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Rotation Projects: Rotation Projects Study the interaction of the ssDNA annealing protein Bet and its cognate exonuclease with dsDNA ends. Compare wild type Bet with one or mutant Bet proteins. Use both genetic and biochemical studies to answer the question of how this annealase binds to ssDNA and promotes recombination. Develop recombineering technologies for M. tuberculosis involving the electroporation of oligos containing clinically relevant single nucleotide polymorphisms (SNPs). Generate a recombineering system for Pseudomonas aeruginosa via the electroporation of PCR substrates into electrocompetent cells containing PA phage Red-like recombination systems.
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Woskie, Susan
first name: Susan
last name: Woskie
full name: Susan Woskie M.S. Occupational & Environmental Hygiene, Ph.D. B
has faculty rank: Professor
latitude: 42.64602850000000
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person in primary position: https://profiles.umassmed.edu/profile/16237479
type: Agent
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Harrold, Leslie
first name: Leslie
last name: Harrold
full name: Leslie R Harrold MD, MPH
has faculty rank: Associate Professor
latitude: 42.27767280000000
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Person ID: 357
person in primary position: Associate Professor
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preferred title: Associate Professor

Haran, John
first name: John
last name: Haran
full name: John P Haran MD, PhD
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latitude: 42.27525000000000
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Person ID: 37
person in primary position: Professor
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Rotation Projects: Rotation projects are available related to microbiota-gut brain axis and antibiotic usage and the sequelae of antibiotic use in hospitalized patients which include Clostridium difficile and multi-drug resistant organism infection and colonization.
preferred title: Professor

Gierasch, Lila
first name: Lila
last name: Gierasch
full name: Lila M Gierasch Ph.D.
has faculty rank: Distinguished Professor
latitude: 42.39565560000000
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Person ID: 3705
person in primary position: Distinguished Professor
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preferred title: Distinguished Professor

Sandler, Steven
first name: Steven
last name: Sandler
full name: Steven J Sandler PhD
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latitude: 42.39565560000000
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person in primary position: Professor
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preferred title: Professor

Emrick, Todd
first name: Todd
last name: Emrick
full name: Todd S Emrick PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 3730
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Kaltashov, Igor
first name: Igor
last name: Kaltashov
full name: Igor Kaltashov PhD
has faculty rank: Professor
latitude: 42.39565560000000
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person in primary position: Professor
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preferred title: Professor

Santore, Maria
first name: Maria
last name: Santore
full name: Maria Santore PhD, BS
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latitude: 42.39565560000000
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Person ID: 3737
person in primary position: Professor
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preferred title: Professor

Tew, Greg
first name: Greg
last name: Tew
full name: Greg Tew Ph.D.
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latitude: 42.39565560000000
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Person ID: 3738
person in primary position: Professor
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type: Person
preferred title: Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
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Person ID: 3741
person in primary position: Department Head
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preferred title: Department Head

Maroney, Michael
first name: Michael
last name: Maroney
full name: Michael J Maroney Ph.D., B.S
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latitude: 42.39565560000000
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person in primary position: Professor
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preferred title: Professor

McClements, David
first name: David
last name: McClements
full name: David J McClements B.S., Ph.D.
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latitude: 42.39565560000000
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Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
type: Agent
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preferred title: Fergus Clydesdale Endowed Chair

Henson, Michael
first name: Michael
last name: Henson
full name: Michael Henson PhD
has faculty rank: Professor
latitude: 42.39565560000000
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Person ID: 3761
person in primary position: Professor
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preferred title: Professor

Forbes, Neil
first name: Neil
last name: Forbes
full name: Neil Forbes PhD
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latitude: 42.39565560000000
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person in primary position: Associate Professor
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preferred title: Associate Professor

Riley, Margaret
first name: Margaret
last name: Riley
full name: Margaret Riley PhD
has faculty rank: Professor
latitude: 42.39565560000000
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Person ID: 3771
person in primary position: Professor
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preferred title: Professor

Hardy, Jeanne
first name: Jeanne
last name: Hardy
full name: Jeanne A Hardy BS, PhD
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latitude: 42.39565560000000
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person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Hayward, Ryan
first name: Ryan
last name: Hayward
full name: Ryan C Hayward B.S.E., Ph.D.
has faculty rank: Associate Professor
latitude: 42.39565560000000
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Person ID: 3784
person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Bermudez, Harry
first name: Harry
last name: Bermudez
full name: Harry Bermudez PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
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Person ID: 3788
person in primary position: Assistant Professor
type: Agent
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preferred title: Assistant Professor

