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Post Docs: The project aims to develop computational algorithms and software programs for analyzing high-throughput sequence data such as ChIP-Seq RNA-Seq small RNA sequencing data. PhD required. A strong background in computational biology especially experience with analyzing high-throughput sequencing data is highly desirable. Excellent communication and writing skills and the ability to work with experimental and computational collaborators are essential. To apply please forward CV cover letter and three references to: Zhiping.Weng@umassmed.edu
Rotation Projects: Please contact Dr. Weng for information on rotations that are available in her lab.
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Gao, Guangping
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Sena-Esteves, Miguel
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Rotation Projects: Rotation Projects for graduate students: Examining the role of cross-reactive CD8 memory T cells in mediating the EBV-induced infectious mononucleosis syndrome in humans. Examining the role of cross-reactive CD8 memory T cells and cytokines in murine models of viral infection. Examining the mechanisms used by these memory T cells to unrelated infections to modulate disease outcome either for the bad or the good.
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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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preferred title: Adjunct Professor

Luban, Jeremy
first name: Jeremy
last name: Luban
full name: Jeremy Luban MD
has faculty rank: Professor
latitude: 42.27587600000000
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Person ID: 1684
person in primary position: Professor
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Endowed Chair Honorary Title: David J. Freelander Memorial Professor in AIDS Research
Post Docs: PostDoc Position available
Rotation Projects: Lab rotation position is available
preferred title: Professor

Fitzgerald, Katherine
first name: Katherine
last name: Fitzgerald
full name: Katherine A Fitzgerald PhD
has faculty rank: Professor
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Person ID: 202
person in primary position: Professor
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Endowed Chair Honorary Title: Worcester Foundation for Biomedical Research Chair III
Rotation Projects: Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866427
webpage: https://profiles.umassmed.edu/profile/28866493

Serreze, David
first name: David
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full name: David V Serreze PhD
has faculty rank: Associate Professor
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person in primary position: Associate Professor
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preferred title: Associate Professor

Shultz, Leonard
first name: Leonard
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full name: Leonard Donald Shultz PhD
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preferred title: Professor

Klempner, Mark
first name: Mark
last name: Klempner
full name: Mark Steven Joel Klempner MD
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preferred title: Professor

Lapane, Kate
first name: Kate
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full name: Kate L Lapane PhD
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Rock, Kenneth
first name: Kenneth
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Endowed Chair Honorary Title: UMass Chan Medical School Chair in Biomedical Research
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
preferred title: Chair and Professor

Heneka, Michael
first name: Michael
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person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Behar, Samuel
first name: Samuel
last name: Behar
full name: Samuel M Behar MD, PhD
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Person ID: 3437
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Rotation Projects: LAB ROTATION PROJECTS AVAILABLE -- PLEASE CONTACT SAM BEHAR FOR MORE INFORMATION
Summary: Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
preferred title: Professor

Yoon, Seongkyu
first name: Seongkyu
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full name: Seongkyu Yoon PhD
has faculty rank: Assistant Professor
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Person ID: 3553
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Szabo, Gyongyi
first name: Gyongyi
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Green, Sharone
first name: Sharone
last name: Green
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Person ID: 367
person in primary position: Associate Professor
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Rotation Projects: Sharone Green, M.D. Academic Role: Associate Professor Faculty Appointment(s) In: Medicine Other Affiliation(s): Center for Infectious Disease and Vaccine Research Potential Rotation Projects Flavivirus-specific T lymphocytes -characterization of T lymphocytes (human or murine) with novel specificities for epitopes ofdengue, yellow fever, Japanese encephalitis or West Nile viruses; functional characterization of T cell effector responses; quantitation of epitope-specific CD4 and/or CD8 T cells
preferred title: Associate Professor

Chasan-Taber, Lisa
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preferred title: Professor

Meyer, Jerrold
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preferred title: Professor

Hardy, Jeanne
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person in primary position: Associate Professor
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preferred title: Associate Professor

Xiao, Hang
first name: Hang
last name: Xiao
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person in primary position: Associate Professor
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preferred title: Associate Professor

Poudel, Krishna
first name: Krishna
last name: Poudel
full name: Krishna Poudel PhD
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Person ID: 3832
person in primary position: Associate Professor
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preferred title: Associate Professor

Brehm, Michael
first name: Michael
last name: Brehm
full name: Michael A Brehm PhD
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Person ID: 474
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
preferred title: Professor

Morrison, Trudy
first name: Trudy
last name: Morrison
full name: Trudy G Morrison PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 525
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Lab URL: https://www.umassmed.edu/maps/research-labs/morrison/
Summary: Focus: Paramyxovirus and Pneumovirius membrane fusion and virus assembly, virus vaccines
preferred title: Professor

Harris, John
first name: John
last name: Harris
full name: John E Harris MD, PhD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.27525000000000
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Person ID: 53
person in primary position: Adjunct Professor
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Endowed Chair Honorary Title: Lambi and Sarah Adams Chair in Genetic Research
Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
preferred title: Adjunct Professor

Schiffer, Celia
first name: Celia
last name: Schiffer
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full name: Celia A Schiffer PhD
has faculty rank: Chair And Professor
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Person ID: 558
person in primary position: Chair and Professor
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Endowed Chair Honorary Title: Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866505

Greiner, Dale
first name: Dale
last name: Greiner
full name: Dale L Greiner PhD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 612
person in primary position: Professor
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Endowed Chair Honorary Title: Herman G. Berkman Chair in Diabetes Care Innovation
preferred title: Professor

Ruiz De Luzuriaga, Katherine
first name: Katherine
last name: Ruiz De Luzuriaga
full name: Katherine Ruiz De Luzuriaga MD
has faculty rank: Professor
latitude: 42.27913100000000
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Person ID: 651
person in primary position: Professor
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Endowed Chair Honorary Title: UMass Memorial Health Care Chair in Biomedical Research
Rotation Projects: Potential Rotation Projects: Contact Dr. Luzuriaga for project details.
preferred title: Professor

Stern, Lawrence
first name: Lawrence
last name: Stern
full name: Lawrence Stern PhD
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 730
person in primary position: Professor
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Rotation Projects: Potential Rotation Projects Several rotation projects are available in structural biology of immune receptors, antigen presentation pathways, T-cell activation, and development of novel T-cell detection reagents. Please see Prof. Stern for details.
preferred title: Professor

Wang, Jennifer
first name: Jennifer
last name: Wang
full name: Jennifer Wang MD
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latitude: 42.27985300000000
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Person ID: 770
person in primary position: Professor
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preferred title: Professor

Byatt, Nancy
first name: Nancy
last name: Byatt
Twitter: https://profiles.umassmed.edu/profile/28867062
full name: Nancy Byatt DO, MS, MBA
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webpage: https://profiles.umassmed.edu/profile/28866465
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Ram, Sanjay
first name: Sanjay
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Person ID: 993
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Friedmann, Peter
first name: Peter
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preferred title: Professor

UMass Chan – Baystate Regional Campus
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Engelman, Kathleen
first name: Kathleen
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person in primary position: Assistant Professor
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Cadavid, Diego
first name: Diego
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Magnani, Diogo
first name: Diogo
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Person ID: 5281
person in primary position: Associate Professor
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preferred title: Associate Professor
webpage: https://profiles.umassmed.edu/profile/28866462
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Chair and Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Microbiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Dermatology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School