Psychology And Neuroscience & Behavior Program
Health Informatics And Implementation Science
Elisabeth Chair for the Dean of Medicine
Robert M. and Shirley S. Siff Chair in Autism
Dr. Strambio-De-Castillia (ORCID: https://orcid.org/0000-0002-1069-1816) is an internationally recognized cell biologist and imaging scientist who specializes in developing easy-to-use and openly accessible strategies for image data management and sharing to promote scientific discovery in health and disease.
Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
Richard M. Haidack Professor in Medicine
There is a current project opening for using deep learning to train and ultimately perform automatic segmentation for multiple brain structures of interest in Multiple Sclerosis. Helpful background would include some proficiency in shell and Python. Please email me if interested.
Dr. Hemond is a board-certified neurologist with clinical subspecialty training in neuroimmunology and multiple sclerosis. His research focuses on the development and validation of MRI-based biomarkers to improve (1) early identification and (2) pathophysiological understanding of the neurodegenerative processes underlying MS.
Population and Quantitative Health Sciences
The Yemini Lab investigates how nervous systems change during development and evolution to generate new behaviors. We use cutting-edge tools and a multiscale systems-biology approach to study the genes, circuitry, and neural activity driving behavioral changes. Our findings provide a foundation to understand normal brain development and brain disorders (e.g., autism and intellectual disabilities).
https://www.umassmed.edu/globalassets/radiology/documents/King-Graduate Student-Training-UpTo-2020.pdf
List of Graduate Students and Post-Doctoral Fellows
Physics Review for Radiology Residents Taking the ABR Exam
Nuclear Medicine Physics Imaging Laboratory
Emergency Medicine at UMass Chan - Baystate
Healthcare Delivery and Population Sciences at UMass Chan - Baystate
In Living Color: Whole-Nervous-System Cell IDs
Dr. Edmiston's research focuses on bottom-up sensory perception in people with or at risk for mood and anxiety disorders. He uses neuroimagingand neuromodulation techniques to assess the function of the ventral visual stream during emotion and novelty perception in children, adolescents, and young adults. Dr. Edmiston has secondary interests in transgender health education and healthcare access.
Worcester Foundation for Biomedical Research Chair I
Preventing Osteoarthritis After an ACL Injury
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA
Preventing Osteoarthritis After an ACL Injury Playing the Long Game: Consensus for Preventing OA Characteristics of Accelerated Hand Osteoarthritis
Joseph D. Early Chair in Biomedical Research
4DN-BINA-OME (NBO) Microscopy Metadata Specifications landing page
2025 BINA Community Congress Presentation
Presentation at BINA 2025 Community Congress
Presentation at BINA 2024 Community Congress
Presentation at BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress FocalPlane features... data managent webinar
Presentation at the BINA 2024 Community Congress FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress FoundingGIDE: BioImage DMS for Everyone
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress OME 2025 | Session 1 - Pre-publication BioImage DMS
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone OME 2025 | Session 1 - Pre-publication BioImage DMS Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar OME 2025 | Session 1 - Pre-publication BioImage DMS FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
OME 2025 | Session 1 - Pre-publication BioImage DMS FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
OME 2025 | Pre-publication BioImage Data Management and Sharing FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress