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Hypothalamus
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Adenylate Cyclase Toxin
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Semen
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Algorithms
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Bronchodilator Agents
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Luteal Phase
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Bronchi
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Caffeine
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Inositol Phosphates
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Indicators and Reagents
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Biomarkers
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Anal Canal
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Oxytocin
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Quaternary Ammonium Compounds
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Mice
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Fura-2
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Receptors, Oxytocin
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Muscle, Smooth
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MeSH semantic group name: Anatomy
number of authors: 33
number of publications: 134
uniqueness weight: 0.930814
type: Concept

Photolysis
MeSH DescriptorUI: D010782
MeSH semantic group name: Phenomena
number of authors: 13
number of publications: 16
uniqueness weight: 0.993977
type: Concept

Albuterol
MeSH DescriptorUI: D000420
MeSH semantic group name: Chemicals & Drugs
number of authors: 17
number of publications: 24
uniqueness weight: 0.987755
type: Concept

Viral Proteins
MeSH DescriptorUI: D014764
MeSH semantic group name: Chemicals & Drugs
number of authors: 94
number of publications: 263
uniqueness weight: 0.853006
type: Concept

Chromatography, High Pressure Liquid
MeSH DescriptorUI: D002851
MeSH semantic group name: Procedures
number of authors: 100
number of publications: 231
uniqueness weight: 0.944442
type: Concept

Immunity, Innate
MeSH DescriptorUI: D007113
MeSH semantic group name: Physiology
number of authors: 174
number of publications: 795
uniqueness weight: 0.641295
type: Concept

Patch-Clamp Techniques
MeSH DescriptorUI: D018408
MeSH semantic group name: Procedures
number of authors: 49
number of publications: 130
uniqueness weight: 0.968786
type: Concept

Sarcoplasmic Reticulum
MeSH DescriptorUI: D012519
MeSH semantic group name: Anatomy
number of authors: 8
number of publications: 13
uniqueness weight: 0.993904
type: Concept

Exocytosis
MeSH DescriptorUI: D005089
MeSH semantic group name: Physiology
number of authors: 28
number of publications: 60
uniqueness weight: 0.96994
type: Concept

Mice, Inbred C57BL
MeSH DescriptorUI: D008810
MeSH semantic group name: Living Beings
number of authors: 472
number of publications: 3396
uniqueness weight: 0.583871
type: Concept

Proto-Oncogene Proteins c-akt
MeSH DescriptorUI: D051057
MeSH semantic group name: Chemicals & Drugs
number of authors: 97
number of publications: 207
uniqueness weight: 0.895074
type: Concept

Gene Expression Regulation
MeSH DescriptorUI: D005786
MeSH semantic group name: Physiology
number of authors: 432
number of publications: 1617
uniqueness weight: 0.600897
type: Concept

Male
MeSH DescriptorUI: D008297
MeSH semantic group name: Physiology
number of authors: 2235
number of publications: 29939
uniqueness weight: 0.228556
type: Concept

Cells, Cultured
MeSH DescriptorUI: D002478
MeSH semantic group name: Anatomy
number of authors: 494
number of publications: 2157
uniqueness weight: 0.713736
type: Concept

Mice, Transgenic
MeSH DescriptorUI: D008822
MeSH semantic group name: Living Beings
number of authors: 327
number of publications: 1277
uniqueness weight: 0.760382
type: Concept

Cell Separation
MeSH DescriptorUI: D002469
MeSH semantic group name: Procedures
number of authors: 96
number of publications: 147
uniqueness weight: 0.959818
type: Concept

Nifedipine
MeSH DescriptorUI: D009543
MeSH semantic group name: Chemicals & Drugs
number of authors: 12
number of publications: 19
uniqueness weight: 0.995928
type: Concept

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
MeSH DescriptorUI: D019796
MeSH semantic group name: Chemicals & Drugs
number of authors: 7
number of publications: 7
uniqueness weight: 0.997156
type: Concept

Cytoplasm
MeSH DescriptorUI: D003593
MeSH semantic group name: Anatomy
number of authors: 143
number of publications: 276
uniqueness weight: 0.889913
type: Concept

Excitation Contraction Coupling
MeSH DescriptorUI: D056966
MeSH semantic group name: Physiology
number of authors: 4
number of publications: 4
uniqueness weight: 0.99581
type: Concept

Chickens
MeSH DescriptorUI: D002645
MeSH semantic group name: Living Beings
number of authors: 59
number of publications: 95
uniqueness weight: 0.96759
type: Concept

Signal Transduction
MeSH DescriptorUI: D015398
MeSH semantic group name: Physiology
number of authors: 506
number of publications: 3035
uniqueness weight: 0.48133
type: Concept

