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preferred title: Professor

Karellas, Andrew
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preferred title: Adjunct Professor

Vedantham, Srinivasan
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Lemon, Stephenie
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Person ID: 689
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Endowed Chair Honorary Title: Barbara Helen Smith Chair in Preventive & Behavioral Medicine
preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/28866492

Goldberg, Robert
first name: Robert
last name: Goldberg
full name: Robert Joel Goldberg PhD
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Person ID: 78
person in primary position: Professor Emeritus
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preferred title: Professor Emeritus

Cantor, Sharon
first name: Sharon
last name: Cantor
full name: Sharon B Cantor PhD
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Person ID: 828
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Endowed Chair Honorary Title: Gladys Smith Martin Chair in Oncology
Post Docs: A post-doctoral position is available immediately to study the role of genes found in a genome-wide RNAi screen to regulate the cellular response to the chemotherapy agent, cisplatin. The goal is to determine whether these genes function as tumor suppressor and/or regulate the mechanism of DNA repair processing. The laboratory is interested in understanding the role of hereditary cancer genes of the BRCA-Fanconi anemia pathway in DNA damage repair and tumor suppression. We seek motivated candidates with a PhD and background in cancer cell biology. Experience in mouse cancer models is desirable. The exceptional training environment within the Department of Cancer Biology at UMASS Medical School offers a rigorous and interactive research environment covering several aspects of tumor biology. Applicants should have excellent communication skills, and ability to conduct research independently and as a team. To apply, please send your CV with bibliography, a brief description of research experience and contact information for at least two references via email.
Rotation Projects: The laboratory is interested in a range of DNA replication/repair-related topics including (i) Defining biomarkers of “BRCAness” that signifies deficiency in the hereditary breast/ovarian cancer genes, BRCA1 or BRCA2, (ii) Targeting BRCAness as a replication gap vulnerability, (iii) Defining why replication proficiency requires the FANCJ helicase disengage mismatch repair proteins, (iv) Determining if suppressing gaps improves the health of Fanconi anemia patient cells, (v) Hunting down the cancer vulnerability that defines curability, (vi) performing functional genomic screens to uncover mechanisms regulating chemotherapy resistance.
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Vijayaraghavan, Gopal
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Shaw, Leslie
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Mercurio, Arthur
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Rotation Projects: <p >Rotation Projects <p >Rotation projects are designed to expose students to the molecular cell biology of solid tumors and to provide them with an appreciation for translational cancer research. Specific rotation projects, which are focused on the major themes of the lab, include: <p >Function and Regulation of Integrins (Cell Adhesion Receptors) in Cancer Epigenetic mechanisms that regulate integrin gene expression in human cancers Regulation of integrin expression and function during the EMT Role of specfic microRNAs (miRs) in regulating integrin function and signaling Contribution of integrins to carcinoma progression using mouse models of breast carcinoma <p >Vascular Endothelial Growth Factor (VEGF) Signaling, EMT and Carcinoma Progression Function and expression of VEGF receptors in carcinoma cells Regulation of VEGF transcription in response to EMT stimuli Role of miRs in regulating VEGF receptors and signaling Contribution of VEGF signaling to the behavior of aggressive, de-differentiated carcinomas <p >Nuclear Hormone Receptors and EMT Role of estrogen receptors in regulating the EMT Regulation of VEGF transcription by estrogen receptors
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McManus, David
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Research
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Friedmann, Peter
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UMass Chan – Baystate Regional Campus
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Otis, Christopher
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Mason, Holly
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Crisi, Giovanna
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Lagu, Tara
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Lindenauer, Peter
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Schneider, Sallie
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Kaufman, Seth
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ADJUNCT ASSOCIATE PROFESSOR
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ADJUNCT PROFESSOR
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Makari-Judson, Grace
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Gurwitz, Jerry
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Usmani, Saad
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Population and Quantitative Health Sciences
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Dinh, Kate
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Caragacianu, Diana
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Bloch, Boris
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Bokhour, Barbara
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Casaubon, Jesse
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