Molly McGovern Chair in Biomedical Research
There are a variety of rotation projects that use a variety of imaging and biochemical techniques to assess microglial function in the CNS. The main projects are highlighted below. 1. Dissecting novel molecular mechanisms underlying microglial function at synapses. 2. Exploring new roles for microglia in the spread of neuroinflammation in neurological disease. 3. Identifying novel ways microglia regulate other glial cell populations (astrocytes and oligodendrocytes) in the CNS.
Dr. Eileen L. Berman and Stanley I. Berman Foundation Chair in Biomedical Research
School of Public Health and Health Sciences
Health Informatics And Implementation Science
Biostatistics And Health Services Research
Dr. Ionete is a clinical neuroimmunologist and educator with special interests including clinical trials in multiple sclerosis and other autoimmune neurological diseases, and neurological complications of HIV infections. She chairs the Department of Neurology's education committee.
A postdoctoral position is available to study in this laboratory. Clickhereto apply.
<p >Rotations <p >Potential rotations <p >1. To examine how TCR affinity and specificity for MHC + peptide influences the development and activation of CD4 T cells. <p >2. To assess the impact of self tolerance on the specificity, affinity and pathogenic potential of T cells reactive to proteins expressed in the central nervous system and b-islet cells of the pancreas.
Elisabeth Chair for the Dean of Medicine
Penelope Booth Rockwell Chair in Biomedical Research
Focus: Adeno-associated virus vector mediated gene transfer for gene therapy, gene therapy of inherited neurodegenerative Canavan Disease
Dr. Esteves is a neuroscientist with interest in gene therapy to help treat neurodegenerative diseases.
Governor Paul Cellucci Chair in Neuroscience Research
Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
A Postdoctoral position is available in the Trivedi lab to study roles of novel chromatin and epigenetic modifications during cardiovascular development and disease (for details of our research: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). Candidates with a PhD in Biochemistry, Molecular Biology, Stem Cell Biology or Developmental Biology are encouraged to apply. Previous experience with mice handling and biochemistry-molecular biology-epigenetics related techniques such as ChIP-seq is strongly desired. Candidate will be required to learn new techniques in the area of translational biology to advance their project.
Rotation Projects: Please contact Chinmay Trivedi (chinmay.trivedi@umassmed.edu) for information regarding potential rotation projects (for details - research performed by graduate students in the trivedi lab: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, JCI Insight, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). We will develop a specific rotation project based on student's interest, background, and goals of the rotation. Students can rotate either for a half- or full-semester.
Worcester Foundation for Biomedical Research Chair III
Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
One rotation student is expected in the lab to characterize the expression and function of Drosophila gustatory receptor 28b (Gr28b) in phototransduction and taste sensation. Please contact Dr. Yang Xiang for details.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p> <o:p> </o:p> Yang Xiang, Ph.D. University of Massachusetts Medical School Department of Neurobiology, LRB 725 364 Plantation Street Worcester, MA 01605 USA phone: 508-856-6816 (office) e-mail: yang.xiang@umassmed.edu<o:p></o:p>
Remondi Family Chair in Biomedical Research
POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
Rotation Projects Please contact Nathan Lawson (nathan.lawson@umassmed.edu) for information regarding potential rotation projects. For information concerning recent research in the lab, please see:lawsonlab.umassmed.edu/research.html
Richard M. Haidack Professor in Medicine
Idanis Berrios Morales, MD, is a board-certified neurologist and educator with clinical subspecialty training in neuroimmunology and multiple sclerosis. Her research interest is shared decision making in patients with multiple sclerosis.
There is a current project opening for using deep learning to train and ultimately perform automatic segmentation for multiple brain structures of interest in Multiple Sclerosis. Helpful background would include some proficiency in shell and Python. Please email me if interested.
Dr. Hemond is a board-certified neurologist with clinical subspecialty training in neuroimmunology and multiple sclerosis. His research focuses on the development and validation of MRI-based biomarkers to improve (1) early identification and (2) pathophysiological understanding of the neurodegenerative processes underlying MS.
Population and Quantitative Health Sciences
Biochemistry and Molecular Biotechnology
https://www.umassmed.edu/globalassets/radiology/documents/King-Graduate Student-Training-UpTo-2020.pdf
List of Graduate Students and Post-Doctoral Fellows
Physics Review for Radiology Residents Taking the ABR Exam
Nuclear Medicine Physics Imaging Laboratory
Healthcare Delivery and Population Sciences at UMass Chan - Baystate
Preventing Osteoarthritis After an ACL Injury
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA Current State of the OAI & Intro to the Knowledgebase
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Current State of the OAI & Intro to the Knowledgebase The Inverse OARSI-OMERACT Criteria for Knee OA
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Current State of the OAI & Intro to the Knowledgebase Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Current State of the OAI & Intro to the Knowledgebase Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
Preventing Osteoarthritis After an ACL Injury Current State of the OAI & Intro to the Knowledgebase Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis Earlier Than Early Osteoarthritis (OA): Pre-OA Illness The Inverse OARSI-OMERACT Criteria for Knee OA
Preventing Osteoarthritis After an ACL Injury Current State of the OAI & Intro to the Knowledgebase Playing the Long Game: Consensus for Preventing OA Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
Current State of the OAI & Intro to the Knowledgebase Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
Current State of the OAI & Intro to the Knowledgebase Preventing Osteoarthritis After an ACL Injury Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
Current State of the OAI & Intro to the Knowledgebase Earlier Than Early Osteoarthritis (OA): Pre-OA Illness Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis The Inverse OARSI-OMERACT Criteria for Knee OA
Joseph D. Early Chair in Biomedical Research
Alan Charles Hartford MD, PhD, FACR, FASTRO