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Rotation Projects: Rotations We always welcome rotation students who are interested in learning more about the eye and the techniques the lab utilizes. Most rotation projects can be integrated into a Ph.D. thesis afterwards if the candidate desires to continue with this line of research. In my lab we use molecular biology, genetics, histology, virology and surgical procedures on mice to conduct our research. You will be working in an environment that is focused on translational research and gaining basic science knowledge on disease that affect vision in order to develop better therapeutic strategies to the currently available strategies. The goal of the lab is to move as quickly as possible from a basic science discovery to a therapeutic application. The basic science research the lab is conducting focuses around the role of metabolism and the Insulin/mTOR pathway in photoreceptors. Interested in a rotation? Email Dr. Punzo and ask if a project is currently available.
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Latz, Eicke
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Czech, Michael
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Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Czech for additional details.
Rotation Projects: Mentoring……………………………………………………………………………………………………… The Czech laboratory is active in mentoring graduate students and postdoctoral fellows. Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include: Paul Pilch, Professor of Biochemistry, Boston University School of Medicine Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine Joan Massague, Director, Sloan Kettering Institute Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center Assia Shisheva, Professor of Physiology, Wayne State School of Medicine. Mark Sleeman, Professor of Physiology, Monash University, Australia John Harris, Associate Professor of Medicine, UMASS Medical School Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University Vishu Puri, Professor of Biomedical Sciences, Ohio University Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute Adilson Guilherme, Associate Professor, University of Massachusetts Medical School Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research …
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Rotation Projects: Rotation Projects Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
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Zierath, Juleen
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Endowed Chair Honorary Title: Remondi Family Chair in Biomedical Research
Post Docs: POSTDOCTORAL POSITION: RNAI PRECLINICAL DEVELOPMENT Excellent training opportunity for a person considering industrial carrier in drug development Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several classes of oligonucleotides which can efficiently silence genes in various tissues with acceptable level of toxicity. There are also new chemistries being developed to further improve oligonucleotide tissue distribution and cellular uptake. The successful candidate will be a key part of an intra-disciplinary team working with biologists and chemists to develop novel types of therapeutics for treatment of neurological disease, liver disease and orphan indications. The work will include compounds identification, screening, characterization, in vivo efficacy and PK/PD studies, novel assays development etc. In addition exposure and training in nucleic acid pre-clinical development, project management etc will be provided. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular cell biology or pharmacology.
Post Docs: RNAI MEDICINAL CHEMISTRY/ RNA OLIGONUCLEOTIDE CHEMISTRY Develop and characterize novel RNA chemistries to promote efficient oligonucleotide internalization and tissue distribution. Oligonucleotides represent a new class of drugs, which have the promise to become a major class of future therapeutics. There are several chemistries and formulations developed by us and others that effectively support oligo internalization and favorable PK/PD. In most cases in vivo efficacy is limited by (1) poor PK (2) inefficient tissue distribution (3) compound entrapment in biologically inactive intracellular compartments. The objective of future studies will be development of novel chemistries, which promote receptor mediated cellular internalization and/ or endosomal escape. The successful candidate will be responsible for the design and synthesis of novel RNA precursors, optimization of RNA synthesis and conjugation protocols and interface with the biology part of the lab. In addition, exposure to pre-clinical development programs and oligonucleotide manufacturing will be available. QUALIFICATIONS: Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and have previous experience in nucleic acid / oligonucleotide chemistry.
Post Docs: SMALL RNA TRAFFICKING Discover, characterize and adapt mechanisms of small RNA extracellular and intracellular trafficking for development of novel classes of oligonucleotide drugs. A serious limitation in realizing the potential of oligonucleotide based therapies has been the exceedingly inefficient transit of oligonucleotides from outside cells to the intracellular compartments where the biologically relevant activity happens. On the other hand, there are multiple lines of evidence supporting the notion that nature has implemented evolutionarily conserved mechanisms and pathways for efficiently trafficking small RNAs across cellular boundaries. The objective of future studies will be the systematic evaluation of mechanisms of cellular uptake of different classes of oligonucleotides and their comparison to mechanisms of native RNA trafficking using a combination of experimental approaches, including advanced RNA chemistry and high temporal and spatial resolution microscopy in living cells, Mass spectrometry, cell biology and others. The successful candidate will work closely with Victor Ambros and Silvia Corvera labs and the UMASS imaging group and receive training in RNA chemistry, biochemistry, cell biology and pre-clinical development. QUALIFICATIONS:Applicants must have (or expect to obtain shortly) a Ph.D. in Chemistry, Organic Chemistry Biochemistry, Cell Biology, Molecular Biology or a related field , be bright, ambitious, independent and collaborative and ideally, have research experience in nucleic acid molecular and cell biology
Rotation Projects: Our laboratory uses a combination of nucleic acid and oligonucleotide chemistry, biochemistry, cell biology, and pharmacology and develops and evaluate novel technologies for development of oligonucleotide therapeutics. A rotation project is available to develop and identify chemically modified self-delivering RNAi compounds for treatment of Huntington and other diseases.
preferred title: Professor

