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Summary: My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
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Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
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Czech, Michael
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Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
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Trivedi, Nitin
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Davis, Roger
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Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
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Zierath, Juleen
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Adjunct Assistant Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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HR job title: Adjunct Assistant Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
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HR job title: Instructor
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Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Associate Professor
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sort order: 1
type: Position
HR job title: Associate Professor
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Associate Professor
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position in department: Medicine
position in division: Rheumatology
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HR job title: Associate Professor
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Professor
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position in division: General Internal Medicine
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Singhal, Amit
first name: Amit
last name: Singhal
full name: Amit Singhal PhD
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Person ID: 10247306
person in primary position: Adjunct Associate Professor
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preferred title: Adjunct Associate Professor

Assistant Professor
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position in department: Medicine
position in division: Renal Medicine
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type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Chair and Professor
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type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Evans, Elizabeth
first name: Elizabeth
last name: Evans
full name: Elizabeth A Evans PhD
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Person ID: 10247438
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Professor
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HR job title: Professor
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Professor
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position in department: Surgery
position in division: Vascular Surgery
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HR job title: Professor
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Family Medicine and Community Health
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HR job title: Associate Professor
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Walkey, Allan
first name: Allan
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full name: Allan Jay Walkey MD, MSc
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Person ID: 10247602
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Upadhyay, Jagriti
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last name: Upadhyay
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latitude: 42.48526100000000
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Person ID: 10247667
person in primary position: Assistant Professor
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preferred title: Assistant Professor

Medicine at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Assistant Professor
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Radiology at UMass Chan - Lahey
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Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
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HR job title: Chair and Professor
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Professor
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position in division: Rheumatology
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type: Position
HR job title: Professor
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Professor
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position in division: Biostatistics And Health Services Research
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Health Informatics And Implementation Science
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HR job title: Professor
position in organization: UMass Chan Medical School

Endocrinology & Diabetes
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Health System Science
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Infectious Diseases
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type: Organization

Pulmonary Medicine
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Professor Emeritus
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position in division: Epidemiology
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HR job title: Professor Emeritus
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Professor
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position in division: Pulmonary Medicine
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type: Position
HR job title: Professor
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Professor
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position in division: Geriatrics
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Medicine
position in division: Endocrinology & Diabetes
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type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Epidemiology
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Surgery
position in division: General Surgery
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Anesthesiology and Perioperative Medicine
position in division: Anesthesiology- Pediatric
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Anesthesiology- Pediatric
type: Division
type: Organization

Chair and Professor
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position in department: Medicine
position in division: Cardiovascular Medicine
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type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Ramsey, David
first name: David
last name: Ramsey
full name: David J Ramsey MD, PhD, MPH
has faculty rank: Associate Professor
latitude: 42.53749440000000
longitude: -70.94678520000000
Person ID: 10247796
person in primary position: Associate Professor
type: Agent
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preferred title: Associate Professor

Associate Professor
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position in department: Surgery at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Tan Chingfen Graduate School of Nursing
type: Department
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Professor
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position in department: Tan Chingfen Graduate School of Nursing
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

McAlindon, Timothy
first name: Timothy
last name: McAlindon
full name: Timothy Edward McAlindon MD, MPH, MRCP
has faculty rank: Professor
latitude: 42.27222560000000
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Person ID: 10247852
person in primary position: Professor
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preferred title: Professor

Dani, Sourbha
first name: Sourbha
last name: Dani
full name: Sourbha S Dani MD, MSc, GDCE, CCDS, FACC,FACP
has faculty rank: Associate Professor
latitude: 42.48526100000000
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Person ID: 10247888
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Martinez, Fernando
first name: Fernando
last name: Martinez
full name: Fernando J Martinez MD, MS
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latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 10247895
person in primary position: Professor
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type: Person
Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
preferred title: Professor

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Krings, Timo
first name: Timo
last name: Krings
full name: Timo Krings MD, PhD, FRCP
has faculty rank: Professor
latitude: 42.48526100000000
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Person ID: 10247952
person in primary position: Professor
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preferred title: Professor

