: Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells.

Authorship 146305
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linked information resource: Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

Authorship 146310
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linked author: Finethy, Ryan
linked information resource: Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.

Authorship 146314
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linked author: Finethy, Ryan
linked information resource: Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.

Authorship 146315
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linked information resource: Copper tolerance in Frankia sp. strain EuI1c involves surface binding and copper transport.

Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.
PubMed Identifier: 30967464
author list: Giebel AM, Hu S, Rajaram K, Finethy R, Toh E, Brothwell JA, Morrison SG, Suchland RJ, Stein BD, Coers J, Morrison RP, Nelson DE
published in: mBio
information resource reference: Giebel AM, Hu S, Rajaram K, Finethy R, Toh E, Brothwell JA, Morrison SG, Suchland RJ, Stein BD, Coers J, Morrison RP, Nelson DE. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. mBio. 2019 04 09; 10(2).
journal title abbreviation: mBio
publication date: 2019-04-09T00:00:00
year: 2019
type: Academic Article
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Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility.
PubMed Identifier: 29233899
author list: Piro AS, Hernandez D, Luoma S, Feeley EM, Finethy R, Yirga A, Frickel EM, Lesser CF, Coers J
published in: mBio
information resource reference: Piro AS, Hernandez D, Luoma S, Feeley EM, Finethy R, Yirga A, Frickel EM, Lesser CF, Coers J. Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. mBio. 2017 12 12; 8(6).
journal title abbreviation: mBio
publication date: 2017-12-12T00:00:00
year: 2017
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Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.
PubMed Identifier: 28193861
author list: Feeley EM, Pilla-Moffett DM, Zwack EE, Piro AS, Finethy R, Kolb JP, Martinez J, Brodsky IE, Coers J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Feeley EM, Pilla-Moffett DM, Zwack EE, Piro AS, Finethy R, Kolb JP, Martinez J, Brodsky IE, Coers J. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1698-E1706.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2017-02-13T00:00:00
year: 2017
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Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.
PubMed Identifier: 28201690
author list: Finethy R, Coers J
published in: FEMS microbiology reviews
information resource reference: Finethy R, Coers J. Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis. FEMS Microbiol Rev. 2016 11 01; 40(6):875-893.
journal title abbreviation: FEMS Microbiol Rev
publication date: 2016-11-01T00:00:00
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Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
PubMed Identifier: 27965446
author list: Haldar AK, Piro AS, Finethy R, Espenschied ST, Brown HE, Giebel AM, Frickel EM, Nelson DE, Coers J
published in: mBio
information resource reference: Haldar AK, Piro AS, Finethy R, Espenschied ST, Brown HE, Giebel AM, Frickel EM, Nelson DE, Coers J. Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. mBio. 2016 12 13; 7(6).
journal title abbreviation: mBio
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The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs.
PubMed Identifier: 28041929
author list: Sixt BS, Bastidas RJ, Finethy R, Baxter RM, Carpenter VK, Kroemer G, Coers J, Valdivia RH
published in: Cell host & microbe
information resource reference: Sixt BS, Bastidas RJ, Finethy R, Baxter RM, Carpenter VK, Kroemer G, Coers J, Valdivia RH. The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. Cell Host Microbe. 2017 Jan 11; 21(1):113-121.
journal title abbreviation: Cell Host Microbe
publication date: 2016-12-29T00:00:00
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
PubMed Identifier: 26416908
author list: Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J
published in: Infection and immunity
information resource reference: Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. Infect Immun. 2015 Dec; 83(12):4740-9.
journal title abbreviation: Infect Immun
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Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.
PubMed Identifier: 26417105
author list: Haldar AK, Foltz C, Finethy R, Piro AS, Feeley EM, Pilla-Moffett DM, Komatsu M, Frickel EM, Coers J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Haldar AK, Foltz C, Finethy R, Piro AS, Feeley EM, Pilla-Moffett DM, Komatsu M, Frickel EM, Coers J. Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):E5628-37.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-09-28T00:00:00
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Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells.
