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Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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Luban, Jeremy
first name: Jeremy
last name: Luban
full name: Jeremy Luban MD
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Person ID: 1684
person in primary position: Professor
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Endowed Chair Honorary Title: David J. Freelander Memorial Professor in AIDS Research
Post Docs: PostDoc Position available
Rotation Projects: Lab rotation position is available
preferred title: Professor

Silk, Hugh
first name: Hugh
last name: Silk
full name: Hugh J Silk MD
has faculty rank: Professor
latitude: 42.28551490000000
longitude: -71.79048800000000
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Person ID: 178
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preferred title: Professor

Czech, Michael
first name: Michael
last name: Czech
full name: Michael Paul Czech PhD
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Person ID: 289
person in primary position: Professor Emeritus
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type: Person
Endowed Chair Honorary Title: Isadore and Fannie Foxman Chair in Medical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
preferred title: Professor Emeritus

Rosen, Amy
first name: Amy
last name: Rosen
full name: Amy K Rosen PhD
has faculty rank: Professor
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Person ID: 3040
person in primary position: Professor
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preferred title: Professor

Theurkauf, William
first name: William
last name: Theurkauf
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Person ID: 306
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Theurkauf for additional details.
Rotation Projects: Rotation Projects Proper control of cell division and accurate chromosome segregation are fundamental to cell function and normal development. Chromosome segregation errors lead to birth defects, and abnormal cell division control is associated with essentially all cancers. A major aim of research in the laboratory is to understand cell cycle control and chromosome segregation mechanisms. We use a combination of classical and molecular genetics, high-resolution in vivo imaging, and biochemical techniques to define pathways that control the cell cycle and chromosome segregation in response to environmental insult (DNA damaging agents) and developmental queues. Rotation projects focus on the role of cell cycle checkpoint and tumor suppressor pathways during the earliest stages of embryogenesis, and cell cycle control of actin and microtubule reorganization during mitosis. Through these projects, students gain exposure of the art in vivo imaging and genetic and molecular manipulations of gene function to define pathways controlling cell division and chromosome segregation. Embryonic Patterning Essentially all cells are asymmetric, with structurally distinct surfaces and polarized internal organization. This asymmetry is essential to the specialized functions cells serve within complex multi-cellular organisms . A second area of interest focuses on the mechanisms that establish cellular asymmetry. In Drosophila, the embryonic axes are specified during oogenesis through the asymmetric localization of key morphogenetic molecules within the developing oocyte. We use axis specification in the fly as a model for the processes that establish cellular asymmetry. An intact microtubule network is essential to axis specification in the fly oocyte and to polarization of somatic. We hope to define the molecular functions for microtubules in establishing cellular asymmetry. We are currently using in vivo imaging techniques to directly characterize the microtubule dependent mRNA tran…
preferred title: Professor

Lapane, Kate
first name: Kate
last name: Lapane
full name: Kate L Lapane PhD
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Person ID: 3252
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preferred title: Professor

Puri, Ajit
first name: Ajit
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Person ID: 3253
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preferred title: Professor

Henninger, Nils
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full name: Nils Henninger MD, PhD
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Person ID: 3265
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Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
preferred title: Associate Professor

Khvorova, Anastasia
first name: Anastasia
last name: Khvorova
full name: Anastasia Khvorova PhD
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Person ID: 3413
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Endowed Chair Honorary Title: Remondi Family Chair in Biomedical Research
Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Hayman, Laura
first name: Laura
last name: Hayman
full name: Laura L Hayman PhD
has faculty rank: ADJUNCT PROFESSOR
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Person ID: 3620
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Chandler, Genevieve
first name: Genevieve
last name: Chandler
full name: Genevieve E Chandler PhD. RN
has faculty rank: Associate Professor
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Person ID: 3713
person in primary position: Associate Professor
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preferred title: Associate Professor

Bertone-Johnson, Elizabeth
first name: Elizabeth
last name: Bertone-Johnson
full name: Elizabeth R Bertone-Johnson ScD SM
has faculty rank: Associate Professor
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Person ID: 3724
person in primary position: Associate Professor
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preferred title: Associate Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
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Person ID: 3741
person in primary position: Department Head
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preferred title: Department Head

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 418
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
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Aronin, Neil
first name: Neil
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Person ID: 490
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Higgins Family Professor in Neuroscience
Rotation Projects: Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
preferred title: Professor

Morrison, Trudy
first name: Trudy
last name: Morrison
full name: Trudy G Morrison PhD
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Person ID: 525
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Lab URL: https://www.umassmed.edu/maps/research-labs/morrison/
Summary: Focus: Paramyxovirus and Pneumovirius membrane fusion and virus assembly, virus vaccines
preferred title: Professor

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Gounis, Matthew
first name: Matthew
last name: Gounis
full name: Matthew J Gounis PhD
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Person ID: 986
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preferred title: Professor

McManus, David
first name: David
last name: McManus
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Person ID: 994
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
preferred title: Chair and Professor

Watts, Jonathan
first name: Jonathan
last name: Watts
full name: Jonathan K Watts PhD
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Person ID: 4224
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Janardhana, Priya
first name: Priya
last name: Janardhana
full name: Priya M Janardhana MD
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Person ID: 4244
person in primary position: Assistant Professor
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preferred title: Assistant Professor

Friedmann, Peter
first name: Peter
last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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Person ID: 4333
person in primary position: Professor
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preferred title: Professor

UMass Chan – Baystate Regional Campus
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Schaal, Shlomit
first name: Shlomit
last name: Schaal
full name: Shlomit Schaal MD, PhD
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Person ID: 4423
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preferred title: Professor

Associate Professor
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Associate Professor
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Department Head
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Lindenauer, Peter
first name: Peter
last name: Lindenauer
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Person ID: 4845
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Hassler, Matthew
first name: Matthew
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Alcusky, Matthew
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full name: Matthew James Alcusky PhD, PharmD, MS
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Person ID: 5243
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Seddon, Johanna
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type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/88604938
number of subject areas: 7
type: Connection Details

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/92766629
number of subject areas: 5
type: Connection Details

https://profiles.umassmed.edu/profile/92770724
number of subject areas: 9
type: Connection Details

Assistant Professor
is primary position: true
position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School