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Rich, Stephen
first name: Stephen
last name: Rich
full name: Stephen M Rich MS, PhD
has faculty rank: Professor
latitude: 42.39565560000000
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Person ID: 3778
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Pederson, Thoru
first name: Thoru
last name: Pederson
full name: Thoru Pederson PhD
has faculty rank: Professor Emeritus
latitude: 42.28050130000000
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Person ID: 379
person in primary position: Professor Emeritus
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Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
has faculty rank: Associate Professor
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person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Nugen, Sam
first name: Sam
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person in primary position: Assistant Professor
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preferred title: Assistant Professor

Chien, Peter
first name: Peter
last name: Chien
full name: Peter Chien PhD
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latitude: 42.39565560000000
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Person ID: 3812
person in primary position: Assistant Professor
type: Agent
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preferred title: Assistant Professor

Rogaev, Evgeny
first name: Evgeny
last name: Rogaev
full name: Evgeny I Rogaev PhD
has faculty rank: Professor
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person in primary position: Professor
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rogaev for additional details.
preferred title: Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 418
person in primary position: Chair and Professor
type: Agent
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Schiffer, Celia
first name: Celia
last name: Schiffer
Featured Videos: https://profiles.umassmed.edu/profile/28867214
full name: Celia A Schiffer PhD
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Person ID: 558
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

Wolfe, Scot
first name: Scot
last name: Wolfe
full name: Scot Wolfe PhD
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Post Docs: Postdoctoral Fellow Applications are being accepted for one position. A position is available to develop Cys2His2 zinc finger proteins (ZFPs) for the treatment of monogenic disorders. This project will focus on the creation of ZFPs with novel DNA-binding specificity to recognize sequence elements within genomic loci of therapeutic interest. In collaboration with other laboratories, we will evaluate the activity of these ZFP-based gene therapy reagents in vitro and in vivo in relevant disease models. Applicants will also have the opportunity to learn to apply Cas9 and Cas12a editing systems in vivo.
Rotation Projects: Potential Rotation Projects Improving the Precision of CRISPR/Cas9 nucleases for gene therapy applications: We are working to improve the precision of the CRISPR/Cas9 system to generate nucleases that will cleave at only a single site in the genome. These engineering efforts focus on increasing the DNA-editing precision of Cas9 and using protein engineering to introduce new properties into the nuclease. Much of this work is now transitioning to the use of Cas9 (and Cas12a) protein-RNA complexes. These modified nucleases will then be applied to patient derived cell-culture systems for the targeted repair or inactivation of disease-causing alleles. With the eventual goal of creating therapeutics for Sickle Cell Disease, beta-Thalassemia, HIV, Limb Girdle Muscular Dystrophy, Hermansky Pudlak Syndrome and other monogenic disorders. ex vivo genome editing in CD34+ HSPCs: We are developing improved Cas9 proteins for delivery ex vivo into CD34+ HSPCs for therapeutic application to sickle cell disease and beta-thalassemia. The goal is to modify the hematopoietic stem cells of a patient to complement the loss of function of the beta-globin gene and then return these cells to the patient through an autologous transplant. Development of Cys2His2 Zinc fingers proteins (ZFPs) as targeted therapeutics: We are developing artificial ZFPs for the regulation of target genes to change their gene expression profiles for therapeutic applications.
preferred title: Professor

Walhout, Marian
first name: Marian
last name: Walhout
full name: Marian Walhout PhD
has faculty rank: Chair And Professor
latitude: 42.27587600000000
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Person ID: 758
person in primary position: Chair and Professor
type: Agent
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Endowed Chair Honorary Title: Maroun Semaan Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Please contact Dr. Walhout for additional details.
preferred title: Chair and Professor

Sassetti, Christopher
first name: Christopher
last name: Sassetti
full name: Christopher M Sassetti PhD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 878
person in primary position: Professor
type: Agent
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Endowed Chair Honorary Title: Elisabeth Chair II
Lab URL: https://www.umassmed.edu/sassettilab/
Rotation Projects: Rotation Projects <p >We have identified a number of bacterial pathways that are required for bacterial viability or virulence. We are particularly interested in: Phosphosignaling systems that regulate cell wall synthesis Metabolic regulatory mechanisms that trigger the “dormancy” response observed during infection. <p >A variety of genetic, biochemical, and informatic methods will be used to define the functions of these genes and the role played by each during infection. <p >
Summary: Focus: Pathogenesis of tuberculosis
preferred title: Professor

Rice, Peter
first name: Peter
last name: Rice
full name: Peter A Rice MD
has faculty rank: Professor Emeritus
latitude: 42.27985300000000
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Person ID: 908
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Bolon, Daniel
first name: Daniel
last name: Bolon
full name: Daniel N Bolon PhD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 948
person in primary position: Professor
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Rotation Projects: Potential Rotation Projects <p >Our laboratory combines genetic and biochemical approaches to investigate the molecular underpinnings of adaptation. Potential rotation projects are available in two general (and partially overlapping) areas: exploring fitness landscapes through systematic approaches and investigating the molecular mechanism of the Hsp90 chaperone in signal transduction. Please contact the lab to discuss specific rotation projects in more detail.
preferred title: Professor

Ram, Sanjay
first name: Sanjay
last name: Ram
full name: Sanjay Ram MD
has faculty rank: Professor
latitude: 42.27636250000000
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Person ID: 993
person in primary position: Professor
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preferred title: Professor

Brewster, Robert
first name: Robert
last name: Brewster
full name: Robert Charles Brewster PhD
has faculty rank: Associate Professor
latitude: 42.27721220000000
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Person ID: 4192
person in primary position: Associate Professor
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preferred title: Associate Professor

Research
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UMass Chan – Baystate Regional Campus
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Mitchell, Amir
first name: Amir
last name: Mitchell
Twitter: https://profiles.umassmed.edu/profile/28867035
full name: Amir Zadok Mitchell PhD
has faculty rank: Associate Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 4429
person in primary position: Associate Professor
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Lab URL: https://www.mitchell-lab.umassmed.edu/
Rotation Projects: We are looking for rotation students to visit our lab and participate in one of our ongoing research projects. Different aspects of the projects require different toolsets ranging from experimental biology to quantitative biology and mathematical modeling. Rotation students will have a chance to acquire new skill-sets and develop expertise required for implementing a quantitative approach for understanding cell regulation, signaling and evolution. Interested students should email Amir directly and briefly describe their academic background, future plans and interest in the lab. Current rotation projects: Investigating bacterial response to host-targeted drugs: As part of our research into the tumor-microbiome (tumor assosiated bacteria), we are testing how bacterial growth is inhibited by cytotoxic drugs that target cancer cells. Rotation students will run genetic screens in bacteria to identify bacterial toxicity and resistance mechanisms. In addition the students will test if bacteria can rapidly become drug resistance by evolutionary adaptation. Monitoring recovery dynamcis of melanoma cells in response to targeted therapy: The project involves examining and quantifying different aspects of cell behavior, population dynamics and adaptive resistance to targeted therapy. Rotation students will examine cellular behavior of established cell-lines and will clone and engineer new live-cell reporters for microscopy based assays.
preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866551

Sela, David
first name: David
last name: Sela
full name: David A Sela PhD
has faculty rank: ADJUNCT ASSISTANT PROFESSOR
latitude: 42.39208790000000
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Person ID: 4775
person in primary position: Adjunct Assistant Professor
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preferred title: Adjunct Assistant Professor

Distinguished Professor
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Department Head
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https://profiles.umassmed.edu/profile/16237433
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Department Head
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Fergus Clydesdale Endowed Chair
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Fu, Tianmin
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