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Post Docs: An entry level postdoctoral position is open immediately in the laboratory of Dr. Susan L. Swain to study the factors that control the development and survival of CD4 and CD8 T cell memory. Graduate student experience with tissue culture, in vitro assay, flow cytometry, experience in mouse models on infectious disease and a knowledge of cellular and molecular immunology are all strongly desired.
Rotation Projects: <p >Rotations: Projects in the following areas <p >CD4 T cell memory. We can generate in vitro CD4 T cells that are for all extents and purposes identical to the memory CD4 T cells observed in vivo. In situ memory CD4 T cells persist at very low frequency and in most instances it is difficult to analyze them thoroughly using tetramer or multimer reagents both because of their low frequency and the relatively low specific affinity of the Class II reagents for the TcR. Being able to generate “recent” memory cells in vitro gives us the opportunity to analyze in detail the mechanisms by which memory CD4 T cells may contribute to secondary immunity and immune protection. Once identified. will determine if particular pathways are relevant in situ. We have discovered that memory CD4 T cells are superior in protection to those from the primary response and that they display pleitropic functions that have not been previously identified. <p > Cytotoxic CD4 Effectors. One unexpected function of CD4 T cells we identified is robust, perforin-dependent cytotoxic activity (7, 16). Cytotoxic activity by CD4 T cells has been reported in response to several infections, but its significance has not heretofore been established. We find that “Th1 polarized” CD4 effectors and more relevantly the CD4 effectors found in the lung following influenza infection, are able to kill infected or peptide-pulsed Class II-bearing targets and we find that this perforin dependent activity can work together with antibody to provide protection against lethal influenza challenge in otherwise unprimed mice (17). We also will determine when memory CD4 T cells re-express cytotoxic activity following in vivo challenge and how cytotoxic killing contributes to the memory cell mediated protection. We want to analyze how the program of cytotoxicity is induced in these “ThCTL”. <p > Memory CD4 Cells Enhance an Innate Response. Memory cells can act by becoming secondary effectors but they are best characterized by …
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sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
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type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Medicine at UMass Chan - Baystate
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan – Baystate Regional Campus

Evans, Elizabeth
first name: Elizabeth
last name: Evans
full name: Elizabeth A Evans PhD
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Person ID: 10247438
person in primary position: Adjunct Professor
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type: Person
preferred title: Adjunct Professor

Adjunct Associate Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Adjunct Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
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position in department: Surgery
position in division: Vascular Surgery
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Family Medicine and Community Health
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Assistant Professor
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position in department: Medicine
position in division: Hospital Medicine
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type: Position
HR job title: Assistant Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Medicine at UMass Chan - Baystate
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sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Walkey, Allan
first name: Allan
last name: Walkey
full name: Allan Jay Walkey MD, MSc
has faculty rank: Professor
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Person ID: 10247602
person in primary position: Professor
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preferred title: Professor
webpage: https://profiles.umassmed.edu/profile/104051488

Medicine at UMass Chan - Lahey
type: Department
type: Organization

Surgery at UMass Chan - Lahey
type: Department
type: Organization

Radiology at UMass Chan - Lahey
type: Department
type: Organization

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Basic Pathology
type: Division
type: Organization

Health System Science
type: Division
type: Organization

Infectious Diseases
type: Division
type: Organization

Pulmonary Medicine
type: Division
type: Organization

Professor Emeritus
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Geriatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Pathology
position in division: Basic Pathology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Epidemiology
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Biostatistics And Health Services Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

General Pediatrics
type: Division
type: Organization

Ob/Gyn General
type: Division
type: Organization

Chair and Professor
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position in department: Medicine
position in division: Cardiovascular Medicine
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Geissler, Kimberley
first name: Kimberley
last name: Geissler
full name: Kimberley Geissler PhD
has faculty rank: Associate Professor
latitude: 42.12711190000000
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Person ID: 10247743
person in primary position: Associate Professor
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preferred title: Associate Professor

Associate Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Tan Chingfen Graduate School of Nursing
type: Department
type: Organization

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Di Pentima, M. Cecilia
first name: M. Cecilia
last name: Di Pentima
full name: M. Cecilia Di Pentima MD, MPH
has faculty rank: Professor
latitude: 42.12294230000000
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Person ID: 10247818
person in primary position: Professor
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preferred title: Professor

Professor
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position in department: Pediatrics at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan – Baystate Regional Campus

