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Gaspari, Romolo
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Ellison, Richard
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Castilla, Lucio
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Post Docs: The Castilla laboratory is accepting applications for postdoctoral positions. The candidates should be close to or have recently graduated with a Ph.D. or M.D./Ph.D. degree (within 1 year) in the fields of Cancer Biology, Genetics, Biochemistry, Cell Biology or related field. The candidates must also have a proven track record of productivity and research experience. Previous experience using immunocompromised and transgenic mice, in vitro and in vivo assays with small molecules or nanoparticles, or hematopoietic stem cells is preferred. We are looking for highly motivated candidates with excellent communication skills, and able to work independently and in cooperation with other members of the laboratory. Applicants should send their CV, a cover letter summarizing background and research interests, and three letters of references by electronic mail to: Dr. Lucio H. Castilla, Associate Professor University of Massachusetts Medical School Lucio.Castilla@umassmed.edu
Rotation Projects: Potential Rotation Projects<?xml:namespace prefix = u5 /><u5:p></u5:p><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p> <u5:p> </u5:p><o:p></o:p> 1. Role of core binding factors on hematopoietic stem cell function and survival. We use molecular pharmacologic and functional approaches to study the role of the RUNX factors in self renewal and proliferation of hematopoietic stem and progenitor cells, using genetically modified mice and human progenitor cells. <u5:p></u5:p><o:p></o:p> <u5:p> </u5:p><o:p></o:p> 2. Study the molecular mechanism of leukemia initiation and maintenance. Transcription factors and components of cytokine signaling are frequently mutated in human cancer, including leukemia. These mutations deregulate the proliferation, differentiation and survival of hematopoietic stem cells. We study the role of members of RUNX and RAS protein families in the function of hematopoietic stem cell function, pre-leukemic progenitors, and leukemia-initiating cells. <u5:p></u5:p><o:p></o:p> <u5:p> </u5:p><o:p></o:p> 3. Translational research: Recent evidence suggests that inhibition of pathways activated by gene mutations can be used to eliminate leukemia cells, and not affecting normal cells. We use small molecule inhibitors of leukemia oncogenes to test whether repression of activated pathways hinder survival of leukemia initiating cells, and eliminate leukemia. We use a combination of mouse models and human leukemia cells to test the efficacy, specificity and toxicity of candidate inhibitors, as single agents or in combination with first line leukemia drugs.<u5:p></u5:p><o:p></o:p>
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Lemon, Stephenie
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Goldberg, Robert
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label: https://trial.medpath.com/news/61960d9f316e3daa/ihc-testing-enables-rapid-tp53-mutation-detection-in
link anchor text: IHC Enables Rapid Identification of TP53-Mutant MDS/AML

https://profiles.umassmed.edu/profile/91385159
type: URLLink
label: https://www.umassmed.edu/cuidamos/
link anchor text: CUIDAMOS

https://profiles.umassmed.edu/profile/95558627
publication date: 2025
type: URLLink
label: https://ashpublications.org/ashclinicalnews/news/8743/p53-IHC-Testing-May-Be-Reliable-Surrogate-for
link anchor text: ASH Clinical News: p53 Immunohistochemistry for TP53-Mutant MDS/AML

Adjunct Professor
is primary position: true
position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
is primary position: true
position in department: Pediatrics
position in division: Pediatrics Hematology/Oncology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/99769701
publication date: 2025
type: URLLink
label: https://journals.lww.com/oncology-times/fulltext/2025/11000/immunostaining_offers_shortcut_to_detect_high_risk.20.aspx
link anchor text: p53 Immunostain in TP53-Mutant MDS and AML