Heneka, Michael
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Yoon, Seongkyu
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Szabo, Gyongyi
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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
preferred title: Adjunct Professor

Lian, Jane
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Rotello, Vincent
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Fissore, Rafael
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McClements, David
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Pederson, Thoru
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Endowed Chair Honorary Title: Vitold Arnett Professor of Cell Biology
Rotation Projects: Background for Student Rotation Projects <p >See Politz, Hogan and Pederson (2009) and Politz et al. (2005) in the above list. The novel microRNA work may be the most suitable for student rotations. Potential Rotation Projects <p >Are the nucleolar microRNAs pri-, pre- or mature? <p >Are they complexed with other nucleolar RNAs? <p >Do the cell cycle related proteins in the nucleolus exist as heterotypic complexes? <p >Does the nucleolus of human embryonic stem cells also share these features (which we have so far looked for, and found, only in transformed human cell lines)? <p >Can vanadium tagging be used to detect specific proteins by electron microscopy, perhaps exceeding the limitations of immuno-EM?
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Xiao, Hang
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Donahue, J.
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Endowed Chair Honorary Title: David J. and Barbara D. Milliken Professor in Preventive Cardiology
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Zamore, Phillip
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Endowed Chair Honorary Title: Gretchen Stone Cook Chair in Biomedical Sciences
Post Docs: A postdoctoral position is available to study in this laboratory. Contact Dr. Zamore for additional details
Rotation Projects: Potential Rotation Projects Our laboratory uses a combination of biochemistry, cell biology, and genetics to dissect the RNAi pathway. A rotation project is available to explore the mechanisms that underlie the RNAi phenomenon or the biological pathways in which RNAi enzymes participate in flies, mice and humans.
preferred title: Chair and Professor
webpage: https://profiles.umassmed.edu/profile/28866555
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Brehm, Michael
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Endowed Chair Honorary Title: Harvey A. Shultz Chair in Diabetes
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Aronin, Neil
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Endowed Chair Honorary Title: Higgins Family Professor in Neuroscience
Rotation Projects: Potential Rotation Projects Project #1: Molecular Mechanisms in the Pathogenesis of Neurodegenerative Disease. The student can select projects emphasizing either molecular mechanisms of huntingtin in trafficking in neurons or receptor stimulated effects on gene expression in neurons. Techniques include: Generation of fusion proteins, raising antisera Preparation of organelles Immunocytochemistry, light microscopy and electron microscopy Immunoprecipitation methods PCR Protein separation techniques, gel electrophoresis, immunoblotting Autoradiography
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Richter, Joel
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Greiner, Dale
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Sullivan-Bolyai, Susan
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Bogdanov, Alexei
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Cataltepe, Oguz
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Gounis, Matthew
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Pediatric Genetics
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UMass Chan – Baystate Regional Campus
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Shim, Jae-Hyuck
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Post Docs: Jungmin Kim
Post Docs: Zheni Stavre
Post Docs: Chujiao Lin
Post Docs: Sachin Ramdas
Post Docs: Aijaz John
Post Docs: Yeon-Suk Yang
Post Docs: Eun-Hye Son
Post Docs: Zhihao Chen
Post Docs: Tadatoshi Sato
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Gruntman, Alisha
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Krieg, Arthur
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Keeler-Klunk, Allison
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Tai, Phillip
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Summary: Focus: Virology and vectorology of adeno-associated viruses
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ADJUNCT PROFESSOR
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Gray-Edwards, Heather
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Wang, Dan
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Post Docs: We are looking for motivated postdoctoral researchers. Send in your application and get in touch today!
Rotation Projects: - AAV gene therapy for genetic diseases - Therapeutic genome editing - RNA-based approaches to treating genetic diseases - Interactions between AAV vector and host cell - AAV vector capsid engineering
preferred title: Assistant Professor
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Strauss, Kevin
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Ophthalmology and Visual Sciences
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Neurological Surgery
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Shazeeb, Mohammed
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Batista, Ana
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Schlaug, Gottfried
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Muhuri, Manish
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Taghian, Toloo
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position in organization: UMass Chan Medical School

Chair and Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Medicine
position in division: Endocrinology & Diabetes
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: RNA Therapeutics Institute
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Program in Molecular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor Emeritus
is primary position: true
position in department: Radiology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Medicine
position in division: Endocrinology & Diabetes
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Associate Professor
is primary position: true
position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Chair and Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
is primary position: true
position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor Emeritus
is primary position: true
position in department: Biochemistry and Molecular Biotechnology
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Professor Emeritus
is primary position: true
position in department: Medicine
position in division: Endocrinology & Diabetes
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Assistant Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/93081542
number of subject areas: 36
type: Connection Details

https://profiles.umassmed.edu/profile/93262457
is also coauthor: true
number of subject areas: 35
type: Connection Details

Associate Professor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
is primary position: true
position in department: Pediatrics
position in division: Pediatric Genetics
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

https://profiles.umassmed.edu/profile/97543599
is also coauthor: true
number of subject areas: 41
type: Connection Details

Instructor
is primary position: true
position in department: Genetic and Cellular Medicine
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Instructor
position in organization: UMass Chan Medical School