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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Miron, Patricia
first name: Patricia
last name: Miron
full name: Patricia M Miron PhD
has faculty rank: Professor
latitude: 42.27635970000000
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Person ID: 1531
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

He, Feng
first name: Feng
last name: He
full name: Feng He PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
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photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 188
person in primary position: Associate Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/maps/research-labs/he/
Summary: Focus: Post-transcriptional gene regulation in eukaryotes
preferred title: Associate Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
has faculty rank: Professor
latitude: 42.27985300000000
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photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 202
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Khan, Ashraf
first name: Ashraf
last name: Khan
full name: Ashraf Khan MD
has faculty rank: Chair And Professor
latitude: 42.12294230000000
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Person ID: 203
person in primary position: Chair and Professor
type: Agent
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preferred title: Chair and Professor

Lyons, Michael
first name: Michael
last name: Lyons
full name: Michael John Lyons MD
has faculty rank: Assistant Professor
latitude: 42.54128260000000
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Person ID: 2597
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Fischer, Andrew
first name: Andrew
last name: Fischer
full name: Andrew H Fischer MD
has faculty rank: Professor Emeritus
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Person ID: 284
person in primary position: Professor Emeritus
type: Agent
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preferred title: Professor Emeritus

Lapane, Kate
first name: Kate
last name: Lapane
full name: Kate L Lapane PhD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 3252
person in primary position: Professor
type: Agent
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preferred title: Professor

Woda, Bruce
first name: Bruce
last name: Woda
full name: Bruce A Woda MD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 328
person in primary position: Professor
type: Agent
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preferred title: Professor

Rock, Kenneth
first name: Kenneth
last name: Rock
full name: Kenneth L Rock MD
has faculty rank: Chair And Professor
latitude: 42.27525000000000
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Person ID: 332
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: UMass Chan Medical School Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
preferred title: Chair and Professor

Epstein, Mara
first name: Mara
last name: Epstein
full name: Mara Meyer Epstein ScD, ScM
has faculty rank: Associate Professor
latitude: 42.27767280000000
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Person ID: 3469
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
longitude: -71.76564740000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 36
person in primary position: Adjunct Professor
type: Agent
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
longitude: -71.76070940000000
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Person ID: 370
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Arcaro, Kathleen
first name: Kathleen
last name: Arcaro
full name: Kathleen F Arcaro PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
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Person ID: 3726
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Spencer, Rebecca
first name: Rebecca
last name: Spencer
full name: Rebecca Spencer PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3797
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Wolf, Greg
first name: Greg
last name: Wolf
Twitter: https://profiles.umassmed.edu/profile/28867023
full name: Greg Wolf
has faculty rank: Other
latitude: 42.28346030000000
longitude: -71.72665900000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3864
person in primary position: Chief Information Officer
type: Agent
type: Person
preferred title: Chief Information Officer
webpage: https://profiles.umassmed.edu/profile/28866533

Lawrence, Jeanne
first name: Jeanne
last name: Lawrence
Featured Videos: https://profiles.umassmed.edu/profile/28867178
full name: Jeanne B Lawrence PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 399
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Leo P. and Theresa M. LaChance Chair in Medical Research
Lab URL: https://www.umassmed.edu/lawrencelab
Summary: Lawrence lab research bridges fundamental questions of developmental epigenetics with translational research into the common problem of chromosome abnormalities, particularly Down syndrome.
preferred title: Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 418
person in primary position: Chair and Professor
type: Agent
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 507
person in primary position: Professor
type: Agent
type: Person
Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 78
person in primary position: Professor Emeritus
type: Agent
type: Person
preferred title: Professor Emeritus

Cosar, Ediz
first name: Ediz
last name: Cosar
full name: Ediz F Cosar MD
has faculty rank: Associate Professor
latitude: 42.27222560000000
longitude: -71.79196510000000
Person ID: 794
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 901
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

Ryder, Sean
first name: Sean
last name: Ryder
Twitter: https://profiles.umassmed.edu/profile/28867044
full name: Sean P Ryder PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 942
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects A variety of rotation projects are available to study RNP assembly and post-transcriptional regulation during development using quantitative biochemical and modern molecular methods. Project 1: Characterization of the RNA-protein complexes that guide C. elegans early development. Several projects ranging in scope from biochemical characterization of RNA-binding protein complexes to genetic dissection of RNA binding protein function in development are currently available. Contact Sean for more details. Project 2: Post-transcriptional regulation of oligodendrocyte differentiation. Projects are available to monitor changes in gene expression as a function of differentiation with a focus on changes in alternative splicing and mRNA stability. Contact Sean for more details.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866432

Cataltepe, Oguz
first name: Oguz
last name: Cataltepe
full name: Oguz I Cataltepe MD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 985
person in primary position: Professor
type: Agent
type: Person
preferred title: Professor

McManus, David
first name: David
last name: McManus
full name: David D McManus MD
has faculty rank: Chair And Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 994
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
preferred title: Chair and Professor

Pediatric Genetics
type: Division
type: Organization

UMass Chan – Baystate Regional Campus
type: Organization

Otis, Christopher
first name: Christopher
last name: Otis
full name: Christopher N Otis MD
has faculty rank: Professor Emeritus
latitude: 42.12294230000000
longitude: -72.60372970000000
Person ID: 4468
person in primary position: Professor Emeritus
type: Agent
type: Person
preferred title: Professor Emeritus

Associate Professor
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position in department: College of Natural Sciences
position in division: Psychology And Neuroscience & Behavior Program
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Garg, Arvin
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Professor
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Professor
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Assistant Professor
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Chief Information Officer
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Parker, Margaret
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Weiss, Glen
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Hemming, Matthew
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Stevenson, Brian
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Sheldrick, Radley
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Dadras, Soheil
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Professor
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Professor
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Laus, Ana
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Genomics and Computational Biology
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Medicine at UMass Chan - Lahey
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Pulmonary Medicine
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General Pediatrics
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Geissler, Kimberley
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Professor
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Professor
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Martinez, Fernando
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Microbiology
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Krings, Timo
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Perrino, Carmen
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Maron, Barry
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Gregory, Richard
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Carrasquillo, Robert
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Chair and Professor
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Shin, Dong-Soo
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Professor
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