Dosa, David
first name: David
last name: Dosa
full name: David Michael Dosa MD, MPH
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 10247830
person in primary position: Professor
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preferred title: Professor

Martinez, Fernando
first name: Fernando
last name: Martinez
full name: Fernando J Martinez MD, MS
has faculty rank: Professor
latitude: 42.27525000000000
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Person ID: 10247895
person in primary position: Professor
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
preferred title: Professor

Professor
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position in department: Medicine
position in division: Pulmonary Medicine
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type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor Emeritus
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sort order: 1
type: Position
HR job title: Professor Emeritus
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Professor
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position in department: Emergency Medicine
position in division: Research
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HR job title: Professor
position in organization: UMass Chan Medical School

Krings, Timo
first name: Timo
last name: Krings
full name: Timo Krings MD, PhD, FRCP
has faculty rank: Professor
latitude: 42.48526100000000
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Person ID: 10247952
person in primary position: Professor
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preferred title: Professor

Goldsweig, Andrew
first name: Andrew
last name: Goldsweig
full name: Andrew Goldsweig MD, MS
has faculty rank: Associate Professor
latitude: 42.12294230000000
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Person ID: 10248018
person in primary position: Associate Professor
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preferred title: Associate Professor

Ghogawala, Zoher
first name: Zoher
last name: Ghogawala
full name: Zoher Ghogawala MD, FACS
has faculty rank: Professor
latitude: 42.48526100000000
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Person ID: 10248062
person in primary position: Professor
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preferred title: Professor

Associate Professor
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan – Baystate Regional Campus

Professor
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position in department: Surgery at UMass Chan - Lahey
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sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Maron, Martin
first name: Martin
last name: Maron
full name: Martin S Maron MD, MSPH
has faculty rank: Associate Professor
latitude: 42.48526100000000
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Person ID: 10248121
person in primary position: Associate Professor
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preferred title: Associate Professor

Maron, Barry
first name: Barry
last name: Maron
full name: Barry J Maron MD
has faculty rank: ADJUNCT PROFESSOR
latitude: 42.48526100000000
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Person ID: 10248130
person in primary position: Adjunct Professor
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preferred title: Adjunct Professor

Adjunct Professor
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sort order: 1
type: Position
HR job title: Adjunct Professor
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Professor
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position in department: Medicine
position in division: Geriatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Family Medicine and Community Health
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sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan – Baystate Regional Campus

Reynolds, Matthew
first name: Matthew
last name: Reynolds
full name: Matthew R Reynolds MD, MSc
has faculty rank: Professor
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Person ID: 10248173
person in primary position: Professor
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Professor
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HR job title: Professor
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Instructor
sort order: 17
type: Faculty Rank

Professor
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type: Faculty Rank

Professor Emeritus
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type: Faculty Rank

Assistant Professor
sort order: 13
type: Faculty Rank

Associate Professor
sort order: 10
type: Faculty Rank

Chair And Professor
sort order: 4
type: Faculty Rank

Professor Emeritus
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position in department: Medicine
position in division: Health System Science
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Professor
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position in department: Tan Chingfen Graduate School of Nursing
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Chair and Professor
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position in department: Obstetrics and Gynecology
position in division: Ob/Gyn General
sort order: 1
type: Position
HR job title: Chair and Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Preventive And Behavioral Medicine
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Emergency Medicine
position in division: Research
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Population and Quantitative Health Sciences
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Surgery at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Population and Quantitative Health Sciences
position in division: Health Informatics And Implementation Science
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
first name: Dong-Soo
last name: Shin
full name: Dong-Soo Shin PhD, RN
has faculty rank: ADJUNCT PROFESSOR
Person ID: 10248397
person in primary position: Adjunct Professor
type: Agent
type: Person
preferred title: Adjunct Professor

Professor Emeritus
is primary position: true
position in department: Medicine
position in division: Infectious Diseases
sort order: 1
type: Position
HR job title: Professor Emeritus
position in organization: UMass Chan Medical School

Associate Professor
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position in department: Medicine at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Radiology at UMass Chan - Lahey
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Professor
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position in department: Pediatrics
position in division: General Pediatrics
sort order: 1
type: Position
HR job title: Professor
position in organization: UMass Chan Medical School

Adjunct Professor
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position in department: Healthcare Delivery and Population Sciences at UMass Chan - Baystate
position in division: https://profiles.umassmed.edu/profile/15590085
sort order: 1
type: Position
HR job title: Adjunct Professor
position in organization: UMass Chan – Baystate Regional Campus