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Cavacini, Lisa
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Person ID: 3911
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Rotation Projects: Rotation projects include development of nanobodies for prevention and treatment of mucosal disease (viral and bacteria).
preferred title: Professor

Chai, Peter
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Molecular, Cell and Cancer Biology
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Levitz, Stuart
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Lu, Shan
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Rotation Projects: Additional information about lab rotations within the CPHR program can be found athttp://www.umassmed.edu/cphr/program/rotations.aspx
preferred title: Professor Emeritus

Baehrecke, Eric
first name: Eric
last name: Baehrecke
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Endowed Chair Honorary Title: Our Danny Cancer Fund Chair in Biomedical Research II
Post Docs: Postdoctoral positions are available for this lab. Please contact Eric Baehrecke directly, 508-856-6733 or via email, Eric.Baehrecke@umassmed.edu
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866477

Gonzalez Perez, Maria Paz
first name: Maria Paz
last name: Gonzalez Perez
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Brown, Robert
first name: Robert
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Endowed Chair Honorary Title: Donna M. and Robert J. Manning Chair in Neurosciences
Lab URL: https://www.umassmed.edu/brownlab/
Summary: Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
preferred title: Professor

Swain, Susan
first name: Susan
last name: Swain
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
preferred title: Professor

Gao, Fen-Biao
first name: Fen-Biao
last name: Gao
full name: Fen-Biao Gao PhD
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Person ID: 1368
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Endowed Chair Honorary Title: Governor Paul Cellucci Chair in Neuroscience Research
Lab URL: https://www.umassmed.edu/fen-biaogaolab
Rotation Projects: Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Summary: Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
preferred title: Professor

Clapham, Paul
first name: Paul
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Rotation Projects: Rotation Projects Rotation projects are available in support of our research. See the research description section of this page.
preferred title: Professor Emeritus

Latz, Eicke
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Luban, Jeremy
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Endowed Chair Honorary Title: David J. Freelander Memorial Professor in AIDS Research
Post Docs: PostDoc Position available
Rotation Projects: Lab rotation position is available
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Kurt Yilmaz, Nese
first name: Nese
last name: Kurt Yilmaz
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Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
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Person ID: 202
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Corvera, Silvia
first name: Silvia
last name: Corvera
full name: Silvia Corvera MD
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Person ID: 220
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Endowed Chair Honorary Title: Endowed Chair in Diabetes Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Corvera for additional details.
Rotation Projects: Rotation Projects Our rotation projects are in the area of diabetes and obesity, and we are interested in basic mechanisms of cell proliferation, differentiation and communication. Diabetes is highly correlated with obesity, but why obesity causes disease in some humans and not others is not understood. Amazingly, we still don’t understand how adipose tissue grows in human adults. A better understanding of this fascinating process can give us insight into basic mechanisms of cell growth, differentiation and communication, as well as mechanisms of disease, not only diabetes but also cancer and developmental defects. During your rotation, you will work on an important piece of a larger project, that has a well-defined outcome. Thus, your successful completion of the rotation project will allow you to be included at the time of publication of the work. Project 1: Adipose tissue is not only formed by adipocytes, but by other cells such as endothelial, mural and immune cells. Also, there are multiple kinds of adipocytes with different functions. We have recently developed conditions to develop adipose tissue from humans in-vitro (adipose tissue “organoids”). From this tissue we have been able to separated single cells, and find that they grow into different kinds of clones. We are now conducting RNAseq on >300 of those clones, to determine how many cell types exist in human adipose tissue, and what their roles are. In this rotation, you will be able to analyze RNAseq data to define what genes characterize these cells, and you will use virus transduction to create immortalized cells for further study. Project 2: Adipose tissue has many functions besides storing and releasing lipids. It also has to coordinate metabolism in the whole body. We have found that human “beige” adipose tissue, which is found in people who are metabolically healthy, expresses genes for secreted factors that communicate with the immune system and the brain. These include IL-33 and enkephalins. In t…
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866593

Peters, Paul
first name: Paul
last name: Peters
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preferred title: Instructor

Shultz, Leonard
first name: Leonard
last name: Shultz
full name: Leonard Donald Shultz PhD
has faculty rank: Professor
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Person ID: 2863
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Greenough, Thomas
first name: Thomas
last name: Greenough
full name: Thomas C Greenough MD
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Person ID: 291
person in primary position: Associate Professor
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preferred title: Associate Professor