Calcium Channel Agonists
MeSH DescriptorUI: D002120
MeSH semantic group name: Chemicals & Drugs
number of authors: 8
number of publications: 11
uniqueness weight: 0.995115
type: Concept

Female
MeSH DescriptorUI: D005260
MeSH semantic group name: Physiology
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number of publications: 32932
uniqueness weight: 0.215424
type: Concept

Lung
MeSH DescriptorUI: D008168
MeSH semantic group name: Anatomy
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number of publications: 956
uniqueness weight: 0.676966
type: Concept

Phenanthrolines
MeSH DescriptorUI: D010618
MeSH semantic group name: Chemicals & Drugs
number of authors: 6
number of publications: 10
uniqueness weight: 0.995659
type: Concept

Neurons
MeSH DescriptorUI: D009474
MeSH semantic group name: Anatomy
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number of publications: 923
uniqueness weight: 0.644118
type: Concept

Intracellular Fluid
MeSH DescriptorUI: D007424
MeSH semantic group name: Anatomy
number of authors: 26
number of publications: 32
uniqueness weight: 0.989558
type: Concept

Time Factors
MeSH DescriptorUI: D013997
MeSH semantic group name: Concepts & Ideas
number of authors: 1033
number of publications: 3770
uniqueness weight: 0.572466
type: Concept

alpha-Glucosidases
MeSH DescriptorUI: D000520
MeSH semantic group name: Chemicals & Drugs
number of authors: 7
number of publications: 10
uniqueness weight: 0.981623
type: Concept

Muscle Hypotonia
MeSH DescriptorUI: D009123
MeSH semantic group name: Disorders
number of authors: 7
number of publications: 7
uniqueness weight: 0.991526
type: Concept

Magnesium Sulfate
MeSH DescriptorUI: D008278
MeSH semantic group name: Chemicals & Drugs
number of authors: 8
number of publications: 9
uniqueness weight: 0.997305
type: Concept

Carbachol
MeSH DescriptorUI: D002217
MeSH semantic group name: Chemicals & Drugs
number of authors: 9
number of publications: 17
uniqueness weight: 0.996782
type: Concept

Potassium Chloride
MeSH DescriptorUI: D011189
MeSH semantic group name: Chemicals & Drugs
number of authors: 13
number of publications: 15
uniqueness weight: 0.993461
type: Concept

Egtazic Acid
MeSH DescriptorUI: D004533
MeSH semantic group name: Chemicals & Drugs
number of authors: 8
number of publications: 8
uniqueness weight: 0.997766
type: Concept

Myocytes, Smooth Muscle
MeSH DescriptorUI: D032389
MeSH semantic group name: Anatomy
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number of publications: 61
uniqueness weight: 0.953395
type: Concept

Adrenergic alpha-Antagonists
MeSH DescriptorUI: D000317
MeSH semantic group name: Chemicals & Drugs
number of authors: 14
number of publications: 16
uniqueness weight: 0.990639
type: Concept

Radioligand Assay
MeSH DescriptorUI: D011869
MeSH semantic group name: Procedures
number of authors: 14
number of publications: 24
uniqueness weight: 0.997167
type: Concept

Viral Tropism
MeSH DescriptorUI: D056189
MeSH semantic group name: Physiology
number of authors: 21
number of publications: 51
uniqueness weight: 0.947747
type: Concept

Peptides, Cyclic
MeSH DescriptorUI: D010456
MeSH semantic group name: Chemicals & Drugs
number of authors: 13
number of publications: 22
uniqueness weight: 0.990726
type: Concept

Nerve Endings
MeSH DescriptorUI: D009411
MeSH semantic group name: Anatomy
number of authors: 7
number of publications: 8
uniqueness weight: 0.995276
type: Concept

Microscopy, Fluorescence
MeSH DescriptorUI: D008856
MeSH semantic group name: Procedures
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number of publications: 401
uniqueness weight: 0.875004
type: Concept

Synaptic Membranes
MeSH DescriptorUI: D013570
MeSH semantic group name: Anatomy
number of authors: 4
number of publications: 8
uniqueness weight: 0.995352
type: Concept

Ion Transport
MeSH DescriptorUI: D017136
MeSH semantic group name: Physiology
number of authors: 14
number of publications: 21
uniqueness weight: 0.991754
type: Concept

Uterine Contraction
MeSH DescriptorUI: D014590
MeSH semantic group name: Physiology
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number of publications: 10
uniqueness weight: 0.986542
type: Concept

Litter Size
MeSH DescriptorUI: D008098
MeSH semantic group name: Concepts & Ideas
number of authors: 9
number of publications: 10
uniqueness weight: 0.997884
type: Concept