Pederson, Thoru
first name: Thoru
last name: Pederson
full name: Thoru Pederson PhD
has faculty rank: Professor Emeritus
latitude: 42.28050130000000
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Person ID: 379
person in primary position: Professor Emeritus
type: Agent
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Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3795
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Shao, Rong
first name: Rong
last name: Shao
full name: Rong Shao Ph.D. M.D.
has faculty rank: Research Assistant Professor
latitude: 42.39565560000000
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Person ID: 3798
person in primary position: Research Assistant Professor
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preferred title: Research Assistant Professor

Nugen, Sam
first name: Sam
last name: Nugen
full name: Sam R Nugen BS, MS, PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
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Person ID: 3808
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Chien, Peter
first name: Peter
last name: Chien
full name: Peter Chien PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3812
person in primary position: Assistant Professor
type: Agent
type: Person
preferred title: Assistant Professor

Morita, Yasu
first name: Yasu
last name: Morita
full name: Yasu S Morita PhD
has faculty rank: Assistant Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3826
person in primary position: https://profiles.umassmed.edu/profile/16241114
type: Agent
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Schiffer, Celia
first name: Celia
last name: Schiffer
Featured Videos: https://profiles.umassmed.edu/profile/28867214
full name: Celia A Schiffer PhD
has faculty rank: Chair And Professor
latitude: 42.27985300000000
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Person ID: 558
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

Han, Gang
first name: Gang
last name: Han
Twitter: https://profiles.umassmed.edu/profile/28867140
full name: Gang Han PhD
has faculty rank: Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
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Person ID: 734
person in primary position: Professor
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Post Docs: Positions for postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School. Research will focus on developing novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging. Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments, spectroscopy and microscopy are desired. Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively. To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu
Rotation Projects: Rotation projects <p >(1) Specific cell membrane component labeling using bioconjugated nanoparticles <p >(2) To develop tools for targeted and traceable siRNA delivery <p >(3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids
preferred title: Professor

Sassetti, Christopher
first name: Christopher
last name: Sassetti
full name: Christopher M Sassetti PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
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Person ID: 878
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
preferred title: Professor

Miller, Stephen
first name: Stephen
last name: Miller
full name: Stephen C Miller PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 890
person in primary position: Professor
type: Agent
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Post Docs: Postdoctoral positions are available in the Miller laboratory to investigate and extend the scope of bioluminescence imaging. Lab projects range from molecular-level studies of the mechanism of luciferases, to non-invasive imaging of specific biological processes and disease states in live animals. Motivated and inherently curious critical thinkers with backgrounds in biology, chemistry, or both are encouraged to apply.
Rotation Projects: Rotation Projects Work in our lab uses optical imaging to study live cells and organisms. This multi-disciplinary approach brings together the areas of synthetic organic chemistry, molecular biology, biochemistry and cell biology, with translation into mouse models of disease. 1) Broadening the scope of bioluminescence: Bioluminescence results from the chemical generation of light that occurs when a luciferase enzyme oxidizes its small molecule luciferin substrate. We have synthesized a wide variety of novel luciferin substrates designed to improve the ability to detect bioluminescence signals. In parallel, we have mutated luciferases to best accommodate these substrates, and have also found that a homologous protein in the fruit fly can act as a luciferase. Projects in the lab range from basic molecular-level biochemical, chemical, and evolutionary studies of luciferases and luciferins, to powerful applications such as imaging of enzyme activity and drug action in the brains of live mice. 2) Fluorescent probes beyond the visible range: Fluorescent sensors of enzymatic activity, metal ions, and small molecules allow the optical detection of biologically-important molecules. However, most of these sensors are based on visible-wavelength fluorophores that suffer from photoxicity and high background. These probes thus have limited utility in live cells, and are generally unusable in live organisms such as mice. We are designing and constructing sensors that fluoresce in the near-IR, beyond the visible range, which is most suitable for non-invasive optical imaging of the physiological state of live cells and organisms.
preferred title: Professor

