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Post Docs: Immediate opening! Two postdoctoral positions are available immediately to study cellular andmolecular mechanisms resulting in immunosuppression after alcohol use. Thefocus of this research is the role of monocytes and dendritic cells indecreased antigen-specific T cell activation after alcohol use.Intracellular signalling mechanisms resulting in decreased NF-kBactivation and inflammatory cytokine induction after acute alcoholconsumption are being investigated. Please contact Dr. Szabo for details.
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Xiao, Hang
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Rotation Projects: Rotations: Targeting the IFN-?-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking real-time autoreactive T cell migration and interactions within the skin: We are usin…
Rotation Projects: Rotations: Targeting the IFN-g-chemokine axis for treatment of vitiligo: We are using our newly developed mouse model and human tissues from patients with vitiligo to identify the cytokines and chemokines that are expressed within the depigmenting skin and which skin cells produce them. We are using genetically modified mouse strains (knockouts, conditional knockouts, fluorescent reporter strains), and cytokine and chemokine neutralizing antibodies to identify the key proteins required for disease. This data will permit us to rationally develop and test new therapeutic agents. Understanding the proinflammatory signals generated by melanocytes under cellular stress. Melanocytes from vitiligo patients have intrinsic abnormalities, including cellular stress evidenced by increased production of reactive oxygen species (ROS) and activation of the unfolded protein response (UPR). The immune system has evolved to recognize this stress as damage-associated molecular patterns (DAMPs), which activate innate immunity. We are using human cells and tissues to determine how cellular stress, innate immunity, and adaptive immunity cooperate to initiate and perpetuate depigmentation in vitiligo. Developing a humanized mouse model of immune-skin interactions to serve as a pre-clinical bridge to clinical studies: We are developing a humanized mouse model of skin disease that consists of an immunodeficient mouse strain as a host for an autologous human skin graft and immune reconstitution in order to study mechanisms of inflammation in the skin, including allergic contact dermatitis, response to infection, tumor immunotherapy, and autoimmunity, all within a fully human environment. This model system will act as a pre-clinical bridge between mouse models and human clinical trials, providing an opportunity to test new treatments on human cells and tissues prior to initiating trials on patients. Tracking autoreactive T cell interactions within the skin: We are using fluorescently tagged C…
Summary: Interests: Vitiligo, autoimmunity, immunology, translational research
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Karellas, Andrew
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Vedantham, Srinivasan
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Goldberg, Robert
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Professor
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Adjunct Professor
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HR job title: Adjunct Professor
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Driban, Jeffrey
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Featured Videos: https://profiles.umassmed.edu/profile/40402890
full name: Jeffrey B Driban PhD, AT Ret, CSCS
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Chair and Professor
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Professor
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Chair and Professor
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Chair and Professor
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Associate Professor
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Walkey, Allan
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Servais, Elliot
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Moffatt-Bruce, Susan
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Mosenthal, Anne
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Medicine at UMass Chan - Lahey
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Psychiatry at UMass Chan - Lahey
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Surgery at UMass Chan - Lahey
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Professor
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Professor
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https://profiles.umassmed.edu/profile/40402890
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Associate Professor
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Pathology at UMass Chan - Lahey
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Radiology at UMass Chan - Lahey
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Wald, Christoph
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Cardio Thoracic Radiology
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Health System Science
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Neurointerventional Radiology
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Pulmonary Medicine
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Professor Emeritus
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Professor Emeritus
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Professor
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Cardio Thoracic Surgery
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Stroke and Vascular Neurology
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Chair and Professor
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Assistant Professor
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Patel, Smita
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Person ID: 10247840
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Assistant Professor
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McAlindon, Timothy
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Hesketh, Paul
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Professor
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Martinez, Fernando
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Endowed Chair Honorary Title: Joseph D. Early Chair in Biomedical Research
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Professor
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Krings, Timo
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Goldsweig, Andrew
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Person ID: 10248018
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Perrino, Carmen
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Person ID: 10248039
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Assistant Professor
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Associate Professor
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HR job title: Associate Professor
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Hartford, Alan
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Person ID: 10248071
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Professor
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Maron, Martin
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Maron, Barry
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Person ID: 10248130
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Adjunct Professor
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Professor
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position in division: Rheumatology
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Chair and Professor
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Reynolds, Matthew
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Professor
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Instructor
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Professor
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Professor Emeritus
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Assistant Professor
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Associate Professor
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Chair And Professor
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Chair And Associate Professor
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Professor Emeritus
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position in division: Health System Science
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Psychiatry and Behavioral Sciences
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Associate Professor
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Assistant Professor
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Professor
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Associate Professor
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Professor
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Adjunct Professor
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position in division: Health Informatics And Implementation Science
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Assistant Professor
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HR job title: Assistant Professor
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Assistant Professor
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HR job title: Assistant Professor
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Professor
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HR job title: Professor
position in organization: UMass Chan Medical School

Shin, Dong-Soo
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Lamb, Carla
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Watkins, Ammara
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Vanni, Alex
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Summary: Dr. Alex J. Vanni is an internationally recognized expert in reconstructive urologic surgery and a Professor of Urology at Lahey Hospital and Medical Center, where he serves as Director of the Center for Reconstructive Urologic Surgery. He specializes in the treatment of urethral stricture disease and advanced male genitourinary reconstruction.
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webpage: https://profiles.umassmed.edu/profile/111866126

Associate Professor
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HR job title: Associate Professor
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Canes, David
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Associate Professor
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HR job title: Associate Professor
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Professor
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HR job title: Professor
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Chair and Professor
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HR job title: Chair and Professor
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Assistant Professor
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HR job title: Assistant Professor
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Rieger-Christ, Kimberly
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Person ID: 10248582
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Chair and Associate Professor
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sort order: 1
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HR job title: Chair and Associate Professor
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Adjunct Professor
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sort order: 1
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Associate Professor
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HR job title: Associate Professor
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Associate Professor
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