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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Yalcindag, Ali
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Szabo, Gyongyi
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Hayman, Laura
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Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
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UMass Chan – Baystate Regional Campus
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Goff, Sarah
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McIntosh, Lacey
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Engelman, Daniel
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Singh, Sonal
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Lindenauer, Peter
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ADJUNCT ASSISTANT PROFESSOR
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Gerber, Jonathan
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Robertson, David
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Population and Quantitative Health Sciences
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Bokhour, Barbara
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Garg, Arvin
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Soni, Apurv
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Biochemistry and Molecular Biotechnology
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ProfilesRNS Plugin Searchable Data: Tweets by @DrSherryPagoto
ProfilesRNS Plugin Searchable Data: Twitter Tweets Harvard Tweets

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Medicine at UMass Chan - Baystate
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Pfefferle, Susan
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Parker, Margaret
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Binder, Raquel
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Johnson-Agbakwu, Crista
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Medicine at UMass Chan - Lahey
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General Pediatrics
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Ramsey, David
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Tan Chingfen Graduate School of Nursing
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Dani, Sourbha
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Martinez, Fernando
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Wilcox, Susan
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Martin, Rosemarie
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Maron, Barry
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Farmer, Jocelyn
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Ganatra, Sarju
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Professor
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Professor
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Professor
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Professor
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Genetic and Cellular Medicine
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https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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https://profiles.umassmed.edu/profile/66923959
publication date: 2020
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link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
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https://profiles.umassmed.edu/profile/66924043
publication date: 2018
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link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
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link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
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link anchor text: Podcast summary of articles from the June 2021 edition of the Journal of Emergency Medicine

Adjunct Professor
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Professor Emeritus
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Professor
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Adjunct Professor
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