Bogdanov, Alexei
first name: Alexei
last name: Bogdanov
full name: Alexei A Bogdanov PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
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Person ID: 906
person in primary position: Professor Emeritus
type: Agent
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preferred title: Professor Emeritus
webpage: https://profiles.umassmed.edu/profile/28866578
webpage: https://profiles.umassmed.edu/profile/28866620

Rice, Peter
first name: Peter
last name: Rice
full name: Peter A Rice MD
has faculty rank: Professor Emeritus
latitude: 42.27985300000000
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Person ID: 908
person in primary position: Professor Emeritus
type: Agent
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preferred title: Professor Emeritus

Ostroff, Gary
first name: Gary
last name: Ostroff
full name: Gary R Ostroff PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
Person ID: 941
person in primary position: Professor
type: Agent
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preferred title: Professor

Song, Jie
first name: Jie
last name: Song
full name: Jie Song PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 982
person in primary position: Professor
type: Agent
type: Person
Lab URL: http://www.umassmed.edu/Songlab/
Post Docs: A postdoc opening is available to participate in the development of functional biomaterials for skeletal tissue regeneration focusing on immune regulation and inflammation resolution. The fellow is expected to work both independently and collaboratively, and contribute to a productive and cordial team environment. Salary follows NIH postdoctoral fellowship compensation guideline. Requirements: • Recent PhD in Chemical Biology, Bioengineering, Biology, or Polymer Science • Expertise in examining cell-material interactions (e.g. immune cell regulations, stem cell lineage commitment) OR synthesis and characterization of functional biomaterials expected • Experience with animal studies desired but not required • Self-motivated and organized, good written and oral communication skills. To apply for this position: Send your CV and the contact information for three references to Jie.Song@umassmed.edu
Rotation Projects: Potential Rotation Projects Degradable viscoelastic synthetic hydrogels for therapeutic cell delivery Prophylactic implant coatings against periprosthetic infections Shape memory polymer-based composite bone grafts
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866451

Ram, Sanjay
first name: Sanjay
last name: Ram
full name: Sanjay Ram MD
has faculty rank: Professor
latitude: 42.27636250000000
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Person ID: 993
person in primary position: Professor
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preferred title: Professor

Brewster, Robert
first name: Robert
last name: Brewster
full name: Robert Charles Brewster PhD
has faculty rank: Associate Professor
latitude: 42.27721220000000
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Person ID: 4192
person in primary position: Associate Professor
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Research
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UMass Chan – Baystate Regional Campus
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Mitchell, Amir
first name: Amir
last name: Mitchell
Twitter: https://profiles.umassmed.edu/profile/28867035
full name: Amir Zadok Mitchell PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 4429
person in primary position: Associate Professor
type: Agent
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Lab URL: https://www.mitchell-lab.umassmed.edu/
Rotation Projects: We are looking for rotation students to visit our lab and participate in one of our ongoing research projects. Different aspects of the projects require different toolsets ranging from experimental biology to quantitative biology and mathematical modeling. Rotation students will have a chance to acquire new skill-sets and develop expertise required for implementing a quantitative approach for understanding cell regulation, signaling and evolution. Interested students should email Amir directly and briefly describe their academic background, future plans and interest in the lab. Current rotation projects: Investigating bacterial response to host-targeted drugs: As part of our research into the tumor-microbiome (tumor assosiated bacteria), we are testing how bacterial growth is inhibited by cytotoxic drugs that target cancer cells. Rotation students will run genetic screens in bacteria to identify bacterial toxicity and resistance mechanisms. In addition the students will test if bacteria can rapidly become drug resistance by evolutionary adaptation. Monitoring recovery dynamcis of melanoma cells in response to targeted therapy: The project involves examining and quantifying different aspects of cell behavior, population dynamics and adaptive resistance to targeted therapy. Rotation students will examine cellular behavior of established cell-lines and will clone and engineer new live-cell reporters for microscopy based assays.
preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866551

Visintainer, Paul
first name: Paul
last name: Visintainer
full name: Paul Visintainer PhD
has faculty rank: Professor Emeritus
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person in primary position: Professor Emeritus
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Distinguished Professor
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https://profiles.umassmed.edu/profile/16236512
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Professor
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https://profiles.umassmed.edu/profile/16237433
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https://profiles.umassmed.edu/profile/16237479
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Fergus Clydesdale Endowed Chair
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Surgery at UMass Chan - Lahey
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Infectious Diseases
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Innate Immunity
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Jiang, Ying
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