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Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
has faculty rank: Professor
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Person ID: 202
person in primary position: Professor
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Shultz, Leonard
first name: Leonard
last name: Shultz
full name: Leonard Donald Shultz PhD
has faculty rank: Professor
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Person ID: 2863
person in primary position: Professor
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preferred title: Professor

Hoaglin, David
first name: David
last name: Hoaglin
full name: David C Hoaglin PhD
has faculty rank: Professor
latitude: 42.27767280000000
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Person ID: 3066
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preferred title: Professor

Davis, Roger
first name: Roger
last name: Davis
full name: Roger J Davis PhD, FRS
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Person ID: 3130
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: H. Arthur Smith Chair in Cancer Research
Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866429

Zierath, Juleen
first name: Juleen
last name: Zierath
full name: Juleen R Zierath PhD
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person in primary position: Adjunct Professor
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Lapane, Kate
first name: Kate
last name: Lapane
full name: Kate L Lapane PhD
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latitude: 42.27587600000000
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Person ID: 3252
person in primary position: Professor
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preferred title: Professor

Henninger, Nils
first name: Nils
last name: Henninger
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full name: Nils Henninger MD, PhD
has faculty rank: Associate Professor
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Person ID: 3265
person in primary position: Associate Professor
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Summary: Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
preferred title: Associate Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
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latitude: 50.70274210000000
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Person ID: 3432
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Yaroslavsky, Anna
first name: Anna
last name: Yaroslavsky
full name: Anna N Yaroslavsky PhD, Physics
has faculty rank: Associate Professor
latitude: 42.64602850000000
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Person ID: 3513
person in primary position: https://profiles.umassmed.edu/profile/16236502
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Bello, Dhimiter
first name: Dhimiter
last name: Bello
full name: Dhimiter Bello ScD, MSc
has faculty rank: Associate Professor
latitude: 42.64602850000000
longitude: -71.36462360000000
Person ID: 3522
person in primary position: https://profiles.umassmed.edu/profile/16236512
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Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27636250000000
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Person ID: 36
person in primary position: Adjunct Professor
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Blaustein, Jeffrey
first name: Jeffrey
last name: Blaustein
full name: Jeffrey D Blaustein BS, PhD
has faculty rank: Professor
latitude: 42.39565560000000
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Person ID: 3698
person in primary position: Professor
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preferred title: Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
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latitude: 42.27723620000000
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Person ID: 370
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Kamen, Gary
first name: Gary
last name: Kamen
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latitude: 42.39565560000000
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Person ID: 3702
person in primary position: Professor
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preferred title: Professor

Siegelmann, Hava
first name: Hava
last name: Siegelmann
full name: Hava Siegelmann PhD
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latitude: 42.39565560000000
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Person ID: 3712
person in primary position: Professor
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preferred title: Professor

Freedson, Patty
first name: Patty
last name: Freedson
full name: Patty S Freedson BS, MS, PhD
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latitude: 42.39565560000000
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Person ID: 3733
person in primary position: Chair and Professor
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preferred title: Chair and Professor

Zoeller, R.
first name: R.
last name: Zoeller
full name: R. Thomas Zoeller Ph.D.
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latitude: 42.39565560000000
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Person ID: 3739
person in primary position: Professor
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preferred title: Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
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latitude: 42.39565560000000
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Person ID: 3741
person in primary position: Department Head
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preferred title: Department Head

Van Emmerik, Richard
first name: Richard
last name: Van Emmerik
full name: Richard Van Emmerik Ph.D.
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latitude: 42.39565560000000
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Person ID: 3742
person in primary position: Professor
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preferred title: Professor

Meyer, Jerrold
first name: Jerrold
last name: Meyer
full name: Jerrold S Meyer BS, MS, PhD
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latitude: 42.39565560000000
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Person ID: 3743
person in primary position: Professor
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preferred title: Professor

McClements, David
first name: David
last name: McClements
full name: David J McClements B.S., Ph.D.
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latitude: 42.39565560000000
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Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
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preferred title: Fergus Clydesdale Endowed Chair

Henson, Michael
first name: Michael
last name: Henson
full name: Michael Henson PhD
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latitude: 42.39565560000000
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Person ID: 3761
person in primary position: Professor
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preferred title: Professor

