Biostatistics And Health Services Research
Johnnie Ray Cox Term Chair in Biomedical Research
Elisabeth Chair for the Dean of Medicine
Cutler Chair in Vascular and Endovascular Surgery
Rotations <p >Project 1: Genetic screens for proteins that modify or regulate the activity of microRNAs in C. elegans.
Lab rotations are currently available in this lab. Please contact Dr. Kim.
My research for almost 30 years has focused on obesity, insulin resistance, and type 2 diabetes and explores the molecular link between inflammation and insulin resistance using transgenic mice with elegant in vivo metabolic experiments and molecular approaches. My research also investigates the role of inflammation and altered metabolism in diabetic heart disease.
Melvin S. and Sandra L. Cutler Chair in Biomedical Research
William and Doris Krupp Professor in Medicine
Governor Paul Cellucci Chair in Neuroscience Research
Project 1: Dervelop RNA-based therapies for frontotemporal dementia (FTD) and related disroders. Project 2: Study pathogenic mechanisms of FTD and related disorders in mouse models.
Our lab uses a combination of molecular, cellular, genetic, and behavioral approaches to further dissect the pathogenic mechanisms of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis with a focus on mutant CHMP2B, progranulin and C9ORF72. We will identify common underlying pathways as potential targets for therapeutic interventions.
A Postdoctoral position is available in the Trivedi lab to study roles of novel chromatin and epigenetic modifications during cardiovascular development and disease (for details of our research: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). Candidates with a PhD in Biochemistry, Molecular Biology, Stem Cell Biology or Developmental Biology are encouraged to apply. Previous experience with mice handling and biochemistry-molecular biology-epigenetics related techniques such as ChIP-seq is strongly desired. Candidate will be required to learn new techniques in the area of translational biology to advance their project.
Rotation Projects: Please contact Chinmay Trivedi (chinmay.trivedi@umassmed.edu) for information regarding potential rotation projects (for details - research performed by graduate students in the trivedi lab: The Journal of Clinical Investigation, Science Advances, Journal of Experimental Medicine, JCI Insight, ATVB, Human Molecular Genetics, Journal of Biological Chemistry). We will develop a specific rotation project based on student's interest, background, and goals of the rotation. Students can rotate either for a half- or full-semester.
Worcester Foundation for Biomedical Research Chair III
Please email Kate.Fitzgerald@umassmed.edu if you are interested in rotations.
A postdoctoral position is available
H. Arthur Smith Chair in Cancer Research
Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
UMass Chan Medical School Chair in Biomedical Research
A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.
Potential Rotation Projects <p >Rotations are available in Dr. Rock’s laboratory for graduate students in the GSBS program. The rotation projects will explore various aspects of how the immune system carries out surveillance to detect viral infections and cancers. Among the potential areas of research are: (1) The alarm signals that alert the immune system to potential danger; (2) The initial innate immune and inflammatory response to infection or other dangerous situations; (3) The biology of the sentinel cells (e.g. dendritic cells) that sense danger and report it the adaptive immune system; (4) The mechanisms by which sentinel cells (e.g. dendritic cells) acquire and display antigens to T cells; and, (5) The antigen presentation pathways by which virally infected or cancer cells display a sampling of their expressed gene products to the activated T cells. Specific rotation projects are chosen based on the student’s interests and state/availability of the various projects in the laboratory. The goals of rotations are for the student to gain knowledge in immunology, to learn how to approach experimental problems, to learn new techniques and methods, and to actually generate data that moves our knowledge forward. In addition, the rotation provides the student the opportunity to evaluate the laboratory as a possible place to conduct their thesis research in the future.
Nikolaos Kakouros MD, PhD, FRCP, FACC, FSC
Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
David J. and Barbara D. Milliken Professor in Preventive Cardiology
Herman G. Berkman Chair in Diabetes Care Innovation
We are seeking a post-doctoral fellow to study toll/interleukin 1 receptors and their role in inflammatory disease pathogenesis using human cells and mouse models. Candidates should have a Ph.D. or M.D. degree, or have completed degree requirements. Experience in immunology, molecular biology and/or biochemistry and publication of papers in the areas of cytokine biology, receptor biochemistry and/or cell signaling required.
Potential Rotation Projects Expression of Toll-like receptors: Patterns of TLR expression in normal cells. Control of TLR receptor expression by environmental factors and cytokines. TLR expression in diseased tissues. Role of TLRs in disease pathogenesis: Use of knockout and genetically defined animals to study the role of TLRs in the control of bacterial or viral diseases. Structure-function studies of TLR signaling: Assessing the signaling activity of wild type and mutant TLRs (altered by site-directed mutageneis) using transient transfection and luciferase reporter gene analysis.
Richard M. Haidack Professor in Medicine
Research in Dr. Koupenova's lab focuses on the contribution of platelets to the immune response during viral infection and the consequent implications of that response to cardiovascular disease. For additional information about projects or joining the lab, contact Dr. Koupenova @ milka.koupenova@umassmed.edu
Population and Quantitative Health Sciences
Dr. Ghasemi completed his adult neurology residency training (2014-2018) at UMass Medical Center and fellowship training in neuromuscular disorders (2018-2019) at Mass General Hospital (MGH) and Brigham & Women’s Hospital (BWH), and more recently graduated from Harvard T. Chan School of Public Health (2021) with master’s degree in public health (MPH). He focuses on neuromuscular diseases.
Our team welcomes applications from individuals interested in advancing clinical care, science, and education through multidisciplinary innovation and research in restorative, regenerative, and global surgery. Positions are available for national and international undergraduate, graduate (including residents), and post-graduate students with a broad range of diverse expertise and backgrounds. Please submit your request along your CV to: giorgio.giatsidis@umassmed.edu Main areas of interest * Biological Sciences (wound healing & burns, tissue engineering, scaffolds, tissue mechanobiology, angiogenesis, lymphangiogenesis, tissue regeneration [skeletal muscle, adipose tissue, skin], scarring and fibrosis, aging, tissue allotransplantation) * Clinical Sciences (trials in plastic surgery [breast reconstruction, post-bariatric surgery, burns, chronic wounds, fat grafting], microsurgery, extremity trauma and replantation, aesthetic surgery/medicine) * Global Surgery & Advocacy * Surgical Education (design and evaluation of skill courses, simulation-based training, cadaver-based training, use of Augmented Reality and Virtual Reality in surgical education) * Biomedical Engineering (design and development of devices or technologies for wound care, tissue preservation, trauma care, surgical robotics, tissue imaging, and tissue diagnostics) * Software Engineering (mHealth applications in surgery, tele-surgery) * Art sciences (Medical illustrations)
Our team is committed to provide opportunities to UMMS students to both advance their education and produce scholarly work. Committment and goals are individually discussed and tailored based on the student's interests, goals, needs, and availability. Projects are commonly designed to be led by the student under guidance, and to result in a scientific publication authored by the student. For applications please contact: giorgio.giatsidis@umassmed.edu. Areas of specific interest include (but are not limited to): - Surgical Education - Global Surgery
Restorative & Regenerative Surgery Innovation Center
National Mouse Metabolic Phenotyping Center
Emergency Medicine at UMass Chan - Baystate
Worcester Foundation for Biomedical Research Chair I