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Summary: My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
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Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
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Czech, Michael
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Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
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Davis, Roger
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Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
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Zierath, Juleen
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https://profiles.umassmed.edu/profile/28867128
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Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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Adjunct Professor
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Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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Professor
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Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Adjunct Professor
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Assistant Professor
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position in department: Pediatrics
position in division: Community Pediatrics
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HR job title: Assistant Professor
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Professor
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HR job title: Professor
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Headley, Samuel
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Adjunct Professor
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Chair and Professor
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Driban, Jeffrey
first name: Jeffrey
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full name: Jeffrey B Driban PhD, AT Ret, CSCS
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Associate Professor
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HR job title: Associate Professor
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
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Professor
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Radiology at UMass Chan - Lahey
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Professor Emeritus
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Professor Emeritus
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Professor
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HR job title: Professor
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Chair and Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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Professor
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position in division: Biostatistics And Health Services Research
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Professor
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Endocrinology & Diabetes
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Health System Science
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Infectious Diseases
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Pulmonary Medicine
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Professor Emeritus
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HR job title: Professor Emeritus
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Professor
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position in division: Geriatrics
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
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Professor
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Adjunct Professor
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Professor
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HR job title: Professor
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Ob/Gyn General
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Chair and Professor
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position in department: Medicine
position in division: Cardiovascular Medicine
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HR job title: Chair and Professor
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Tan Chingfen Graduate School of Nursing
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Professor Emeritus
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HR job title: Professor Emeritus
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McAlindon, Timothy
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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position in division: Pulmonary Medicine
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HR job title: Professor
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Krings, Timo
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Person ID: 10247952
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Maron, Martin
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has faculty rank: Associate Professor
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Person ID: 10248121
person in primary position: Associate Professor
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Maron, Barry
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Person ID: 10248130
person in primary position: Adjunct Professor
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Adjunct Professor
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position in department: Medicine at UMass Chan - Lahey
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HR job title: Adjunct Professor
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Professor
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Professor
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position in department: Medicine
position in division: Rheumatology
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HR job title: Professor
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Chair and Professor
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Professor Emeritus
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Professor
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Ganatra, Sarju
first name: Sarju
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Assistant Professor
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Professor
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Professor Emeritus
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Research Professor
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Assistant Professor
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Associate Professor
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Chair And Professor
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Resear Fel
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Professor
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Professor
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Chair and Professor
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position in department: Obstetrics and Gynecology
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Professor
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Professor
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Professor
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Adjunct Professor
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HR job title: Adjunct Professor
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Shin, Dong-Soo
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Adjunct Assistant Professor
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Folgueira, Cintia
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person in primary position: Adjunct Assistant Professor
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preferred title: Adjunct Assistant Professor

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Associate Professor
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HR job title: Associate Professor
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Professor
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