Munson, Mary
first name: Mary
last name: Munson
full name: Mary Munson PhD
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latitude: 42.27985300000000
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Rotation Projects: Potential Rotation Projects <p >Research in the Munson lab is focused on biochemical/biophysical and cell biological characterization of proteins in the exocyst complex. Potential rotation projects include the following: Cloning of various exocyst protein domains and point mutations. These will be expressed in E. coli for biochemical/structural studies, and their functions tested in yeast. Protein expression and purification. Develop purification strategies for several exocyst proteins and their domains, using chromatography methods such as ion exchange and gel filtration (Fig. 2). Characterization of the purified exocyst proteins. Protein structure, stability, oligomerization state and protein:protein interactions will be monitored by such techniques as circular dichroism, analytical ultracentrifugation and gel filtration (Fig. 3). Crystallography. We have determined the structure of the C-terminal domain of Sec6p (Fig. 4). Crystallization trials ofotherexocyst proteins and their domains are in progress. Design and test functional exocyst mutants in yeast. Mutants will be characterized using a variety of biochemical, cell biological, and microscopic techniques. Identify novel regulators of yeast exocytosis using a genetic screen. Mutants created in these screens are currently being tested and identified (Fig. 5). Their role in exocytosis will be explored <p >
preferred title: Professor

Rock, Kenneth
first name: Kenneth
last name: Rock
full name: Kenneth L Rock MD
has faculty rank: Chair And Professor
latitude: 42.27525000000000
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Person ID: 332
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Endowed Chair Honorary Title: UMass Chan Medical School Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
preferred title: Chair and Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
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person in primary position: Adjunct Professor
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Golenbock, Douglas
first name: Douglas
last name: Golenbock
full name: Douglas T Golenbock MD
has faculty rank: Professor
latitude: 42.27985300000000
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Person ID: 345
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Endowed Chair Honorary Title: Neil and Margery Blacklow Chair in Infectious Diseases and Immunology
preferred title: Professor

Royer, William
first name: William
last name: Royer
full name: William E Royer PhD
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Rotation Projects: <Long Text /> Potential Rotation Projects Project #1: Probing the structural basis for cooperativity in a dimeric hemoglobin: Scapharca dimeric hemoglobin is an elegantly simple model system for exploring the structural basis for intersubunit communication. Our analysis to date has established a new paradigm for cooperativity in which tightly bound water molecules are used as sensors for ligand state. In this project, the student will first mutate the gene for the native hemoglobin at a residue that is suspected of playing a role in the intersubunit communication. The mutated protein will then be expressed in E. coli and purified and subjected to functional analysis of oxygen binding. Using conditions already established for the native protein, the mutant hemoglobin will then be crystallized and subjected to preliminary x-ray analysis. This project will provide the student with an introduction to two of the most powerful techniques for investigating the structure and function of proteins: site-directed mutagenesis and x-ray crystallography. Additionally, valuable experience in protein purification will be obtained. Project #2: Structural analysis of the polymerization of sickle-cell hemoglobin Sickle cell disease results from the pathological polymerization of deoxygenated hemoglobin S (ß6E->V) within erythrocytes. This polymerization depends upon a complicated interplay of multiple interactions between tetramers. Our high resolution crystal structure of this molecule has elucidated details of some of the important interactions. Several projects are available for rotation students. These include crystallization of sickle-cell hemoglobin in the presence of an inhibitor to identify its binding site, site-directed mutagenesis of hemoglobin S and crystallization of mutants that show altered polymerization characteristics.
preferred title: Professor Emeritus

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27723620000000
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Person ID: 370
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Gierasch, Lila
first name: Lila
last name: Gierasch
full name: Lila M Gierasch Ph.D.
has faculty rank: Distinguished Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3705
person in primary position: Distinguished Professor
type: Agent
type: Person
preferred title: Distinguished Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

Sullivan, John
first name: John
last name: Sullivan
full name: John L Sullivan MD
has faculty rank: Professor Emeritus
latitude: 42.27719870000000
longitude: -71.75921810000000
Person ID: 376
person in primary position: Professor Emeritus
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Contact Dr. Sullivan for more project details.
preferred title: Professor Emeritus

