Health Informatics And Implementation Science
Elisabeth Chair for the Dean of Medicine
Donna M. and Robert J. Manning Chair in Neurosciences
Dr. Brown’s laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.
Timothy S. and Elaine L. Peterson Chair in Rheumatology
David J. Freelander Memorial Professor in AIDS Research
Dr. Strambio-De-Castillia (ORCID: https://orcid.org/0000-0002-1069-1816) is an internationally recognized cell biologist and imaging scientist who specializes in developing easy-to-use and openly accessible strategies for image data management and sharing to promote scientific discovery in health and disease.
Susan C. Houde PhD Social policy & aging, MS Gerontological Nursi
Arthur F. and Helen P. Koskinas Professor in Biochemistry and Molecular Biotechnology
Postdoctoral Positions are available in this laboratory. Contact Dr. ZhuGe for additional details at ronghua.zhuge@umassmed.edu
Rotation projects are available to study (1) the pathophysiology of Cl- channel TMEM16A in smooth muscle, (2) molecular mechanisms by which bitter tasting compounds relax smooth muscle, and (3) the role of bitter taste receptors in the pathogenesis of smooth muscle disorders.<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>
Focus: The ZhuGe lab studies the molecular mechanisms by which Ca2+ signals and ion channels control neurotransmitter release and smooth muscle contractility. We also exploit new physiological functions of bitter taste receptors in extra-oral tissues and organs. We aim to find novel molecular targets for new therapies to manage asthma, fecal incontinence, preterm labor, and adenomyosis.
Rotation Project Background
In yeast cells, protein translocation across the endoplasmic reticulum can occur by cotranslational or posttranslational pathways. The objective of this project is to develop a rapid method to inactivate the posttranslational pathway in vivo in yeast cells by appending the CMV-ribosome stalling sequence to the C-terminus of a typical posttranslational translocation substrate (carboxypeptidase Y). Complexes between the posttranslational translocation channel (SEC complex) and the stalled ribosomes will be purified for structural and functional analysis.
Pathogen genetics of the host immune response
How the cholinergic nervous system communicates peroxisomal stress to the whole organism during bacteria infection
Role and regulation of novel innate immune effectors that are conserved across animalia
Focus: Microbiota-gut-brain axis in C. elegans; mucosal innate immunity; staphylococcus aureus; transcriptional regulation of host defense; autophagy; lysosomes; peroxisomes
Population and Quantitative Health Sciences
Biochemistry and Molecular Biotechnology
Emergency Medicine at UMass Chan - Baystate
Healthcare Delivery and Population Sciences at UMass Chan - Baystate
Joseph D. Early Chair in Biomedical Research
4DN-BINA-OME (NBO) Microscopy Metadata Specifications landing page
2025 BINA Community Congress Presentation
Presentation at BINA 2025 Community Congress
Presentation at BINA 2024 Community Congress
Presentation at BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress FocalPlane features... data managent webinar
Presentation at the BINA 2024 Community Congress FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress Presentation at the BINA 2023 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2023 Community Congress Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar Presentation at the BINA 2024 Community Congress FoundingGIDE: BioImage DMS for Everyone
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress OME 2025 | Session 1 - Pre-publication BioImage DMS
FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone OME 2025 | Session 1 - Pre-publication BioImage DMS Presentation at the BINA 2024 Community Congress
FocalPlane features... data managent webinar OME 2025 | Session 1 - Pre-publication BioImage DMS FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
OME 2025 | Session 1 - Pre-publication BioImage DMS FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress
OME 2025 | Pre-publication BioImage Data Management and Sharing FocalPlane features... data managent webinar FoundingGIDE: BioImage DMS for Everyone Presentation at the BINA 2024 Community Congress