Bufo marinus
MeSH DescriptorUI: D002024
MeSH semantic group name: Living Beings
number of authors: 5
number of publications: 47
uniqueness weight: 0.995201
type: Concept

Cell Membrane
MeSH DescriptorUI: D002462
MeSH semantic group name: Anatomy
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number of publications: 496
uniqueness weight: 0.817538
type: Concept

Electric Stimulation
MeSH DescriptorUI: D004558
MeSH semantic group name: Procedures
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number of publications: 139
uniqueness weight: 0.964177
type: Concept

Thapsigargin
MeSH DescriptorUI: D019284
MeSH semantic group name: Chemicals & Drugs
number of authors: 14
number of publications: 17
uniqueness weight: 0.99786
type: Concept

Analysis of Variance
MeSH DescriptorUI: D000704
MeSH semantic group name: Concepts & Ideas
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number of publications: 608
uniqueness weight: 0.893299
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Virulence Factors, Bordetella
MeSH DescriptorUI: D010566
MeSH semantic group name: Chemicals & Drugs
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number of publications: 15
uniqueness weight: 0.994071
type: Concept

Reverse Transcriptase Polymerase Chain Reaction
MeSH DescriptorUI: D020133
MeSH semantic group name: Procedures
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Respiratory System
MeSH DescriptorUI: D012137
MeSH semantic group name: Anatomy
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Evoked Potentials
MeSH DescriptorUI: D005071
MeSH semantic group name: Physiology
MeSH semantic group name: Procedures
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number of publications: 39
uniqueness weight: 0.974609
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Pregnancy
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Tongue
MeSH DescriptorUI: D014059
MeSH semantic group name: Anatomy
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number of publications: 15
uniqueness weight: 0.990131
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Action Potentials
MeSH DescriptorUI: D000200
MeSH semantic group name: Physiology
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number of publications: 105
uniqueness weight: 0.954959
type: Concept

Adrenal Glands
MeSH DescriptorUI: D000311
MeSH semantic group name: Anatomy
number of authors: 27
number of publications: 33
uniqueness weight: 0.977381
type: Concept

Calcium Channels, L-Type
MeSH DescriptorUI: D020746
MeSH semantic group name: Chemicals & Drugs
number of authors: 15
number of publications: 26
uniqueness weight: 0.980121
type: Concept

Trachea
MeSH DescriptorUI: D014132
MeSH semantic group name: Anatomy
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number of publications: 85
uniqueness weight: 0.953443
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Microscopy
MeSH DescriptorUI: D008853
MeSH semantic group name: Procedures
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number of publications: 91
uniqueness weight: 0.933279
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Calcium Signaling
MeSH DescriptorUI: D020013
MeSH semantic group name: Physiology
number of authors: 61
number of publications: 157
uniqueness weight: 0.891553
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Glycogen Storage Disease Type II
MeSH DescriptorUI: D006009
MeSH semantic group name: Disorders
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number of publications: 8
uniqueness weight: 0.987657
type: Concept

Chloride Channels
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MeSH semantic group name: Chemicals & Drugs
number of authors: 13
number of publications: 28
uniqueness weight: 0.978025
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Fluorescence
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MeSH semantic group name: Phenomena
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uniqueness weight: 0.956045
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Guinea Pigs
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MeSH semantic group name: Living Beings
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number of publications: 84
uniqueness weight: 0.98612
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Endothelin-1
MeSH DescriptorUI: D019332
MeSH semantic group name: Chemicals & Drugs
number of authors: 7
number of publications: 7
uniqueness weight: 0.997623
type: Concept

Calcium-Transporting ATPases
MeSH DescriptorUI: D000252
MeSH semantic group name: Chemicals & Drugs
number of authors: 7
number of publications: 7
uniqueness weight: 0.996503
type: Concept

Potassium Channels, Calcium-Activated
MeSH DescriptorUI: D024681
MeSH semantic group name: Chemicals & Drugs
number of authors: 9
number of publications: 15
uniqueness weight: 0.987242
type: Concept

Image Processing, Computer-Assisted
MeSH DescriptorUI: D007091
MeSH semantic group name: Activities & Behaviors
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uniqueness weight: 0.751345
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Aniline Compounds
MeSH DescriptorUI: D000814
MeSH semantic group name: Chemicals & Drugs
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number of publications: 36
uniqueness weight: 0.986763
type: Concept

Infant, Newborn
MeSH DescriptorUI: D007231
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uniqueness weight: 0.719193
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Electrophysiological Phenomena
MeSH DescriptorUI: D055724
MeSH semantic group name: Physiology
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number of publications: 21
uniqueness weight: 0.990718
type: Concept

