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Ambros, Victor
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Summary: Dr. Muehlschlegel is a neurointensivist devoted to improving the care of patients with catastrophic neurological injuries. Her research interests concentrate on outcome prognostication in neurocritical care, particularly in moderate-severe traumatic brain injury. She is the principal investigator for several research studies at the UMASS Neuro-Intensive care unit (NeuroICU).
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Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Heneka, Michael
first name: Michael
last name: Heneka
full name: Michael Thomas Heneka MD
has faculty rank: ADJUNCT PROFESSOR
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person in primary position: Adjunct Professor
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type: Person
preferred title: Adjunct Professor

Szabo, Gyongyi
first name: Gyongyi
last name: Szabo
full name: Gyongyi Szabo MD, PhD
has faculty rank: ADJUNCT PROFESSOR
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
first name: Jane
last name: Lian
full name: Jane B Lian PhD
has faculty rank: ADJUNCT PROFESSOR
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person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Rotello, Vincent
first name: Vincent
last name: Rotello
full name: Vincent Rotello PhD
has faculty rank: Professor
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Person ID: 3741
person in primary position: Department Head
type: Agent
type: Person
preferred title: Department Head

McClements, David
first name: David
last name: McClements
full name: David J McClements B.S., Ph.D.
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Person ID: 3760
person in primary position: Fergus Clydesdale Endowed Chair
type: Agent
type: Person
preferred title: Fergus Clydesdale Endowed Chair

Pederson, Thoru
first name: Thoru
last name: Pederson
full name: Thoru Pederson PhD
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person in primary position: Professor Emeritus
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type: Person
Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
preferred title: Professor Emeritus

Xiao, Hang
first name: Hang
last name: Xiao
full name: Hang Xiao PhD
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person in primary position: Associate Professor
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type: Person
preferred title: Associate Professor

Shao, Rong
first name: Rong
last name: Shao
full name: Rong Shao Ph.D. M.D.
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person in primary position: Research Assistant Professor
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preferred title: Research Assistant Professor

Zamore, Phillip
first name: Phillip
last name: Zamore
full name: Phillip D Zamore PhD
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Person ID: 418
person in primary position: Chair and Professor
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type: Person
Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
webpage: https://profiles.umassmed.edu/profile/28866537
webpage: https://profiles.umassmed.edu/profile/28866541

Imbalzano, Anthony
first name: Anthony
last name: Imbalzano
full name: Anthony N Imbalzano PhD
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Person ID: 507
person in primary position: Professor
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Post Docs: Please contact Dr. Imbalzano to discuss the possibility of a postdoctoral training.See lab research interests and publications for recent topics of research. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
Rotation Projects: Please contact Dr. Imbalzano to discuss the possibility of a rotation project. Rotation projects are generally based on current work and tailored to the interests of the student. See lab research interests and publications for recent topics. http://www.umassmed.edu/imbalzanolab/ http://www.umassmed.edu/imbalzanolab/publications/
preferred title: Professor

Richter, Joel
first name: Joel
last name: Richter
Featured Videos: https://profiles.umassmed.edu/profile/28867186
full name: Joel Richter PhD
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Person ID: 554
person in primary position: Professor
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Endowed Chair Honorary Title: Arthur F. Koskinas Chair in Neuroscience
Rotation Projects: Many rotation projects are available so please inquire.
preferred title: Professor

Ross, Alonzo
first name: Alonzo
last name: Ross
full name: Alonzo H Ross PhD
has faculty rank: Professor Emeritus
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Person ID: 584
person in primary position: Professor Emeritus
type: Agent
type: Person
Rotation Projects: Rotation Projects Potential Rotation Projects Allostericregulation of PTEN using biophysical techniques. Analysis of PTEN structure by NMR. Therapies directed against cancer stem cells for human glioblastomas. Signaling directed therapies for meningioma brain tumors. <p > <p >
preferred title: Professor Emeritus

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
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Person ID: 78
person in primary position: Professor Emeritus
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type: Person
preferred title: Professor Emeritus

Shaw, Leslie
first name: Leslie
last name: Shaw
full name: Leslie M Shaw PhD
has faculty rank: Professor
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Person ID: 900
person in primary position: Professor
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preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866558

Mercurio, Arthur
first name: Arthur
last name: Mercurio
full name: Arthur M Mercurio PhD
has faculty rank: Professor
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Person ID: 901
person in primary position: Professor
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
preferred title: Professor

Bogdanov, Alexei
first name: Alexei
last name: Bogdanov
full name: Alexei A Bogdanov PhD
has faculty rank: Professor Emeritus
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Person ID: 906
person in primary position: Professor Emeritus
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type: Person
preferred title: Professor Emeritus
webpage: https://profiles.umassmed.edu/profile/28866578
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Gounis, Matthew
first name: Matthew
last name: Gounis
full name: Matthew J Gounis PhD
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person in primary position: Professor
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McManus, David
first name: David
last name: McManus
full name: David D McManus MD
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Person ID: 994
person in primary position: Chair and Professor
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type: Person
Endowed Chair Honorary Title: Richard M. Haidack Professor in Medicine
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Friedmann, Peter
first name: Peter
last name: Friedmann
full name: Peter D Friedmann MD, MPH, DFASAM, FACP
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person in primary position: Professor
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preferred title: Professor

Politi, Letterio
first name: Letterio
last name: Politi
full name: Letterio Salvatore Politi MD
has faculty rank: Associate Professor
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Person ID: 4360
person in primary position: Associate Professor
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preferred title: Associate Professor

UMass Chan – Baystate Regional Campus
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Yang, Hongwei
first name: Hongwei
last name: Yang
full name: Hongwei Yang MD, PhD
has faculty rank: Associate Professor
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Person ID: 4652
person in primary position: Associate Professor
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preferred title: Associate Professor

Johnson, Mark
first name: Mark
last name: Johnson
full name: Mark Damone Johnson MD, PhD
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Person ID: 4642
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Maroun Semaan Chair in Neurosurgery
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position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor Emeritus
is primary position: true
position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology
position in division: Neuroradiology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School