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Sena-Esteves, Miguel
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Rotation Projects: Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
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Khvorova, Anastasia
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Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
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Heneka, Michael
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Yaroslavsky, Anna
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Rotello, Vincent
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person in primary position: Department Head
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preferred title: Department Head

Minter, Lisa
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Person ID: 3753
person in primary position: Professor
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McClements, David
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person in primary position: Fergus Clydesdale Endowed Chair
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preferred title: Fergus Clydesdale Endowed Chair

Crosby, Alfred
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Person ID: 3762
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preferred title: Professor

Forbes, Neil
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latitude: 42.39565560000000
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Person ID: 3764
person in primary position: Associate Professor
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preferred title: Associate Professor

Hayward, Ryan
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Bermudez, Harry
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Xiao, Hang
first name: Hang
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latitude: 42.39565560000000
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Person ID: 3795
person in primary position: Associate Professor
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preferred title: Associate Professor

Shao, Rong
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Peyton, Shelly
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person in primary position: Assistant Professor
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Donahue, J.
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latitude: 42.27721310000000
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Person ID: 3838
person in primary position: Professor
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Endowed Chair Honorary Title: David J. and Barbara D. Milliken Professor in Preventive Cardiology
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Ross, Alonzo
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last name: Ross
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latitude: 42.27636250000000
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Person ID: 584
person in primary position: Professor Emeritus
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Rotation Projects: Rotation Projects Potential Rotation Projects Allostericregulation of PTEN using biophysical techniques. Analysis of PTEN structure by NMR. Therapies directed against cancer stem cells for human glioblastomas. Signaling directed therapies for meningioma brain tumors. <p > <p >
preferred title: Professor Emeritus

Han, Gang
first name: Gang
last name: Han
Twitter: https://profiles.umassmed.edu/profile/28867140
full name: Gang Han PhD
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Person ID: 734
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Post Docs: Positions for postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School. Research will focus on developing novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging. Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments, spectroscopy and microscopy are desired. Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively. To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu
Rotation Projects: Rotation projects <p >(1) Specific cell membrane component labeling using bioconjugated nanoparticles <p >(2) To develop tools for targeted and traceable siRNA delivery <p >(3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids
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Mercurio, Arthur
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Person ID: 901
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
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Bogdanov, Alexei
first name: Alexei
last name: Bogdanov
full name: Alexei A Bogdanov PhD
has faculty rank: Professor Emeritus
latitude: 42.27525000000000
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Person ID: 906
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus
webpage: https://profiles.umassmed.edu/profile/28866578
webpage: https://profiles.umassmed.edu/profile/28866620

Song, Jie
first name: Jie
last name: Song
full name: Jie Song PhD
has faculty rank: Professor
latitude: 42.27525000000000
longitude: -71.76233800000000
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Person ID: 982
person in primary position: Professor
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Lab URL: http://www.umassmed.edu/Songlab/
Post Docs: A postdoc opening is available to participate in the development of functional biomaterials for skeletal tissue regeneration focusing on immune regulation and inflammation resolution. The fellow is expected to work both independently and collaboratively, and contribute to a productive and cordial team environment. Salary follows NIH postdoctoral fellowship compensation guideline. Requirements: • Recent PhD in Chemical Biology, Bioengineering, Biology, or Polymer Science • Expertise in examining cell-material interactions (e.g. immune cell regulations, stem cell lineage commitment) OR synthesis and characterization of functional biomaterials expected • Experience with animal studies desired but not required • Self-motivated and organized, good written and oral communication skills. To apply for this position: Send your CV and the contact information for three references to Jie.Song@umassmed.edu
Rotation Projects: Potential Rotation Projects Degradable viscoelastic synthetic hydrogels for therapeutic cell delivery Prophylactic implant coatings against periprosthetic infections Shape memory polymer-based composite bone grafts
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webpage: https://profiles.umassmed.edu/profile/28866451

Cataltepe, Oguz
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Moser, Richard
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Watts, Jonathan
first name: Jonathan
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Kim, Dohoon
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person in primary position: Associate Professor
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Politi, Letterio
first name: Letterio
last name: Politi
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Person ID: 4360
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UMass Chan – Baystate Regional Campus
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Yang, Hongwei
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Johnson, Mark
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Endowed Chair Honorary Title: Maroun Semaan Chair in Neurosurgery
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Carroll, Rona
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E&R Isenberg Prof Intg Env Sci
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Fergus Clydesdale Endowed Chair
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Schneider, Sallie
first name: Sallie
last name: Schneider
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has faculty rank: Associate Professor
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Keeler-Klunk, Allison
first name: Allison
last name: Keeler-Klunk
full name: Allison May Keeler-Klunk PhD
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Person ID: 4941
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Lab URL: https://www.umassmed.edu/keelerlab
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ADJUNCT ASSISTANT PROFESSOR
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ADJUNCT PROFESSOR
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Wang, Dan
first name: Dan
last name: Wang
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Person ID: 5276
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Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
preferred title: Assistant Professor
webpage: https://profiles.umassmed.edu/profile/28866581
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Usmani, Saad
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Neurological Surgery
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Camci-Unal, Gulden
first name: Gulden
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Ward, Sarah
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Person ID: 5751
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preferred title: Assistant Professor

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