Poudel, Krishna
first name: Krishna
last name: Poudel
full name: Krishna Poudel PhD
has faculty rank: Associate Professor
latitude: 42.39565560000000
longitude: -72.52196170000000
Person ID: 3832
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Brehm, Michael
first name: Michael
last name: Brehm
full name: Michael A Brehm PhD
has faculty rank: Professor
latitude: 42.27694690000000
longitude: -71.76568470000000
Person ID: 474
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
preferred title: Professor

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
has faculty rank: Professor
latitude: 42.27767280000000
longitude: -71.76163720000000
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Person ID: 507
person in primary position: Professor
type: Agent
type: Person
Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
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Person ID: 554
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Schiffer, Celia
first name: Celia
last name: Schiffer
Featured Videos: https://profiles.umassmed.edu/profile/28867214
full name: Celia A Schiffer PhD
has faculty rank: Chair And Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
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Person ID: 558
person in primary position: Chair and Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

McCollum, Dannel
first name: Dannel
last name: McCollum
full name: Dannel McCollum PhD
has faculty rank: Professor
latitude: 42.27491030000000
longitude: -71.76424060000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 561
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. McCollum for additional details.
Rotation Projects: Rotation Projects Analog sensitive LATS kinase: The goal of this project is to use CRISPR based genome modification to make mutations in the endogenous LATS kinase that cause it to be inhibited by a synthetic ATP analog. This will allow LATS kinase activity to be turned on and off using the ATP analog. The analog sensitive cell line will be a valuable tool for studying Hippo pathway responses to various stimuli and will be used to test whether dephosphorylation of LATS substrates is an important regulatory mechanism. This project will also set the stage for future experiments to create mice that have analog sensitive versions of LATS. These mice will be used to test whether LATS inhibition is a viable treatment for regenerative therapies for the heart, gut, pancreas and other organs. TRIP6 and Angiomotin interacting proteins: We know that cells monitor their mechanical environment by sensing F-actin levels and by measuring tension at cell-cell junctions. We have identified angiomotins as sensors for F-actin and the TRIP6 protein as part of a tension sensor at cell-cell junctions. However, to understand how these sensors work, we need know the network of proteins that they each interact with, and how those networks change in response to mechanical perturbations. To do this we will fuse each sensor to the promiscuous biotin ligase protein BirA, and express the fusion proteins in cells under various conditions. The biotin ligase will label proteins in close proximity with biotin. Labeled proteins will be purified and analyzed by mass spectrometry, and the spectrum of interacting partners under different conditions will be compared.
preferred title: Professor

Lambright, David
first name: David
last name: Lambright
full name: David Lambright PhD
has faculty rank: Professor
latitude: 42.27932700000000
longitude: -71.76549170000000
Person ID: 604
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Lambright for additional details.
Rotation Projects: Lab Rotations <p >Our lab takes an interdisciplinary approach to the study of fundamental problems in cell biology, signal transduction and membrane trafficking. Rotation projects are available in any of the areas of interest to the lab. Projects are tailored to the individual interests of the students and often involve a combination of molecular, biochemical, biophysical, structural and/or cell based analyses to investigate signaling and trafficking mechanisms. <p >
preferred title: Professor

Ip, Yicktung
first name: Yicktung
last name: Ip
full name: Yicktung T Ip PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
Person ID: 609
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Ip for additional details.
Rotation Projects: Rotation Projects Project #1: Mechanistic study of isolated mutants that show abnormal intestinal stem cell division phenotypes. Project #2:Perform transgenic RNAi-based genetic screen for genes required for intestinal stem cell response to tissue damage.
preferred title: Professor

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 612
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Somasundaran, Mohan
first name: Mohan
last name: Somasundaran
full name: Mohan Somasundaran PhD
has faculty rank: DISTINGUISHED ASSOCIATE PROFESSOR
latitude: 42.27491030000000
longitude: -71.76424060000000
Person ID: 616
person in primary position: Distinguished Associate Professor
type: Agent
type: Person
preferred title: Distinguished Associate Professor

Pazour, Gregory
first name: Gregory
last name: Pazour
full name: Gregory J Pazour PhD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 621
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Rotation projects in my laboratory will involve questions of how cilia are assembled and the function these organelles play in mammals. Projects vary depending on ongoing work in the laboratory and interests of the rotation student. Rotations in my laboratory can give students exposure to a range of techniques from mouse breeding and histological analysis of mouse tissues to mammalian cell culture and other cell biological techniques.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/41661165