Type C Phospholipases
MeSH DescriptorUI: D010738
MeSH semantic group name: Chemicals & Drugs
number of authors: 17
number of publications: 33
uniqueness weight: 0.983215
type: Concept

Muscle Cells
MeSH DescriptorUI: D032342
MeSH semantic group name: Anatomy
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number of publications: 28
uniqueness weight: 0.98953
type: Concept

Potassium Channels
MeSH DescriptorUI: D015221
MeSH semantic group name: Chemicals & Drugs
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number of publications: 58
uniqueness weight: 0.968049
type: Concept

Enzyme Inhibitors
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MeSH semantic group name: Chemicals & Drugs
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number of publications: 373
uniqueness weight: 0.848343
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Models, Theoretical
MeSH DescriptorUI: D008962
MeSH semantic group name: Concepts & Ideas
MeSH semantic group name: Procedures
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number of publications: 271
uniqueness weight: 0.862376
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Ryanodine Receptor Calcium Release Channel
MeSH DescriptorUI: D019837
MeSH semantic group name: Chemicals & Drugs
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number of publications: 44
uniqueness weight: 0.972277
type: Concept

Epinephrine
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number of publications: 44
uniqueness weight: 0.982501
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Paracrine Communication
MeSH DescriptorUI: D019899
MeSH semantic group name: Physiology
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number of publications: 15
uniqueness weight: 0.992826
type: Concept

Swine
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number of publications: 380
uniqueness weight: 0.908113
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Protein Isoforms
MeSH DescriptorUI: D020033
MeSH semantic group name: Chemicals & Drugs
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number of publications: 197
uniqueness weight: 0.939838
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Phenotype
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MeSH semantic group name: Physiology
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uniqueness weight: 0.740485
type: Concept

Gene Deletion
MeSH DescriptorUI: D017353
MeSH semantic group name: Physiology
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number of publications: 309
uniqueness weight: 0.891926
type: Concept

Osmolar Concentration
MeSH DescriptorUI: D009994
MeSH semantic group name: Phenomena
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number of publications: 88
uniqueness weight: 0.975727
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Asthma
MeSH DescriptorUI: D001249
MeSH semantic group name: Disorders
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number of publications: 459
uniqueness weight: 0.705725
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Bethanechol
MeSH DescriptorUI: D018723
MeSH semantic group name: Chemicals & Drugs
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number of publications: 4
uniqueness weight: 0.998507
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Cytosol
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Defecation
MeSH DescriptorUI: D003672
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uniqueness weight: 0.993544
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Intracellular Space
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Cyclic AMP
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Base Sequence
MeSH DescriptorUI: D001483
MeSH semantic group name: Chemicals & Drugs
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Muscle, Skeletal
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Immunohistochemistry
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MeSH semantic group name: Procedures
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Receptors, Adrenergic, alpha-2
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MeSH semantic group name: Chemicals & Drugs
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uniqueness weight: 0.981186
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Pyrrolidinones
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MeSH semantic group name: Chemicals & Drugs
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Respiratory Mucosa
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Cytomegalovirus
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number of publications: 91
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Molecular Sequence Data
MeSH DescriptorUI: D008969
MeSH semantic group name: Concepts & Ideas
MeSH semantic group name: Genes & Molecular Sequences
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uniqueness weight: 0.766262
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Pertussis Toxin
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Xanthenes
MeSH DescriptorUI: D014966
MeSH semantic group name: Chemicals & Drugs
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number of publications: 9
uniqueness weight: 0.99805
type: Concept

UMass Chan Medical School
type: Organization

ZhuGe, Ronghua
first name: Ronghua
last name: ZhuGe
full name: Ronghua ZhuGe PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 611
person in primary position: Professor
type: Agent
type: Person
Lab URL: https://www.umassmed.edu/zhugelab/
Post Docs: Postdoctoral Positions are available in this laboratory. Contact Dr. ZhuGe for additional details at ronghua.zhuge@umassmed.edu
Rotation Projects: Rotation projects are available to study (1) the pathophysiology of Cl- channel TMEM16A in smooth muscle, (2) molecular mechanisms by which bitter tasting compounds relax smooth muscle, and (3) the role of bitter taste receptors in the pathogenesis of smooth muscle disorders.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>
Summary: Focus: The ZhuGe lab studies the molecular mechanisms by which Ca2+ signals and ion channels control neurotransmitter release and smooth muscle contractility. We also exploit new physiological functions of bitter taste receptors in extra-oral tissues and organs. We aim to find novel molecular targets for new therapies to manage asthma, fecal incontinence, preterm labor, and adenomyosis.
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