Maron, Martin
first name: Martin
last name: Maron
full name: Martin S Maron MD, MSPH
has faculty rank: Associate Professor
latitude: 42.48526100000000
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
first name: Barry
last name: Maron
full name: Barry J Maron MD
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latitude: 42.48526100000000
longitude: -71.20221980000000
Person ID: 10248130
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Adjunct Professor
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Rheumatology
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/55778719
number of subject areas: 17
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https://profiles.umassmed.edu/profile/55780437
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https://profiles.umassmed.edu/profile/55785752
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https://profiles.umassmed.edu/profile/55791021
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type: Connection Details

https://profiles.umassmed.edu/profile/55798616
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type: Connection Details

https://profiles.umassmed.edu/profile/55808668
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type: Connection Details

https://profiles.umassmed.edu/profile/55822343
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type: Connection Details

https://profiles.umassmed.edu/profile/55827744
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type: Connection Details

https://profiles.umassmed.edu/profile/55831308
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type: Connection Details

https://profiles.umassmed.edu/profile/55836276
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type: Connection Details

https://profiles.umassmed.edu/profile/55837585
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type: Connection Details

https://profiles.umassmed.edu/profile/55840299
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https://profiles.umassmed.edu/profile/55861748
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https://profiles.umassmed.edu/profile/55877630
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type: Connection Details

https://profiles.umassmed.edu/profile/55886419
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https://profiles.umassmed.edu/profile/55888059
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https://profiles.umassmed.edu/profile/55890605
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type: Connection Details

https://profiles.umassmed.edu/profile/55898088
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https://profiles.umassmed.edu/profile/55907805
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https://profiles.umassmed.edu/profile/55909376
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https://profiles.umassmed.edu/profile/55913189
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https://profiles.umassmed.edu/profile/55914950
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Chair and Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor Emeritus
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position in department: Program in Molecular Medicine
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sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Professor
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position in department: Program in Molecular Medicine
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/57645289
number of subject areas: 9
type: Connection Details

Ganatra, Sarju
first name: Sarju
last name: Ganatra
full name: Sarju Ganatra MD
has faculty rank: Assistant Professor
latitude: 42.48526100000000
longitude: -71.20221980000000
Person ID: 10248218
person in primary position: Assistant Professor
type: Agent
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preferred title: Assistant Professor

Assistant Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Instructor
sort order: 17
type: Faculty Rank

Professor
sort order: 3
type: Faculty Rank

Professor Emeritus
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type: Faculty Rank

Research Professor
sort order: 9
type: Faculty Rank

Assistant Professor
sort order: 13
type: Faculty Rank

Associate Professor
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type: Faculty Rank

Chair And Professor
sort order: 4
type: Faculty Rank

Professor Emeritus
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position in department: Medicine
position in division: Health System Science
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Psychiatry and Behavioral Sciences
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Professor
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position in department: Psychiatry and Behavioral Sciences
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Health System Science
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/67138967
number of subject areas: 18
type: Connection Details

Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Associate Professor
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position in department: Medicine
position in division: Pulmonary Medicine
sort order: 1
type: Position
HR job title: Adjunct Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
has faculty rank: ADJUNCT PROFESSOR
Person ID: 10248397
person in primary position: Adjunct Professor
type: Agent
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preferred title: Adjunct Professor

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/92764792
number of subject areas: 18
type: Connection Details

https://profiles.umassmed.edu/profile/92765984
number of subject areas: 14
type: Connection Details

https://profiles.umassmed.edu/profile/92770572
number of subject areas: 11
type: Connection Details

https://profiles.umassmed.edu/profile/92770614
number of subject areas: 17
type: Connection Details

https://profiles.umassmed.edu/profile/92772408
number of subject areas: 18
type: Connection Details

https://profiles.umassmed.edu/profile/92775284
number of subject areas: 18
type: Connection Details

https://profiles.umassmed.edu/profile/93082833
number of subject areas: 16
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Adjunct Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan – Baystate Regional Campus