Ruiz De Luzuriaga, Katherine
first name: Katherine
last name: Ruiz De Luzuriaga
full name: Katherine Ruiz De Luzuriaga MD
has faculty rank: Professor
latitude: 42.27913100000000
longitude: -71.76550320000000
Person ID: 651
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: UMass Memorial Health Care Chair in Biomedical Research
Rotation Projects: Potential Rotation Projects: Contact Dr. Luzuriaga for project details.
preferred title: Professor

Gilmore, James Reid
first name: James Reid
last name: Gilmore
full name: James Reid Gilmore PhD
has faculty rank: Professor Emeritus
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 669
person in primary position: Professor Emeritus
type: Agent
type: Person
Rotation Projects: Rotation Project Background
Rotation Projects: In yeast cells, protein translocation across the endoplasmic reticulum can occur by cotranslational or posttranslational pathways. The objective of this project is to develop a rapid method to inactivate the posttranslational pathway in vivo in yeast cells by appending the CMV-ribosome stalling sequence to the C-terminus of a typical posttranslational translocation substrate (carboxypeptidase Y). Complexes between the posttranslational translocation channel (SEC complex) and the stalled ribosomes will be purified for structural and functional analysis.
preferred title: Professor Emeritus

Ali, Akbar
first name: Akbar
last name: Ali
full name: Akbar Ali PhD
has faculty rank: Associate Professor
latitude: 42.27985300000000
longitude: -71.79190270000000
photo: https://profiles.umassmed.edu/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 699
person in primary position: Associate Professor
type: Agent
type: Person
preferred title: Associate Professor

Stern, Lawrence
first name: Lawrence
last name: Stern
full name: Lawrence Stern PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
Person ID: 730
person in primary position: Professor
type: Agent
type: Person
Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
preferred title: Professor

Dekker, Job
first name: Job
last name: Dekker
full name: Job Dekker PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 759
person in primary position: Professor
type: Agent
type: Person
Endowed Chair Honorary Title: Joseph J. Byrne Chair in Biomedical Research
Rotation Projects: ? Rotation Projects Multiple rotation projects are available in several areas related to long-range gene regulation and higher order chromosome organization. Projects include thorough analyses of the biochemical mechanisms of long-range gene regulation of specific disease-related genes, as well as large-scale analyses of chromosome organization using high-throughput genomics technologies (5C and Hi-C). The lab employs a wide range of experimental approaches, including cell culture, protein biochemistry, microscopy, genomics as well computational approaches such as bioinformatics and modeling. Specific rotation projects are determined dependent on the interest of the student.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866525
webpage: https://profiles.umassmed.edu/profile/28866572

Gottlinger, Heinrich
first name: Heinrich
last name: Gottlinger
full name: Heinrich Gottlinger MD, PhD
has faculty rank: Professor
latitude: 42.27587600000000
longitude: -71.76211600000000
Person ID: 886
person in primary position: Professor
type: Agent
type: Person
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Gottlinger for additional details.
Rotation Projects: Potential Rotation Projects 1.The identification of novel binding partners for cellular proteins required for HIV-1 budding using a double tag immunoaffinity purification approach. 2.The characterization of mutant ESCRT-III components that block HIV-1 budding with regard to subcellular localization and their ability to interact with certain phosphoinositol lipids and with other proteins involved in late endosomal sorting. 3.The mapping of binding sites for cellular proteins that we have identified as specific components of HIV-1 using GST pulldown, yeast two-hybrid, and co-immunoprecipitation approaches. 4.The generation and functional characterization of mutant viral Gag proteins that fail to interact with specific cellular partners.
preferred title: Professor

Usami, Yoshiko
first name: Yoshiko
last name: Usami
full name: Yoshiko Usami PhD
has faculty rank: Instructor
latitude: 42.27985300000000
longitude: -71.79190270000000
Person ID: 894
person in primary position: Instructor
type: Agent
type: Person
preferred title: Instructor

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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
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Rotation Projects: Potential Rotation Projects <p >Our laboratory combines genetic and biochemical approaches to investigate the molecular underpinnings of adaptation. Potential rotation projects are available in two general (and partially overlapping) areas: exploring fitness landscapes through systematic approaches and investigating the molecular mechanism of the Hsp90 chaperone in signal transduction. Please contact the lab to discuss specific rotation projects in more detail.
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