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Rotation Projects: <p >Potential rotation projects My lab primarily investigates Plasmodium falciparum malaria-induced dysregulation of EBV-specific T cell immunity and its role in the etiology of endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in Equatorial Africa. Within the context of our ongoing studies of healthy Kenyan children with divergent malaria exposure histories (chronic/repeated infections in a holoendemic area versus low infection rates in a nearby highland, malaria hypoendemic area) and by examining children diagnosed with eBL we have established a repository of samples that can be used to address this question. <p >1. One avenue of exploration involves homeostatic cytokine regulation of memory T cells. IL-15 and/or IL-7 responsiveness of EBV-specific memory T cells may be impaired in children with chronic malaria exposure and in children with endemic Burkitt lymphoma (eBL). We would like to investigate IL-15Ra and IL-7Ra surface expression, and CFSE proliferation of EBV-specific T cells in response to cognate antigen with and without IL-15 or IL-7 stimulation and compared children with divergent malaria exposure histories and children diagnosed with eBL. T cell responsiveness to IL-15 and IL-7 can be measured by STAT5 phosphorylation and the specificity of this effect for EBV-specific T cells can be evaluated by comparing IL-15Ra and IL-7Ra expression and responsiveness on other lymphocyte subsets and CMV-specific T cells. <p >2. Another putative mechanism by which malaria may interfere with the development of immunologic memory and influence EBV-specific T cell immunity is through the Programmed death-1 (PD-1) pathway. PD-1 is an immune inhibitory molecule that negatively regulates activated immune cells upon interacting with its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2) resulting in down-regulation of immune responses. Previous studies in murine and primate viral and parasitic diseases have reported the up-r…
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Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in division: Biostatistics And Health Services Research
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in organization: UMass Chan Medical School

Associate Professor
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General Pediatrics
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Chair and Professor
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position in division: Cardiovascular Medicine
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Neurology at UMass Chan - Lahey
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Geissler, Kimberley
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Associate Professor
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HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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position in division: Pulmonary Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Wilcox, Susan
first name: Susan
last name: Wilcox
full name: Susan Renee Wilcox MD
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Summary: Dr. Wilcox trained in EM at the Harvard Affiliated EM Residency, then completed an Anesthesia Critical Care fellowship. In addition to the ED, she has attended in Surgical, Medical, and Cardiac ICUs. She joined Lahey Hospital in 2022 as the Medical Director of the 5C Medical ICU. She is Vice Chair for Academic Affairs and a Professor of Medicine. She is the Associate CMO for Boston MedFlight.
preferred title: Professor

Professor
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Professor Emeritus
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HR job title: Professor Emeritus
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Krings, Timo
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Goldsmith, Andrew
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Associate Professor
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HR job title: Associate Professor
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Maron, Martin
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Maron, Barry
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Person ID: 10248130
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Adjunct Professor
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HR job title: Adjunct Professor
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Chair and Professor
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HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Reynolds, Matthew
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Person ID: 10248173
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Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Instructor
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Professor
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Professor Emeritus
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Assistant Professor
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type: Faculty Rank

Associate Professor
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Chair And Professor
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Other
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type: Faculty Rank

Clements, Matthew
first name: Matthew
last name: Clements
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Person ID: 10248274
person in primary position: Assistant Professor
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Assistant Professor
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position in department: Surgery at UMass Chan - Lahey
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Psychiatry and Behavioral Sciences
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Professor
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position in department: Emergency Medicine
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HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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Professor
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position in department: Population and Quantitative Health Sciences
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sort order: 1
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HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/66923911
publication date: 2016
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label: https://emcrit.org/emcrit/pulmonary-hypertension-right-ventricular-failure/
link anchor text: EMCrit 181 – Pulmonary Hypertension and Right Ventricular Failure with Susan Wilcox

https://profiles.umassmed.edu/profile/66923959
publication date: 2020
type: URLLink
label: https://www.edx.org/learn/healthcare/harvard-university-mechanical-ventilation-for-covid-19
link anchor text: HarvardX: Mechanical Ventilation for COVID-19

https://profiles.umassmed.edu/profile/66924015
publication date: 2017
type: URLLink
label: https://emergencymedicinecases.com/pulmonary-hypertension/
link anchor text: CritCases 7 Pulmonary Hypertension – A Fine Balance

https://profiles.umassmed.edu/profile/66924043
publication date: 2018
type: URLLink
label: https://www.aliem.com/2018/06/myth-vasopressors-ischemia/
link anchor text: Academic Life in Emergency Medicine: The Myth of Vasopressors and Ischemia

https://profiles.umassmed.edu/profile/66924060
publication date: 2020
type: URLLink
label: https://www.acep.org/corona/covid-19-field-guide/treatment/icu-care-in-the-emergency-department/
link anchor text: ACEP COVID-19 Field Guide: ICU Care in the Emergency Department

https://profiles.umassmed.edu/profile/66924233
publication date: 2021
type: URLLink
label: https://podcasts.apple.com/us/podcast/jem-june-2021-podcast-summary/id1141686910
link anchor text: Podcast summary of articles from the June 2021 edition of the Journal of Emergency Medicine

Associate Professor
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position in department: Emergency Medicine at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Associate Professor
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sort order: 1
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology at UMass Chan - Lahey
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sort order: 1
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HR job title: Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan – Baystate Regional Campus

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Di Guglielmo, Matthew
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last name: Di Guglielmo
full name: Matthew D Di Guglielmo MD, PhD
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Chair and Professor
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position in department: Pediatrics at UMass Chan - Baystate
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HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

https://profiles.umassmed.edu/profile/94538056
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Associate Professor
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position in division: Pediatric Emergency Medicine
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Pediatrics
position in division: Pediatric Emergency Medicine
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in division: Pediatric Critical Care
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Pediatrics
position in division: Pediatric Genetics
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HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Professor
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position in division: General Pediatrics
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HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Pediatrics
position in division: General Pediatrics
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HR job title: Associate Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Neurology at UMass Chan - Lahey
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sort order: 1
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HR job title: Assistant Professor
position in organization: UMass Chan Medical School