PubMed Identifier: 25184567
author list: Furuse Y, Finethy R, Saka HA, Xet-Mull AM, Sisk DM, Smith KL, Lee S, Coers J, Valdivia RH, Tobin DM, Cullen BR
published in: PloS one
information resource reference: Furuse Y, Finethy R, Saka HA, Xet-Mull AM, Sisk DM, Smith KL, Lee S, Coers J, Valdivia RH, Tobin DM, Cullen BR. Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells. PLoS One. 2014; 9(9):e106434.
journal title abbreviation: PLoS One
publication date: 2014-09-03T00:00:00
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Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.
PubMed Identifier: 33124745
author list: Finethy R, Dockterman J, Kutsch M, Orench-Rivera N, Wallace GD, Piro AS, Luoma S, Haldar AK, Hwang S, Martinez J, Kuehn MJ, Taylor GA, Coers J
published in: EMBO reports
information resource reference: Finethy R, Dockterman J, Kutsch M, Orench-Rivera N, Wallace GD, Piro AS, Luoma S, Haldar AK, Hwang S, Martinez J, Kuehn MJ, Taylor GA, Coers J. Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020 11 05; 21(11):e50830.
journal title abbreviation: EMBO Rep
publication date: 2020-10-30T00:00:00
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Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.
PubMed Identifier: 30335469
author list: Ajayi TA, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB
published in: American journal of physiology. Gastrointestinal and liver physiology
information resource reference: Ajayi TA, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB. Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues. Am J Physiol Gastrointest Liver Physiol. 2019 01 01; 316(1):G95-G105.
journal title abbreviation: Am J Physiol Gastrointest Liver Physiol
publication date: 2018-10-18T00:00:00
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C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo.
PubMed Identifier: 31544161
author list: Clough B, Finethy R, Khan RT, Fisch D, Jordan S, Patel H, Coers J, Frickel EM
published in: Wellcome open research
information resource reference: Clough B, Finethy R, Khan RT, Fisch D, Jordan S, Patel H, Coers J, Frickel EM. C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo. Wellcome Open Res. 2019; 4:124.
journal title abbreviation: Wellcome Open Res
publication date: 2019-08-20T00:00:00
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Copper tolerance in Frankia sp. strain EuI1c involves surface binding and copper transport.
PubMed Identifier: 24903815
author list: Rehan M, Furnholm T, Finethy RH, Chu F, El-Fadly G, Tisa LS
published in: Applied microbiology and biotechnology
information resource reference: Rehan M, Furnholm T, Finethy RH, Chu F, El-Fadly G, Tisa LS. Copper tolerance in Frankia sp. strain EuI1c involves surface binding and copper transport. Appl Microbiol Biotechnol. 2014 Sep; 98(18):8005-15.
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
PubMed Identifier: 28974614
author list: Finethy R, Luoma S, Orench-Rivera N, Feeley EM, Haldar AK, Yamamoto M, Kanneganti TD, Kuehn MJ, Coers J
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information resource reference: Finethy R, Luoma S, Orench-Rivera N, Feeley EM, Haldar AK, Yamamoto M, Kanneganti TD, Kuehn MJ, Coers J. Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. mBio. 2017 10 03; 8(5).
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Gastroenterology
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T.H. Chan School of Medicine
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UMass Chan Medical School
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Latz, Eicke
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Fitzgerald, Katherine
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Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
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Heneka, Michael
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Golenbock, Douglas
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Sassetti, Christopher
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Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
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position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Microbiology
type: Department
type: Organization

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
sort order: 17
type: Faculty Rank

Professor
sort order: 3
type: Faculty Rank

Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection.
PubMed Identifier: 39955299
author list: Pullen KM, Finethy R, Ko SB, Reames CJ, Sassetti CM, Lauffenburger DA
published in: NPJ systems biology and applications
information resource reference: Pullen KM, Finethy R, Ko SB, Reames CJ, Sassetti CM, Lauffenburger DA. Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection. NPJ Syst Biol Appl. 2025 Feb 15; 11(1):19.
journal title abbreviation: NPJ Syst Biol Appl
publication date: 2025-02-15T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource