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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Soni, Apurv
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Biochemistry and Molecular Biotechnology
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Pfefferle, Susan
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Assistant Professor
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Parker, Margaret
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Professor
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Professor
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Johnson-Agbakwu, Crista
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Evans, Elizabeth
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Professor
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Professor
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Associate Professor
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Ryan, Grace
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Chair and Professor
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Abdominal Imaging
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Chair and Professor
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Health System Science
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Infectious Diseases
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Pulmonary Medicine
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Professor Emeritus
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Professor
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Professor
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Professor
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Assistant Professor
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Professor
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Ob/Gyn General
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Pediatric Neonatology
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Ramsey, David
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Associate Professor
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Tan Chingfen Graduate School of Nursing
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Dani, Sourbha
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Wilcox, Susan
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
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Professor
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Professor
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Krings, Timo
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Martin, Rosemarie
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Goldsweig, Andrew
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Maron, Martin
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Maron, Barry
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Associate Professor
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Chair and Professor
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Reynolds, Matthew
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Farmer, Jocelyn
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Professor
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Ganatra, Sarju
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Instructor
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Professor Emeritus
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Psychiatry and Behavioral Sciences
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Professor
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Professor
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Professor
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Assistant Professor
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Professor
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Genetic and Cellular Medicine
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https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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link anchor text: EMCrit 181 – Pulmonary Hypertension and Right Ventricular Failure with Susan Wilcox

https://profiles.umassmed.edu/profile/66923959
publication date: 2020
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link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
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link anchor text: CritCases 7 Pulmonary Hypertension – A Fine Balance

https://profiles.umassmed.edu/profile/66924043
publication date: 2018
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link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
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label: https://www.acep.org/corona/covid-19-field-guide/treatment/icu-care-in-the-emergency-department/
link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
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link anchor text: Podcast summary of articles from the June 2021 edition of the Journal of Emergency Medicine

Adjunct Professor
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Shin, Dong-Soo
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Adjunct Professor
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position in department: Medicine
position in division: Infectious Diseases
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HR job title: Adjunct Professor
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Associate Professor
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sort order: 1
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Professor
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sort order: 1
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Professor Emeritus
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sort order: 1
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Professor
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Adjunct Professor
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