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Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
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Driban, Jeffrey
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Walkey, Allan
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Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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https://profiles.umassmed.edu/profile/40402890
ProfilesRNS Plugin Searchable Data: Preventing Osteoarthritis After an ACL Injury
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Radiology at UMass Chan - Lahey
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Health System Science
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Infectious Diseases
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Innate Immunity
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor
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Stroke and Vascular Neurology
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Chair and Professor
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Ramsey, David
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Associate Professor
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McAlindon, Timothy
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Professor Emeritus
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Wilcox, Susan
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
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Professor
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Krings, Timo
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Goldsweig, Andrew
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Maron, Martin
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Maron, Barry
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Adjunct Professor
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Professor
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Chair and Professor
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Reynolds, Matthew
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Rowin, Ethan
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Associate Professor
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Professor
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Professor
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Plumptre, Isabella
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Instructor
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Professor
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Waseem, Hena
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Assistant Professor
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Professor Emeritus
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Associate Professor
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Professor
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Professor
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Professor
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Associate Professor
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https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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link anchor text: EMCrit 181 – Pulmonary Hypertension and Right Ventricular Failure with Susan Wilcox

https://profiles.umassmed.edu/profile/66923959
publication date: 2020
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label: https://www.edx.org/learn/healthcare/harvard-university-mechanical-ventilation-for-covid-19
link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
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label: https://emergencymedicinecases.com/pulmonary-hypertension/
link anchor text: CritCases 7 Pulmonary Hypertension – A Fine Balance

https://profiles.umassmed.edu/profile/66924043
publication date: 2018
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link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
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link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
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Associate Professor
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Adjunct Professor
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Professor
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Shin, Dong-Soo
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Vanni, Alex
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https://profiles.umassmed.edu/profile/78102095
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Adjunct Assistant Professor
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Associate Professor
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Professor
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Mandeville, Jessica
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Assistant Professor
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Professor
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Adjunct Professor
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