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Pransky, Glenn
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Rosen, Amy
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Lapane, Kate
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Puri, Ajit
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Henninger, Nils
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Kotkowski, Kevin
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Rosen, Max
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Heneka, Michael
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Harrold, Leslie
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Lian, Jane
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Bertone-Johnson, Elizabeth
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Crawford, Sybil
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Rosal, Milagros
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Wolfe, Scot
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
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Vedantham, Srinivasan
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Goldberg, Robert
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Bogdanov, Alexei
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McManus, David
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Research
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Friedmann, Peter
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Politi, Letterio
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UMass Chan – Baystate Regional Campus
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Remenschneider, Aaron
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Swart, Eric
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Singh, Sonal
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Lindenauer, Peter
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Gurwitz, Jerry
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Usmani, Saad
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Population and Quantitative Health Sciences
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Lareau, Craig
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Bankier, Alexander
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Schlaug, Gottfried
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Wint, Jeffrey
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Summary: Jeffrey C. Wint, MD is an orthopedic hand surgeon with over 30 years of experience. Formerly at The Hand Center of Western Massachusetts, he took call at Baystate (Level I trauma) and operated at Pioneer Valley Surgicenter. At Shriners Children’s New England, he staffs the Upper Limb Prosthetics and Hand Clinics. He has been active for many years in ASSH committee work.
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Lin, Honghuang
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https://profiles.umassmed.edu/profile/28866620
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https://profiles.umassmed.edu/profile/28867032
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Medicine at UMass Chan - Baystate
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Neurology at UMass Chan - Baystate
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Saranathan, Manojkumar
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Associate Professor
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Vachha, Behroze
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Chamberlin, Karl
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Driban, Jeffrey
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Professor
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Walkey, Allan
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Administrative Leadership
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Abdominal Imaging
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Chair and Professor
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Professor
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Chair and Professor
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Cardio Thoracic Radiology
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Health System Science
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Infectious Diseases
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Neurointerventional Radiology
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Orthopedics Research
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Pulmonary Medicine
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Professor Emeritus
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Adjunct Professor
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Professor
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Professor
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Professor
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Professor
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Adjunct Professor
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Professor
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Professor
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Professor
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Associate Professor
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Professor
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Orthopedics General
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Sports
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Stroke and Vascular Neurology
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Chair and Professor
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Professor
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Tan Chingfen Graduate School of Nursing
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https://profiles.umassmed.edu/profile/44403713
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label: https://www.umassmed.edu/lanai/
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McAlindon, Timothy
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Associate Professor
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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position in division: Pulmonary Medicine
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Wilcox, Susan
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
preferred title: Professor

Professor
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Krings, Timo
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Goldsweig, Andrew
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Associate Professor
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Maron, Martin
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Maron, Barry
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Person ID: 10248130
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Adjunct Professor
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Professor
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position in division: Rheumatology
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Chair and Professor
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Reynolds, Matthew
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Person ID: 10248173
person in primary position: Professor
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Rowin, Ethan
first name: Ethan
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full name: Ethan Rowin MD, MBA
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Person ID: 10248175
person in primary position: Associate Professor
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preferred title: Associate Professor

Associate Professor
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HR job title: Associate Professor
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Professor
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Professor
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position in department: Radiology
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number of subject areas: 27
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https://profiles.umassmed.edu/profile/58609396
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https://profiles.umassmed.edu/profile/59649572
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Instructor
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type: Faculty Rank

Professor
sort order: 3
type: Faculty Rank

Professor Emeritus
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Assistant Professor
sort order: 13
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Associate Professor
sort order: 10
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Chair And Professor
sort order: 4
type: Faculty Rank

Professor Emeritus
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position in department: Medicine
position in division: Health System Science
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HR job title: Professor Emeritus
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Professor
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Associate Professor
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position in department: Neurology
position in division: Stroke and Vascular Neurology
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type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Emergency Medicine
position in division: Research
sort order: 1
type: Position
HR job title: Professor
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
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HR job title: Professor
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Professor
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position in department: Population and Quantitative Health Sciences
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Professor
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position in department: Medicine
position in division: Health System Science
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position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/66923911
publication date: 2016
type: URLLink
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link anchor text: EMCrit 181 – Pulmonary Hypertension and Right Ventricular Failure with Susan Wilcox

https://profiles.umassmed.edu/profile/66923959
publication date: 2020
type: URLLink
label: https://www.edx.org/learn/healthcare/harvard-university-mechanical-ventilation-for-covid-19
link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
type: URLLink
label: https://emergencymedicinecases.com/pulmonary-hypertension/
link anchor text: CritCases 7 Pulmonary Hypertension – A Fine Balance

https://profiles.umassmed.edu/profile/66924043
publication date: 2018
type: URLLink
label: https://www.aliem.com/2018/06/myth-vasopressors-ischemia/
link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
type: URLLink
label: https://www.acep.org/corona/covid-19-field-guide/treatment/icu-care-in-the-emergency-department/
link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
type: URLLink
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link anchor text: Podcast summary of articles from the June 2021 edition of the Journal of Emergency Medicine

https://profiles.umassmed.edu/profile/68003571
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Associate Professor
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position in department: Surgery at UMass Chan - Lahey
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sort order: 1
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HR job title: Associate Professor
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https://profiles.umassmed.edu/profile/69780154
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Adjunct Professor
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position in division: Health Informatics And Implementation Science
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Professor
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Shin, Dong-Soo
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Vanni, Alex
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https://profiles.umassmed.edu/profile/72125711
number of subject areas: 22
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Professor Emeritus
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Associate Professor
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Professor
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Professor
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https://profiles.umassmed.edu/profile/92774863
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