Crosby, Alfred
first name: Alfred
last name: Crosby
full name: Alfred J Crosby PhD
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latitude: 42.39565560000000
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Person ID: 3762
person in primary position: Professor
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preferred title: Professor

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
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Person ID: 3795
person in primary position: Associate Professor
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preferred title: Associate Professor

Boyer, Katherine
first name: Katherine
last name: Boyer
full name: Katherine Boyer PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
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Person ID: 3831
person in primary position: Assistant Professor
type: Agent
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preferred title: Assistant Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 418
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Paydarfar, David
first name: David
last name: Paydarfar
full name: David Paydarfar MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27525000000000
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Person ID: 523
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Harris, John
first name: John
last name: Harris
full name: John E Harris MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 53
person in primary position: Adjunct Professor
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Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
preferred title: Adjunct Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
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Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Wolfe, Scot
first name: Scot
last name: Wolfe
full name: Scot Wolfe PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 595
person in primary position: Professor
type: Agent
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
preferred title: Professor

Wiss, Karen
first name: Karen
last name: Wiss
full name: Karen Wiss MD
has faculty rank: Professor Emeritus
latitude: 42.28554670000000
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Person ID: 599
person in primary position: Professor Emeritus
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Summary: Interests: Pediatric dermatology, epidermolysis bullosa, genodermatoses, midline developmental defects, childhood exanthems, medical education, pediatric laser
preferred title: Professor Emeritus

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
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Person ID: 612
person in primary position: Professor
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Lalikos, Janice
first name: Janice
last name: Lalikos
full name: Janice F Lalikos MD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 745
person in primary position: Professor
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Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Lyle, Stephen
first name: Stephen
last name: Lyle
full name: Stephen R Lyle MD, PhD
has faculty rank: Associate Professor
latitude: 42.27985300000000
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Person ID: 912
person in primary position: Associate Professor
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Rotation Projects: Rotation projects are designed to expose students to the biology of adult stem cells, the mechanisms of tumorigenesis and to provide them with an appreciation for translational cancer research. These projects are focused on the major themes of the lab, which are: 1. Understanding the relative effects of oncogenic mutations on stem cells compared to the non-stem cell population from adult human skin. A key component of this project is to evaluate the Beta-catenin/Lef-1 signaling pathway on cultured epithelial stem cells and non-stem cells. 2. Studying the function of differently expressed genes in mediating stem cell behavior. The goal of this project is to understand the molecular mechanisms which control the critical properties of stem cell self-renewal, proliferation, adhesion and migration. 3. Identifying, isolating and characterizing “cancer stem cells” from human and mouse model tumors. Cancers are thought to possess a sub-population of slowly-cycling cancer stem cells which are responsible for tumor growth, recurrence and metastasis. The goal of this project is to begin to characterize these cells to help better target them therapeutically. The goal for all of these projects is to use the data obtained to help understand human tumorigenesis at the molecular, cellular and tissue levels, and be able to devise better treatments.
preferred title: Associate Professor

UMass Chan – Baystate Regional Campus
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Richmond, Jillian
first name: Jillian
last name: Richmond
full name: Jillian M Richmond PhD
has faculty rank: ADJUNCT ASSISTANT PROFESSOR
latitude: 42.27767280000000
longitude: -71.76163720000000
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Person ID: 4448
person in primary position: Adjunct Assistant Professor
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Summary: Interests: Autoimmunity, Immunology, Fibrosis, Translational Research, Lupus
preferred title: Adjunct Assistant Professor

Dermatology
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https://profiles.umassmed.edu/profile/16236502
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https://profiles.umassmed.edu/profile/16236512
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Chair and Professor
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Professor
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Fergus Clydesdale Endowed Chair
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Professor
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Assistant Professor
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Lindenauer, Peter
first name: Peter
last name: Lindenauer
full name: Peter K Lindenauer MD, MSc
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Elaba, Zendee
first name: Zendee
last name: Elaba
full name: Zendee Rose Plateros Elaba MD
has faculty rank: Associate Professor
latitude: 42.27731390000000
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Person ID: 5148
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Population and Quantitative Health Sciences
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Rashighi Firoozabadi, Mehdi
first name: Mehdi
last name: Rashighi Firoozabadi
full name: Mehdi Rashighi Firoozabadi MD
has faculty rank: Assistant Professor
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ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
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Microbiology
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