Large-Conductance Calcium-Activated Potassium Channels
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Reverse Transcriptase Polymerase Chain Reaction
Ryanodine Receptor Calcium Release Channel
Postdoctoral Positions are available in this laboratory. Contact Dr. ZhuGe for additional details at ronghua.zhuge@umassmed.edu
Rotation projects are available to study (1) the pathophysiology of Cl- channel TMEM16A in smooth muscle, (2) molecular mechanisms by which bitter tasting compounds relax smooth muscle, and (3) the role of bitter taste receptors in the pathogenesis of smooth muscle disorders.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>
Focus: The ZhuGe lab studies the molecular mechanisms by which Ca2+ signals and ion channels control neurotransmitter release and smooth muscle contractility. We also exploit new physiological functions of bitter taste receptors in extra-oral tissues and organs. We aim to find novel molecular targets for new therapies to manage asthma, fecal incontinence, preterm labor, and adenomyosis.
Antidiuretic Hormone Receptor Antagonists